About
I am a commercially focused sales and marketing professional with a proven track record…
Activity
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Finishing the year with a little festive fun with my team Azenta Life Sciences 💜🌍 We all need a little motivation for those year- end admin tasks!…
Finishing the year with a little festive fun with my team Azenta Life Sciences 💜🌍 We all need a little motivation for those year- end admin tasks!…
Liked by Lucy Cook
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At Supreme, we help life science, biotech, and pharma companies enhance their online presence and maximize ROI through paid advertising and ABM…
At Supreme, we help life science, biotech, and pharma companies enhance their online presence and maximize ROI through paid advertising and ABM…
Liked by Lucy Cook
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Education
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Publications
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Can toxicogenomics provide information on the bioreactivity of diesel exhaust particles?
Toxicology
Epidemiologists have linked increased cardio-respiratory hospital admissions, morbidity and mortality rates and increases in particulate matter with an aerodynamic diameter less than 10 microns (PM10) concentrations (Anderson et al., 1991). PM10 consist of a heterogeneous mixture of particles that include minerals, metal oxides, sea salt, biological components and soot. In urban locations, soot, especially ultrafine diesel exhaust particles (DEP), accounts for 20–80% by mass of the airborne…
Epidemiologists have linked increased cardio-respiratory hospital admissions, morbidity and mortality rates and increases in particulate matter with an aerodynamic diameter less than 10 microns (PM10) concentrations (Anderson et al., 1991). PM10 consist of a heterogeneous mixture of particles that include minerals, metal oxides, sea salt, biological components and soot. In urban locations, soot, especially ultrafine diesel exhaust particles (DEP), accounts for 20–80% by mass of the airborne PM10 arising from vehicular activities. In the experiment described here, control [NaCl] and 1.25 mg of DEP were instilled into rat lung and the responses assessed using changes in lung permeability, inflammation and epithelial cell markers in lavage fluid, with the addition of a new technique of gene expression profiling using macroarrays. The aim of the study was to use these macroarrays as a sensitive measurement of acute up- or down-regulation of genes that were taking place in the rat lung in response to the small instilled mass of DEP. DEP instillation caused a slight oedematous lung with no overt inflammation and ten out of a possible 207 (5%) rat stress genes were repeatedly changed in response to DEP instillation. Therefore, the conclusion from the macroarray analysis is in agreement with the conventional toxicology and suggest that DEP elicits a low bioreactive response in a healthy rat lung.
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Conventional and toxicogenomic assessment of the acute pulmonary damage induced by the instillation of Cardiff PM10 into the rat lung.
Sci Total Environ. 2006 May 1;360(1-3):60-7. Epub 2006 Apr 4.
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Elastolytic activity and alveolar epithelial type-1 cell damage after chronic LPS inhalation: effects of dexamethasone and rolipram
Toxicol Appl Pharmacol. 2005 Sep 15;207(3):257-65.
Languages
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French
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Thinking of my children, I am so interested in this …
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Join Ganesh Nawale #TODAY at 11:50am, 14 November, to take a deep dive into #process considerations for your oligo therapeutics #manufacturing…
Join Ganesh Nawale #TODAY at 11:50am, 14 November, to take a deep dive into #process considerations for your oligo therapeutics #manufacturing…
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My FOMO is off the charts! Come and meet my colleagues at booth 408.
My FOMO is off the charts! Come and meet my colleagues at booth 408.
Shared by Lucy Cook
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