Muhammad Usman

#PostdocPosition!!!.The project is to understand Pf protein degradation in the context of artemisinin resistance. Valued skills: CRISPR/Cas gene editing, IP/WB, microscopy, proteomics.Apply: https://lnkd.in/e8jkpT7c #Malaria #Plasmodium #Microscopy #ArtemisininResistance #GeneEditing #Proteomic

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Novel Mechanism Supports Antitumor Response and T-cell Survival https://lnkd.in/da4ksju2

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2 Postdoc positions in tumor heterogeneity (wet-lab or dry-lab) Postdoc Position - Investigating Tumor Heterogeneity German Cancer Research Center See the full job description on jobRxiv: https://lnkd.in/dp8NARN7 #cancer_genomics #epigenomics #immunotherapy #precision_oncology #sarcoma #translational_research #tumor_microenvironment

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Proud of our last publication on Pharmacological Research entitled "Nanoparticles Encapsulating Phosphatidylinositol Derivatives Promote Neuroprotection and Functional Improvement via a long-lasting activation of TRPML1 lysosomal channel in Preclinical Models of ALS" Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease currently incurable, in which motor neuron degeneration leads to voluntary skeletal muscle atrophy. Self-assembled nanoparticles releasing PI(3,5)P2 may prolong ALS animal survival and reduce ALS motor symptoms. These nanoparticles can be used to co-deliver RNAs for combined therapies against ALS. Thank you to the team of prof. Agnese Secondo and all the other collegues for the stimulating collaboration. #ALS #Amyotrophiclateralsclerosis #lipidnanoparticles #selfassemblingnanoparticles #LNP #SANP #lysosomaldisfunction #TRPLM1 #neurodegenerativedisease https://lnkd.in/dDRgCXnw

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https://lnkd.in/gpb9NJf9   Article title: Comparison of hipO and ceuE Gene Based PCR Assays for the Detection of Campylobacter Jejuni   Author(S): Naim Deniz Ayaz*, Muammer Goncuoglu, Omer Cakmak and Irfan Erol   Journal: Journal of Clinical Microbiology and Biochemical Technology   Journal ISSN: 2581-527X Abstract: The objective of this study was to find out the reproducibility and specifity of hipO and ceuE genes based PCR assays for the detection of Campylobacter jejuni isolated from turkey meat samples in a previous study. A total of 44 Campylobacter isolates including 41 C. jejuni, two C. coli and one C. lari were used in this study. Although all of the C. jejuni isolates were verified by hipO based PCR assay, only 18 of the 41 C. jejuni were detected as positive by ceuE based PCR assay. Both of the methods showed negative reaction with C. coli and C. lari isolates. The results showed that, hipO gene based PCR assay is more reproducibly and specific than ceuE gene specific PCR analyze for the detection and identification of C. jejuni. #Campylobacterjejuni #hipO #ceuE #PCR   #CellularMicrobiology #EnvironmentalMicrobiology #MedicalMicrobiology #IndustrialMicrobiology #MarineMicrobiology #AquacultureMicrobiology #Bacteriology #Chlamydiology #Rickettsiology #Peertechz #PeertechzPublications #Mycobacteriology #AerobicActinomycetes #Mycology #Parasitology #Virology #ClinicalVeterinaryMicrobiology #Epidemiology #Biochemical #Endocytosis #Exocytosis #MembraneBiology #CellMigration #CellMatrix #OrganelleBiogenesis #Cytoskeleton #Proteolysis #CellDeath #CellCycle #CancerResearch #CellGrowth #CellDeath #CellDifferentiation #DrugTargets #GeneTherapy #DiseaseModels #Proteomics #StemCells #Bioenergetics #Mitochondria #FreeRadicals #RedoxSignaling #IonTransport #OxidativeStress #CellularMetabolism #XenobioticMetabolism #Metabolomics #CircadianControls #Hormones #Photosynthesis #CellSignaling #NitrogenFixation #PlantDisease #TransportProcesses #PlastidSystems #CellWallSynthesis #Phosphorylation #ProteinKinases #Phosphates #Ubiquitination #LipidSignaling #SecondMessengers #Cytokines #Receptors #GrowthFactors #GProteins #Integrins #NitricOxide #Enzymology #MolecularMechanisms #Biophysics #BiomolecularAssociations #SystemsBiology #ChemicalBiology #ProteinStructure #NucleicAcids #AminoAcids #DrugDesign #BiomolecularTargets #Lipids #Carbohydrates #EnvironmentalBiotechnology #MetabolicEngineering #TissueEngineering #Biodiversity #AgroBiotechnology #MedicalBiotechnology

