Creative Biostructure

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New Article: Development of mirror-image monobodies targeting the oncogenic BCR::ABL1 kinase In this work, the authors develop mirror-image monobodies (Mb) made of D-amino acids against the BCR::ABL1 SH2 domain with high binding affinities. The heterochiral Mb-SH2 structures reveal an unusual binding mode. The D-Mbs are protease-resistant, inhibit BCR::ABL1 kinase activity and bind BCR::ABL1 in cell lysates. https://lnkd.in/gbNH32A2

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New Article: Structural insights into context-dependent inhibitory mechanisms of chloramphenicol in cells The authors visualize how the antibiotic chloramphenicol reshapes the translation landscape and induces ribosome collision in bacterial cells, illuminating its context-dependent action across atomic, molecular and cellular scales. https://lnkd.in/gDjbMTnn

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New Article: A core network in the SARS-CoV-2 nucleocapsid NTD mediates structural integrity and selective RNA-binding The authors use solution-state NMR and X-ray crystallography to study mutations in the SARS-CoV-2 Nucleocapsid NTD, uncovering a network essential for protein integrity and the selectively of RNA binding. https://lnkd.in/gJ2ZWijE

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New Article: Substrate translocation and inhibition in human dicarboxylate transporter NaDC3 The authors show cryo-electron microscopy structures of the human high-affinity sodium–dicarboxylate cotransporter, responsible for dicarboxylate import into the cell, in complex with various substrates and in different states establish the basis of substrate recognition, differentiation and release, as well as regulation of transport domain movement. https://lnkd.in/gRyTRZBa

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New Article: Critical assessment of LC3/GABARAP ligands used for degrader development and ligandability of LC3/GABARAP binding pockets Autophagosome tethering compounds (ATTECs) are small molecule degraders hijacking the autophagy system. Here, the authors show that current ATTEC ligands did not bind to their designated targets but establish good ligandability of ATG8 isoforms through fragment screening and docking. https://lnkd.in/d4HsQxfA