Traumatic Brain Injury Acc
Traumatic Brain Injury Acc
Traumatic Brain Injury Acc
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ACC14261-1-PLINK 8/23/06 12:08 PM Page 2
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E iti noa ana, na te aroha
Though my present be small, my love goes with it
The guideline also points to other resources that come with the guideline. These resources can be found at
www.nzgg.org.nz and www.acc.co.nz.
List of figures
1.1 Presentations and admissions for head injury at Christchurch Hospital
Emergency Department, 2004 ........................................................................................................23
3.1 Diagnostic management and selection for imaging of children and
young people aged <17 years .........................................................................................................56
4.1 Interaction of concepts ...................................................................................................................71
4.2 ‘Stages of rehabilitation’ model for people with traumatic brain injury ............................................72
4.3 A functionally oriented model of community-based rehabilitation ..................................................73
14.1 Assessment of depression in traumatic brain injury ......................................................................180
14.2 Reasons for depression following traumatic brain injury................................................................184
14.3 Algorithm: Safe steps to return to play after a possible traumatic brain injury ................................191
This guideline is intended for use primarily by all practitioners involved in the acute management and
rehabilitation of those with TBI, including Emergency Departments, primary and secondary care practitioners,
rehabilitation and allied health practitioners, providers of residential care, private providers, and case managers
and educationalists.
The guideline will also be a resource for the Accident Compensation Corporation (ACC) and District Health Board
(DHB) funders and planners as it identifies the necessary aspects of care and services that should be provided.
In addition, it identifies where there is a need for targeted research to improve the evidence base.
11
Foreword
The New Zealand Guidelines Group Incorporated (NZGG) is a not-for-profit, independent organisation
established to promote effective health and disability services. NZGG oversees the development and
implementation of guidelines across the health and disability sectors in New Zealand. Guidelines make an
effective contribution to this aim by reviewing the latest national and international studies and synthesising
their findings into practical recommendations for use in the New Zealand setting.
The Traumatic Brain Injury Rehabilitation Guideline,1 published jointly in 1998 by ACC and the National
Health Committee, describes essential features of a TBI rehabilitation service, but does not offer guidance
on the management and rehabilitation of people with TBI. A Clinical Guideline for the Acute Management of
Traumatic Brain Injury2 was developed in 2001, which defines TBI and provides the main principles for clinical
management of acute TBI. However, the previous guideline did not cover the diagnosis, classification or
management of people with TBI after the acute phase. ACC is also currently developing generic guidelines for
claims assessors, but these will not cover specialised assessments, such as those required for claimants with
TBI. ACC commissioned the development of this new guideline for use in the management and care of people
with TBI.
Scope
This guideline provides a diagnostic, acute management and rehabilitation framework for the care and
management of TBI. It is intended to inform and guide: all TBI acute and rehabilitation treatment providers and
specialists throughout New Zealand; funding agencies such as ACC and DHBs; and people with TBI and the
people who care for them, including family/whānau and unpaid carers. The guideline will also inform ACC’s
purchasing strategy and the development of contracts.
This guideline addresses the acute care and post-acute rehabilitation for all levels of severity of TBI, for all ages,
and in all locations of care (ie, pre-hospital, hospital and community-based assessment and management).
For the purpose of this guideline, TBI is broadly defined as brain injury resulting from externally inflicted
trauma, ie, due to head injury or post-surgical damage. Therefore, the guideline does not specifically address
other categories of brain injury, including those resulting from poisoning and anoxia, or stroke and other
cardiovascular events. (For current guidelines on brain injury secondary to stroke see Life after Stroke: a New
Zealand guideline for management of stroke, available at www.nzgg.org.nz.)
This guideline also excludes pre- and peri-natal brain damage resulting from prenatal and birth-related events.
The management of TBI-related issues including prevention, drug and alcohol abuse, and family violence is also
outside the scope of this guideline. Where other guidelines have relevance to TBI management, they are cross-
referenced in the text.
This guideline is not a service framework and does not extend to a detailed analysis of the most effective
service configurations to support the recommended assessment and rehabilitation strategies. The section on
implementation is similarly intended as a broad conceptual guide. This edition does not specifically address the
needs of all minority populations within New Zealand, although they may be considered in future reviews.
The guideline is informed by the International Classification of Functioning, Disability and Health (ICF).3
Therefore, there is a focus on the impact of the TBI on a person’s functioning and participation rather than
specific impairments.
12
Terms routinely used to describe the severity of the injury, such as the term mild brain injury, may be
unacceptable to people who have suffered a brain injury that falls within this category, as the impact on their
health and functioning that they experience as a result of the injury may be far from ‘mild’. There are also
anecdotal accounts that use of this term impacts on the interactions with case managers and health care
professionals so that the injured person feels that the professionals are dismissive and do not accept the full
extent of their problems. Although classification of the initial severity of TBI is useful in the prediction of some
short- and long-term outcomes, the relationship between initial severity of injury and medium- and long-term
outcomes has been questioned.4
Following recent international practice, the Guideline Development Team has used the terms mild, moderate or
severe TBI to describe the initial severity of injury in a few sections of this guideline, particularly in Chapter 1
where the size and impact of the problem of TBI are discussed.
In most other sections of the guideline, the Guideline Development Team has followed the convention of
other recent international evidence-based guidelines, and used, where possible, clinically significant TBI or
symptomatic TBI to refer to TBI with a need for intervention or other care or support, irrespective of the initial
severity of injury. Additional specific terminology used in this guideline is defined in the Glossary.
Results of a preliminary literature search (conducted to inform the scope of the guideline) made it apparent
that a risk to the effectiveness of any guideline for rehabilitation from TBI would be the impact of treatment
recommendations in the acute stage of management. This preliminary literature search also identified a
rigorous, evidence-based guideline for care of the acute stage of TBI: Head Injury: Triage, Assessment,
Investigation and Early Management of Head Injury in Infants, Children and Adults, produced by the United
Kingdom’s (UK) National Institute of Clinical Excellence (NICE) in 2003.7 ACC agreed that this guideline should
be adapted for the New Zealand environment to produce a guideline that would cover the entire process of care
and rehabilitation from the point of injury. A sub-group with a focus on the adaptation of the NICE guideline was
formed from the main Guideline Development Team, with the addition of clinicians with expertise in emergency
medicine and the acute phase of care.
The specific topics to be covered by the guideline, in addition to those in the NICE acute care guideline, were
agreed as follows:
• the epidemiology of TBI in New Zealand
• appropriate assessments (including neuropsychological testing) to confirm diagnosis, classify severity
and identify people at high risk of long-term sequelae (including work loss), and to identify important early
complications
• effective identification of TBI in a variety of non-clinical settings, such as schools and prisons
• appropriate strategies that minimise subsequent disability and work loss and maximise quality of life,
including effective rehabilitative therapies and interventions appropriate to New Zealand clinical settings
• the effectiveness of complementary and alternative medications and therapies, such as osteopathy and
acupuncture, in the rehabilitation of people with TBI
• appropriate management strategies for post-acute complications of TBI (including physical, cognitive,
behavioural impairments, spasticity, and intervention strategies) that are associated with improved
outcomes if recovery is slower than expected
• appropriate follow-up strategies for people with TBI or specific sub-groups of people with TBI
• the most appropriate TBI outcome measurements for New Zealand clinical settings, including assessment of
when people can return to sporting, educational, work and leisure activities
14
It was agreed that for each topic, consideration would be given to whether the evidence and recommendations
would apply equally well to both adults and children, and to Māori and Pacific peoples, and to provide differing
recommendations for these populations, where appropriate.
These topics were operationalised as searchable questions by the NZGG research team, and a systematic
hierarchical search for evidence was conducted. The search strategy for the guideline is available online at www.
nzgg.org.nz – select ‘Publications’ then ‘Guidelines’ then ’Neurology/Rehabilitation’ then the guideline title,
then ‘Search Strategy’.
Research identified through the search was assessed for relevance by the NZGG research team, and papers
identified as potentially relevant were retained to be included in the critical appraisal process.
A number of recent and rigorously produced ‘seed’ guidelines and syntheses of relevant evidence to inform the
development of this guideline for New Zealand were identified. The Guideline Development Team acknowledges
the help and support received from the authors and editors of these works, which include:
1. Head Injury: Triage, Assessment, Investigation and Early Management of Head Injury in Infants, Children and
Adults, 2003. Produced by NICE and the National Collaborating Centre for Acute Care.7
2. Rehabilitation following Acquired Brain Injury: National Clinical Guidelines, 2003. Ed: Turner-Stokes L.
Produced by the Royal College of Physicians and British Society of Rehabilitation Medicine.8
3. Management and Prognosis of Severe Traumatic Brain Injury, 2000. Produced by Bullock MR, Chesnut RM,
Clifton GL, et al., for the Brain Trauma Foundation and American Association of Neurological Surgeons.9
4. Evidence Report on Rehabilitation of Persons with Traumatic Brain Injury, 1998. Produced by Chesnut RM,
Carney N, Maynard H, et al., of the Oregon Health Sciences University Agency for Health Care Policy and
Research.10
5. Rehabilitation for Traumatic Brain Injury in Children And Adolescents. Evidence report no. 2, supplement,
1999. Produced by Carney N, du Coudray H, Davis-O’Reilly C, et al., of Oregon Health Sciences University
Agency for Health Care Policy and Research.11
6. Joint Framework and Guidelines on Vocational Assessment and Rehabilitation after Acquired Brain Injury,
2004. Produced by the Inter-Agency Advisory Group on Vocational Rehabilitation after Brain Injury and in
association with the British Society of Rehabilitation Medicine Working Party on Rehabilitation following
Acquired Brain Injury, British Society of Rehabilitation Medicine.12
7. Concise Guidance for the Use of Anti-depressant medication in Adults Undergoing Recovery or Rehabilitation
Following Acquired Brain Injury, 2005. Ed: Turner-Stokes L. Produced by the British Society of Rehabilitation
Medicine and the British Geriatrics Society with the Royal College of Physicians’ Clinical Effectiveness and
Evaluation Unit.13
15
17
Rowena Cave
Senior Project Manager, until September 2005
Rob Cook
Medical Advisor
Naomi Brewer
Researcher, until September 2004
Rose Matthews
Researcher, until April 2005
Mark Ayson
Researcher, from October 2005
Harry McNaughton has received funding for research and fees for consulting from ACC
Kate Hall received funding to attend the Epilepsy Symposium 2002 from Janssen-Cilag
Elizabeth Rowland is a director of a private limited company providing occupational therapy services
Consultation
A draft of this guideline was widely circulated to more than 250 individuals/organisations for comment in
June 2005 as part of the peer review process. Comments were received from the following organisations or
individuals:
• Andrew Swain, ACEM
• Anna McRae, Auckland DHB
• Anne Smith, Wilson Centre
• Blair Donkin, Otago DHB
• Bridget Kool, University of Auckland
• Brigette Larkins, TBI Guideline Development Team
• Chris Milne, Anglesea Sports Medicine
• Colin McArthur, Auckland DHB
• Derek Keith Sage (Dr), Bay of Plenty DHB
• Dharan Vijaya, Ministry of Education
• Elizabeth Rowland, Capital and Coast DHB
• Garry Clearwater, Waitemata DHB
• Gillian Robb, University of Auckland, School of Population Health
• Helen Cosgrove, MidCentral Health
• Kathryn McPherson, Auckland University of Technology
• Janis Henry, Integrated Partners in Health
• Jenni Coles, Counties Manukau DHB
• Jiff Stewart, Ministry for Social Development
• Jocelyn Neutze, Kidzfirst and Middlemore Hospital Emergency Department
• Jock Muir, Canterbury DHB
• John Clink, Canterbury DHB
• Judith Roessink-Berryman, Unimed, Grange House
18
Acknowledgements
NZGG and the Guideline Development Team would like to acknowledge, in particular, the help and support of
the following people and organisations for provision of additional information and permission to include and
adapt their work:
The UK NICE and the UK National Collaborating Centre for Acute Care
Professor Kathleen Bell, Department of Rehabilitation Medicine, University of Washington, Seattle, USA
Dr Scott Bezeau, Department of Psychology, University of Victoria, Victoria, British Columbia, Canada
Professor R Chesnut and the Oregon Health Sciences University, Portland, USA
Professor Lynne Turner-Stokes, the British Society of Rehabilitation Medicine and the UK Royal College of
Physicians, London, UK
Professor Mark Ylvisaker, School of Education, College of Saint Rose, Albany, New York, USA
Thanks to Dr Monique Faleafa, Dr Matire Harwood, Dr Rob Cook, Margaret Dudley and Sarah Howard for their
development of the chapters on TBI in Māori and Pacific populations.