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Thank Allah, another paper has been published in ChemistrySelect, an ISI-indexed journal (Q3). Link: https://lnkd.in/gqdPkNky Title: Nucleoside-Based Drug Target with General Antimicrobial Screening and Specific Computational Studies against SARS-CoV-2 Main Protease Important results: ·        The review article aims to enhance progress in the development of nucleoside-based medications for the treatment of SARS-CoV-2 and other newly emerging infectious illnesses. ·         The primary focus is on the main viral protease (Mpro) and the investigation of nucleoside-based drugs as potential therapeutic agents. ·        The research examines the effects of acylation-induced alterations on the nucleoside hydroxyl group and its subsequent attributes. ·        Nucleoside analogs are synthesized and then subjected to thorough screening to evaluate their effectiveness in combating microorganisms, leveraging their varied biochemical characteristics. ·         Computational pharmacokinetics is essential in drug design as it helps forecast pharmacokinetic characteristics, enzyme interactions, and the stability of analogs in biological settings. ·        Computational investigations have revealed complex interactions between analogs and the active site of the main protease, leading to a better understanding of nucleoside candidates with inhibitory efficacy against SARS-CoV-2 Mpro. ·        This review incorporates computational findings on the interactions between nucleoside analogs and SARS-CoV-2 Mpro, offering significant insights for drug development.

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Discovery of Antimicrobial Lysins from the “Dark Matter” of Uncharacterized Phages Using Artificial Intelligence https://lnkd.in/dFw9MyYs https://lnkd.in/dmPhmqj3

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#openposition_alert See the below for detailed information and application To #stayinformed on the latest #jobopenings & #openpositions by #connecting with me on LinkedIn! #jobs #openpositions #Biotechjobs #microbiologyjobs #lifesciencejobs #MolecularBiologyJobs #careeroppurtunities #Labopportunities #ResearchJobs #LifeSciCareers #clinicalresearch #opportunities2024 #postdoc

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Download and read the following in first column on on page 2 (P934)"As strongly requested by the reviewers, here we cite some references [35–47] although they are completely irrelevant to the present work." It seems funny but it is quite serious. Everything can be manipulated and we talk about numbers now a days in terms of citations, impact factors and ranking. It is sad but it is reality of what is going on now a days.

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Postdoc vs Assistant Prof 👉 6 key differences you need to know: Make an informed decision for your future in academia. Thinking about your next career move? Consider these differences carefully before making a choice. ⌛ Duration: - Postdoc: Short-term, typically 2 years - Assistant Prof: Long-term, permanent 👥 Key responsibilities: - Postdoc: Conduct research - Assistant Prof: Teaching, research, and service to the university 🌐 Academic Freedom: - Postdoc: Limited autonomy in research direction - Assistant Prof: Greater autonomy in research, teaching, and academic pursuits 💰 Grant Writing: - Postdoc: Assists in grant writing efforts - Assistant Prof: Expected to write and secure grant funding for research 🚀 Career Promotion: - Postdoc: Limited, primarily based on research output - Assistant Prof: Based on teaching, research, service 🏦 Funding Source: - Postdoc: Typically funded by grants or fellowships - Assistant Prof: Salary from the university Which path aligns best with your goals and aspirations? What did I miss? #postdoc #professor #phd #academia 🔄 repost to help a friend :) ------------------------------ Are you ready to unlock the secrets to crafting an application that grabs hiring committees' attention? Then grab my comprehensive insider guide "Get Shortlisted" plus get templates for CV, Cover Letter, Teaching Statement, Research Statement: https://lnkd.in/e87Tdgnd

