vv

Medical Group

Journal of Cardiovascular Medicine and

Cardiology
DOI http://doi.org/10.17352/2455-2976.000062 ISSN: 2455-2976 CC By

Suraj Wasudeo Nagre1* and

Krishnarao N Bhosle2 Research Article
1
Associate Professor, Department of CVTS, Grant
Medical College, Mumbai, India
Cardiac Myxomas - Symptomology,
2
Professor and Head of Department CVTS, Grant
Medical College, Mumbai, India Investigations and Surgical Treatment
Received: 16 April, 2018
Accepted: 30 April, 2018 - Single Centre Experience of Fifteen
Published: 01 May, 2018

*Corresponding author: Dr. Suraj Wasudeo Nagre,

Years at Grant Medical College, Mumbai,
Associate Professor, MBBS, MS, M.Ch [CVTS], DNB.
[CVTS], F.I.A.C.S. 31, Department of CVTS, Grant Maharashtra
Medical College Trimurti Building, JJ Hospital
Compound, Byculla , Mumbai, Pin -400008, India,
Tel: 09967795303; E-mail:

Keywords: Atrial myxomas; Biatrial approach Abstract

https://www.peertechz.com Introduction: The aim of study is to describe the clinical symptoms, investigation findings and
surgical treatment of cardiac myxomas.

Method: From May 2002 to May 2017, 50 patients of primary or recurrent intracardiac myxoma
underwent surgical excision at our institute. Their age ranged from 25 years to 55 years. Out of which
20 males and 30 females. Commonest presenting symptoms are dyspnea and palpitation. 35 Left
atrial, 13 Right atrial, one right ventricular and one left ventricular myxoma. The diagnosis was done by
transthoracic and transesophageal echocardiography. The complete wide excision with margin of 3-5 mm
normal surrounding tissue was the main principle of surgery. Right atriotomy, right ventricular and left
ventricular surgical approach was used. Post-operative echocardiogram was done in all patients before
discharge. Maximal follow-up of five years and minimum follow-up of 6 months was done after surgery.

Results: No mortality. On followup after five years of surgery, all patients were in NYHA class 1 and
their echocardiography showed good ventricular function with normal pulmonary artery pressure with
patch in situ. One of patient right atrial myxoma developed left atrial myxoma after five years of first
surgery that also excised.

Conclusion: We recommend right atriotomy approach for both right and left atrial myxomas. Right
ventricle approach for right ventricular myxoma and left ventricular for left ventricular myxoma. Biatrial
approach in large and unusually located left atrial myxoma. To prevent recurrence the surgical excision
must include a substantial portion of normal surrounding tissue near the base of implantation. With
proper surgical technique no mortality and recurrence with complete recovery.

Introduction heritable disorder with some clinical manifestations. The aim

of study is to describe the clinical symptoms, investigation
Over 72% of primary cardiac tumors are benign. In adults, findings and surgical treatment of cardiac myxomas in our
the majority of benign lesions are myx-omas. Cardiac myxoma institute Grant Medical College, Mumbai.
are uncommon tumours found in 0.5 million population per
year with left atrium being the predominant site. They vary Material and Method
widely in size, and very little is known about their growth rate.
The reported growth rates of left atrial myxomas from several From May 2002 to May 2017, 50 patients of primary or
published case reports appears to vary from no growth, to recurrent intracardiac myxoma underwent surgical excision
between 1.3 to 6.9 mm/month in diameter within patients with at our institute. Their age ranged from 25 years to 55 years.
established myxoma who have not undergone surgery. The Out of which 20 males and 30 females. Commonest presenting
prevalence of cardiac tumors at autopsy ranges from 0.001% to symptoms are dyspnea and palpitation. Common sites found
0.3%, more than 50% of be-nign cardiac tumors are myxomas. are Left atrial 35, Right atrial 13, one right ventricular and one
In 7%, it has genetic origin and rises as a component of a left ventricular myxoma (Table 1).

013

Citation: Suraj WN, Krishnarao NB (2018) Cardiac Myxomas - Symptomology, Investigations and Surgical Treatment - Single Centre Experience of Fifteen Years at
Grant Medical College, Mumbai, Maharashtra. J Cardiovasc Med Cardiol 5(2): 013-015. DOI: http://doi.org/10.17352/2455-2976.000062.
 The diagnosis was done by transthoracic and transesophageal
echocardiography. The complete wide excision with margin of
3-5 mm normal surrounding tissue under GA and CPB with no
touch technique with closure of defect by autologous pericardial
patch was the main principle of surgery (Figure 1).

We has used right atriotomy approach for both right

and left atrial myxomas, right ventricle approach for right
Figure 4: Histopathology of Myxoma showing hemosiderin-laden macrophages,
ventricular myxoma and left ventricular for left ventricular delicate blood vessels and stellate cells in abundant myxoid matrix.
myxoma. Biatrial approach was used only in one patient with
large and unusually located left atrial myxoma. Defect created
by excision closed with pericardial patch. Excised specimen Results
was sent for histopathological examination and confirmation
No short and long term mortality in any of operated cases. On
of diagnosis (Figure 2).
follow-up after five years of surgery, all patients were in NYHA
One of the patient was known case of ischemic heart disease class 1 and their echocardiography showed good ventricular
function with normal pulmonary artery pressure with patch in
preopt diagnosed with left ventrical free clot (Figure 3), but
situ. One of patient right atrial myxoma developed left atrial
on histopathological examination diagnosed as left ventricular
myxoma after five years of first surgery that also excised. So
myxoma (Figure 4).
it is not recurrence as site of origin was different from the
Post-operative echocardiogram was done in all patients previous site of myxoma.