Funding
This guideline was funded by ACC and development and production was independently managed by NZGG.
ACC staff members were co-opted onto the Guideline Development Team to provide advice about ACC internal
processes. All evidence appraisal, reporting and formulation of recommendations is independent of ACC, and
NZGG retains editorial independence.
19
20
Chapter 1:
Traumatic brain injury in New Zealand
Overview
• A consumer survey suggests that people with TBI experience significant health disadvantage, in terms of
both physical and mental health, compared with their peers. TBI, an injury to the brain rather than an injury
to the head, is identified by confusion or disorientation, loss of consciousness, post-traumatic amnesia and
other neurological abnormalities.
• The Glasgow Coma Scale score and ‘duration of post-traumatic amnesia’ can be used to classify the severity
of TBI.
• Accurate data on the incidence and prevalence of TBI and TBI sequelae is needed to aid the planning and
evaluation of service delivery.
• A number of pre-injury, injury-related and post-injury factors have been shown to be associated with better or
poorer outcomes.
• Some people with mild TBI will have effects lasting greater than 12 months, while in those with moderate
and severe TBI there may be a residual impact on functioning throughout the lifespan.
• Carers of individuals with TBI have a poorer quality of life and increased psychological morbidity compared
with the general population.
• Considerable variation currently exists in New Zealand TBI rehabilitation service provision.
• Rehabilitation services are provided by both DHBs and private providers.
• ACC funds a range of residential and non-residential rehabilitation services.
The main difficulty with defining TBI is differentiating between those people who have had a head injury (a
definite episode of external force to the head, including a deceleration force without actual impact to the head),
and those who also have TBI. Most international definitions of TBI require some neurological symptoms or signs
such as loss of consciousness, a period of amnesia and/or focal neurological deficit.14
There is no ‘gold standard’ for the diagnosis of TBI, as some forms of radiological imaging are neither sensitive
nor specific for TBI. There are also instances where individuals who do not meet low-threshold criteria for the
diagnosis of TBI (those with no loss of consciousness, with a normal Glasgow Coma Scale score [see Section
2.2.1 Glasgow Coma Scale for more details] and no amnesia) have evidence of injury to the brain, such as a
contusion, on magnetic resonance imaging (MRI) scan.
The World Health Organization (WHO) Collaborating Centre Task Force on Mild Traumatic Brain Injury performed
a systematic review of explicit case definitions to produce a working definition for TBI and then applied a
specific definition for mild TBI.15 In the absence of a ‘gold standard’ diagnostic test, its definition of TBI is
currently the best available, and it has been adapted by the Guideline Development Team to delineate the lower
threshold of ‘definite TBI’.
21
TBI is an acute brain injury resulting from mechanical energy to the head from external physical forces.
Operational criteria for clinical identification include one or more of the following:
• confusion or disorientation
• loss of consciousness
• post-traumatic amnesia
• other neurological abnormalities, such as focal neurological signs, seizure and/or intracranial lesion.
These manifestations of TBI must not be due to drugs, alcohol or medications, caused by other injuries or
treatment for other injuries (eg, systemic injuries, facial injuries or intubation), or caused by other problems (eg,
psychological trauma, language barrier or co-existing medical conditions).
TBI can occur in the context of penetrating craniocerebral injuries but in this situation, focal neurological deficits
are generally more important than any diffuse element.
The most commonly used criterion for classifying severity has been the Glasgow Coma Scale score. This is
usually used for assessment when a person with suspected TBI presents to an Emergency Department or
general practitioner.15
The scores are categorised as follows: ‘mild TBI’ 13 to 15 (of a maximum 15); ‘moderate TBI’ 9 to 12; and
‘severe TBI’ 3 to 8 (with 3 being the minimum score).15 There is some evidence that people with an initial
Glasgow Coma Scale score of 13 have worse outcomes than those with a Glasgow Coma Scale score of 14 to
15,16 with those authors advocating a subset of ‘mild TBI’ called ‘high-risk mild TBI’ for people with an initial
Glasgow Coma Scale score of 13 to 14 and/or radiological abnormalities. Nevertheless, current international
consensus, including the recent WHO Task Force on Mild Traumatic Brain Injury,15 supports the severity
classification using the Glasgow Coma Scale as described here (ie, initial Glasgow Coma Scale of 13–15 = mild
TBI).
See Chapter 2, Pre-hospital assessment, management and referral to hospital and Appendix C for more details
about the adult and paediatric versions of the Glasgow Coma Scale.
Another useful indicator of the severity of a TBI is post-traumatic amnesia, as it is strongly related to
outcomes.17–23 Post-traumatic amnesia is calculated from the time of the accident and includes any period of
loss of consciousness or coma.
Assessment of post-traumatic amnesia can be inaccurate if trying to determine it retrospectively through clinical
interview, and should commence before the resolution of post-traumatic amnesia, where possible.24 There is
little difference between particular assessment measures of post-traumatic amnesia, although the Tools Review6
concluded there were some qualitative advantages to the Modified Oxford Post-traumatic Amnesia Scale
(MOPTAS),25 which is similar to the widely-used Westmead Post Traumatic Amnesia Scale.26
22
In this guideline, unless otherwise stated, the definitions of severity of TBI used are those given in Table 1.1.
table 1.1:
criteria for classifying the severity of traumatic brain injury*
* If there is a discordance between the severity level for the Glasgow Coma Scale score and post-traumatic
amnesia, it is appropriate to use the more severe category, eg, Glasgow Coma Scale of 14, but mild TBI, post-
traumatic amnesia two days = moderate TBI.
† Teasdale, et al. Acta Neurochir (Wien) 1979; 28:13–16.
‡ Carroll LJ, et al. J Rehabil Med 2004(43 Suppl):113–25.
age head
(years) injuries
0–2 87
2133 head injuries 3–16 467
(including people with other injuries and conditions) 17–25 574
26–65 776
66–100 228
69% (1467) discharged 31% (666) admitted
31% (666) 54% (359)
admitted wards
Reproduced from: MacFarlane, MC. Director, Department of Neurosurgery Christchurch Hospital, New Zealand.27
In the absence of prospectively acquired New Zealand hospital and community data with consistent criteria for
the definition of TBI, the Guideline Development Team has been unable to determine the exact extent of TBI in
New Zealand. These caveats need to be considered alongside the data in this section.
23
A systematic review of the literature by the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury30
concluded that a ‘true’ population-based rate of mild TBI would be more than 600 cases per 100,000 per year.
Assuming this is true for New Zealand, this would give an estimate of more than 24,000 cases of mild TBI in
New Zealand each year and approximately 60 per 100,000 per year of moderate to severe TBI (an estimated
2400 cases per year in New Zealand). Therefore, the total TBI incidence (including all levels of severity) in New
Zealand, projected from the WHO Task Force data, would be approximately 660 per 100,000 per year (ie, 26,400
cases per year).
In reviewing ACC data on TBI incidence, it is important to recognise that ACC uses operational definitions to
classify severity. These definitions differ from the classification of severity used in this guideline. An ACC
classification of ‘moderate to severe’ TBI thus refers to the need for extensive care, support and lifetime
planning. Other categories are aggregated under the heading ‘concussion’. In 2003, ACC recorded 17,514 new
cases of ‘concussion’ (about 437 cases per 100,000 per year) and 123 moderate to severe TBI cases in 2002.
Assuming these figures are correct and the proportion of all TBI that is ‘moderate and severe’ is around 10%,
there should be 2000 to 3000 cases of moderate and severe TBI per year. It seems probable that the majority
of people with moderate and severe TBI are assessed at hospital, and the figure of 8.1% moderate to severe4,30
seems conservatively realistic.
Based on the national and international data available, the Guideline Development Team calculates that an
estimate of hospital attendance with TBI in New Zealand for all ages would be in the range of 10,000 to 17,000
cases per year, with 8% to 10% of those in the moderate to severe category.4,30 A significant proportion (perhaps
as high as 25%) of these people may have ‘suspected TBI’, not meeting the criteria for ‘definite TBI’. Our best
estimate of all ‘medically attended TBI’ in New Zealand would be 16,000 to 22,500 per year with an even
stronger caveat applied regarding the proportion of ‘definite TBI’ in this group. The best estimate of all TBI will,
necessarily, have a large range. A total TBI incidence figure for New Zealand, including those people with TBI
who do not seek medical attention, is likely to be in the range of 20,000 to 30,000 cases per year.
In order to plan and evaluate service delivery for people with TBI, and test interventions in a TBI population,
accurate information about the incidence and prevalence of TBI in New Zealand, together with information about
the consequences directly attributable to TBI for those people, is required. Currently that information is not
available to a sufficient level of accuracy.
24
1.4 Cost
In 2004, ACC figures indicated that it paid over $100 million a year for post-acute treatment and rehabilitation
of claimants with concussion and TBI.32 This excludes costs incurred during the acute phase of care. ACC also
supports the operation of Emergency Departments through funds to DHBs. However, it is not possible to identify
the proportion of this funding that is used for treating people with TBI. In 2003, 17,514 new cases of concussion
led to claim payments of $12,532,834 for that year alone while in 2002, the 132 new cases labelled moderate
to severe TBI led to claim payments of $3,603,579 for that year. In 2003, there were 1477 ongoing cases of
TBI (ie, people with claims originating more than a year previously), which led to claim payments of a further
$93,728,240.
In those aged under five years at the time of injury, the causes of the injuries (ACC Injury Statistics, 2004)32 were
as follows:
• 17% motor vehicle related
• 17.2% ‘other loss of balance/personal control’
• 16.1% resulting from being struck by a person, animal or object
• 43% of cases could not be classified according to the criteria used or the cause was unclear.33
Injury-related factors
• TBI resulting from physical abuse in both adults and children and young people is related to poorer
outcomes.41–43
25
Post-injury factors
• Multiple TBIs: there is some evidence that multiple or repeated mild TBI, over an extended period of months
or years, may in some cases result in cumulative neurological and cognitive deficits. Very rarely, where the
repeated mild TBIs occur within a period of hours, days or weeks, the outcomes can be severe or fatal.49,50
• Social deprivation and lower socioeconomic status are related to poorer outcomes.51–53
• Good or poor family functioning is related to better or poorer outcomes respectively.11,54
Injury-related factors
• Mechanism and type of injury influences outcome:59 people who have an injury where an object strikes their
head have a poorer outcome compared with people whose heads strike an object; the type of injury (ie,
motor vehicle collision, fall, assault, motor vehicle-pedestrian collision, falling object, sports/recreation)
also has some effect on outcome – people whose injury results from being hit by a falling object, assault or a
motor vehicle accident generally have poorer outcomes than people whose injury was due to other causes.
• Better cognitive status as assessed by cognitive testing during the acute stage (inpatient stay) is related to
better outcomes.60
• In mild TBI, headache, dizziness and/or nausea acutely following injury (ie, in the Emergency Department) is
strongly associated with the severity of post-traumatic sequelae six months post-injury.61
• Serum markers: the specific serum markers S-100B and neurone-specific enolase (NSE) are thought to be
markers of cell damage in the human central nervous system, and after damage to brain tissue, increased
concentrations of NSE and S-100B can be measured in peripheral blood serum. In mild TBI, one small
study found an increase in severity of forgetfulness, dizziness or headache after six months in people
with increased early serum NSE or S-100B concentrations. All people with mild TBI without increased
serum markers or symptoms in the Emergency Department were symptom free after six months.61 In TBI
of all severities, a serum S-100B concentration of >0.32 mcg/L as measured acutely post-injury (ie, in the
Emergency Department) has been shown to predict severe disability as measured by the Glasgow Outcome
Scale (GOS <5) at one month post-injury, with a sensitivity of 93% (95% CI: 68–100%), a specificity of 72%
(54–79%), and a negative predictive value of 99% (93–100%).62 Although these results are interesting, the
use of serum markers as a predictive tool is still part of ongoing research rather than of clinical utility.
