Refeyn

And now for some holiday fun… Our colleagues recently hosted Refeyn’s 4th employee-led blind taste test extravaganza at our Oxford HQ – Christmas Feastathon 2024. 🎄 The goal? To discover which Oxford supplier offers the best holiday-themed sandwich and best mince pie (a traditional British holiday dessert consisting of dried fruits and spices in a pastry shell). Participants rigorously sampled treats from Taylors Of Oxford, Pret, Marks & Spencer, Sainsbury's and Tesco. They were rated across five categories including: Taste (Fa la la la Flavor), Jingle Smell, and Appearance (Frost impressions). 🏆 Taylors emerged as the People's Champion, winning hearts with their seasonal delights. In a surprising upset, Marks & Spencer came in last place. Shout outs to our colleagues who made it all happen: R&D Engineer Charles Wright and R&D Manager Lee Priest, and to ‘tasting veteran’ and Senior R&D Engineer Nathan Curry, as well as to everyone who took part! 😋 What do you think we should test next time?

So proud to see our own in-house counsel, Roshni Thakkar, recognized in this list!🎉 We know Roshni as a highly trusted and valuable member of the Refeyn team, who navigates the broad array of legal queries we send her way with remarkable patience and skill. Congratulations Roshni! 👏

“You pipette in 20 µL of sample and press go; in just over a minute, you have your data.” 😍 Our Stephen Maughan recently spoke to Aimee Cichocki from Separation Science, explaining how #MassPhotometry works and why it is revolutionizing bioanalytics across both research and industry. Read it here 👉 https://lnkd.in/d47vvYTb

Have you met MassFluidix HC? It's an add-on for the TwoMP mass photometer 🔬 that allows you to analyze samples at high concentration with mass photometry. 💡 Check it out! 👇 https://lnkd.in/es6hTzFD

"Mass photometry is much faster, cheaper and easier to use than current technologies while offering comparable accuracy."🎯 Our Gabriella Kiss, Ph.D. sends a clear message in her interview for Pharma Industrial India Magazine. She talks about how #MassPhotometry is transforming vector analytics with fast, user-friendly, single-particle analysis. She also goes over the different analytical solutions that Refeyn offers – from antibody aggregation 🧬 to AAV payload 🧪, to large viral vector characterization and more! Read the whole piece here ➡️ https://lnkd.in/dmG4XUv9

See how #MassPhotometry can be used for epitope binning in #antibody characterization in a recent paper from Ben Spiller's lab at Vanderbilt University School of Medicine. The authors created a library of #nanobodies against Streptococcus pyogenes Cas9 (SpCas9). After screening, three nanobody variants were found that tightly bound different epitopes in SpCas9 without interfering with its enzymatic activity or each other – a helpful toolbox for attaching genome-modifying enzymes or fluorescent tags to Cas9. We note that the anti SpCas9 nanobodies were provided by Flower Blossom the alpaca. Read the full story here! 👉 https://lnkd.in/diWar5Uw #MassPhotometryStories

Your AAVs may be filled, but is that genome too long, too short or just right? Our latest app note, in collaboration with Asklepios BioPharmaceutical, Inc. (AskBio) shows that #MassPhotometry can help you find out.🧬🔬 Mass photometry not only gives you the empty/full ratio in your AAV sample in minutes, but its mass-based analysis also gives you information about the genome length distribution in your sample 📊. Discover how to make sure your packed genomes are Goldilocks-compliant without wasting time and sample🧪; read our new application note here: https://lnkd.in/dq_9wcQk

Great news- we look forward to seeing what The University of Sheffield will do with their new TwoMP and MassFluidix! The MassFluidix allows you to apply mass photometry analysis to samples with concentration up to the tens of micromolar - enabling studies of low-affinity interactions. Read more here: https://lnkd.in/es6hTzFD

With #MassPhotometry a simple dilution step and a few minutes is enough to analyze how different conditions affect protein behavior – like pH conditions in malaria parasite exonemes. This paper conclusively shows that the aspartic protease PMX is required for the maturation of the SUB1 proenzyme – which is in turn required to egress from red blood cells by Plasmodium falciparum. Chrislaine Withers-Martinez and colleagues from The Francis Crick Institute also provide structural details on how PMX cleaves the SUB1 prodomain and use mass photometry to describe the oligomerization behavior of SUB1 at the pH values found in P. falciparum exonemes. Read the full paper here! https://lnkd.in/d499AiYY #MassPhotometryStories 

We teamed up with Cube Biotech, whose copolymer-derived native nanodiscs make it possible to solubilize and stabilize membrane proteins in one step, without detergents🧬. In just minutes, mass photometry gave clear insights into sample purity and heterogeneity, and protein interactions of G-protein coupled receptors (GPCRs) within copolymer nanodiscs 🔬💡. The results confirm that mass photometry is an excellent tool for quality checks before diving deeper into structural and functional studies. Our new application note shares the results – check it out here! 👉 https://lnkd.in/du4jy5rQ