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    Thalassemia: Rajesh Kumar Sharma Himalayan College of Nursing

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    Rajesh Sharma
    Thalassemia is a hereditary blood disorder characterized by defective hemoglobin synthesis resulting in anemia. It is caused by total or partial deficiency in the beta polypeptide chain, impairing hemoglobin and red blood cell production. Symptoms include severe anemia starting at 6 months, bone abnormalities, pallor, jaundice, spleen or liver enlargement, infections, and bleeding tendencies. Complications include fractures, arrhythmias, and heart failure. Diagnosis involves blood tests showing microcytic anemia and high fetal hemoglobin levels. Treatment consists of folic acid, blood transfusions, splenectomy or bone marrow transplantation.

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    Thalassemia: Rajesh Kumar Sharma Himalayan College of Nursing

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    Rajesh Sharma
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    Thalassemia is a hereditary blood disorder characterized by defective hemoglobin synthesis resulting in anemia. It is caused by total or partial deficiency in the beta polypeptide chain, impairing hemoglobin and red blood cell production. Symptoms include severe anemia starting at 6 months, bone abnormalities, pallor, jaundice, spleen or liver enlargement, infections, and bleeding tendencies. Complications include fractures, arrhythmias, and heart failure. Diagnosis involves blood tests showing microcytic anemia and high fetal hemoglobin levels. Treatment consists of folic acid, blood transfusions, splenectomy or bone marrow transplantation.

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    Thalassemia

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    Thalassemia

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    Thalassemia is a hereditary blood disorder characterized by defective hemoglobin synthesis resulting in anemia. It is caused by total or partial deficiency in the beta polypeptide chain, impairing hemoglobin and red blood cell production. Symptoms include severe anemia starting at 6 months, bone abnormalities, pallor, jaundice, spleen or liver enlargement, infections, and bleeding tendencies. Complications include fractures, arrhythmias, and heart failure. Diagnosis involves blood tests showing microcytic anemia and high fetal hemoglobin levels. Treatment consists of folic acid, blood transfusions, splenectomy or bone marrow transplantation.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    13 views9 pages

    Thalassemia: Rajesh Kumar Sharma Himalayan College of Nursing

    Uploaded by

    Rajesh Sharma
    Thalassemia is a hereditary blood disorder characterized by defective hemoglobin synthesis resulting in anemia. It is caused by total or partial deficiency in the beta polypeptide chain, impairing hemoglobin and red blood cell production. Symptoms include severe anemia starting at 6 months, bone abnormalities, pallor, jaundice, spleen or liver enlargement, infections, and bleeding tendencies. Complications include fractures, arrhythmias, and heart failure. Diagnosis involves blood tests showing microcytic anemia and high fetal hemoglobin levels. Treatment consists of folic acid, blood transfusions, splenectomy or bone marrow transplantation.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 9

    Thalassemia

    Rajesh Kumar Sharma


    Lecture
    Himalayan College of Nursing
    Thalassemia
    It is a hereditary group of hemolytic anemia's,
    is characterized by defective synthesis in
    polypeptide chains of the protein component
    of hemoglobin. Consequently, RBC synthesis is
    also impaired.
    Causes:- Homozygous or heterozygous
    inharitance
    Pathophysiology
    Total or partial deficiency of beta polypeptide
    chain production impairs hemoglobin synthesis
    and results in continual production of fetal
    hemoglobin. Normally, immunoglobulin
    synthesis switches at birth time. This conversion
    does not happen in thalassemic infants. Their red
    cells are hypochromic and microcytic.
    Sign & symptoms
    Sever anemia @ 6 months of life
    Bone abnormalities
    Pallor
    Yellowish skin
    Splenomegaly or hepatomegaly
    Frequent infection
    Bleeding tendencies
    Small body & large head
    Possibly mental retardation
    Complications
    Pathological fracture
    Cardiac arrhythmias
    Heart failure
    Diagnosis
    CBC
    Microcytosis
    Long bones X-ray
    Fetal Hb level
    Treatment
    Folic acid supplement
    Transfusion of Packed cells
    Splenectomy & bone marrow transplantation
    Nursing considerations

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