Post-injury factors
• Development of post-TBI mental illness, such as depression or anxiety, may be related to poorer outcomes.63
• Better social support is related to better outcomes.34
26
* See Glossary
27
These deficits limit the functioning of the person with clinically significant TBI to differing degrees, depending
on the severity and combination of the brain injury with consequent deficits, presence of other injuries, and
other circumstances such as the person’s intellectual background, environment, and family and social support.
People who have had a clinically significant TBI may have impairment in their ability to live independently,
return to work, education and leisure activities, and maintain relationships. These impairments may impact not
only on the injured person, but also on their family/whānau and carers.8
Neurological recovery after a clinically significant TBI may take months or years, and people may be left
with permanent deficits. Most people with ‘mild’ brain injuries recover completely over the subsequent few
months.67 However, some may have symptoms which persist for longer than this, reporting headache, dizziness,
concentration and memory problems, mood changes and irritability.
People who have suffered a clinically significant TBI are an extremely heterogeneous group. Thus, rehabilitative
care needs to be tailored to the individual, with consideration of individual deficits and rates of progress.
Specific recommendations on rehabilitation are contained within Chapter 5, Rehabilitation following clinically
significant traumatic brain injury – assessment and Chapter 6, Rehabilitation following clinically significant
traumatic brain injury – intervention.
A recent UK study of 526 children aged between 5 and 15 years with varying severity of TBI used the King’s
Outcome Scale for Childhood Head Injury (KOSCHI) to assess outcomes at approximately two years post-injury.
Frequent behavioural, emotional, memory and attention problems occurred in one-third of those who had
sustained a severe TBI, one quarter of those who had had a moderate TBI, and in 10% to 18% of those who
had had a mild TBI. Personality change after TBI was reported for 148 children (28% of the total, of whom 21%
had a mild TBI, 46% a moderate TBI, and 69% a severe TBI). Significant associations were noted between injury
severity and KOSCHI outcomes, and between social deprivation and poorer outcomes.51
28
There is some international evidence that children and young people may not have adequate post-TBI follow-up
and treatment. A population study found that at around two years post-injury, 43% of those with mild TBI, 64%
of those with moderate TBI and 69% of those with severe TBI had moderate disability (n=252), while 57% of
those with mild TBI, 36% of those with moderate TBI and 22% of those with severe TBI made a good recovery
(n=270).51 A total of 30% of children received follow-up, but whereas all of the children who had a severe
disability (30%) received appropriate follow-up, 64% of children with moderate disability received no follow-
up.51 Although this study did not analyse the influence of pre-injury factors in measurement of outcomes, it is
illustrative of the need for follow-up of children with less severe, as well as more severe TBI.
Another study of carers in New Zealand found that in addition to distress, many carers reported health problems
and a change in roles. Partners who were carers were more likely to report health problems, distress and
changes in role than were parents who were carers.72 Similarly, a study in South Africa of the effects of caring
for a partner with a TBI found that the injured person’s altered communication patterns affected interpersonal
relationships and quality of life extensively and the carers had decreased income due to the low incidence of
return to work.73 Carers also reported changes in family relationships, particularly between the injured person
and their children, as well as a deterioration in marital relationships. Most carers reported feeling ‘tied down’
due to the dependence of the injured person, and loneliness predominated as a social consequence despite
the support of pre-injury friendships.
Families who have a child with clinically significant TBI frequently experience work loss and financial difficulties
as a consequence of the care needs of the child.11 There is substantial evidence for a negative impact on family
functioning when a child in the family has had a TBI, with deteriorating functioning associated with the severity
of the child’s injury. Families with severely injured children have been shown to be more likely to actively seek
help than families of children with less severe TBI, although the latter families are also likely to have need of
help.11
A small number of very severely injured people are transported to tertiary care centres with neurosurgical
services (Auckland, Hamilton, Wellington, Christchurch and Dunedin).
Many people with TBI who are assessed in an Emergency Department are not admitted or, if they are admitted,
stay only a very short time in hospital (see Section 1.2, Estimates of the incidence of traumatic brain injury in
New Zealand. Christchurch Hospital data).27
29
Most children with TBI are admitted to paediatric wards in general hospitals and are managed by general
paediatric teams. For children with severe TBI there is a single specialist residential rehabilitation service, the
Wilson Home in Auckland, which accepts referrals from around New Zealand.
Services for people with TBI are available in all major centres in New Zealand. Service provision is restricted to
providers who can show a high level of expertise and commitment to rehabilitation following TBI. The service
providers tender for each of the services, and through this tendering process must demonstrate to ACC that
they have the resources, competence/training and community links to provide rehabilitation matched to the
particular needs of the relevant client group.
The mild TBI service is intended to provide early access and timely assessment and rehabilitation for people
who have a mild TBI. The aim of this service is to rehabilitate people to maximum independence through case
management and appropriate assessment and rehabilitation. It allows entry for people either early in the post-
acute stage of a mild TBI, or later on for people who have persisting symptoms following mild TBI. The service
allows for the assessment of people who may have had a TBI and need assessment to establish cover and
entitlement.
There are seven mild TBI clinics, sometimes known as ‘concussion clinics’, around New Zealand. Two further
clinics provide specific care for children with TBI. The clinics provide a combination of specialist medical
assessment, screening neuropsychological assessment, and assessment and intervention from an occupational
therapist, although this is usually limited to a few sessions.
However, most services report also seeing a varying proportion of people with more severe injuries.
30
Rehabilitation can be provided in a person’s own home. Where residential rehabilitation options are being
considered, the advantages and disadvantages of living at home, with appropriate inputs and support, need to
be discussed. Particular consideration should be given to the needs of family and/or carers in this situation.
Almost exclusively, people with TBI who are managed in residential rehabilitation services have had a severe
TBI, and/or have a complication of the initial TBI or other injuries. Occasionally there may be significant
comorbidities (particularly mental health disorders) which, in addition to a less severe TBI, may require
residential placement for rehabilitation. Table 1.2 provides an approximate outline of the current pathway into
residential rehabilitation following severe TBI in New Zealand.
table 1.2:
intervention settings: the progression into residential rehabilitation
2. Post-acute but medical problems Few days to a few Stay on acute ward, OR transferred to
weeks inpatient rehabilitation ward
A decade ago the residential rehabilitation services described were provided almost exclusively in hospitals.
The 2004 Current Practice Review5 shows that a minority of people with TBI requiring residential rehabilitation
are now managed in hospital environments. A common model for these services in 2005 is for small numbers of
people with TBI to be managed in a privately owned ‘community house’, with 24-hour supervision and varying
amounts of health-professional input. These environments are more ‘real life’ than hospital rehabilitation
wards, and therefore may facilitate transition back to independent (or assisted) community living.
31
This service is designed for people who have suffered a moderate to severe TBI, and the emphasis on
community-based care is to aid the person’s eventual re-integration into the community. People who receive
this service usually have substantial cognitive and/or physical needs. From a clinical and rehabilitation
management perspective, this client group presents a challenge in that they require 24-hour supervision and
care, often with more than one person working with each person at any given time.
The key distinction between ‘active residential rehabilitation’ and ‘residential rehabilitation support’ (described
in the following section) is the intensity of rehabilitation input, linked to expectations regarding speed of
recovery. Where significant functional gains are possible over weeks to a few months with appropriate input,
active rehabilitation (ie, providing a rehabilitation environment and intensive [at least daily] rehabilitation) input
is indicated.
This service is aimed at a broad spectrum of people who have TBI long term, and provides community-based
rehabilitation of serious injury claimants (most commonly TBI). These claimants may remain in the service in
the long term. The service may rehabilitate the person who has had a serious injury into community living with
appropriate support. People using this service generally have a need for ‘slower-stream’ rehabilitation.
In residential support services, there is no necessary expectation of improving levels of independence and/
or participation in the community; there is monitoring to identify secondary problems, which may lead to
deterioration and an ongoing need to provide sufficient support to realise the person’s full ability to function.
This includes provision of physical supports (eg, appropriate wheelchair, communication device), social
supports (eg, day programmes) and emotional supports (eg, appropriate management of mood, interaction with
family/whānau or friends).
A residential environment with people of similar age and interests should contribute to appropriate levels of
social and emotional support. However, residential support programmes providing such an environment are
not currently available in many parts of New Zealand. In addition, some people with severe TBI can be difficult
to manage in existing residential support programmes, due to behavioural difficulties in particular. Such issues
32
require careful consideration from appropriately trained rehabilitation clinicians, including trial placements,
before long-term decisions are made.
Residential support services also provide for people who may not have suffered a serious injury, but are
nonetheless unable to rehabilitate to the community (eg, an older person with a relatively minor injury but no
carer).
Open-ended responses from providers about effective interventions, barriers to effectiveness, gaps in services
and ideas for better services provided further information, and are presented as verbatim responses in the full
report. The full report can be accessed at www.nzgg.org.nz.
Although there is little robust comparative evidence to demonstrate whether specialisation of services for TBI
leads to better outcomes, strong evidence from related conditions and international expert opinion suggests
that this would be the case.8 One issue that needs to be considered for New Zealand is whether specialist
TBI rehabilitation services should be pursued, acknowledging that this would require centralisation and the
potential disadvantages that might engender – particularly the difficulties for family and other support. It should
be noted that consumers supported the idea of a small number of expert TBI specialist units rather than the
current widely dispersed services – that is, they preferred the ‘best possible treatment available’ over the ‘most
convenient treatment option’. The ‘centralisation’ model has been applied to spinal injury services for the acute
phase of spinal cord injury (SCI) treatment in New Zealand; however, SCI and TBI are not identical conditions.
34
Overview
• Pre-hospital assessment can be undertaken by a range of trained health care professionals, in order to
establish whether a trauma to the brain has occurred and factors associated with serious complications of
head trauma are present.
• There are limited, well designed studies on the efficacy of pre-hospital intervention.
• There are a number of risk indicator assessment tools for acute complication of TBI, including the Glasgow
Coma Scale.
• The Glasgow Coma Scale is used for immediate, pre-hospital and hospital assessment of the acute
complication risk associated with TBI.
• People with symptoms/signs that are defined as risk factors for acute intracranial complications of TBI
should be promptly referred to an Emergency Department. Emergency transport services should also be used
if the signs of acute complications are more serious, if the person assessing has additional concerns, or for
some other circumstances, such as a lack of suitable transport.
• Rapid transfer to an Emergency Department using emergency services is appropriate if there is deterioration
in the person’s condition, a loss of consciousness, focal neurological deficit, skull fracture or penetrating
head injury, seizure, or suspected neck injury.
• People with none of the signs or symptoms for Emergency Department assessment should seek further
medical assessment from a general practitioner or accident and medical clinic.
• There is consistent evidence that coordinated trauma systems reduce mortality for serious injury, including
serious neurotrauma. A coordinated system of trauma care for TBI that provides an organised and responsive
system of care for people is required.
This chapter deals with the pre-hospital phase of assessment and management for people with suspected TBI.
It provides advice about who should be referred for an assessment at hospital and who should be transported
by ambulance, along with recommendations about appropriate public health and educational material for the
general public.
This chapter is adapted and updated for New Zealand from the NICE Head Injury Guidelines.7
There are four important reasons for undertaking pre-hospital assessment, which are outlined below.
1. Identifying actual or potential hypotension and/or hypoxia, which untreated will magnify TBI effects.
2. Identifying risk factors for acute complications of TBI, which may require intervention, particularly bleeding
inside the skull and/or brain.
