Mati Kargren

Mati Kargren

台灣 臺北市 台北
1930 人關注 500+ 位聯絡人

關於

Dynamic and results-driven clinical trial professional with a robust background in…

工作經歷

  • Parexel 圖片

    Parexel

    Taipei City, Taiwan

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    Taipei City, Taiwan

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    Taipei City, Taiwan

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    Taipei City, Taiwan

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    Taipei City, Taiwan

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    Taipei City, Taiwan

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    Melbourne, Victoria, Australia

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    Stockholm, Stockholm County, Sweden

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    Stockholm, Stockholm County, Sweden

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    Stockholm, Stockholm County, Sweden

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    Stockholm, Stockholm County, Sweden

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教育背景

  • Karolinska Institutet 圖片

    Karolinska institutet

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    活動和社團:Karolinska Institutet student union (Medicinska Föreningen)

    ★ Graduated with distinction, participated in the Erasmus Programme at the Leiden University (Leiden, the Netherlands), and carried out bachelor thesis research on Identification of Key Immunometabolic Markers in Cells of HIV+ Persons at the Monash University & Burnet Institute (Melbourne, Australia) under the supervision of Dr Clovis Palmer and Prof Suzanne Crowe.
    ★ Acquired in-depth knowledge in the fields of Molecular Medicine, Integrative Physiology & Cardiovascular Diseases…

    ★ Graduated with distinction, participated in the Erasmus Programme at the Leiden University (Leiden, the Netherlands), and carried out bachelor thesis research on Identification of Key Immunometabolic Markers in Cells of HIV+ Persons at the Monash University & Burnet Institute (Melbourne, Australia) under the supervision of Dr Clovis Palmer and Prof Suzanne Crowe.
    ★ Acquired in-depth knowledge in the fields of Molecular Medicine, Integrative Physiology & Cardiovascular Diseases, Pharmacology & Toxicology, Infectious Diseases & Immunology, Molecular Oncology & Applied Biostatistics, Neuroscience & Neurology, Histology, Medical Biochemistry, and General & Organic Chemistry at one of the top 3 medical institutes in Europe.

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    ★ Received the Taiwan Ministry of Education (MOE) scholarship for conducting research on Anti Metastatic Therapies for Neuroblastoma under the supervision of Prof Lee Hsinyu (李心予 教授) and Dr Liao Yung-Feng (廖永豐 博士), while maintaining a perfect score in Molecular & Cell Biology, Business Chinese, and Taiwanese History & Culture.

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    ★ Carried out my bachelor thesis project as an exchange student at the Monash University in Melbourne, Australia. More information about the university on: http://www.monash.edu .

    ★ Laboratory research carried out at the laboratory of Dr. Clovis Palmer (Immunometabolism Lab) at the Burnet Institute, associated with the Monash University. The laboratory's profile can be viewed at: http://www.burnet.edu.au/working_groups/45_palmer_laboratory .

    ★ My research project title was…

    ★ Carried out my bachelor thesis project as an exchange student at the Monash University in Melbourne, Australia. More information about the university on: http://www.monash.edu .

    ★ Laboratory research carried out at the laboratory of Dr. Clovis Palmer (Immunometabolism Lab) at the Burnet Institute, associated with the Monash University. The laboratory's profile can be viewed at: http://www.burnet.edu.au/working_groups/45_palmer_laboratory .

    ★ My research project title was ''Mitochondrial and metabolic dysfunctions in monocytes of aging individuals living with HIV infection''. The focus of the laboratory practice is to investigate how chronic HIV infections affect monocyte metabolism and stimulation of inflammatory responses, and how this may be linked to the development of frailty. Such investigation is important in the context of aging HIV-positive individuals, as they experience an increased rate of immunosenescence.

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    ★ The Erasmus+ programme aims to boost skills and employability, as well as modernising Education, Training, and Youth work.

    ★ It also provides opportunities for European citizens to study, train, gain work experience and volunteer abroad.

    ★ As part of the programme, I carried out a study abroad semester at the Leiden University Medical Center (LUMC) in Leiden, Netherlands.

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    ★ Aced a course in Chinese rhetorics (CEFR level: C1/C2), which was concluded by examination of language proficiency.

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    ★ The Natural Science Programme at Kungsholmens Gymnasium is a three-year programme following the syllabus for the Swedish Natural Science Programme using English as the language of instruction.

    ★ The programme includes, besides core subjects such as English and Swedish, also programme specific subjects such as Mathematics, Biology, Chemistry and Physics.

資格認證

志工經歷

  • EternalOne BioIndustry Club 圖片

    International Team Lead

    EternalOne BioIndustry Club

    - 1 年

    科學與技術

    EternalOne Bioindsutry Club (EBC), founded in December 2020, is an online community that connects Taiwanese biotech professionals in the world and foreign professionals in Taiwan.

    During my time with the EBC, I lead the International Team and achieved the following goals:
    • Recruited, onboarded, and supervised 12 association members
    • Built a network of ~100 foreign professionals and students in the biotech- and pharma-related fields in Taiwan or planning on moving to Taiwan in…

    EternalOne Bioindsutry Club (EBC), founded in December 2020, is an online community that connects Taiwanese biotech professionals in the world and foreign professionals in Taiwan.

