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    Acid Phosphatase - Wikipedia, The Free Encyclopedia

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    Binu George
    Acid phosphatase - marker enzyme

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    © All Rights Reserved
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    Acid Phosphatase - Wikipedia, The Free Encyclopedia

    Uploaded by

    Binu George
    68 views3 pages
    Acid phosphatase - marker enzyme

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    © © All Rights Reserved

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    PDF, TXT or read online from Scribd

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    Acid phosphatase - marker enzyme

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    68 views3 pages

    Acid Phosphatase - Wikipedia, The Free Encyclopedia

    Uploaded by

    Binu George
    Acid phosphatase - marker enzyme

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 3

    Acid phosphatase - Wikipedia, the free encyclopedia https://en.wikipedia.

    org/wiki/Acid_phosphatase

    Acid phosphatase
    From Wikipedia, the free encyclopedia

    Acid phosphatase (EC 3.1.3.2


    (http://enzyme.expasy.org/EC/3.1.3.2), Acid phosphatase
    acid phosphomonoesterase, Identifiers
    phosphomonoesterase,
    EC 3.1.3.2 (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1
    glycerophosphatase, acid
    number /3/2.html)
    monophosphatase, acid
    phosphohydrolase, acid CAS 9001-77-8 (https://tools.wmflabs.org/magnustools
    phosphomonoester hydrolase, number /cas.php?language=en&cas=9001-77-8&title=)
    uteroferrin, acid nucleoside Databases
    diphosphate phosphatase,
    orthophosphoric-monoester IntEnz IntEnz view (http://www.ebi.ac.uk/intenz
    phosphohydrolase (acid optimum)) is a /query?cmd=SearchEC&ec=3.1.3.2)
    phosphatase, a type of enzyme, used to BRENDA BRENDA entry (http://www.brenda-enzymes.org
    free attached phosphoryl groups from /enzyme.php?ecno=3.1.3.2)
    other molecules during digestion. It can
    be further classified as a ExPASy NiceZyme view (http://www.expasy.org/enzyme/3.1.3.2)
    phosphomonoesterase. Acid phosphatase KEGG KEGG entry (http://www.genome.ad.jp/dbget-
    is stored in lysosomes and functions bin/www_bget?enzyme+3.1.3.2)
    when these fuse with endosomes, which
    MetaCyc metabolic pathway (http://biocyc.org/META/substring-
    are acidified while they function;
    search?type=NIL&object=3.1.3.2)
    therefore, it has an acid pH optimum.[1]
    This enzyme is present in many animal PRIAM profile (http://priam.prabi.fr/cgi-bin
    and plant species.[2] /PRIAM_profiles_CurrentRelease.pl?EC=3.1.3.2)
    PDB RCSB PDB (http://www.rcsb.org/pdb/search
    Different forms of acid phosphatase are
    structures /smartSubquery.do?smartSearchSubtype=EnzymeClassificationQuery&
    found in different organs, and their
    Enzyme_Classification=3.1.3.2) PDBe (http://www.ebi.ac.uk
    serum levels are used to evaluate the
    success of the surgical treatment of /pdbe/entry/search/index?ec_number:3.1.3.2) PDBsum

    prostate cancer.[1] In the past, they were (https://www.ebi.ac.uk/thornton-srv/databases/cgi-bin/enzymes


    also used to diagnose this type of cancer. /GetPage.pl?ec_number=3.1.3.2)

    Search
    Acid phosphatase catalyzes the following
    PMC articles (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&
    reaction at an optimal acidic pH (below
    term=3.1.3.2%5BEC/RN%20Number
    7):
    %5D%20AND%20pubmed%20pmc%20local%5Bsb%5D)
    Orthophosphoric monoester + PubMed articles (http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=pubmed&
    H2O → alcohol + H3PO4 term=3.1.3.2%5BEC/RN%20Number%5D)
    NCBI proteins (http://www.ncbi.nlm.nih.gov/protein?term=3.1.3.2%5BEC
    Phosphatase enzymes are also used by /RN%20Number%5D)
    soil microorganisms to access organically
    bound phosphate nutrients. An
    assay on the rates of activity of
    these enzymes may be used to
    ascertain biological demand for
    phosphates in the soil. Reference ranges for blood tests, showing acid phosphatase in red at left.
    Some plant roots, especially
    cluster roots, exude carboxylates that perform acid phosphatase activity, helping to mobilise phosphorus in
    nutrient-deficient soils.

    1 of 3 06-05-2016 13:47
    Acid phosphatase - Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Acid_phosphatase

    Certain bacteria like Nocardia, can degrade this enzyme and utilize it as a carbon source.

    Contents
    1 Bone acid phosphatase
    2 Genes
    3 See also
    3.1 Internal links
    4 References
    5 External links

    Bone acid phosphatase


    Tartrate-resistant acid phosphatase may be used as a biochemical marker of osteoclast function during the
    process of bone resorption.[3]

    Genes
    The following genes encode the polypeptide components for various acid phosphatase isoenzymes.

    ACP1
    ACP2
    ACPP (ACP3), Prostatic acid phosphatase
    ACP5, Tartrate-resistant acid phosphatase
    ACP6
    ACPT, Testicular acid phosphatase
    Tissue acid phosphatase, or Lysosomal acid phosphatase

    See also
    Internal links

    Alkaline phosphatase

    References
    1. Henneberry, M.O.; Engel, G.; Grayhack, J.T. (October 1979). "Acid phosphatase". The Urologic clinics of North
    America 6 (3): 629–41. PMID 388794.
    2. Bull, H.; Murray, P.G.; Thomas, D.; Fraser, A.M.; Nelson, P.N. (April 2002). "Acid phosphatases". Molecular
    Pathology 55 (2): 65–72. doi:10.1136/mp.55.2.65. PMC 1187150. PMID 11950951.
    3. Minkin, Cedrick (1982). "Bone Acid Phosphatase: Tartrate-resistant Acid Phosphatase as a Marker of
    Osteoclast Function". Calcified Tissue International 34: 285–290. doi:10.1007/BF02411252. PMID 6809291.
    Retrieved 11 May 2015.

    External links
    Acid phosphatase (https://www.nlm.nih.gov/cgi/mesh/2011/MB_cgi?mode=&term=Acid+phosphatase)
    at the US National Library of Medicine Medical Subject Headings (MeSH)
    EC 3.1.3.2 (http://enzyme.expasy.org/EC/3.1.3.2)

    2 of 3 06-05-2016 13:47
    Acid phosphatase - Wikipedia, the free encyclopedia https://en.wikipedia.org/wiki/Acid_phosphatase

    Retrieved from "https://en.wikipedia.org/w/index.php?title=Acid_phosphatase&oldid=703058193"

    Categories: EC 3.1.3.2 Biochemistry

    This page was last modified on 3 February 2016, at 06:35.


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    3 of 3 06-05-2016 13:47

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