Malvern Panalytical Pharmaceuticals’ Post

Automated mRNA Extraction from Lipid Nanoparticles Using the SOTAX TPW #itsvietnam #sotax #extraction

🚀 𝗔𝘂𝘁𝗼𝗺𝗮𝘁𝗶𝗻𝗴 𝗺𝗥𝗡𝗔 𝗘𝘅𝘁𝗿𝗮𝗰𝘁𝗶𝗼𝗻: 𝗔 𝗚𝗮𝗺𝗲 𝗖𝗵𝗮𝗻𝗴𝗲𝗿 𝗳𝗼𝗿 𝗟𝗡𝗣 𝗣𝘂𝗿𝗶𝘁𝘆 𝗧𝗲𝘀𝘁𝗶𝗻𝗴 💉🔬 The race to bring mRNA-based therapeutics to market requires precision and efficiency. Traditional manual extraction methods for lipid nanoparticles (LNPs) are not only time-consuming but also prone to contamination risks. 🧪⚠️ 🎉 𝗔𝘂𝘁𝗼𝗺𝗮𝘁𝗶𝗻𝗴 𝗺𝗥𝗡𝗔 𝗘𝘅𝘁𝗿𝗮𝗰𝘁𝗶𝗼𝗻: 𝗔 𝗚𝗮𝗺𝗲 𝗖𝗵𝗮𝗻𝗴𝗲𝗿 𝗳𝗼𝗿 𝗟𝗡𝗣 𝗣𝘂𝗿𝗶𝘁𝘆 𝗧𝗲𝘀𝘁𝗶𝗻𝗴 Presented by Merck at the ACS Fall Meeting, researchers demonstrated how the SOTAX TPW – traditionally used for small molecule applications – was successfully adapted for mRNA extraction with impressive results: ✅ 𝗜𝗺𝗽𝗿𝗼𝘃𝗲𝗱 𝗥𝗲𝗰𝗼𝘃𝗲𝗿𝘆: >98% mRNA recovery with automation compared to ~81% manually. ✅ 𝗛𝗶𝗴𝗵 𝗧𝗵𝗿𝗼𝘂𝗴𝗵𝗽𝘂𝘁: One analyst using the TPW can process 30-120 samples/day – equivalent to the work of 2-3 analysts using manual methods. ✅ 𝗖𝗼𝗻𝘁𝗮𝗺𝗶𝗻𝗮𝘁𝗶𝗼𝗻 𝗖𝗼𝗻𝘁𝗿𝗼𝗹: Significantly reduces the risk of RNAse contamination, ensuring consistent sample integrity. This breakthrough highlighted how automation can streamline LNP-mRNA purity testing, transforming the landscape for labs worldwide. 🌐🔧 👉 Want to explore how the SOTAX TPW can elevate your lab’s workflow? Let's connect and discuss how automation can enhance your mRNA analysis! 💬✨ https://lnkd.in/dyiNM-CC #Automation #PharmaInnovation #mRNAExtraction #LNP #SOTAX #LabEfficiency #Biotech #ACSFallMeeting

Struggling with immunoassays to quantify drug-mAbs ? Why not considering LC-MS instead ? Mass spectrometry has emerged as a powerful alternative with specific analytical advantages, including: - Selective quantification of the target drug-mAb - Capability for multiple mAbs measurement within a single analysis (multiplexing) - A relatively fast, versatile and cost-effective development cycle - Stable-isotopically standards available for more accurate and robust data At Promise Proteomics, we have developed a range of solutions dedicated to therapeutic monoclonal quantification using mass spectrometry. Our goal is to facilitate and speed-up your projects. Explore our range of dedicated products: https://hubs.la/Q02zfWXy0 https://hubs.la/Q02zfVrg0 Or contact us at [email protected] ✉ #protein #antibody #analysis #quantification #biomarkers #research #pharma #massspectrometry #LCMS #ASCO

Struggling with immunoassays to quantify drug-mAbs ? Why not considering LC-MS instead ? Mass spectrometry has emerged as a powerful alternative with specific analytical advantages, including: - Selective quantification of the target drug-mAb - Capability for multiple mAbs measurement within a single analysis (multiplexing) - A relatively fast, versatile and cost-effective development cycle - Stable-isotopically standards available for more accurate and robust data At Promise Proteomics, we have developed a range of solutions dedicated to therapeutic monoclonal quantification using mass spectrometry. Our goal is to facilitate and speed-up your projects. Explore our range of dedicated products: https://hubs.la/Q02zfV6w0 https://hubs.la/Q02zfVXZ0 Or contact us at [email protected] ✉ #protein #antibody #analysis #quantification #biomarkers #research #pharma #massspectrometry #LCMS #ASCO

Headed to Biologics by Oxford Global meeting next week? Our biologists have worked on many types of #biologics including #genetherapy #celltherapy #antibodies #vaccines #proteinresearch If you need reliable #assaydevelopment or #translationalresearch for your biologic speak to Andrew Scott or Luka Wright

