About
PhD trained biochemist with expertise in early and late-stage downstream process…
Activity
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🎅🏼 Merry everything! 🤶🏼 The beautiful children at our Rentschler Biopharma daycare center in Germany painted this photo and were excited to see…
🎅🏼 Merry everything! 🤶🏼 The beautiful children at our Rentschler Biopharma daycare center in Germany painted this photo and were excited to see…
Liked by Jessica Feldman, PhD
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From all of us at Rentschler Biopharma, we wish you and your loved ones a wonderful festive season filled with peace, joy and health. The children…
From all of us at Rentschler Biopharma, we wish you and your loved ones a wonderful festive season filled with peace, joy and health. The children…
Liked by Jessica Feldman, PhD
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Last week, we were honored to welcome Martin Gerster, member of the German Federal Parliament, and his employee Maria Brumme, to our headquarters in…
Last week, we were honored to welcome Martin Gerster, member of the German Federal Parliament, and his employee Maria Brumme, to our headquarters in…
Liked by Jessica Feldman, PhD
Experience
Education
Publications
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Identification of and Molecular Basis for SIRT6 Loss-of-Function Point Mutations in Cancer
Cell Reports
Kugel, S.*, Feldman, J.L.*, Klein, M.A., Silberman, D.M., Sebastián, C., Mermel, C., Dobersch, S., Clark, A.R., Getz, G., Denu, J.M., Mostoslavsky, R. (2015) Identification and molecular basis for loss-of-function, cancer- associated point mutations in SIRT6. Cell Reports 13, 479–488
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Kinetic and Structural Basis for Acyl-Group Selectivity and NAD+ Dependence in Sirtuin-Catalyzed Deacylation
ACS Biochemistry
Feldman JL*, Dittenhafer-Reed KE*, Kudo N*, Thelen JN, Ito A, Yoshida M, Denu JM.
Biochemistry. 2015 May 19;54(19):3037-50. doi: 10.1021/acs.biochem.5b00150. Epub 2015 May 4. -
Metabolic regulation of histone post-translational modifications.
ACS Chemical Biology
Fan J., Krautkramer K.A., Feldman J.L., Denu J.M. (2015) Metabolic regulation of histone post-translational modifications. ACS Chemical Biology. 10(1):95-108
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Structural basis of improved second generation 3-nitro-tyrosine tRNA synthetases
ACS Biochemistry
Cooley, R.B., Feldman, J.L., Driggers, C.M., Bundy, T., Stokes, A.L., Karplus P.A., Mehl, R.A.
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Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins
Journal of Biological Chemistry
Jessica L. Feldman, Josue Baeza, and John M. Denu (2013) Activation of the Protein Deacetylase SIRT6 by Long-chain Fatty Acids and Widespread Deacylation by Mammalian Sirtuins. J. Biol. Chem. 288, 31350-31356
*Selected as a paper of the week in the JBC
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Nitration of Hsp90 induces cell death
PNAS
Franco, M.C., Ye, Y., Refakis, C.A., Feldman, J.L, Stokes, A.L., Basso, M., Fernández de Mera, R.M.M, Sparrow, N.A., Calingasan, N.Y., Kiaei, M., Rhoades, T.W., Ma, T., Grumet, M., Barnes, S., Beal, M.F., Beckman, J.S., Mehl, R., Estévez, A. (2013) Nitration of Hsp90 induces cell death. Proc Natl Acad Sci USA 110(12), E1102-1111
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Sirtuin catalysis and regulation
Journal of Biological Chemistry
Feldman J.L.*, Dittenhafer-Reed K.E.*, Denu J.M. (2012) Sirtuin catalysis and regulation J. Biol. Chem. 276 (51), 42419-42427
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The deacetylase SIRT6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis.