    During my time with the EBC, I lead the International Team and achieved the following goals:
    • Recruited, onboarded, and supervised 12 association members
    • Built a network of ~100 foreign professionals and students in the biotech- and pharma-related fields in Taiwan or planning on moving to Taiwan in the near future
    • Planned, coordinated, and hosted 3 speaker events followed by networking sessions
    • Edited an English article on the scientific, medical, and commercial applications of genomic testing

  • Red Cross Youth 圖片

    District member

    Red Cross Youth

    - 11 個月

    社會服務

    Active member of the Swedish Red Cross Youth. Assigned role of organising social events for refugee youth arriving in Stockholm.

出版作品

  • Managing protocol development with international teams: Soft skill perspectives from a global team of protocol writers

    EMWA Medical Writing Journal

    Clinical trial protocol development forms part of the critical path for launching a trial, which means timelines are tight and progress must be fast and sustained throughout the protocol’s development. In order to be successful, medical writers require well-developed soft skills to meet the needs of the trial team and to produce a high-quality protocol. We focus on five critical soft skills that are essential for medical writers working with international teams: critical thinking, leadership…

    Clinical trial protocol development forms part of the critical path for launching a trial, which means timelines are tight and progress must be fast and sustained throughout the protocol’s development. In order to be successful, medical writers require well-developed soft skills to meet the needs of the trial team and to produce a high-quality protocol. We focus on five critical soft skills that are essential for medical writers working with international teams: critical thinking, leadership, communication, teamwork, and adaptability. Based on our experience as a global team of protocol subject matter experts from Asia-Pacific, Europe, India, South Africa, and the US, we also discuss soft skills that are important for working with team members across different regions.

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  • Unlocking new efficiencies: How structured content authoring is streamlining the production of clinical documents for the pharmaceutical industry

    EMWA Medical Writing Journal

    Current practice requires clinical and regulatory documents to be created and updated manually by medical writers throughout a product’s development. Conventionally, document content is unstructured, with freeform text, figures, and tables that the medical writer can arrange in any configuration. By structuring and standardising clinical and regulatory content, the pharmaceutical industry can shift from a document-based to a content-based approach. This transition will require adopting…

    Current practice requires clinical and regulatory documents to be created and updated manually by medical writers throughout a product’s development. Conventionally, document content is unstructured, with freeform text, figures, and tables that the medical writer can arrange in any configuration. By structuring and standardising clinical and regulatory content, the pharmaceutical industry can shift from a document-based to a content-based approach. This transition will require adopting structured content management tools and common structures, and standardising content. In tandem, medical writers must evolve their skillset and ways of working, primarily through planning and producing content and adopting structured content authoring practices to facilitate content creation and reuse. This article introduces structured content authoring and outlines how the medical writing role in the pharmaceutical industry may soon evolve.

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  • Activation of Aryl Hydrocarbon Receptor by Kynurenine Impairs Progression and Metastasis of Neuroblastoma.

    Cancer Research - American Association for Cancer Research

    Neuroblastoma (NB) is the most common malignant disease of infancy, and amplification of the MYCN oncogene is closely associated with poor prognosis. Recently, expression of MYCN was shown to be inversely correlated with aryl hydrocarbon receptor (AHR) expression in NB, and overexpression of AHR downregulated MYCN expression, promoting cell differentiation. Therefore, we further investigated the potential of AHR to serve as a prognostic indicator or a therapeutic target in NB. First, the…

    Neuroblastoma (NB) is the most common malignant disease of infancy, and amplification of the MYCN oncogene is closely associated with poor prognosis. Recently, expression of MYCN was shown to be inversely correlated with aryl hydrocarbon receptor (AHR) expression in NB, and overexpression of AHR downregulated MYCN expression, promoting cell differentiation. Therefore, we further investigated the potential of AHR to serve as a prognostic indicator or a therapeutic target in NB. First, the clinical significance of AHR in NB was examined. Positive AHR immunostaining strongly correlated with differentiated histology of NB and predicted better survival for patients. The mouse xenograft model showed that overexpression of AHR significantly suppressed NB tumor growth. In addition, activation of AHR by the endogenous ligand kynurenine (Kyn) inhibited cell proliferation and promoted cell differentiation in vitro and in vivo. Kyn treatment also upregulated the expression of KISS1, a tumor metastasis suppressor, and attenuated metastasis in the xenograft model. Lastly, analysis of KISS1 levels in NB patient tumors using the R2: Genomics Analysis and Visualization Platform revealed that KISS1 expression positively correlated with AHR, and high KISS1 expression predicted better survival for patients. In conclusion, our results indicate that AHR is a novel prognostic biomarker for NB, and that overexpression or activation of AHR offers a new therapeutic possibility for NB patients.

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測驗成績

  • Test of Chinese as a Foreign Language

    成績:Level 4

語言能力

  • English

    母語

  • Swedish

    母語

  • Polish

    母語

  • Spanish

    中級(日常會話)

  • Mandarin

    精通

  • Dutch

    中級(日常會話)

  • French

    初級

組織

  • Students' Medical Union, Karolinska Institutet

    Active member

    - 目前

    Participating in associations under the Students' Medical Union (Swe: Medicinska föreningen) at the Karolinska Institutet.

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