Biopharmaceutical products are often produced in Chinese hamster ovary (CHO) cell cultures, which release retrovirus-like particles and are vulnerable to infections by adventitious viruses. Therefore, it is a regulatory requirement that downstream purification steps for biopharmaceuticals can remove viruses from feedstocks. In his article “Mechanistic modeling of minute virus of mice surrogate removal by anion exchange chromatography in micro scale”, published in Journal of Chromatography A, Lukas Döring, our Doctoral Researcher Process Science – in collaboration with Johannes Winderl, our Process Manager Process Science, Matthias Kron, our Senior Director Process Science Downstream of Rentschler Biopharma and Professor Jürgen Hubbuch from the Karlsruhe Institute of Technology – discusses how the virus clearance of a MVM mock virus particle by Q Sepharose FF resin can be accurately described by mechanistic modeling.
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A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins | X-Chem
https://www.x-chemrx.com
Interested? Then read the article and download the accompanying poster here: https://www.rentschler-biopharma.com/en-us/news-events/experts-insights-en/article-mechanistic-modeling-of-minute-virus-of-mice-surrogate-removal-by-anion-exchange-chromatography-in-micro-scale