3. Identifying other injuries that may require urgent management.
4. Estimating the severity of any injury to the brain that has implications for subsequent management and
follow-up.
35
A person with a suspected traumatic brain injury should initially be assessed and managed C
according to clear principles and standard practice as embodied in the Advanced Trauma
Life Support (ATLS)/Early Management of Severe Trauma (EMST) system and for children the
Advanced Paediatric Life Support (APLS) system.
The first priority for those administering immediate care is to treat the greatest threat to life C
and avoid further harm.
A person who has sustained a suspected traumatic brain injury should have full cervical spine C
immobilisation attempted, unless they have all of the following:
• no alteration of consciousness
• no neck pain/tenderness
• no focal neurological deficit
• no major distracting injury.
A person who has sustained a suspected traumatic brain injury should be transported directly C
to a centre where traumatic brain injury is managed in entirety.
Where this type of facility is unavailable, the person should be transported to a centre that
can stabilise the person’s condition prior to transfer to a centre where traumatic brain injury is
managed in entirety.
It is expected that all acute hospitals accepting people who have sustained a suspected
traumatic brain injury should have the resources to expeditiously assess and intervene to
optimise outcome and that these resources should be appropriate for the person’s age.
Paramedics should be fully trained in the use of the adult and paediatric versions of the C
Glasgow Coma Scale and its derived score.
Paramedics should have training in the detection of non-accidental injury and should pass C
this information to Emergency Department personnel when the relevant signs and symptoms
arise.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
The first assessment of a person suspected of having sustained a TBI may be performed by a general
practitioner or other primary health care practitioner, a sports coach, an ambulance officer, a member of the
public, or telephone operator for a telephone health ‘helpline’. The aim of this assessment is to establish
whether trauma to the head has occurred and whether any of the factors associated with serious complications
of head trauma are present.
When assessing a person with a suspected TBI who is apparently intoxicated, it should not be assumed that
the signs and symptoms of the person’s injury are due to the intoxication from alcohol or drugs. There should
be particular caution with people who are vomiting or who may be intoxicated, due to the risk of aspiration and
consequent hypoxia.
There are specific questions regarding the very early management of people with severe head injuries (ie,
Glasgow Coma Scale score of 8 or less). Recent systematic reviews have examined evidence on the management
36
A general principle in immediate management is that the first priority for those administering immediate care
is to treat the greatest threat to life and avoid further harm.7 See also Chapter 3, Acute phase of traumatic brain
injury care.
These tools and factors are used to assess whether a person with a suspected TBI requires assessment at an
Emergency Department or other medical assessment and with what urgency.
Recommendations concerning the assessment itself are made in Chapter 5, Rehabilitation following clinically
significant traumatic brain injury – assessment.
recommendation grade
The adult and paediatric versions of the Glasgow Coma Scale should be used to assess people C
with a head injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
A fall in the Glasgow Coma Scale score of two or more points, no matter what the original ✓
score, requires urgent investigation and/or referral.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
The adult and paediatric versions of the Glasgow Coma Scale are widely used to assess and monitor people
in the acute phase after a suspected TBI. The Glasgow Coma Scale score gives a useful indication of level of
consciousness at a given point in time, allows for serial measurement and provides a useful shorthand for
communicating information to ambulance or Emergency Department staff.6,7 It is also a familiar tool that enables
the collection and comparison of data, both nationally and internationally. Recommended versions are included
in Appendix C.
The risk of intracranial complications and the consequent need for surgery increases as the Glasgow Coma Scale
score declines.7,75 A recent study calculated that the rate of clinically significant brain injury in hospital attenders
who had experienced some loss of consciousness and/or amnesia since their head injury, increased from 5%
with an initial Glasgow Coma Scale score of 15, to 17% for a Glasgow Coma Scale score of 14, and to 41% for
a Glasgow Coma Scale score of 13.7 A further study on paediatric head injury found that a Glasgow Coma Scale
score of less than 13 was a significant predictor of an abnormal CT scan in children with head injury aged 14
years or younger.7
Any fall in a Glasgow Coma Scale score, after an initial recording, is of concern and may represent the
development of intracranial bleeding, such as an extradural haematoma. A fall of two or more points, no matter
37
The Glasgow Coma Scale is composed of three separate responses: eye opening, verbal and motor. These
are summed for a total Glasgow Coma Scale score out of 15. The following is a brief guide on how to use the
Glasgow Coma Scale.
• Monitoring and exchange of information about individual people is based on the three separate responses
on the Glasgow Coma Scale (eg, a score of 13 based on scores out of 4 for eye opening, 4 for verbal response
and 5 for motor response should be reported as E4, V4, M5).
• If a total score is recorded or communicated, it is based on a total possible score of 15, and this denominator
should be specified (eg, 13/15) to avoid confusion.
• Describe the eye opening, verbal response and motor response components of the Glasgow Coma Scale in all
communications and notes, which should always accompany the total score.
• For the paediatric version of the Glasgow Coma Scale, include a ‘grimace’ alternative to the verbal score to
facilitate scoring in pre-verbal or intubated infants or children (see Appendix C).
recommendation grade
Any loss of, or alteration in, consciousness should be recorded and assessed in people with a C
suspected traumatic brain injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
People with altered consciousness should have their blood glucose levels checked routinely ✓
as part of their assessments.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
A history of loss of or altered consciousness after a brain injury is associated with an increased risk of
developing an intracranial complication, such as an expanding haematoma, although the absolute risk remains
low.7 In most cases, a longer duration of loss of or altered consciousness is associated with greater severity of
injury. Momentary loss of or altered consciousness is difficult to measure when no independent observer is
available, and there is debate about its importance.
There is some evidence that intracranial complications can occur even when there has been no loss of or altered
consciousness. However, as most studies in this area exclude people who have not experienced any loss of
or altered consciousness, there is a lack of published research on this aspect of risk. Loss of, or change in,
consciousness may have other causes, and blood glucose levels should be checked routinely in all people with
loss of or altered consciousness.
recommendation grade
38
Services assessing people with traumatic brain injury should choose one of the available ✓
validated post-traumatic amnesia measurement tools and ensure all staff are familiar with its
use.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Post-traumatic amnesia, also known as anterograde amnesia, is the impaired memory for events after
brain trauma. It is usually considered the most important amnesic disorder for assessing the risk of acute
complications of TBI. However, a recent rigorous study has suggested that retrograde amnesia (ie, impairment of
memories before the trauma) is a more important indicator of significant injury.75
Even though post-traumatic amnesia is associated with an increased risk of intracranial complications, evidence
on the length and type of amnesia is inconsistent.7,76 There is some evidence that the duration of post-traumatic
amnesia is a more accurate predictor of longer-term outcomes than the Glasgow Coma Scale score.77 However,
there is a lack of robust evidence to support the use of any particular form of assessment of post-traumatic
amnesia.76,78 Assessing post-traumatic amnesia is less useful in infants and young children because it is difficult
to measure.
The Guideline Development Team recommends the assessment of post-traumatic amnesia in all people with
suspected TBI. Measurement should commence prospectively (ie, before it has resolved) to increase accuracy.24
The Tools Review identified three measures of post-traumatic amnesia suitable for use in New Zealand:
the Galveston Orientation and Amnesia Test (GOAT), the Westmead Post-traumatic Amnesia Scale, and the
MOPTAS.6
The Tools Review concluded that while there is no strong empirical evidence to favour one of these measures of
post-traumatic amnesia over another, qualitative arguments have been made in favour of the MOPTAS.6
recommendation grade
Neurological signs should be assessed and recorded when assessing people with a suspected C
traumatic brain injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Post-traumatic neurological signs, such as focal neurological deficits or seizure, are highly associated with the
risk of an intracranial complication.7,76 Consequently, people with these signs are commonly excluded from
studies developing clinical decision rules for the management of acute brain injury.
recommendation grade
People with coagulopathy or who are on anticoagulant medication, such as warfarin, have an elevated risk of
intracranial complications but there is no robust evidence that has established this relationship.7,76
39
There is variation in diagnostic practice for skull fracture. Some international guidelines advocate a skull X-ray
for the diagnosis of skull fracture.81
Skull X-rays have limited effectiveness in the diagnosis of TBI. Skull X-rays will be normal in many people
with clinically significant acute complications of TBI. In addition, skull X-rays are associated with exposure
to radiation, and come at a cost in terms of resources and time. Therefore, the routine use of skull X-ray as a
decision-making tool cannot be recommended. However, the clinical assessment of signs of skull fracture,
including signs of basal skull fracture, such as cerebrospinal fluid leak, periorbital haematoma, depressed or
open skull injury, and penetrating injury, should be undertaken.7 If an imaging study is indicated in people with
suspected TBI, it should be a CT head scan (see Section 3.2, Primary investigation for people with suspected
traumatic brain injury).
2.2.7 Seizure
A seizure alone, with no other neurological signs and full recovery, is almost never a sign of an intracranial
haematoma. The difficulty with seizures is that the person may become unconscious as a result of the seizure
or from a drug, such as diazepam, used to stop the seizure. This alteration in consciousness level cannot be
differentiated from that caused by an intracranial bleeding complication of TBI. Unless recovery is prompt and
complete a (further) CT scan is necessary to exclude such a complication.
The height threshold for a high-risk fall is sometimes defined as three feet, and sometimes as one metre. For
consistency, this guideline uses the term ‘one metre’. Falls from lower heights may be risk factors with infants
and children less than five years of age.
A further study has defined ‘axial load to head’ as a high-risk factor for cervical spine injury after an accident.7
This includes: diving; high-speed motor vehicle collision; rollover motor accident; ejection from a motor vehicle;
accident involving motorised recreational vehicles; and bicycle collision. In addition, there are many other high-
energy mechanism injuries considered to be important which cannot be readily listed (eg, the variety of blunt
instruments that could be used in an assault).7
40
This guideline adopts a standard age threshold of 65 years and over. An odds ratio of 4.1 (95% CI 2.8–6.1)
for clinically significant acute complication of TBI is associated with this threshold when the person has
experienced loss of consciousness or amnesia.75
There is evidence that the incidence of intracranial complications in children and infants is much lower than
in adults.7 In young infants (under 12 months) age is inversely related to the risk of intracranial complications
requiring intervention, with those under two months old being at highest risk.82
Although alcohol intoxication can reduce the Glasgow Coma Scale, it is always safer to assume that such signs
are due to TBI or a complication of TBI rather than intoxication and proceed accordingly.
2.2.11 Headache
Strong analgesia for headache should be avoided, if possible, until a full assessment has ✓
been made in the Emergency Department.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Headache – any head pain either diffuse or localised – is a symptom that may be associated with raised
intracranial pressure and is a risk factor for intracranial complications.76 Headache can, however, be difficult to
define in terms of duration and severity, particularly in infants and young children.
Analgesic medications carry a risk of sedation or ‘masking’ symptoms of complications of TBI. If possible, strong
analgesics should be avoided until the person has been fully assessed in the Emergency Department, so that an
accurate measure can be made of consciousness and other neurological signs. For people with headache alone,
simple analgesics, such as paracetamol, may be appropriate. There are situations where strong analgesics are
required (eg, fractures) prior to hospital and their use should be clearly documented.
2.2.12 Vomiting
Vomiting is a symptom associated with raised intracranial pressure and is consistently identified as a high risk
factor for those with a TBI. However, there is some debate about the number of vomiting episodes required to
identify high risk.7,75
Vomiting is quite common in infants and children, and its predictive power is uncertain in this age group. It has
been estimated that around 16% of infants and children aged 12 years or under vomit after relatively minor
head injury, and the cause of vomiting may be related to individual intrinsic factors (eg, previous tendency to
vomit) rather than specific features of the head injury.7 However, a recent rigorous systematic review concluded
that any vomiting should be considered a risk factor for intracranial complications.
41
Signs and symptoms that are risk factors for acute intracranial complications of TBI (see Section 2.1, Pre-
hospital assessment – acute) should initiate referral to the Emergency Department. Promptly transport the
injured person to an Emergency Department by emergency services if:
• there are more serious signs
• the person assessing the injured person has concerns
• there are other circumstances, such as the lack of suitable alternative transport.
