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    Granulomatous Mastitis: The Histological Differentials: Click To Edit Master Subtitle Style

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    Asmara Syed
    This document discusses two types of granulomatous mastitis: idiopathic granulomatous mastitis (IGM) and tuberculous mastitis (TBM). A study of 62 cases found that TBM tended to occur in younger patients and presented with larger lesions than IGM. Histologically, TBM showed more fibrosis, eosinophils, and necrosis, while IGM was associated with more plasma cells. However, characteristics of granulomas and giant cells were not distinguishing between the two conditions. The study aims to help differentiate between IGM and TBM, as accurate diagnosis is important for determining appropriate treatment.

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    Granulomatous Mastitis: The Histological Differentials: Click To Edit Master Subtitle Style

    Uploaded by

    Asmara Syed
    53 views13 pages
    This document discusses two types of granulomatous mastitis: idiopathic granulomatous mastitis (IGM) and tuberculous mastitis (TBM). A study of 62 cases found that TBM tended to occur in younger patients and presented with larger lesions than IGM. Histologically, TBM showed more fibrosis, eosinophils, and necrosis, while IGM was associated with more plasma cells. However, characteristics of granulomas and giant cells were not distinguishing between the two conditions. The study aims to help differentiate between IGM and TBM, as accurate diagnosis is important for determining appropriate treatment.

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    GRANULOMATOUS MASTITIS

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    This document discusses two types of granulomatous mastitis: idiopathic granulomatous mastitis (IGM) and tuberculous mastitis (TBM). A study of 62 cases found that TBM tended to occur in younger patients and presented with larger lesions than IGM. Histologically, TBM showed more fibrosis, eosinophils, and necrosis, while IGM was associated with more plasma cells. However, characteristics of granulomas and giant cells were not distinguishing between the two conditions. The study aims to help differentiate between IGM and TBM, as accurate diagnosis is important for determining appropriate treatment.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    53 views13 pages

    Granulomatous Mastitis: The Histological Differentials: Click To Edit Master Subtitle Style

    Uploaded by

    Asmara Syed
    This document discusses two types of granulomatous mastitis: idiopathic granulomatous mastitis (IGM) and tuberculous mastitis (TBM). A study of 62 cases found that TBM tended to occur in younger patients and presented with larger lesions than IGM. Histologically, TBM showed more fibrosis, eosinophils, and necrosis, while IGM was associated with more plasma cells. However, characteristics of granulomas and giant cells were not distinguishing between the two conditions. The study aims to help differentiate between IGM and TBM, as accurate diagnosis is important for determining appropriate treatment.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 13

    Click to edit Master subtitle style

    GRANULOMATOUS MASTITIS: THE HISTOLOGICAL DIFFERENTIALS


    4/24/12

    INTRODUCTION
    The management of granulomatous

    mastitis depends on the causative factor and accurate diagnosis between IGM( Idiopathic granulomatous mastitis and tuberculous mastitis (TBM) is indespensible.This is particularly problematic in the cases of granulomatous mastitis in which the microbiological studies are negative. In this study, in a large cohort, the 4/24/12

    METHODS
    The histopathology files from the two

    participating hospitals were searched for cases of granulomatous inflammation of the breast over 8 year period.The parameters assessed included age of the patient, lesional size, systemic and local symptoms and histological findings of inflammatory cells, granulomas, necrosis, multinucleated giant cells, fibrosis and calcifications. 4/24/12

    RESULTS
    29 cases of IGM and 33 cases of TBM TBM occurred in a significantly

    younger population (p<0.05) and larger lesional size than IGM(p<0.01)


    No significant difference between

    mass, local and systemic symptoms.


    Histological parameters: TBM showed

    more fibrosis,eosinophils(p<0.01) & necrosis(P<0.01)


    4/24/12

    IGM group showed more plasma

    cells(p<0.01)
    Taking all the cases together as one

    group to evaluate the relationship between the histological parameters, there was significant positive correlation between eosinophils & fibrosis(p<0.01) and negative correlation between vague and well formed granulomas (p<0.01).
    4/24/12

    CONCLUSION
    TBM was more likely to occur in

    youger patients with a larger clinical mass at presentation. Histologically, TBM tends to show more eosinophils and necrosis and IGM is associated with more plasma cells. The characterstics of the granulomas and giant cells are not distinguishing features.
    4/24/12

    4/24/12

    Click to edit Master subtitle style RELEVANCE TO HISTOLOGIC

    OF DIFFERENTIATION

    GRADE AND DEGREE

    OCT4 EXPRESSION IN IMMATURE TERATOMA OF THE OVARY


    4/24/12

    INTRODUCTION
    Immature teratoma of the ovary

    uncommon tumor- 1% of ovarian malignancies


    Amount of immature neuroepithelium

    is an important prognostic factor. Biological significance of immature neuroepithelium is poorly understood.


    The aim of the study was to

    systemically evaluate the expression of OCT4 along with that of two other 4/24/12

    MATERIALS AND METHODS


    19 cases of primary immature

    teratoma of the ovary between 1992 to 2009.


    18 cases were pure immature

    teratomas.
    7 were grade 3, 6 were grade 2 and 5

    were grade 1.
    15 cases of mature teratoma with

    neural tissue were also assessed for 4/24/12 comparison

    RESULTS
    OCT4 was expressed in the immature

    neuroepithelium all 7 gradeIII cases and 2 grade II cases.


    PAX6 was expressed in the immature

    neuroepithelium of all immature teratomas but not in OCT4 positive cells.


    CD56 was expressed in neural tissue

    of various maturities.
    4/24/12

    So neural tissue was classified into 3

    distinct categories:
    OCT4 positive/PAX6 negative/CD56

    (Possibly the most immature neuroepithelium)


    OCT4-/PAX6+/CD56+ (Possibly

    neuroepithelium of intermediate maturity)


    OCT4-/PAX6-/CD56+ (Possibly mature

    neuroepithelium)

    4/24/12

    CONCLUSION
    The finding that OCT4 expression was

    exclusively detected in immature neuroepithelium of high grade immature teratomas indicates that OCT4 might serve as a promising biomarker for the diagnosis of highly malignant cases of immature teratoma.

    4/24/12

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