Cutaneous Malignancies

CUTANEOUS MALIGNANCIES
Asmara Syed Click to edit Master subtitle style
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35 year-old male with 9 year history of a skin rash presented with hypopigmented patches on trunk and extremities.
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DIFFERENTIAL
DIAGNOSIS??????
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MYCOSIS
FUNGOIDES
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Most common primary cutaneous T cell lymphoma Usually elderly or other adults May arise from progression of large plaque psoriasis Usually protracted clinical course over years By definition, are negative for HIV1,
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Premycotic General
(patch) stage
Usually indolent course
Gross
description
Erythematous, scaly and pruritic skin
Microscoy
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Tumorous General
stage
Treatment:
Systemic chemotherapy
Microsopy
Dense dermal infiltrates of atypical T cells with cerebroid nuclei (with thin sections) 8/12/12
42-year-old male with a scalp mass
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DIFFERENTIAL
DIAGNOSIS??????
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ECTOPIC
MENINGIOMA
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Extra-cranial
meningiomas can occur in three settings. First, in children, they represent developmental abnormalities related to neural tube closure defects. These seem to have a similar pathogenesis as meningoceles and are associated with a good prognosis when excised. Second, they may occur as primary soft tissue meningiomas derived from arachnoid nests associated with cranial or spinal nerves.
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46-year-old
female with a skin nodule
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DIFFERENTIAL
DIAGNOSIS????
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LANGERHANS CELL HISTIOCYTOSIS
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Also
called histiocytosis X
Langerhans
cells are derived from bone marrow, circulate freely from skin to regional lymph nodes or multiple lesions (papules, nodules, plaques) infants, resembles seborrheic keratosis diffuse dermal infiltrate of Langerhans cells (large, ovoid, pale pink cytoplasm, indented bland nuclei) or clusters of Langerhans cells which 8/12/12
Solitary In
Micro:(1)
(2)
The
patient is a 51-year old female with a plaque-like tumor on the back.
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DIFFERENTIAL
DIAGNOSIS??????
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DERMATOFIBROSARCOMA
PROTUBERANS (DFSP)
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31-year-old
female with forehead lesion
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DIFFRENTAIL
DIAGNOSIS?????
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ANGIOLYMPHOID
HYPERPLASIA WITH
EOSINOPHILIA
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23-year-old
female with a lower lip
lesion.
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DIFFERENTIAL
DIAGNOSIS?????
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ANGIOMATOID
FIBROUS HISTIOCYTOMA
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68
year old male with patches on his elbows and buttocks.
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DIFFERENTIAL
DIAGNOSIS????
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LYMPHOMATOID
PAPULOSIS
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Rare,
self-healing, recurrent papular eruption Indolent clinical course, although 10% are associated with or evolve to anaplastic large cell lymphoma May be self healing benign phase of anaplastic large cell lymphoma
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Micro
description
Wedge shaped on low power with base of lymphocytes at epidermis and tip deep within reticular dermis Polymorphic superficial dermal infiltrate, usually perivascular, with thin epidermis Occasional atypical lymphoid cells resembling Reed-Sternberg cells or lumps of coal Often obscures dermoepidermal junction with variable epidermotropism
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Differential
diagnosis ======================== ======================== ======================== = Arthropod bite
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Nine
month old with a neck mass.
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DIFFERENTIAL
DIAGNOSIS????
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JUVENILE
XANTHOGRANULOMA
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This
patient had numerous pigmented skin lesions and a subcutaneous nodule. The nodule was resected.
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DIFFERENTIAL
DIAGNOSIS????
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PLEXIFORM
NEUROFIBROMA
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Definition Benign peripheral nerve sheath tumor that surrounds multiple nerve fascicles Has irregularly thickened, distorted, tortuous structure Plexiform:complex; in the form of a plexus or network Site Orbit, face, neck, back, inguinal Nodular or diffuse Diffuse cases are also known as 8/12/12 elephantiasis neurofibromatosa;
Positive
stains
S100 in scattered cells (unlike strong staining in schwannoma) Perineurial cells are EMA+ in plexiform but not in ordinary neurofibromas Diagnosis Plexiform schwannoma
Differential
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Cutaneous Malignancies

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Cutaneous Malignancies

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CUTANEOUS MALIGNANCIES

Asmara Syed Click to edit Master subtitle style

Usually indolent course

Erythematous, scaly and pruritic skin

42-year-old male with a scalp mass

female with a skin nodule

LANGERHANS CELL HISTIOCYTOSIS

patient is a 51-year old female with a plaque-like tumor on the back.

female with forehead lesion

female with a lower lip

year old male with patches on his elbows and buttocks.

diagnosis ======================== ======================== ======================== = Arthropod bite

month old with a neck mass.

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