Molecular Cell
Dominy J.E. Jr., Lee Y., Jedrychowski M.P., Chim H, Jurczak, M.J., Camporez J.P., Ruan H.B., Feldman J., Pierce K., Mostoslavsky R., Denu J.M., Clish C.B., Yang X., Shulman G.I., Gygi S.P., Puigserver P. (2012) The deacetylase SIRT6 activates the acetyltransferase GCN5 and suppresses hepatic gluconeogenesis. Mol. Cell 48, 1-14
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Structure and biochemical functions of SIRT6
Journal of Biological Chemistry
Pan, P. W.*, Feldman, J.L.*, Devries, M. K., Dong, A., Edwards, A. M., Denu, J. M. (2011) Structure and biochemical functions of SIRT6. J. Biol. Chem. 286, 14575-14587
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Catalysis and mechanistic insights into sirtuin activation.
ChemBioChem
Dittenhafer-Reed, K. E.*, Feldman, J. L.*, Denu, J. M. (2011) Catalysis and mechanistic insights into sirtuin activation. ChemBioChem 12 (2), 281-289
Honors & Awards
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GSBS Faculty Award for trainee mentoring
Dean of the Graduate School of Biomedical Sciences, UMass Medical School
GSBS Faculty Award for mentoring - outstanding contributions to trainee mentoring and/or professional advancement by a postdoctoral associate
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Postdoc selected speaker UMMS 22nd Annual Research Retreat
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NIH NRSA Postdoctoral Fellow
National Institutes of Health
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FASEB Conference Travel Award
FASEB
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American Heart Association Predoctoral Fellow
American Heart Association
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Merck Index Award in Chemistry
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Phi Beta Kappa National Honor Society
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Isaac E. Roberts Award in Biology
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Pi Mu Epsilon National Mathematics Honor Society
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Centennial Conference Academic Honor Roll
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2007-2009
More activity by Jessica
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“Sometimes the most beautiful cellular music comes not just from knowing when to play but knowing when to be quiet.” - Rickard Sandberg, PhD, during…
“Sometimes the most beautiful cellular music comes not just from knowing when to play but knowing when to be quiet.” - Rickard Sandberg, PhD, during…
Liked by Jessica Feldman, PhD
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Victor R. Ambros, PhD, dedicated his Nobel lecture to Rosalind “Candy” Lee and Rhonda Feinbaum, his co-authors on the seminal 1993 paper describing…
Victor R. Ambros, PhD, dedicated his Nobel lecture to Rosalind “Candy” Lee and Rhonda Feinbaum, his co-authors on the seminal 1993 paper describing…
Liked by Jessica Feldman, PhD
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Biopharmaceutical products are often produced in Chinese hamster ovary (CHO) cell cultures, which release retrovirus-like particles and are…
Biopharmaceutical products are often produced in Chinese hamster ovary (CHO) cell cultures, which release retrovirus-like particles and are…
Liked by Jessica Feldman, PhD
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In today’s Nobel Prize lecture, Victor R. Ambros, PhD, of UMass Chan Medical School discussed growing up in New England as an amateur astronomer, the…
In today’s Nobel Prize lecture, Victor R. Ambros, PhD, of UMass Chan Medical School discussed growing up in New England as an amateur astronomer, the…
Liked by Jessica Feldman, PhD
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A great chance to listen in! Join the fireside chat: From lab to market: the CGT biotech journey 🔥
A great chance to listen in! Join the fireside chat: From lab to market: the CGT biotech journey 🔥
Liked by Jessica Feldman, PhD
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Happy holidays! Thank you to Women in Bio for a fabulous event! Women In Bio - Engage. Educate. Empower.
Happy holidays! Thank you to Women in Bio for a fabulous event! Women In Bio - Engage. Educate. Empower.
Liked by Jessica Feldman, PhD
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Are you attending Cell 2024 in London from November 6-8? Our ATMP Technical Strategy Director, Nathan Sweeney will be there and eager to engage with…
Are you attending Cell 2024 in London from November 6-8? Our ATMP Technical Strategy Director, Nathan Sweeney will be there and eager to engage with…
Liked by Jessica Feldman, PhD
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It is always a pleasure to meet with our Xpert Alliance colleagues from Vetter Pharma! We are currently all at BIO Europe in Stockholm, and we invite…
It is always a pleasure to meet with our Xpert Alliance colleagues from Vetter Pharma! We are currently all at BIO Europe in Stockholm, and we invite…
Liked by Jessica Feldman, PhD
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