Biological Sciences Group Journals’ Post

Investigation of genetic regulation of infection- and defence- processes is key in phytopathological research. Molecular and biochemical analyses are accompagnied by phenotypic studies to evaluate the effect of pathogen activities on plant development and to rate pathogen-induced symptoms. Increasingly imaging and image processing are applied to measure phenotypic effect in plant pathology. In the current example, LemnaTec phenotyping technology was used to determine growth and development of the plants and it was applied to assess disease severity. In Arabidopsis, systemic resistance was triggered by Trichoderma, and this resistance was active against Botrytis infections. To analyze the (epi-)genetic control of these processes, mutants were studied, and growth and disease phenotypes served to determine gene functions. Casas-Flores S., Rosendo-Vargas M.M., Ávila-Castillo V. (2024) The Arabidopsis Dcl3, Ago9, DNA Methyltransferases and Dcl1 are Required for Triggering the Systemic Resistance Mediated by Trichoderma Atroviride. https://lnkd.in/eYS652PN #phenotyping #plantpathology #phytopathology #science #lifescience

https://lnkd.in/g-r_W2nt   Article title: To Find out the Essentiality of Rv0526 Gene in Virulence of Mycobacterium tuberculosis by using In silico Approaches   Author(S): Shivangi, Amjad Beg, Swati Meena and Laxman S Meena*   Journal: Open Journal of Bacteriology   Journal ISSN: 2640-8007 Abstract: uberculosis has emerged as a major world health problem, with almost one-third of the world population today infected with Mycobacterium tuberculosis H37Rv (M. tuberculosis). This gram-positive bacterium makes so many complications in its eradication completely. We need a proper way to inhibit its pathogenesis. Rv0526 (651bp/ 216 aa) is predicted to be a thioredoxin (Trx) like protein of Rv3673 family form a single transmembrane helix and show similarity to other M. tuberculosis thioredoxin-like proteins Rv1470, Rv1471, Rv1677. Trx are proteins that act as antioxidants by facilitating the reduction of other proteins by cysteine thiol-disulfide exchange, and it acts by its specific motif Cys37-Cys40 (CXXC). By using several bioinformatics tools, we may predict that Rv0526 may be an important component of cytochrome c maturation complex and show interaction with different other proteins. After knowing such specific features of this gene we may predict that mutational studies in Rv0526 gene may open new way towards the drug development. #M #Tuberculosis #CXXC #CCM #Rv0526   #Antibiotics #Bacteria #BacterialAdhesin #BacterialBiochemistry #BacterialCapsule #BacterialCellStructure #BacterialEnzymology #BacterialGeneticNomenclature #BacterialGrowth #BacterialInfections #BacterialMorphologicalPlasticity #BacterialNanowires #Peertechz #PeertechzPublications #BacterialOxidation #BacterialPatterns #BacterialPhyla #BacterialProteins #ClinicalBacteriology #ClinicalMycology #FungalInfections #FungalPharmaceutics #FungalProteins #IndustrialBacteria #IndustrialFungus #MedicinalMushrooms #MedicinalMycology #Mycotoxicology #Mycotoxins #OrganicBiomolecules #PathogenicFungi #Pathology #Prebiotics #Probiotics #SecondaryMetabolites

Unlike conventional phage-resistance mechanisms involving genetic mutations, TM7x induces physiological changes in the host bacterium, altering gene expression without altering its genetic makeup. #phage #phageresistance #microbiome #bacteriophage #thephage #parasite https://lnkd.in/ebQrxjXk