RAPID TRANSFER TO EMERGENCY DEPARTMENT USING EMERGENCY SERVICES is appropriate if any of the
following indicators are present.
• Any deterioration in the injured person’s condition.
• Unconsciousness, or lack of full consciousness (ie, Glasgow Coma Scale score <15).
• Any focal neurological deficit (ie, restricted to a particular part of the body or a particular activity)
since the injury (eg, problems understanding, speaking, reading or writing; loss of feeling in part of
the body; problems balancing; general weakness; any changes in eyesight; difficulty walking).
• Any suspicion of a skull fracture or penetrating head injury (eg, clear fluid running from the ears or
nose; black eye with no associated damage around the eye; bleeding from one or both ears; new
deafness in one or both ears; bruising behind one or both ears; penetrating injury signs; visible
trauma to the scalp or skull).
• Any seizure (ie, ‘convulsion’ or ‘fit’) since the injury.
• A high-energy head injury (eg, pedestrian struck by motor vehicle; occupant ejected from motor
vehicle; a fall from a height of greater than one metre or more than five stairs, or less for infants and
children aged under five; diving accident; high-speed motor vehicle collision; rollover motor accident;
accident involving motorised recreational vehicles; bicycle collision; or any other potentially high-
energy mechanism).
• Suspected neck injury.
• The injured person or their carer is unable to transport the injured person safely to the hospital
Emergency Department without the use of ambulance services (providing any other risk factor
indicating Emergency Department referral is present).
42
EMERGENCY DEPARTMENT REVIEW NEEDED but TRANSPORT could be WITH COMPETENT ADULT if any of
the following indicators are present.
• Any loss of consciousness (‘knocked out’) as a result of the injury, unless trivial, apparently resolved
and alternative observation available.
• Amnesia for events before or after the injury (‘problems with memory’).
Note: The assessment of amnesia will not be possible in pre-verbal children and is unlikely to be
possible in any child aged younger than five years.
• Persistent headache since the injury.
• Irritability or altered behaviour (‘easily distracted’, ‘not themselves’, ‘no concentration’, ‘no interest
in things around them’) particularly in infants and young children (ie, aged younger than five years).
• Any vomiting episodes since the injury.
• History of bleeding or clotting disorder.
• Current anticoagulant therapy such as warfarin, or if the person is taking supplements, such as
Ginkgo biloba, or other supplements with anticoagulant effects.
• Current drug or alcohol intoxication.
• Any previous cranial neurosurgical interventions (‘brain surgery’).
• Suspicion of non-accidental injury.
• Age 65 years and older; one year or younger.
• Concern about the cause of any symptoms by the person undertaking the assessment.
* Depending on local availability, assessment at an after hours medical clinic or accident and medical
clinic may be appropriate for this group of people and this arrangement should be described in local
ambulance and hospital protocols.
People who have none of the factors requiring Emergency Department review fall outside the definition of
‘definite TBI’ used in this guideline (see Chapter 1, Traumatic brain injury in New Zealand). Some people whose
presentation lies outside this definition, but who have one or more risk factors for acute complications (eg, aged
65 years or older or alcohol intoxication) should also be reviewed in the Emergency Department. All people who
meet the definition of ‘definite TBI’ should be referred for an Emergency Department assessment.
People not meeting the criteria for Emergency Department or other further medical assessment can go home
with an information sheet with details of when to seek medical help. The information sheet should state clearly:
• that there are some symptoms (eg, headaches, dizziness, fatigue, difficulty with concentration) that occur
fairly commonly after an external force to the head, which resolve over the first few hours and days up to a
few weeks
• the specific symptoms and/or signs which, if they occur, indicate the need to seek prompt medical attention.
As these people do not meet the definition of ‘definite TBI’, there is no need to arrange routine general
practitioner follow-up or to arrange time off regular activities, including work. People in whom symptoms
persist, worsen or significantly interfere with usual activities should be reassessed by their general practitioner 43
(see Section 2.5, First assessment – delayed).
2.6 No assessment
Some people with definite TBI never present for an initial assessment. This may be due to a variety of reasons:
• the effects of alcohol and other drugs
• an unwitnessed episode with amnesia of the event
• an accident in the context of sports
• unwitnessed or unreported falls in school playgrounds for children and young people
• unwitnessed or unreported falls for older people
• blows to the head where assault may go unreported (eg, a blow from a family member).
In 1991, one population-based survey of self-reported mild TBI in the USA indicated that 25% of those reporting
a brain injury did not seek medical care.29
In a recent New Zealand study, prison inmates reported high rates of previous head injuries.84 Given the
frequency with which TBI is thought to occur, a degree of suspicion that TBI may be implicated in some
instances of otherwise unexplained poor performance is reasonable. However, in the absence of an appropriate
initial assessment, it may prove difficult to substantiate such a link.
New or worsening symptoms indicate a need for the person to seek immediate medical advice.
44
Each District Health Board in New Zealand should develop a plan for maximising the C
coordination of its trauma services to ensure the best possible care for people with severe
traumatic brain injury, including timely referral to services provided by other District Health
Boards.
A system and appropriate protocols for alerting the destination Emergency Department should C
be developed for all hospitals managing suspected traumatic brain injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
There is consistent evidence that coordinated trauma systems reduce mortality in serious injury, including
serious neurotrauma. For example, there is good consistent evidence that implementing trauma systems leads
to considerable reduction in mortality (by 20–50%) from TBI.9 There is similar good evidence of harm; that the
initial treatment of severely injured people at local hospitals without good trauma care capability, followed by
transfer to ‘trauma centres’ doubles the mortality in both adult and paediatric populations.9
A coordinated system of trauma care for TBI requires an organised, responsive system of care for people with
severe TBI, which would include:
• planning of pre-hospital management and triage
• transport directly to the trauma centre
• maintenance of appropriate call schedules for staff
• audit and quality improvement reviews
• staff participation in trauma education programmes.9
Trauma facilities for treating moderate to severe TBI should ideally include:
• a specialist-led emergency medical service
• a neurosurgery service with a neurosurgeon readily and promptly available
• an in-house surgeon with trauma training
• a continuously staffed and available operating room, intensive care unit and laboratory equipped ‘for’
management of people with TBI
• a continuously staffed and available CT scanner and operating staff.9
In areas without access to a neurosurgeon, local surgeons should have competency in:
• performing neurological assessment
• immediate neurotrauma care
• surgical treatment of extracerebral haematoma for people whose condition is deteriorating.9
45
Overview
• Details of good practice and evidence-based guidance for emergency assessment of suspected TBI are
provided in this chapter.
• On arrival at the Emergency Department, the person with a suspected TBI should be assessed by a clinician
to determine the presence of TBI, and whether a CT scan is necessary. A range of data is needed to assess
the person.
• Emergency Department assessment and management of people with a brain injury is focused on the
management or avoidance of hypotension and hypoxia, and on determining whether an imaging study is
required.
• Early imaging, rather than admission and observation, will reduce the time to detection for life-threatening
complications and is associated with better outcomes.
• Skull X-rays are of limited value in determining the presence of acute complications of TBI.
• CT imaging of the head is the primary investigation for the detection of clinically significant acute
complications of TBI.
• The Canadian CT Head Rule has been adapted as a guide for New Zealand.
• Early support can help the injured person’s family/whānau or carer(s) prepare for the effects of TBI; can
reduce the psychological sequelae experienced by the carers; and can result in better outcomes for both the
injured person and their family/whānau.
• Careful assessment of the need for rehabilitation during the acute management of people after TBI should
take place during hospital care, prior to discharge and if the person has continuing or emergent symptoms of
significant brain injury following discharge.
This chapter covers the acute phase of care for people with suspected TBI.
It provides advice about Emergency Department assessment, including selection for CT scanning, and routine
observation protocols. Indications for hospital admission and continuation of hospital stay are presented, along
with guidance on family and carer support and rehabilitation in the acute phase.
Specifically excluded from this chapter is discussion of the intensive care management of people with severe
TBI, which is beyond the scope of this guideline.
47
Emergency Department assessments of people with suspected traumatic brain injury should C
focus on the identification of actual or potential hypotension and/or hypoxia, clinically
significant brain injuries and appropriate referral for imaging.
Co-existing injuries and other concerns, such as possible non-accidental injury or non- C
traumatic aetiology, should also receive attention.
Imaging (for those meeting selection criteria) should be done early, in preference to C
admission and observation for neurological deterioration.
Data to enable decisions to be made about the probability of traumatic brain injury and C
the necessity of referring for a CT scan should be collected on admission by a health care
practitioner appropriately trained in emergency medicine.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
48
The priority for all people attending an Emergency Department is the stabilisation of airways, ✓ 3
breathing and circulation (ABC) before attention to other injuries.
In people with a Glasgow Coma Scale score of 8 or less, there should be early involvement of ✓
an anaesthetist, emergency physician or critical care physician to provide appropriate airway
management and assist with resuscitation.
Anyone found to be high risk on triage for clinically significant traumatic brain injury should be ✓
assessed within 10 minutes by a health care practitioner with experience in the assessment of
such people.
Anyone assessed, on initial triage, as being at low risk for clinically significant traumatic brain
injury should be reassessed within a further hour by a doctor with appropriate experience.
Junior doctors rostered to the Emergency Department should have training in the assessment
of people with traumatic brain injury, and clear protocols detailing when to seek more senior
assistance.
Assessment should establish the need to request CT imaging of the head. All Emergency ✓
Department health care practitioners involved in the assessment of people with suspected
traumatic brain injury should be competent in assessing the presence or absence of risk
factors used to select adults, infants and children appropriately for CT imaging. Training
should be provided to ensure that this is the case.
In general, people with a suspected traumatic brain injury should not receive strong systemic ✓
analgesia until they have been fully assessed, so that an accurate measure can be made
of consciousness and other neurological signs. Local anaesthetic should be delivered for
fractured limbs or other painful injuries.
Throughout the hospital episode, all care professionals should use a standard ‘suspected ✓
traumatic brain injury’ proforma in their documentation when assessing and observing people
with suspected traumatic brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Many of the people presenting to an Emergency Department with a suspected TBI will have had an initial
assessment outside hospital (see Chapter 2, Pre-hospital assessment, management and referral to hospital).
49
There are four important reasons for undertaking an Emergency Department assessment.
1. Identifying actual or potential hypotension and/or hypoxia, which if untreated will magnify TBI effects.
2. Identifying acute complications of TBI that may require intervention, particularly bleeding inside the skull
and/or brain.
3. Identifying other injuries that may require urgent management, including injuries to the cervical spine.
4. Estimating the severity of any injury to the brain that has implications for subsequent management and
follow-up.
A main focus of Emergency Department assessment for people who have sustained a suspected TBI is the
management or avoidance of hypotension and hypoxia, and deciding who needs an imaging study. Early
imaging, rather than admission and observation for neurological deterioration, will reduce the time of detection
for life-threatening complications and is associated with better outcomes.7 See Section 3.2.1, Selection of
adults for CT imaging of the head and Section 3.2.2, Selection of infants and children and young people for CT
imaging of the head).
The good practice outlined above should be followed during Emergency Department assessment. Proformas will
be developed as part of post-guideline documentation to assist health care professionals when assessing and
observing people with suspected TBI.
50
recommendations grade
3
Airways, breathing and circulation (ABC) should be stabilised before attention to other C
injuries.
Signs of possible traumatic brain injury should not be attributed to alcohol intoxication alone C
when assessing people with traumatic brain injury.
Blood alcohol levels should be tested and results recorded for all people with suspected C
traumatic brain injury and a Glasgow Coma Scale score of less than 15 and/or where alcohol
intoxication is suspected.
