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    Confer Ance

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    Hadia Maragha

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    © All Rights Reserved
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    Confer Ance

    Uploaded by

    Hadia Maragha
    2 views14 pages

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    © © All Rights Reserved

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    2 views14 pages

    Confer Ance

    Uploaded by

    Hadia Maragha

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 14

    Faculty Of Science

    Biology Department
    Research
    Presentation

    Evaluation of Recurrent Vulvovaginitis and


    its Correlation with Signs of Chronic Stress
    in Women

    Prepared By: Supervised by:

    Prof.Dr.Bushra hussain
    Khanzad Wsu shnawa
    1
    Outlin
    e

    • Introduction
    • Aim of the study
    • Material and Method
    • Result and Discussions
    • Conclusions and Recommendations

    2
    Introduction

    • Candida albicans is an opportunistic pathogen that


    resides in the intestine, genitourinary tract, and skin as
    a harmless commensal
    • C. albicans has a distinctive effect on women that
    causes recurrent vulvovaginal candidiasis
    • Recurrent vulvovaginal candidiasis (RVVC) remains a
    significant medical and global public health challenge
    and adversely affects the quality of life of the affected
    women.
    3
    Aim Of This Study

    • Investigate the association between recurrent


    vulvovaginal candida with chronic stress hormone, and
    vitamin B12 deficiency
    • In addition to the presence of bacterial vaginitis, and
    blood glucose abnormalities in married, pregnant and
    non-pregnant women.

    4
    Material And Method
    Experimental Design

    Study subjects (female patients


    n (40) and healthy control
    groups n (10))

    collection of blood collection of urine samples


    samples

    Estimation of Vit B12, Culturing and


    cortisol and blood suger. Microscopical examination identification of fungi
    & bacteria
    5
    Results and Discussions

    Sample Collections and microscopic Confirmations

    Blood
    Colection Urine PDA Germ
    Tube

    6
    Results and
    Discussions
    Bacterial Identification

    Figure 1. Candida
    pseudomycilium in
    the urine of patients

    7
    Results and Discussions

    Table 1. Demographic data of study subjects in both candida-infected women and control groups.

    Patients HC
    Demographic information Participants N (%) p Value
    N (%) N (%)
    Age (Mean±SE) 33.8±0.94 33.8±1.07 33.0±1.4 0.0936
    Housewife 26 (100) 20 (50) 6 (60)
    Occupations 0.7278
    Employee 24 (51) 20 (50) 4 (40)
    Urban 28(56) 22(55) 6 (60)
    Location >0.99
    Rural 22(44) 18(45) 4 (40)
    Yes 15 (30) 15 (37.5) -
    Pregnant
    No 35 (70) 25 (62.5) 10(100)
    Yes 18(36) 18(45) -
    Diabetic
    No 32 (64) 22 (55) 10 (100)
    White 21(42.0) 21(52.5) -
    Yellow 13(26.0) 13(32.5) -
    Discharge Brown 1(2.0) 1(2.5) -
    Pinky 2(4.0) 2(5.0) -
    Bloody 2(4.0) 2(5.0) -
    No discharge 11 (22.0) 1(2.5) 10 (100)
    Antibiotics 10 (20.0) 10 (25.0) -
    Drug intake Vitamin supplements 3 (6.0) 3 (7.5) -
    Not intake 37 (74.0) 27 (67.5) 10 (100)
    G-ve 5(10.0) 5(12.5) -
    G+ve 5 (10.0) 5 (12.5) -
    Bacterial infections
    Both 9 (18.0) 9(22.5) -
    None 31 (62.0) 21 (52.5) 10 (100) 8
    Results and Discussions

    Table 2. Mean± SE of serum cortisol, vitamin B12, and blood glucose according to the demographic
    information of RVVC women
    Mean±SE
    Demographic Study
    Vitamin B12 Cortisol Blood glucose
    Housewife 173.1±18.9 4.1± 0.55 114.6± 16.3
    Occupations
    Employee 119.7±11.7* 6.4 ± 0.6* 85.7 ±4.2
    Urban 143.4±12.0 5.9±0.5 99.4±7.2
    Location
    Rural 149.5±11.1 5.3±0.4 101.6±7.2
    yes 153.5±20.0 5.6±0.8 117.4±17.2
    Diabetic
    No 136.0±13.0 5.0±0.5 84.5±3.3
    white 146.3 ± 17.1 4.37± 0.3* 114.2 ±20.3
    Vaginal discharge yellow 129.9 ± 20.5 6.208±0.7 94.1± 10.5
    no discharge 131.5 ± 22.0 7.7± 0.4 86.4 ±5.5
    Yes 118.8 ±10.7 6.3 ±0.6* 100.7 ±4.9
    BV
    No 167.5 ±21.6 4.3± 0.5 97.7 ±14.1
    * pValue <0.05, statistically significant

    9
    Results and
    Discussions

    Figure 2. Levels of serum vitamin B12, cortisol, and blood glucose in control healthy
    women and women infected with vaginal candidiasis.
    10
    Results and
    Discussions

    Figure 3. Levels of serum vitamin B12, cortisol, and blood glucose in pregnant, non-pregnant
    11
    women infected with recurrent vaginal candidiasis.
    Results and
    Discussions

    Figure 4. Associations between serum cortisol, vitamin B12, and blood glucose levels in the patients group. 12
    Conclusions and Recommendations

    • In this study, there was a highly significant increase in serum


    cortisol levels in RVVC women compared to non-RVVC women.
    There was an increase in blood glucose levels in patients with
    RVVC but it was not a significant difference.
    • Results demonstrated a moderate inverse relationship between
    stress hormone (cortisol level) and vitamin B12 in VC patients.
    whereas there was a moderate positive association between
    serum cortisol level and blood glucose levels.
    • The recent study limitation is the few number of samples thus further study is
    warranted with an increased number of samples to validate the current findings.

    13
    14

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