In a study published in Cell on May 22, researchers led by Prof. Li Chuanyou from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences report their discovery that REGENERATION FACTOR1 (REF1) is the primary local wound signal that instigates plant regenerative responses. This discovery suggests a convenient method for improving the transformation efficiency of difficult-to-transform crops by boosting their regeneration capacity. Upon injury, plants immediately activate defense responses to prevent pathogen infection and/or insect attack. In parallel, plants activate cellular reprogramming to repair damaged tissues and regenerate lost body parts. While the wound signals and signaling cascades used by plants to activate wound-induced defense responses are well understood, the molecular mechanisms underlying wound-induced regenerative responses remain obscure. Although wounding is essential for initiating various types of organ regeneration, the biochemical nature of the putative local wound signals governing this process has remained a mystery for centuries. Furthermore, the regenerative capacity of plants in nature varies widely among species and genotypes, which is one of the major hurdles to fully realizing the potential of genetic transformation and genome editing technologies for crop breeding. Therefore, among 125 important unanswered questions listed by the journal Science, "What controls organ regeneration?" was selected as one of the top 25 questions. Considering that regeneration and defense are interconnected facets of plant wound responses, it is reasonable to speculate that tomato mutants defective in the putative regeneration signal would show both compromised regeneration capacity and impaired defense responses. Based on this principle, the researchers identified a spr9 mutant that is defective in both wound-induced defense responses and regenerative responses. spr9 primarily affects local defense responses and abolishes the capacity of wound-induced callus formation and shoot regeneration, suggesting that the SPR9 gene plays a dual role in regulating wound-induced local defense and organ regeneration. Gene cloning studies revealed that the SPR9 gene encodes a precursor of a peptide. Depletion of SPR9 abolished the regenerative capacity of tomatoes, and overexpression of SPR9 resulted in enhanced regenerative capacity. Moreover, application of its peptide product dramatically increased regeneration capacity. Therefore, this peptide was designated as REGENERATION FACTOR1, or REF1. Further studies showed that REF1 is perceived by the receptor PORK1. When plant cells are injured, REF1 binds its receptor PORK1 to activate WIND1, a master regulator of wound-induced cellular reprogramming, thereby initiating regenerative responses.
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New Plant Stem Cells Research: The Key to Stronger, More Resilient Plants New research from the University of Connecticut highlights the significance of plant stem cells and reveals that they play a crucial role in plant growth and development, similar to stem cells in animals. Professor Huanzhong Wang's lab discovered a transcription factor gene called HVA that regulates cell division in vascular stem cells which are essential for forming vascular bundles that transport nutrients and water throughout the plant. This research enhances our understanding of plant biology and has important implications for agriculture, particularly in developing sturdier crops such as corn. #PlantStemCells #AgricultureInnovation #FoodSecurity #HVA #PlantScience #SustainableFarming #CropResilience #ResearchBreakthrough #PlantBiology #UniversityResearch #WissenResearch
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Founder at Bio by Priti| Science Educator 👩🔬🧪 | Graphic designer | Freelancer | Sustainability Enthusiast
🔬 Understanding Cell Reproduction: The Foundation of Life 🔬 Cell reproduction is crucial for growth, development, and survival in all living organisms. There are two main types: 1️⃣ Mitosis – Produces identical cells for growth and tissue repair. 2️⃣ Meiosis – Creates genetically diverse gametes (sperm and eggs) for reproduction. From healing wounds to creating new life, cell division plays an essential role in biology and medicine. Understanding it helps unlock advancements in healthcare, genetics, and biotechnology! #Biology #ScienceEducation #CellReproduction #STEM #LifeSciences #BioByPriti #InnovationInScience #LinkedInLearning #Genetics
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I'm thrilled to share that my latest perspective article has been published in the Journal of Mammary Gland Biology and Neoplasia! The article sheds light on how organoid technology revolutionizes our approach to studying the mammary gland, offering insights across various mammalian species. Stay tuned for how this line of research might influence future therapies and agricultural practices. Read the full article here: https://lnkd.in/e65vy_bt #OrganoidTechnology #StemCellResearch #RegenerativeMedicine #CancerResearch #EvolutionaryBiology #ScienceCommunication
Using Organoids to Tap Mammary Gland Diversity for Novel Insight - Journal of Mammary Gland Biology and Neoplasia