People who present with a suspected traumatic brain injury who are intoxicated following C
drug or alcohol use should have this recorded as part of their assessment.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
The number of people presenting with suspected TBI affected by alcohol has varied from around 40% to 70% in
hospital-based studies.4,85 There is considerable similarity in the signs of alcohol intoxication and TBI, making
the Glasgow Coma Scale unreliable in alcohol-intoxicated people, particularly where levels exceed about 40
mmol/L.86 Conversely, if the blood alcohol concentration (BAC) is below about 40 mmol/L alteration in the
conscious level should not be attributed to alcohol alone. Therefore, the presence of alcohol should signal
caution in the assessment of people with possible TBI, and a lower threshold for CT scan and admission should
be observed.
Routine BAC testing in suspected TBI might allow more accurate risk stratification and eventual diagnosis. An
alternative is to use a decision point two hours from admission for people where it is suspected that intoxication
may account for the symptoms. If the Glasgow Coma Scale has not returned to 15 by that point, a CT scan
is indicated whether or not alcohol is involved.75 Any deterioration during the two hours would necessitate
immediate intervention.
3.2 Primary investigation for people with a suspected traumatic brain injury
recommendations grade
The diagnosis of intracranial haemorrhage should not be ruled out on the basis of negative C
skull X-rays.
The primary investigation of choice for the detection of clinically significant acute A
complications of traumatic brain injury is CT imaging of the head.
Skull X-rays may be requested as part of skeletal surveys for the detection of non-accidental C
injury in children and in addition to a CT scan.
Skull X-rays in conjunction with high-quality inpatient observation have a role where CT C
scanning resources are unavailable.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
51
Firstly, skull X-rays are only of limited value in assisting the diagnosis of intracranial haemorrhage. A meta-
analysis found that the sensitivity and specificity of a skull fracture for predicting the presence of intracranial
haemorrhage were 38% and 95% respectively. A recent meta-analysis, in children, found a sensitivity of 59%
and specificity of 88%. The equivalent predictive values were 0.41 (positive predictive value) and 0.94 (negative
predictive value). These figures imply that if there is a skull fracture diagnosed on radiography, the risk of an
intracranial haemorrhage is elevated (about 4.9 times higher than before testing), but one cannot rule out an
intracranial haemorrhage in people for whom a skull X-ray does not show a skull fracture.
Secondly, the negative predictive power for a CT scan was 99.7%. People with a negative CT scan and no other
body-system injuries or persistent neurological findings can be considered for discharge as they are safe from
the risk of having an intracranial haematoma at that time. However, it should be recognised that some of these
individuals will be too unwell in terms of headache, vertigo, nausea/vomiting, impairment of cognition, motor
performance and coordination to be discharged, despite a normal CT scan. It must also be recognised that there
will be a small number (more often older people) who develop a chronic subdural haematoma over the ensuing
four to six weeks after the injury.
Thirdly, a strategy of either 100% CT imaging of people who present with a head injury or high-quality inpatient
observation for people who have sustained a mild head injury will be 100% sensitive for clinically important
acute complications of TBI. Early imaging, rather than admission and observation for neurological deterioration,
will reduce the time to detection for life-threatening complications and is associated with better outcomes.
Therefore, the task is to derive a more sophisticated clinical decision rule for selection that will improve
specificity without impairing sensitivity.
The current primary investigation of choice for the detection of clinically significant acute complications of TBI is
CT imaging of the head.
For safety, logistic and resource reasons, magnetic resonance imaging (MRI) is not currently indicated as a tool
for primary investigation, although it is recognised that additional information of importance to the person’s
prognosis can sometimes be detected using MRI.7
MRI is contraindicated in head investigations unless there is absolute certainty that the person does not harbour
an incompatible device, implant or foreign body. There should be appropriate equipment for maintaining and
monitoring the person within the MRI environment and all staff involved should be aware of the dangers and
necessary precautions for working near an MRI scanner. MRI safety, availability and speed may improve in the
future to the point where it becomes a realistic option for primary investigation for people with suspected TBI.7
52
recommendations grade
3
CT scans should be immediately requested for adults who have sustained a head injury, if B
they have any one of the following risk factors:
• any deterioration in condition
• a Glasgow Coma Scale score of less than 13 when assessed, irrespective of the time
elapsed since the injury
• a Glasgow Coma Scale score of 13 or 14 two hours after the injury
• a suspected open or depressed skull fracture
• any sign of basal skull fracture (haemotympanum, ‘panda’ eyes, cerebrospinal fluid
otorrhoea, Battle’s sign)
• post-traumatic seizure
• focal neurological deficit
• more than one episode of vomiting
• amnesia for more than 30 minutes for events before the injury.
CT scanning should be immediately requested for adults with any of the following risk factors B
who have experienced an injury to the head with some loss of consciousness or amnesia
since the injury:
• age 65 years or older
• coagulopathy (history of bleeding, clotting disorder, current treatment with warfarin)
• high-risk mechanism of injury (a pedestrian struck by a motor vehicle, an occupant ejected
from a motor vehicle, or a fall from a height of greater than one metre or five stairs).
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
A number of decision rules have been developed for CT imaging in an attempt to identify those at a high risk
of TBI complications (usually intracranial haemorrhage).7 However, the purpose of scanning those who may be
at high risk varies, from the wish to identify any injury requiring medical and/or surgical intervention, through
to attempting to identify any injury to the brain of any degree of severity, sometimes for purposes other than
determining appropriate treatment, such as support for litigation.
For the purposes of this guideline, the Guideline Development Team has considered the balance of risks
and benefits, and recommends that CT scanning be used to identify the need for medical and/or surgical
intervention, or to confirm, where there is doubt on clinical assessment, the safety of discharging a person with
a head injury.
The UK’s NICE Head Injury Guideline Development Team based its decision rules for CT scanning following head
injury on the seven-point Canadian CT Head Rule.75 The Canadian CT Head Rule reported a 50% (95% CI 48–51)
specificity rate for detecting clinically significant brain injury.
This section of the guideline is based on the NICE guideline.7 Since the NICE guideline, there has been further
work on developing clinical decision criteria for determining those who require CT scanning following apparently
mild TBI. One example of such work is the criteria identified by the WHO Collaborating Centre Task Force on Mild
Traumatic Brain Injury.
These criteria were derived from a systematic review of the literature on diagnostic procedures and selection
rules for imaging of people with head injury.76 However, the WHO criteria were specifically developed to identify
people who could be quickly and safely discharged from hospital Emergency Departments.
53
In order to provide comprehensive guidance, the seven-point Canadian CT Head Rule75 has been adapted for the
New Zealand setting as follows:
• deterioration in condition at any time is a strong indicator for an immediate CT scan
• people with post-traumatic seizure, focal neurological deficit or coagulopathy, meet selection criteria for CT
scanning
• drug or alcohol intoxication should not be assumed to be the cause of an altered Glasgow Coma Scale score.
The decision to CT scan should be applied regardless of the influence of intoxication
• people with non-symptomatic risk factors (ie, aged 65 years or older, coagulopathy, high-risk mechanism of
injury) should at least have had an injury to the head and an instance of loss of consciousness or amnesia
(ie, the main signs and symptoms used to screen people for inclusion in the Canadian CT Head Rule study)
before receiving a CT scan. This is to prevent the possibility of people with no signs or symptoms receiving a
CT. For consistency, falls from three feet have been changed to falls from greater than one metre.
The Guideline Development Team acknowledges that for clinicians in rural centres with limited access to CT, it
can be difficult to weigh up the pros and cons of transfer for a CT scan, when the risks of a complication of TBI
are fairly low versus the very real difficulties of managing such a complication at a distance from a neurosurgical
centre. In some situations, observation for 24 hours rather than CT scan is a reasonable compromise.
People with the following factors must be referred for CT scan as observation may not be a safe and effective
alternative for these people:
• any deterioration in condition
• a Glasgow Coma Scale score of less than 13 at time of assessment irrespective of time elapsed since the
injury or Glasgow Coma Scale score of 13 to 14 two hours after injury
• any sign of basal skull fracture (haemotympanum, ‘panda’ eyes, cerebrospinal fluid otorrhoea, Battle’s sign)
• focal neurological deficit.
People without these signs and symptoms, but with any other of the factors indicating a CT scan, may be
admitted for observation for 24 hours, as an alternative to early CT scan.76 It is recommended that the presence
of factors that would normally indicate a need for CT scanning (eg, post-traumatic seizure with full recovery and
no focal signs; amnesia greater than 30 minutes; age of 65 years or older; high-risk mechanism of injury) be
discussed with the relevant neurosurgical centre regarding the appropriateness of observation and possible
need for transfer before making the decision not to transfer for CT scan.
3.2.2 Selection of infants and children and young people for CT imaging of the head
There is some evidence that the prevalence of intracranial complications in children and infants is much
lower than in adults,7 but it is important that any complications requiring neurosurgical intervention are
detected as early as possible. CT scanning in infants and children carries a greater risk than for adults, both
from the increased risk of lifetime fatal cancer from the radiation exposure (see Appendix D for a link to a
supplementary resource) and from the sedation and anaesthesia frequently needed in younger children for
the scanning procedure. Therefore, it is important to ensure that the balance of benefits and harms of CT
54
There are several recent robust studies that have derived clinical decision rules from large study populations,
3
which can be used to select candidates in the paediatric setting for imaging of the head.87,88 These include rules
developed for use specifically with infants under the age of two years.
Although at the time of writing none of these decision rules has been independently validated, there is
considerable concordance between studies on the factors identified, and therefore the validity of these factors
can be inferred.
Current evidence supports the following factors indicating a need for imaging in children aged 0 to 16 years
(see Figure 3.1):
• post-injury adverse events or signs, including focal neurological deficits, seizures, loss of consciousness,
altered mental state, more than one episode of vomiting
• a paediatric Glasgow Coma Scale score of 13 or less, particularly an initial or ‘field’ (pre-hospital) Glasgow
Coma Scale score of 13 or less, or any decrease in Glasgow Coma Scale score
• skull fracture, either obvious or suspected on the basis of clinical signs
• injury resulting from a fall from one metre or five stairs, or less in the case of younger children
• non-accidental cause of injury
• younger age
• lethargy or irritability on examination.76,82,83,87–89
Taken together, these suggest a lower threshold for scanning if a large scalp swelling is present, if the
haematoma is temporal/parietal or occipital rather than frontal, and the age is younger.
55
None
Any non-surgical
Observe and reassess indicators for
at 2 hours GCS = 15? Yes paediatric Yes
Note: Any deterioration consult or
– refer for scan immediately admission?
Paediatric
No consult and/or
admit to hospital
* In younger children, falls from lesser heights may have a high risk of intracranial complications.
†
Use paediatric version of GCS.
‡
Children and young people with a head injury should only be discharged home if they have a responsible
adult who can observe them for any deterioration.
§
CT scanning of infants and children can be difficult and may require anaesthesia and pose a significant
radiation risk. If uncertain about benefits of CT scan versus risks of scan, seek specialist advice (Emergency
Department specialist, intensive care unit specialist, neurosurgeon, paediatrician) before scanning.
Due to the distinct pattern of injuries involved, skull X-ray as part of a series of plain X-rays (skeletal survey),
along with other well established examinations (eg, ophthalmoscopic examination for retinal haemorrhage,
examination for pallor, anaemia, tense fontanelle) and additional investigations (eg, CT and MRI imaging), has a
role in detecting non-accidental head injuries in children (ie, aged less than 12 years).7
Work on the derivation of clinical decision rules to predict non-accidental injury, based on imaging patterns, has
recently started.90 However, decision rules in this area will require substantial validation before they can inform
clinical practice.
All CT scans of the head should be reviewed by a clinician who has been deemed competent ✓
to review such images.
A full or interim written report for the person’s notes should be provided within an hour of all ✓
imaging procedures performed on people with head injury.
Neurosurgical or anaesthetic referral for people with severe head injury should not be delayed ✓
for imaging of any kind.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
It is assumed that clinicians will adhere to general principles of good practice in imaging as outlined by the
Royal College of Radiologists.7 Where necessary, transport or transmission of images should be used to ensure
that a competent clinician reviews the images.7
There may be occasions where the CT scan needs to be repeated, in addition to the recommendation regarding
imaging during observation. For example:
• if an initial scan shows an abnormality, such as a small intracranial haematoma and there is clinical
deterioration
• to check that an original small lesion has not progressed (often scan repeated the next day)
• to check that an initial small lesion has resolved spontaneously (often scan repeated a week or two later).