To mitigate some of the biggest risks in drug development, it’s essential to gather as much information about a candidate early on in development to make better, more informed decisions further down the line. This is where "developability" comes in, to understand whether the drug can be made and if it will work.   At the recent Biologics US conference, our Sr. Director of Bioassays, Dr Erika Kovacs, presented a scientific poster entitled: "Rapid Developability Assessments to Assist Lead Candidate Selection."  The poster highlights our robust developability platform, which integrates in silico approaches with characterization and stability studies to determine the selection of the best candidate to progress.   Using a panel of 7 mAb sequences, the poster details the different computational tools employed to identify sequence liabilities and immunogenicity risks, while advanced biophysical techniques evaluated manufacturability and stability.   Click here to access the poster: https://lnkd.in/euVZDnwG   #Developability #LeadSelection #DrugDevelopment #CRO #CDMO

🧬 𝐑𝐍𝐀-𝐞𝐝𝐢𝐭𝐢𝐧𝐠 𝐝𝐫𝐮𝐠𝐬 𝐢𝐧 𝐜𝐥𝐢𝐧𝐢𝐜𝐚𝐥 𝐭𝐫𝐢𝐚𝐥𝐬 This is another great article on the power of RNA technology, with a list of the companies and drugs currently in clinical trials. More info: https://lnkd.in/dxfrtcu8 #pharma #biotech #cgt #womeninbusiness #drjojo ---------- Hi! I am Joanna, and my friends call me Dr Jojo 🌸 𝐈 𝐭𝐚𝐥𝐤 𝐚𝐛𝐨𝐮𝐭 𝐢𝐧𝐧𝐨𝐯𝐚𝐭𝐢𝐨𝐧 𝐚𝐧𝐝 𝐛𝐮𝐬𝐢𝐧𝐞𝐬𝐬 𝐢𝐧 𝐩𝐡𝐚𝐫𝐦𝐚 𝐚𝐧𝐝 𝐛𝐢𝐨𝐭𝐞𝐜𝐡 ♻️ Share this if you find it interesting 🔔 Follow for insights you won't want to miss

The process showcased in this #biotechanimation is a novel patented cell-based assay for studying GPCR heteromers. Our client has developed a cell-based receptor-HIT assay designed to detect and study GPCR heteromers effectively. This platform is versatile, capable of working with various molecular targets, thereby minimizing the risk of unidentified signaling interactions. The patented assay functions as a three-component system, involving an unlabeled GPCR, a luciferase-fused second GPCR, and a fluorophore-fused signaling molecule. Ligand binding to the unlabeled GPCR and subsequent heteromerization with the labeled GPCR lead to signal generation due to proximity between the fluorophore and luciferase. This proximity-based mechanism ensures a robust assay with minimal background noise, especially when GPCRs form homodimers or in the absence of a ligand. The unique capabilities of this receptor-HIT assay make it ideal for repurposing approved compounds, identifying orphan receptors, and facilitating new drug discovery efforts. Learn more about our work 👉 biotech-animated.com #medicalanimation #moaanimation #pharma #biotechnology #molecularbiology

Struggling with immunoassays to quantify drug-mAbs ? Why not considering LC-MS instead ? Mass spectrometry has emerged as a powerful alternative with specific analytical advantages, including: - Selective quantification of the target drug-mAb - Capability for multiple mAbs measurement within a single analysis (multiplexing) - A relatively fast, versatile and cost-effective development cycle - Stable-isotopically standards available for more accurate and robust data At Promise Proteomics, we have developed a range of solutions dedicated to therapeutic monoclonal quantification using mass spectrometry. Our goal is to facilitate and speed-up your projects. Explore our range of dedicated products: https://hubs.la/Q02zfVW20 https://hubs.la/Q02zfYkf0 Or contact us at [email protected] ✉ #protein #antibody #analysis #quantification #biomarkers #research #pharma #massspectrometry #LCMS #ASCO

Struggling with immunoassays to quantify drug-mAbs ? Why not considering LC-MS instead ? Mass spectrometry has emerged as a powerful alternative with specific analytical advantages, including: - Selective quantification of the target drug-mAb - Capability for multiple mAbs measurement within a single analysis (multiplexing) - A relatively fast, versatile and cost-effective development cycle - Stable-isotopically standards available for more accurate and robust data At Promise Proteomics, we have developed a range of solutions dedicated to therapeutic monoclonal quantification using mass spectrometry. Our goal is to facilitate and speed-up your projects. Explore our range of dedicated products: https://hubs.la/Q02zfVW30 https://hubs.la/Q02zfJ9H0 Or contact us at [email protected] ✉ #protein #antibody #analysis #quantification #biomarkers #research #pharma #massspectrometry #LCMS #ASCO