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#JobAlert Open project assistant/ postdoc positions in #computational biology, #bioinformatics and #immunology We are hiring project assistants & postdocs to explore novel variants of antimicrobial peptides of therapeutic relevance against AMR. Project Name: Exploring novel variants of antimicrobial peptides of therapeutic relevance against AMR Project Profile: Antimicrobial peptides (AMPs) have emerged as an alternative to conventional antibiotics in the face of antimicrobial resistance due to their broad-spectrum antimicrobial, antifungal, and antiviral activities and lower rates of microbial resistance evolution against them. Importantly, the multimodal antimicrobial activity of AMPs significantly reduces the evolution of antimicrobial resistance (AMR) against them. Thus, AMPs are getting integrated into clinical practices where the AMPs work individually or synergistically with other AMPs and conventional antimicrobial agents. A growing number of studies have recently implemented both empirical and computational methods to isolate novel AMP variants from extinct and extant animal taxa or obtain synthetic AMPs with predictably higher antimicrobial efficacy, followed by clinical trials. Using bioinformatics to analyse big genomic, metagenomic or proteomic datasets across species provides a more streamlined and cost-effective solution than directly adopting an empirical paradigm. Therefore, this project aims to understand and analyse the diverse repertoire of natural and synthetic AMPs, their structural and functional characterisation, and the identification of complementary molecules for cocktails. In this context, two positions are available for a project assistant and a postdoctoral fellow to work on a collaborative, co-supervised project in Dr Imroze Khan’s laboratory at Ashoka University. A suggested initial specific focus of the work is on identifying novel variants of AMPs implementing large language models (LLMs) and comparative bioinformatics followed by in-silico modelling of structure and function. #Duration Both positions are expected to start around October 2024. Initially funded for 1.5 years, the postdoctoral candidate is expected to apply for national and, if appropriate, international postdoctoral fellowships. #Remuneration For the project assistant position: A monthly stipend of up to INR 45,000 (based on experience) For the postdoctoral position: A monthly salary of up to INR 70,000 (based on experience). To #apply and for more #details, visit https://lnkd.in/gNQj6mZ5 For any query, write to [email protected]

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Small cell lung cancer (SCLC) is highly aggressive with poor prognosis. Despite a relative prevalence of circulating tumour DNA (ctDNA) in SCLC, liquid biopsies are not currently implemented, unlike non-SCLC where cell-free DNA (cfDNA) mutation profiling in the blood has utility for guiding targeted therapies and assessing minimal residual disease. cfDNA methylation profiling is highly sensitive for SCLC detection and holds promise for disease monitoring and molecular subtyping; cfDNA fragmentation profiling has also demonstrated clinical potential. Extrachromosomal DNA (ecDNA), that is often observed in SCLC, promotes tumour heterogeneity and chemotherapy resistance and can be detected in blood. We discuss how these cfDNA profiling modalities can be harnessed to expand the clinical applications of liquid biopsy in SCLC. New review on the clinical applications of cell-free DNA profiling in small cell lung cancer. The text above is from the author's abstract, the full paper can be found here: https://lnkd.in/ejFS5z-c

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Pay money! Get attention! Get your work recognized! The study ignored one aspect: Review process! The study should have collected data on review process- viz duration, ease, rigor, quality etc followed in OA journals, and should include other publishers too (in addition to Springer)!

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This recent publication introduces a novel approach to bioanalysis for oligonucleotide therapeutics (OT) using a non-ion pairing reverse phase liquid chromatography-mass spectrometry (nonIP-RP-LC-MS) method. The research provides a cost-effective 💰 and efficient ⚙️ alternative to the conventional ion pairing methods, addressing key issues such as reagent costs, memory effects, and ion suppression. This method, utilizing ammonium bicarbonate (ABC) as a mobile phase additive, demonstrates high versatility and sensitivity 🎯, making it applicable to various oligonucleotide types. 🔑 𝐊𝐞𝐲 𝐓𝐚𝐤𝐞-𝐀𝐰𝐚𝐲𝐬: • A new nonIP-RP-LC-MS method was developed for OT bioanalysis, eliminating the need for ion pairing reagents 🧪 • The use of ammonium bicarbonate (ABC) significantly improved sensitivity and reduced issues associated with traditional methods 💡 • This method demonstrated high compatibility with different oligonucleotide types, including chemically modified variants 🌐 • The developed approach provides a broad dynamic range and sensitivity suitable for OT bioanalysis in reconstituted plasma 📊 #Bioanalysis #OligonucleotideTherapeutics #LCMS #ScientificInnovation #Pharmaceuticals Yoshiharu Hayashi and Yuchen Sun

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Join us as #mechanobiology postdoc to study vibrational information transfer between living cells in the extracellular matrix Postdoc/PhD in Cell Mechanobiology Tel-Aviv University See the full job description on jobRxiv: https://lnkd.in/dHCP7X67 #3D_cell_culture #bioengineering #biological_physics #biomechanics #mechanobiology

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Join us as #mechanobiology postdoc to study vibrational information transfer between living cells in the extracellular matrix Postdoc/PhD in Cell Mechanobiology Tel-Aviv University See the full job description on jobRxiv: https://lnkd.in/dfBM25Mu #3D_cell_culture #bioengineering #biological_physics #biomechanics #mechanobiology

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https://lnkd.in/eDyV3gY5 Cyclohexenone oxime esters can be used as substrates for a Cu-catalyzed synthesis of primary arylamines with meta-substituents.

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