Sergio Barberan-Soler’s Post

Source: (bioRxiv : the preprint server for biology) Flavivirus NS1 triggers endothelial dysfunction, enhancing virus dissemination by promoting barrier crossing and increasing target cell infectivity in vitro and in vivo. Anti-NS1 antibodies reduce dissemination, while exogenous NS1 increases it. This study highlights NS1 as a key virulence factor and therapeutic target for preventing flavivirus infections.

New Article: Structure of the Nipah virus polymerase phosphoprotein complex The Nipah virus, known for its high fatality rate, has no approved vaccine or treatments. Here the authors present the cryoEM structure of the Nipah virus RNA polymerase machinery, comprising the large protein L and the phosphoprotein P. https://lnkd.in/gmGZscxJ

I am excited to share the most recent publication of our group on "Unveiling non-classical glycosylation patterns in Bombyx mori nucleopolyhedrovirus GP64: Insights into viral entry and fusion" in Virology. This study highlights: - The discovery of unexpected non-classical N-glycosylation sites in BmNPV GP64, differing from the well-studied AcMNPV GP64. - The critical role of N-glycosylation at residue N367 in determining BmNPV GP64 fusogenicity and viral infectivity. - The impact of signal peptide retention on the glycosylation pattern and functionality of BmNPV GP64. - The identification of four new non-consensus glycosylation sequons in viral proteins. Our findings provide valuable insights into the mechanisms underlying BmNPV infection mediated by GP64 and offer new perspectives on the functional control exerted by signal peptide interactions in viral glycoprotein biogenesis and activity. Kindly take a read and share your thoughts! https://lnkd.in/gwGbfYVC

Virology case study 🦠📝 46 year old man developed sudden low blood pressure, vomiting, shortness of breath and painful sensation evolving from muscle tissue. Microbiology Laboratory isolated golden, beta hemolytic colonies of staphylococcus aureus from the sample which was sent. And these signs were diagnosed as toxic shock due to invading staphylococcus aureus This shock were later suggested to be secondary bacterial infection due to primary viral infection 🦠. Nasopharyngeal aspirates sample was collected to detect viral pathogen. Which virus is most likely to be detected from the sample?. The plate below shows staphylococcus aureus isolated

  Synthesis of Novel 1,3,4-Oxadiazole-Derived α-Aminophosphonates/α-Aminophosphonic Acids and Evaluation of Their In Vitro Antiviral Activity against the Avian Coronavirus Infectious Bronchitis Virus https://lnkd.in/eA77ACjQ

📃Scientific paper: Sialic acids and viruses Year: 2021 Abstract: Let us study viruses and the role of sialic acids in their first step of reproduction, the attachment to cells. We begin our study with the help of the "Earth's virology course", created by Vincent Racaniello, with David Tuller and Gertrud U. Rey. The first virus that we will study is that of influenza A. Actually, "Earth's virology course" is a proper starting point for learning the mechanisms the virus uses to attach and enter the host cells. In the case of the influenza virus, its spike protein is used to attach the virion to sialic acid receptors of the host cells. Then, we will consider coronaviruses, with the help of literature about the role of sialic acids in their attachment by means of spike proteins. In fact, there are seven human coronavirus and they use sialic acid or angiotensin-converting enzyme 2 (ACE2) or other receptors or a combination of them. Let us review the literature to understand if Sars-Cov-2 virus can use sialic acid for the attachment to cells or not. Its main target is considered the ACE2 receptor. The study in 10.1021/acscentsci.0c00855 used a glyco-nanoparticle platform, discovering that N-acetyl neuraminic acid has affinity toward the SARS-COV-2 spike glycoprotein, that is a glycan-binding function. However, a recent study, 10.1016/j.scib.2021.01.010, which has investigated the binding of the spikes of the virus by means of micro-arrays, tells that no binding with sialic acid residues was detected. All the tested protein molecu... Continued on ES/IODE ➡️ https://etcse.fr/l6 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

