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    Centrifugal Analyzer (Clinical Chemistry)

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    Lois Danielle
    The document discusses centrifugal analyzers, which use centrifugal force to transfer solutions and analyze samples. It describes how Dr. Norman Anderson developed the first prototype in 1967 and how the first commercial model was introduced in 1970. The document outlines the principles, advantages, disadvantages, parts, and process of how centrifugal analyzers work. Specific models discussed include the Cobas-Bio, Cobas Mira Plus CC, and Cobas Fara.

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    Centrifugal Analyzer (Clinical Chemistry)

    Uploaded by

    Lois Danielle
    8K views16 pages
    The document discusses centrifugal analyzers, which use centrifugal force to transfer solutions and analyze samples. It describes how Dr. Norman Anderson developed the first prototype in 1967 and how the first commercial model was introduced in 1970. The document outlines the principles, advantages, disadvantages, parts, and process of how centrifugal analyzers work. Specific models discussed include the Cobas-Bio, Cobas Mira Plus CC, and Cobas Fara.

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    The document discusses centrifugal analyzers, which use centrifugal force to transfer solutions and analyze samples. It describes how Dr. Norman Anderson developed the first prototype in 1967 and how the first commercial model was introduced in 1970. The document outlines the principles, advantages, disadvantages, parts, and process of how centrifugal analyzers work. Specific models discussed include the Cobas-Bio, Cobas Mira Plus CC, and Cobas Fara.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    8K views16 pages

    Centrifugal Analyzer (Clinical Chemistry)

    Uploaded by

    Lois Danielle
    The document discusses centrifugal analyzers, which use centrifugal force to transfer solutions and analyze samples. It describes how Dr. Norman Anderson developed the first prototype in 1967 and how the first commercial model was introduced in 1970. The document outlines the principles, advantages, disadvantages, parts, and process of how centrifugal analyzers work. Specific models discussed include the Cobas-Bio, Cobas Mira Plus CC, and Cobas Fara.

    Copyright:

    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
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    At a glance
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    Centrifugal analysis uses centrifugal force to transfer solutions and reagents to samples for analysis. It was developed in 1967 and first commercialized in 1970.

    Centrifugal analysis is a discrete system where the transfer of solutions is carried out by the use of centrifugal force.

    Advantages of centrifugal analysis include batch analysis, simultaneous addition of reagents to all samples, requiring small sample and reagent volumes, and the ability to program different assay methods.

    CENTRIFUGAL ANALYZER

    Group 3
    MT3C
    Ayson
    De Ala
    Elica
    Marilag
    Moral

    CENTRIFUGAL ANALYSIS
    -A discrete system where the transfer of
    solutions is carried out by the use of
    centrifugal force.
    1967 - Dr. Norman Anderson developed a
    prototype at the Oak Ridge National
    Laboratory
    1970 - First commercial centrifugal
    analyzer was introduced as a spin-off
    technology from NASA

    Principle
    Centrifugal forces are applied to
    discretely add reagents to samples
    and to propel the mixtures into the
    corresponding cuvettes
    Uses the force generated by
    centrifugation to transfer and the
    contain liquids in separate cuvettes
    for measurement
    Samples and reagents are added in a
    specially designed centrifugal type
    cuvette that has three main

    Advantages
    Batch Analysis
    Simultaneous addition of
    reagents to all samples
    Requires small sample
    Uses small reagent volumes
    Can be programmed to carry out
    many different assay methods.

    Disadvantages
    Only one test type can be
    performed each time.
    The test done per batch is
    only for a specific analyte.*
    The quality of cuvette and
    uniformity of detection window
    is crucial.

    TECHNICAL PARTS

    ANALYTICAL MODULE
    Teflon transfer disc
    Cuvette rotor
    Stationary photometric, spectrophotometric
    and in some instruments fluorometric
    system
    Synchronisation system
    Device for the control and the
    measurement of the reaction temperature
    Washing and drying part

    DETECTION UNIT
    DETECTOR
    MIXING CHAMBER
    SYRINGE DRIVE
    SIGNAL PROCESSOR
    MONOCHROMATOR

    How does it work?


    1. Rotor disc is loaded with reagents, diluents
    and samples in appropriate wells, including
    the blank and control sera.
    2. The rotor starts spinning and the reagents
    are transferred outward through the
    capillary passages due to the centrifugal
    force.
    3. The reaction proceeds in the peripheral
    cuvettes and is detected by the
    photometer, reading each cuvette several
    times as the disc rotates.
    4. The signals generated by each cuvette is
    read and processed by a computer and the
    results are displayed.

    Cobas-Bio
    The Cobas Bio (Roche) is a
    discrete spectrometric
    centrifugal analyser which is
    capable of monitoring 29
    reaction cuvettes. The
    dispensing and analysing
    systems are contained within
    one unit and an Intel 8080A
    microprocessor controls the
    total system.

    COBAS-MIRA Plus
    The Roche Cobas Mira Plus CC is a benchtop random
    access analyzer is designed to meet laboratory needs under
    virtually any circumstances. This machine uses the same
    advanced technology as the Roche Cobas Mira Plus, however,
    the automated cuvette changer (CC), enables lab operators to
    load up to 312 cuvettes at a time and let the analyzer run
    without intervention.
    This fully programmable analyzer provides trouble-free
    operation, random-access testing flexibility and a broad test
    menu, including STAT capability.

    Key Features

    All consumables available from AS Diagnostics

    104 programmed tests

    Photometric colorimetric optical system

    End point assay method

    Kinetic assay method

    Direct Sampling capability

    COBAS-FARA

    References:
    Bishop, M. et.al.; Clinical Chemistry:
    Principles, Techniques and
    Correlations
    Vonderschmitt, D.J.; Laboratory
    Organization: Automation
    Ochei et.al.; Medical Laboratory
    Science: Theory and Practice
    http://www.ncbi.nlm.nih.gov/pmc/art
    icles/PMC2547363/pdf/JAMMC-04-021.p
    df

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