Avoid corticosteroids in the management of people with acute traumatic brain injury of any A
severity.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
57
Although local centres will need to decide on their own criteria, in general, the person’s condition should be
discussed with the nearest neurosurgeon, with a view to their taking over their care in the following clinical
situations:
• the person is deteriorating, particularly regarding level of consciousness (documented Glasgow Coma Scale
score fall of two or more), has developed pupil dilation or other new neurological deficit
• the person has had a severe TBI (Glasgow Coma Scale score 8 or less), especially if they have remained
unconscious from the time of injury
• the person has a significant neurological deficit following the TBI
• the person has a ‘surgically significant lesion’ on imaging, which may include:
− a mass lesion with >1 cm midline shift or with acute hydrocephalus. Such lesions include acute extradural
and acute subdural haematomas, cerebral contusions and traumatic intracerebral haematomas
− open/compound skull fracture
− obvious brain wounds visible at the bedside
− diffuse brain swelling/cerebral oedema.
A list of examples of abnormalities not considered ‘surgically significant’ was produced by a survey of
neuroradiologists and emergency physicians in Canada.75 However, a survey conducted in the UK in 2003 by the
Society of British Neurological Surgeons found substantial concern about these Canadian criteria.7
Further situations where a neurosurgeon should be consulted, not necessarily with a view to their taking over
care, would be:
• a cerebrospinal fluid leak
• definite or suspected penetrating injury
• a seizure without full recovery.
The exact nature and timing of the neurosurgical interventions are beyond the scope of this guideline. It is
assumed that best practice will be followed once neurosurgeons have become involved with a particular
person. Details of best practice in neurosurgical management for adults are given in an evidence-based
guideline9 available from the Brain Trauma Foundation, at www2.braintrauma.org/guidelines/ and an
evidence-based guideline for infants, children and adolescents92 is available from www.ohsu.edu/news/2003/
neuroGuidelines/.81
58
Local guidelines, consistent with national guidelines, on the transfer of people with suspected C
traumatic brain injury, including the transfer of the responsibility for care, should be drawn up
between the referring hospital and the tertiary care facility.
Resuscitation and stabilisation of the injured person should be completed before transfer. C
A person persistently hypotensive despite resuscitation should not be transported until
stabilised.
All people requiring transfer to tertiary care with Glasgow Coma Scale scores of 8 or less C
should be intubated and ventilated.
A person with suspected traumatic brain injury should be accompanied by a doctor with at C
least two years’ experience in an appropriate specialty, who should:
• be familiar with the pathophysiology of traumatic brain injury, drugs, equipment and
working in the ambulance or helicopter
• have received specialist training in the transfer of people with traumatic brain injury
• have an adequately trained assistant
• be provided with appropriate clothing and medical indemnity and personal insurance.
The transfer of a child or infant to a tertiary care facility should be undertaken by staff C
experienced in the transfer of critically ill children.
The transfer team should have a means of communication with their base hospital and the C
tertiary care facility during the transfer.
59
Indications for intubation and ventilation in people with traumatic brain injury: immediately. C
• Coma (Glasgow Coma Scale score of 8 or less).
• Loss of protective laryngeal reflexes.
• Ventilatory insufficiency:
− hypoxaemia (PaO2 less than 65 mm Hg on air or less than 95 mm Hg on oxygen) or
− hypercarbia (PaCO2 greater than 45 mm Hg).
• Spontaneous hyperventilation causing PaCO2 less than 30 mm Hg.
• Respiratory arrhythmia.
Indications for intubation and ventilation in people with traumatic brain injury: before the C
journey.
• Significantly deteriorating conscious level, even if not coma.
• Bilateral fractured mandible.
• Copious bleeding into mouth.
• Seizures.
Carers and family/whānau should have as much access to the injured person during transfer C
as is practical.
Service provision in the area of paediatric transfer to tertiary care should also follow these C
principles.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
The risk of a further injury to people with TBI during transfer to tertiary care is well established.7
Recommendations in this section have been adapted for New Zealand from the NICE guideline on head injury.7
60
People who require an extended period in a recovery setting due to the use of sedation or C
general anaesthetic during CT imaging should not normally require admission.
Resuscitation and stabilisation of the injured person should be completed before transfer. C
A person persistently hypotensive despite resuscitation should not be transported until
stabilised.
People with multiple injuries should be admitted under the care of the team appropriate to C
their most severe and urgent problem.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
The recommendations are based on the NICE guideline on head injury.7 Although most of the criteria concern
injuries at the more severe end of the spectrum of TBI, a significant number of people with ‘mild’ TBI may also
need admission so as to better manage symptoms of headache, photophobia, nausea and vomiting, amnesia
and other post-concussion sequelae. Admission allows for appropriate input and advice from a neurosurgeon,
neurosciences nurses, and other members of the multidisciplinary team, including occupational therapists
and social workers. Such input and help at this time can be of considerable assistance in the recovery and
rehabilitation process and the benefits should not be underestimated.93
This guideline places emphasis on the early diagnosis of clinically significant brain injuries, using a sensitive
and specific clinical decision rule with early imaging. Admission to hospital is intrinsically linked to imaging
results, on the basis that people who do not require imaging are safe for discharge to the community (provided
no other reasons for admission exist) and those who do require imaging can be discharged following negative
imaging (again, provided no other reasons for admission exist). However, observation of the injured person
still forms an important part of the acute management phase, for people with abnormal CT results who do not
require surgery, and/or for people with unresolved neurological signs, and/or for some people with initially
abnormal Glasgow Coma Scale scores who are observed, without CT, for two hours.
Neurosurgical and intensive care management of severe TBI is outside the scope of this guideline. 61
observation: general
Observation of infants and young children with traumatic brain injury should only be C
performed by units (including normal paediatric observation settings) with staff trained and
experienced in their observation.
For people with an initial Glasgow Coma Scale score of 15, or who have returned to a Glasgow C
Coma Scale of 15 on two consecutive observations, the minimum frequency of observations
following the initial assessment should be:
• half hourly for the first two hours, then
• one hourly for four hours, then
• two hourly thereafter.
If a person with a Glasgow Coma Scale score of 15 deteriorates at any time after the initial C
two-hour period, observations should revert to every 15 minutes or more frequently if
necessary and follow the original frequency schedule.
An urgent reappraisal should be done by the supervising doctor if any of the following signs of C
neurological deterioration occur:
• development of agitation or abnormal behaviour
• a sustained (ie, ≥30 minutes) drop of one point in the Glasgow Coma Scale score
• any drop of more than two points in the Glasgow Coma Scale score
• development of severe/increasing headache or persisting vomiting
• new or evolving neurological symptoms or signs.
62
Further CT or MRI scanning should be considered in the case of a person who has had a C
normal CT scan but who has not achieved a Glasgow Coma Scale score of 15 after 24 hours’
observation.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Observation should occur throughout the person’s stay in the Emergency Department or after admission
following abnormal imaging results. All clinicians should use a standard ‘suspected TBI’ proforma in their
documentation when assessing and observing people with suspected TBI. Separate adult-specific and child and
infant-specific proformas should be used. The adult and paediatric Glasgow Coma Scale and derived scores (see
Appendix C) should form the basis of observation, supplemented by other important observations.
There is some evidence from the UK that Emergency Department observation wards are more efficient than
general acute wards in dealing with people admitted for short-stay observation, with more senior supervision,
fewer tests and shorter stays.7 There have also been concerns about the experience and skills of staff on
general and orthopaedic acute wards in head injury care.7 This resulted in a recommendation by the Royal
College of Surgeons of England in 1999 that adults needing a period of observation be admitted to a dedicated
observation ward within or adjacent to an Emergency Department.7
Where the optimal management of other injuries necessitates management in an orthopaedic or general
surgical ward, the observations and responses described in the recommendations must continue.
It is recommended that in-hospital observation of people with a TBI, including all Emergency Department
observation, should only be conducted by professionals competent in the assessment of TBI.7 The service
configuration and training arrangements required to ensure that this occurs are beyond the scope of this
guideline, but best practice demands that this issue be addressed by future policy.
Observation of infants and young children (ie, those aged less than five years) is a difficult exercise and
therefore should only be performed by units with staff experienced in the observation of infants and young
children with a head injury. Infants and young children may be observed in normal paediatric observation
settings, as long as staff have the appropriate training and experience.
Medical, nursing and other staff caring for people with suspected TBI admitted for observation should all be
capable of performing the observations recommended in this guideline. The acquisition and maintenance of
observation and recording skills require dedicated training and this should be available to all relevant staff.
Specific training is required for the observation of infants and young children.
63
Measures to make the experience less daunting should be put in place.7 There should be a protocol for all
staff to introduce themselves to family/whānau members or carers and briefly explain what they are doing. In
addition, a photographic board with the names and titles of personnel in the hospital departments caring for
people with head injury can be helpful.
Consumer information sheets detailing the nature of head injury and any investigations likely to be used should
be available in the Emergency Department.7 Staff should consider how best to share information with children
and introduce them to the possibility of long-term complex changes in their parents or siblings. Literature
produced by consumer groups may be helpful. Fact sheets prepared for people and their families with TBI are
being prepared (see BIANZ www.brain-injury-nz.org or ACC www.acc.co.nz).
The presence of familiar friends and family/whānau at the early stage following admission can be very helpful.
The person recovering consciousness can easily be confused by unfamiliar faces and the unfamiliar environment
in which they find themselves. Family/Whānau or carers are often willing to assist with simple tasks, which, as
well as helping nursing staff, helps friends and family/whānau to take an active role in the recovery process.
Family/Whānau or carers should be encouraged to talk and make physical contact (eg, holding hands) with the
injured person, although it is important to ensure family/whānau, carers and friends do not feel that they have
to spend many hours at the bedside, and to ensure they also have breaks and sleeps from time to time. This
may be an opportune moment to mention consumer support organisations and introduce their literature.
Voluntary consumer support groups can speak from experience about the real-life impact that follows head
injury and can offer support following discharge from hospital. This is particularly important where statutory
services are lacking. There should be a board or area displaying leaflets or contact details for consumer support
organisations, either locally or nationally, to enable family members to gather further information.
64
• head or cervical spine imaging is normal and the person has returned to a Glasgow Coma
Scale score of 15 (or in children, normal consciousness as assessed by the paediatric
version of the Glasgow Coma Scale)
and
People with suspected traumatic brain injury who have been admitted to hospital may be C
discharged to the community if:
• there is resolution of all significant symptoms and signs
• there are appropriate support structures for their safe transfer and subsequent care and
supervision.
Infants or children presenting with suspected traumatic brain injury who require imaging of C
the head or cervical spine should not be discharged until assessed by a clinician experienced
in the detection of non-accidental injury.
All personnel involved in the triage and assessment of infants and children with suspected C
traumatic brain injury should have training in the detection of non-accidental injury.
All people with any degree of suspected traumatic brain injury who are discharged should C
receive verbal advice which:
• outlines the risk factors in their community setting
• explains that some people make a quick recovery, but may later experience complications
• gives instructions on contacting community services in the event of delayed complications.
People who initially presented with drug or alcohol intoxication and are being discharged C
should receive information and advice on alcohol or drug misuse.
People with any degree of suspected traumatic brain injury with no carer at home should C
be discharged only when there is negligible risk of late complications, or when suitable
supervision arrangements have been organised.
People with mild traumatic brain injury may be advised in their discharge information that bed B
rest may temporarily help alleviate excessive dizziness, but will not aid recovery.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
65
People discharged from hospital after a traumatic brain injury should have had their general ✓
practitioner notified either before or at the point of discharge, with details of any residual
impairments and details of the planned follow-up.
People who are discharged after a suspected traumatic brain injury sustained after a self- ✓
harm or suicide attempt should have a risk assessment performed and should be referred as
appropriate.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
All people discharged from hospital after a TBI should have had their general practitioner notified either before
or at the point of discharge, with details of any residual impairments and details of the planned follow-up.