New preprint from the lab, plus loads of fabulous collaborators, describing how most poxviruses, including avipoxviruses, antagonise DNA-PK to block cGAS/STING-dependent interferon production during infection. These viruses disrupt the interaction between DNA-PK and DNA thereby inhibiting sesnsing of viral DNA. This immune evasion mechanism is conserved across a broader range of species than other poxvirus antagonists, which may reflect the difficulty in evolving escape mechanisms that interfere with a protein that is essential for maintenance of genomic stability. This could also be relevant to the severity of mpox, as the milder clade II virus has lost one of the genes that inhibits DNA-PK. The clade Ib virus has kept this gene and will therefore be able to block host immune responses more effectively. https://lnkd.in/ei-WeMZr

Epitranscriptomic m5C methylation of SARS-CoV-2 RNA regulates viral replication and the virulence of progeny viruses in the new infection Science Advances https://lnkd.in/gp5DuF48

📃Scientific paper: Sialic acids and viruses Abstract: Let us study viruses and the role of sialic acids in their first step of reproduction, the attachment to cells. We begin our study with the help of the "Earth's virology course", created by Vincent Racaniello, with David Tuller and Gertrud U. Rey. The first virus that we will study is that of influenza A. Actually, "Earth's virology course" is a proper starting point for learning the mechanisms the virus uses to attach and enter the host cells. In the case of the influenza virus, its spike protein is used to attach the virion to sialic acid receptors of the host cells. Then, we will consider coronaviruses, with the help of literature about the role of sialic acids in their attachment by means of spike proteins. In fact, there are seven human coronavirus and they use sialic acid or angiotensin-converting enzyme 2 (ACE2) or other receptors or a combination of them. Let us review the literature to understand if Sars-Cov-2 virus can use sialic acid for the attachment to cells or not. Its main target is considered the ACE2 receptor. The study in 10.1021/acscentsci.0c00855 used a glyco-nanoparticle platform, discovering that N-acetyl neuraminic acid has affinity toward the SARS-COV-2 spike glycoprotein, that is a glycan-binding function. However, a recent study, 10.1016/j.scib.2021.01.010, which has investigated the binding of the spikes of the virus by means of micro-arrays, tells that no binding with sialic acid residues was detected. All the tested protein molecu... Continued on ES/IODE ➡️ https://etcse.fr/l6 ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.

📃Scientific paper: Sialic acids and viruses Abstract: Let us study viruses and the role of sialic acids in their first step of reproduction, the attachment to cells. We begin our study with the help of the "Earth's virology course", created by Vincent Racaniello, with David Tuller and Gertrud U. Rey. The first virus that we will study is that of influenza A. Actually, "Earth's virology course" is a proper starting point for learning the mechanisms the virus uses to attach and enter the host cells. In the case of the influenza virus, its spike protein is used to attach the virion to sialic acid receptors of the host cells. Then we will consider coronaviruses, with the help of literature about the role of sialic acids in their attachment by means of spike proteins. In fact, there are seven human coronavirus, and they use sialic acid or angiotensin-converting enzyme 2 (ACE2) or other receptors or a combination of them. We can find in literature that Sars-Cov-2 virus can use sialic acid too for the attachment to cells, but its main target is considered the ACE2 receptor.;The study in 10.1021/acscentsci.0c00855 used a glyco-nanoparticle platform, discovering that N-acetyl neuraminic acid has affinity toward the SARS-COV-2 spike glycoprotein, that is a glycan-binding function. However, a recent study, 10.1016/j.scib.2021.01.010, which has investigated the binding of the spikes of the virus by means of micro-arrays, tells that no binding with sialic acid residues was detected. All the tested protein molecules can bind to... Continued on ES/IODE ➡️ https://etcse.fr/M3s ------- If you find this interesting, feel free to follow, comment and share. We need your help to enhance our visibility, so that our platform continues to serve you.