before discharge. Maximal follow-up of five years and Discussion

minimum follow-up of 6 months was done after surgery.
Atrial myxoma is the most common benign tumor of the
heart and has a greater predilection to the left atrium. Embolic
Table 1: Common sites for myxomas. phenomena is thought to be caused by either tumor detachment
Site of Myxoma Number of patients or clot embolization. Patients can present with dyspnea on
Left Atrium 35 exertion, palpitations or congestive heart failure. Autoimmune
features include: constitutional symptoms, fatigue, fever, my-
Right Atrium 13
algia, arthalgia, muscle weakness, rash, and weight loss [1].
Right Ventricle 1 Activation of pro-inflammatory cytokines such as: IL-6 and
Left Ventricle 1 Tumor Necrosis Factor alpha (TNFa) have been implicated.
Often thrombolysis is given to patients presenting with stroke
prior to diagnosing atrial myxoma. Although, randomized
clinical data is lacking, managing this challenging scenario has
resulted in variable results including: clinical improvement,
persistent neurological deficits or death [2].

The origin can be explained through different theories.

Myxomas are currently thought to originate from entrapped
embryonic foregut and hence they are derived from
Figure 1: Removal of left atrial myxoma via right atrium by no touch technique.
multipotentmesenchymal cells capable of both neural and
epithelial differentiation. Histologically, these tumors are
composed of scattered cells within a mucopolysaccharidestroma
[3]. Myxomas produce vascular endothelial growth factor
(VEGF), which probably contributes to the induction of
angiogenesis and the early stages of tumor growth.

On a macroscopic level, typical myxomas are pedunculated

and gelatinous in consistency; the surface may be smooth,
villous, or friable. Tumors vary widely in size, ranging from
1 to 15 cm in diameter, and weighing between 15 and 180gm.
Figure 2: Excised left atrial myxoma specimen along with part of interatrial septum.
About 35 percent of myxomas are friable or villous, and these
tend to present with emboli. Larger tumors are more likely to
have a smooth surface and to be associated with cardiovascular
symptoms.

Systemic embolisation and sudden death are common,

which warrant an early surgical intervention [4]. Although
quite rare, left atrial myxomas account for 80% of all cardiac
tumors. Diagnosis is often difficult due to the wide array of
Figure 3: Excised left ventricular myxoma as free mobile mass. presenting symptoms. Atrial myxomas are associated with

014

Citation: Suraj WN, Krishnarao NB (2018) Cardiac Myxomas - Symptomology, Investigations and Surgical Treatment - Single Centre Experience of Fifteen Years at
Grant Medical College, Mumbai, Maharashtra. J Cardiovasc Med Cardiol 5(2): 013-015. DOI: http://doi.org/10.17352/2455-2976.000062.
systemic embolization in 30 to 40% of cases. These intracardiac and may require urgent surgical excision to reduce the risk of
growths may mas-querade as mitral stenosis, infective associated complications such as thrombo-embolic events,
endocarditis, and collagen vascular disease, which can further sudden cardiac death and removal of a possibly malignant
impede accurate diagnosis. Constitutional symptoms (e.g., tumor. The potential for rapid growth should be considered if
fever, weight loss) are seen in around 30 percent of patients. there is a plan to delay surgery [9]. Our experience suggests that
Laboratory abnormalities (e.g., anemia and elevations in the surgery for atrial myxoma is safe and simple by precautions
erythrocyte sedimentation rate, C-reactive protein, or globulin to protect from embolisation like minimal handling of
level) are present in 35 percent, usually those with systemic heart before going on bypass and use of heamofilter during
symptoms. cardiopulmonary bypass. Although atrial myxomas are usually
benign or asymptomatic, there is the possibility of diastolic
Common symptoms and signs of dyspnea, orthopnea,
embolization, conduction alterations and disturbances, and
paroxysmal nocturnal dyspnea, pulmonary edema, cough,
lethal valve obstructions occurring [10]. Since surgical excision
hemoptysis, edema, and fatigue lead to a wide differential
has been reported to alleviate symptoms associated with cardiac
diagnoses, making it critical for clinicians to be consider atrial
myxomas, early identification and removal is preferable.
mxyoma. The goals of the initial evaluation are to ascertain
whether or not a cardiac tumor is present, the location Conclusion
of the lesion within the heart and, to the extent possible,
whether a tumor is benign or malignant. This information Early surgical intervention after diagnosis can significantly
is vital in planning further evaluation and management. reduce the possibility of sudden death and other embolic
Echocardiography, cardiac MRI, and ultra-fast CT provide complications. We recommend right atriotomy approach for
complementary information to address these questions [5]. both right and left atrial myxomas. Right ventricle approach
for right ventricular myxoma and left ventricular for left
Echocardiography is widely available and provides a
ventricular myxoma. Biatrial approach was required only in
simple, noninvasive technique for the initial evaluation.
large and unusually located left atrial myxoma. To prevent
Echocardiography images both the myocardium and the
recurrence the surgical excision must include a substantial
cardiac chambers can usually identify the presence of a mass.
portion of normal surrounding tissue near the base of
In addition, echocardiography may provide information about
implantation and closure of defect with pericardial patch. With
any obstruction to the circulation, as well as the likelihood that
proper surgical technique no mortality and recurrence with
the tumor could be a source of emboli [6].
complete recovery.
Although Transthoracic Echocardiography (TTE) is
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Copyright: © 2018 Suraj WN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted
use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Citation: Suraj WN, Krishnarao NB (2018) Cardiac Myxomas - Symptomology, Investigations and Surgical Treatment - Single Centre Experience of Fifteen Years at
Grant Medical College, Mumbai, Maharashtra. J Cardiovasc Med Cardiol 5(2): 013-015. DOI: http://doi.org/10.17352/2455-2976.000062.