link.springer.com
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Breakthrough technology to directly obtain the hidden chemistry of microbiomes, +17,000 Followers, #microbiome #smallmolecules #drugdiscovery #platform #AI #ML #Datasets #Discovery
“Expand on the current understanding of evolution and survival strategies for complex microbiomes, with implications for fields ranging from ecology to biotechnology and medicine.” “species of bacteria (Clostridium acetobutylicum and C. ljungdahlii) were exchanging nutrients, metabolites and cellular material at high rates when they were in close proximity to one another. They found that the cells were using a mechanism called heterologous cell fusion to transfer materials and wanted to see if bacteria could also transfer genetic information through this mechanism” #microbiome #genomics https://lnkd.in/g3rGGrEE
Engineers uncover new mechanism for gene transfer
phys.org
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The fourth edition of EMBO | EMBL Symposium "Innate immunity in host-pathogen interaction" aims to unite immunologists, microbiologists, and cell biologists to discuss recent advancements in understanding host-pathogen interactions. This interdisciplinary gathering will explore interactions among viruses, bacteria, fungi, and parasites, including discussions across phylogenetically distant hosts such as plants and animals. For more details, please check via: https://lnkd.in/gsuc9pcc 📚 Submit your abstract by 26 March 📅 18 – 21 June 🗺 EMBL Heidelberg and Virtual 💡 Keynote speakers: vishva dixit, Genentech, USA Dominique Soldati-Favre, Université de Genève, Switzerland 🔎 Scientific organisers Gordon Brown, University of Exeter, UK Michaela U. Gack, Cleveland Clinic Foundation, USA Felix Randow, MRC Laboratory of Molecular Biology (LMB), UK Dominique Soldati-Favre, Université de Genève, Switzerland Cyril Zipfel, University of Zurich, Switzerland #innateimmunity #cellautonomousimmunity #hostpathogeninteractions #infectionbiology #microbiology #virology #mycology #plantpathology #parasitology #bacteriology
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🎉This week one paper, which I am so proud to collaborate on, was published!📄✨ This is part of my colleague's PhD thesis, and it’s especially meaningful for me, as it relates to the research I did during my Master’s. In this paper, we explore the chloroplast genomes of plants from the Sapindales order. Notably, we made available three newly assembled chloroplast genomes from the Simarouba genus (S. versicolor, S. amara, and S. glauca). Our findings also identify regions with potential as DNA barcodes, which could help overcome challenges in distinguishing between these species. Additionally, our results align with my Master's research, confirming that the expansion of inverted repeat regions can significantly influence gene number in plants of order Sapindales. If you’re interested in learning more, check out the paper here: Link to Paper < https://lnkd.in/gcvWyqm5> Rhewter Nunes, Mariana Telles, Ramilla dos Santos Braga Ferreira and Cintia Targueta #Research #Genomics #PlantScience #ChloroplastGenomes #DNAbarcoding #Sapindales #Simarouba
Chloroplast genomes of Simarouba Aubl., molecular evolution and comparative analyses within Sapindales - Scientific Reports
nature.com
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PhD Positions (Population genetics) Universitat Wien Vienna Graduate School Of Population Genetics Áustria Application deadline: 29th Nov 2024 PhD topics: The role of deleterious mutations for adaptation and maintenance of variation. The evolution of ageing. Long-term adaptation of local Drosophila populations. Inference of selection signatures from time-series data. Making sense of whole-genome polymorphism data. Studying the genotype-phenotype map. Stabilising selection during polygenic adaptation. Evolution of regulatory networks. Apply here: https://lnkd.in/dBNJQaEQ #Postdoc #Microbiology #biology #NIH #Bacteriology #Biomedical sciences #PhD #Molecular #genetics
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I am a Biotechnologist, Molecular Breeder and Population Geneticist by passion (Assistant Professor, Faculty of Applied Sciences and Biotechnology, Shoolini University, PO Box 9, Solan, Himachal Pradesh, 173229, India).
Happy to share that our article entitled "Recent advancements in the physiological, genetic, and genomic research on Rhododendrons for trait improvement" has been published in SCI journal 3 Biotech (Impact factor~3) Here we have targeted the Physiological, Genetics and Genomics domains in rhododendron, So this article will help the researchers around the globe working on Rhododendron specially and Tree species in general, Many congratulations to all the authors, and keep it up. This in my first manuscript from Shoolini-University since I have joined as Assistant Professor in faculty of Biotechnology. Hope this momentum will go on in future also. https://lnkd.in/gEUNtX5m
Recent advancements in the physiological, genetic, and genomic research on Rhododendrons for trait improvement - 3 Biotech
link.springer.com
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