📢 Original article Sharing-Vol. 29 No. 6 💕 Title: Revealing the Role of CYP346 Family Genes on Phosphine Resistance in Indian Populations of Tribolium castaneum 🤵 Authors: Mudagadde G Deeksha,†, Suresh M Nebapure, Doddachowdappa Sagar, Ramcharan Bhattacharya, ANIL DAHUJA, Subramanian Sabtharishi*,† 🔔 Full Text: https://lnkd.in/gzaYMtmV 🔑 Keywords: enzyme activity gene expression fumigant resistance storage pest 😎Welcome to your reading! #Bioscience #biomedicalscience #biochem #medicalscience #ScienceCommunication #Biochemistry #StemCell #Virology #CancerResearch #immunology #Genetics #MolecularBiology #Microbiologyg #medicine #health #CellularHealth #CellCancer

Happy to Share Our Latest Research! I'm happy to announce the publication of our new research paper, "Gene silencing of Histidyl-tRNA synthetase in Leishmania donovani promastigotes inhibits parasite growth and reduces virulence: A comprehensive computational and in vitro study," where I had the privilege of contributing as a co-author. This study delves into the identification of Histidyl-tRNA synthetase as a potential therapeutic target in Leishmania donovani promastigotes. By silencing this crucial gene, we observed significant inhibition of parasite growth and virulence. Our work combines computational approaches and in vitro techniques to provide a comprehensive understanding of this target's role, opening up new avenues in the fight against leishmaniasis, a neglected tropical disease. As antimicrobial resistance (AMR) continues to pose a significant global health challenge, identifying novel targets like this one is critical. This research represents a step forward in developing targeted therapies that could help combat resistant strains and reduce the disease burden. I extend my heartfelt gratitude to my co-authors. link: https://lnkd.in/gqJaVdKD Let's continue the fight against AMR and strive for a healthier future! #research #leishmaniasis #AMR #DrugDevelopment #bioinformatics #GlobalHealth #biotechnology #antimicrobialresistance #sciences https://lnkd.in/gqJaVdKD

Gut microbes in mice edited at will The bacteria found in mouse guts can be altered at will thanks to a gene-editing tool. Researchers used a bacteria-infecting virus to deliver a ‘base editor’, which targeted specific nucleotide bases in the DNA of Escherichia coli in the guts of the living mice. Scientists used the base editor to change A to G in the E. coli gene that produces β-lactamases — enzymes that drive bacterial resistance to several types of antibiotic. After eight hours, 93% of the genes had been edited. The same team also adapted the base editor so it could modify an E. coli gene that produces a protein that is thought to play a part in several neurodegenerative and autoimmune diseases. Next the researchers want to investigate editing genes for microbiome-specific diseases. #gutmicrobiome #geneediting #virusbaseeditor #ecoli #AMR #blactamases #bacteria #mice #DNAedition https://lnkd.in/dtkJvuiB

🌱 New findings on Medicago truncatula's nodulation regulation! SUNN pathway disruption in mutants reveals constitutive gene expression changes, but response to rhizobia resembles wild-type, including induction of nodulation regulators TML1 and TML2. 🌿 🔗 Read the study : https://lnkd.in/eyncjvKh #Nodulation #PlantBiology #SUNNPathway #MedicagoTruncatula

The study in One Health Advances reveals the high prevalence of the beta2 toxin gene cpb2 in Clostridium perfringens from pigs, suggesting a selective advantage for survival in the pig intestine. Interestingly, this enrichment is driven by the cpb2 gene itself, not the pCP13-like plasmids. The cpb2 gene was consistently found on a specific genetic segment linked to a transcriptional regulator (PadR family), highlighting its potential for gene transmission. These findings offer valuable insights into the genetic context and biological function of cpb2, paving the way for future research. #ClostridiumPerfringens #cpb2Gene #GenomicResearch #AnimalHealth #MicrobialGenomics 🔺 Read it here: https://lnkd.in/dqiyhUEx

Bacteriophages are recognized for their pivotal role in facilitating lateral gene transfer among bacterial populations. This phenomenon, termed phage-mediated transduction, involves the transfer of genetic material from one bacterium to another #phagetherapy #bacteria #gene #bacteriophages #thephage https://lnkd.in/eS3Tmm4W