People who are discharged after sustaining a suspected TBI from a self-harm or suicide attempt should have
a risk assessment performed and should be referred as appropriate (also see Chapter 14, Special issues).
For more details of management of people after a suicide attempt, see the guideline, The Assessment and
Management of People at Risk of Suicide available at www.nzgg.org.nz.
3.12 Referral to rehabilitation in the acute phase after traumatic brain injury
The information in this section refers to the rehabilitation issues in the acute phase after TBI. More detailed
information about identifying clinically significant TBI and rehabilitative needs is provided in Chapter 4,
Rehabilitation services. Rehabilitation may begin in hospital, be organised to commence following discharge
from hospital, or begin when the person re-presents with symptoms after discharge. Careful assessment of the
need for rehabilitation during the acute management of head-injured people should take place during hospital
care, prior to discharge and if the person has continuing or emergent symptoms of significant brain injury
following discharge.
A small number of people will also develop late complications despite normal CT results and an initial
absence of signs and symptoms. A well designed system of high-quality discharge advice and post-discharge
observation by a carer is required to ensure that people receive appropriate care as needed, as soon as
possible. The role of carers at home in the early post-discharge observation of people with TBI is important and
should be guided by clear and detailed information. There should be clearly defined pathways back to hospital
care for people who show signs of late complications.7,8 For more details of post-discharge follow-up see
Chapter 8, Management of persistent symptoms and activity limitation following mild traumatic brain injury.
Early rehabilitative intervention in clinically significant TBI improves outcomes.95,96 Therefore, rehabilitation
66
should start as soon as possible.
With more severely injured people, the first stage of rehabilitation may occur at the acute stage of intensive care
in hospital, where interventions focus on reducing impairment and secondary complications. As the person
starts to recover, they may need rehabilitation in a hospital inpatient or community residential environment to
enable their successful discharge to the community.
If a person with TBI is still in hospital (including intensive care unit) 48 hours following the injury, the advice
of and a review by a rehabilitation team should be sought as soon as possible. The purpose of this review
is to determine appropriate referral and interim management to prevent the development of secondary
complications.8
Before a person with TBI is discharged following emergency care, there should be an assessment of their
need for rehabilitation, and referral if necessary. They should be assessed for any residual physical, cognitive,
emotional or behavioural deficits which are negatively affecting their functioning and referred to specialist
follow-up services (hospital based or community) as appropriate.8
The awareness of the person, their family/whānau and carer(s) of the current problems and how to manage
them should also be assessed. All people being discharged after a TBI should be given details of who to contact
if they have any concerns and how to contact them. They should also receive information about any problems
they are likely to face and how to manage them. A member of the person’s family/whānau, or a friend or carer,
with the injured person’s consent, should also be given this information.8,97
67
Ideally, rehabilitation will take place in the person’s usual environment. This does not exclusively mean their
home environment, but also includes other settings in which their usual social role requires them to function.
Where this is not practical, rehabilitation is undertaken in an environment conducive to intervention, and
intervention strategies are generalised (with active support) into the usual environment. See also Chapter 4,
Rehabilitation services.
68
4
Overview
• Over the past 20 years there has been a significant change to the rehabilitation model. Rehabilitation
services for people with TBI should be based on achieving well-being rather than on a model of deficit and
dependency.
• In order for TBI rehabilitation to be effective, rehabilitation services should:
− approach people with TBI from a participation perspective
− have the necessary skills and experience to provide appropriate and context-specific assessments and
interventions for people with TBI.
• Rehabilitation for people with clinically significant TBI has been shown to be effective in terms of improving
outcomes for adults and children with TBI, and their carers, and is cost effective.
• Rehabilitation services must acknowledge that different people require different input at different stages in
their recovery.
• There are distinct stages of rehabilitation and each has a different aim in relation to TBI. The four stages are:
1. acute care/neurosurgery
2. residential rehabilitation
3. non-residential rehabilitation
4. longer-term community support.
• The transition between the stages of TBI rehabilitation should be seamless, which requires effective
communication and sharing of information.
• There is substantial evidence of the effectiveness of community-based rehabilitation.
• People with TBI may be referred to different types of residential services for rehabilitation. There are specific
criteria for referral to these residential services.
• Coordination of services and communication between them, both potentially difficult, are a very necessary
part of effective TBI rehabilitation.
• There is international agreement (both research and expert opinion) on the benefits of individual ‘case
managers’ to support the individual and their family throughout the course of their recovery.
• Delivery of rehabilitation is most effective when done by a coordinated, multidisciplinary team of people from
a range of different disciplines, taking an interdisciplinary approach.
69
These points apply to TBI rehabilitation as well as rehabilitation in general. In order to practise effective TBI
rehabilitation in the current environment, the following approaches are recommended.
1. Approach people with TBI primarily from a participation perspective, considering issues around their ability
to:
− live independently
− drive or use public transport
− return to work or education
− participate in leisure and social activities
− fulfil family roles and maintain personal, sexual and family relationships.
These restrictions are often shared by family members who may be living under considerable long-term
strain.
2. Have the necessary skills and experience to provide appropriate and context-specific assessments and
interventions for people with TBI that are likely to contribute to enhanced participation and/or quality of
life. Despite a primary focus on participation, the ICF model acknowledges that intervention at the level of
pathology and impairment may have substantial benefits for the person. Too rigid a focus on participation
(eg, that issues around pathology and impairment are missed) can have devastating consequences, for
example failing to make a diagnosis of depression or seizures post-TBI or failure to prevent contractures.
This means that the rehabilitation team needs to have the necessary skills to undertake assessment and
management at all levels of health for people following TBI but with an emphasis on the level of participation.
70
4
Body function and Activities Participation
structure (impairment) (limitation) (restriction)
Reproduced from: World Health Organization. Towards a Common Language for Functioning, Disability and
Health: ICF. Geneva: WHO; 2002.
Rehabilitation for people with clinically significant TBI has been shown to be both effective in terms of improving
outcomes for adults and children with TBI and their carers, and cost-effective.10,11,99–103
Rehabilitation for people with clinically significant TBI may differ from rehabilitation in general due to the
influence of executive deficits on the rehabilitation process. Executive deficits refer to limitations associated
with primarily frontal lobe damage, which influences attention and concentration, initiation and goal direction,
judgement and perception, learning and memory, speed of information processing and communication and
other cognitive skills, such as planning and organisation.104,105
Rehabilitation services for individuals after TBI must attend to the following issues for the person with TBI:
• a compromised ability to set goals, plan and organise and initiate behaviour to achieve these goals, and
difficulty inhibiting behaviour incompatible with these goals. The individual with frontal lobe injury may have
reduced ability to apply strategies or actions flexibly to new situations and to think clearly under stress. Thus,
individuals with TBI are more likely to respond to an antecedent approach to intervention. An antecedent
approach is one that is proactive (ie, identifying potential challenges and barriers for the individual in
advance rather than relying on consequences and rewards applied after the event, as in some traditional
approaches to behaviour management)106
• a compromised view of the individual’s world and evaluation of self, which may ‘take the form of perplexity
regarding one’s lack of ability, frank unawareness of deficits, active denial of the effects of the injury or some
combination of these’107
• cognitive and physical fatigue, which frequently accompanies the condition.108 Note that the individual may
be restless, distractable, disorganised or abnormally loquacious. Mood may be exaggerated with ready
laughter or tears. The individual may be swift to argue, difficult to reason with, and may deny fatigue
• a lack of correspondence between the results of conventional assessment of structured tasks and
performance in everyday life.
Neurological recovery following TBI can occur over an extended period of many months or years. Fundamental to
rehabilitation services is the appreciation that different people need different input at different stages in their
recovery, and that sometimes lifelong support may be required. The carers of people with significant TBI may
also require support over long periods of time.
71
Rehabilitation starts as soon as possible, even in the acute stages of intensive care in hospital. Interventions
at this stage focus on reducing impairment and preventing secondary complications (pathology), such as
contractures, malnutrition, pressure sores and pneumonia. As the person starts to recover, intensive residential
rehabilitation may be required to make the successful transition between a residential environment and home.
Post-acute residential rehabilitation has traditionally focused on regaining mobility and independence in self-
care to allow the individual to manage safely at home. This needs to be placed in the context of participation
goals so that discharge to home is not seen as an end in itself but a milestone on a much longer journey.
Discharge home can occur very early, even following very severe injury. Those involved in the rehabilitation
process (particularly the person with TBI and their family/whānau and carer(s)) need to be able to consider all
possible options and choose the most appropriate option for them.
Once back in a home-based setting, people with TBI may need continued input to maximise their ability
to function in their environment. Interventions focus on enhancing participation, improving quality of life,
promoting psychological adjustment and minimising carer stress. These stages are illustrated in the ‘stages of
rehabilitation’ model (see Figure 4.2).
The critical point of the ‘stages of rehabilitation’ model is that people with TBI may need to access different
services as they progress through the different stages. Their transition between services should be smoothed
by effective communication and sharing of information between services so that they progress in a seamless
continuum of care through the different stages.
figure 4.2:
‘stages of rehabilitation’ model for people with traumatic brain injury
Acute care/neurosurgery
Ward-based therapy
Residential rehabilitation
Specialist rehabilitation
Non-residential rehabilitation
Outpatients
TBI clinics/out-reach/home-based/
day activity centres/vocational and social
Adapted from: Turner-Stokes L. Head Injury Rehabilitation – How Should it be Provided?: Head Injury
Rehabilitation – a Parliamentary Select Committee; 2001.
72
Whilst the ‘stages of TBI rehabilitation’ model provides a useful illustration of the need for different services
at different stages, with seamless continuity of care, the reality is much more complex and three-dimensional
in practice. People with TBI progress through the different stages at very different rates. Many may not require
hospitalisation at all and pass straight on to services in the community. A small minority with very severe TBI
spend many months in hospital. People with TBI may also need to access services at different times as their
needs change. This may involve re-access to inpatient services or a review of community rehabilitation and
support needs as appropriate.
figure 4.3:
a model of functionally oriented, community-based rehabilitation
Community services
iplinary rehabilitation team
Interdisc
TBI case coordinator
Family/whānau/carers
Person with TBI
Reproduced from: Bilbao A, Kennedy C, Chatterji S, et al. The ICF: Applications of the WHO model of functioning,
disability and health to brain injury rehabilitation. Neurorehabilitation 2003;18(3):239–50.
73
74
recommendations grade
People with traumatic brain injury who require rehabilitation should have a case coordinator/ B
key worker appointed.
A paediatric case coordinator/key worker should be appointed for children and young people B 4
with traumatic brain injury.
Any change of case coordinator or ACC case manager should be immediately advised to the ✓
person with traumatic brain injury and their carer(s).
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Case coordination is a concept with an established history in both adult and paediatric rehabilitation, although
the label can vary. For example, it can be called key working or case management. Case coordination implies
a role for a specified individual who takes responsibility for coordinating the assessment, management and
support activities for a specified client. These terms are used interchangeably here.
Following consultation on the draft guideline, the Guideline Development Team has suggested that the term
‘case coordinator’ or ‘key worker’ is generally used in New Zealand to describe the person who undertakes this
role. The Guideline Development Team acknowledges that this person may be an ACC case manager (or lifetime
planner), the person’s general practitioner or a member of an established multidisciplinary rehabilitation team,
depending on the individual circumstances of the client. Ultimately it is a matter of finding the right person to
fulfil the role of case coordinator in the context of the person’s life at that time. The roles of the case coordinator
are specified below, following a discussion of some of the relevant literature on effectiveness.
Apart from the obvious logistic need for coordination in multidisciplinary rehabilitation, a controlled study
showed that participants receiving coordinated care showed greater gains throughout the study period and
maintained the treatment effect after treatment ended, and that their carers exhibited less distress compared
with the control group.116
There is international support from both the research evidence and experts in the rehabilitation field for the
benefits of individual ‘case management’ or an equivalent system to support the individual and their family
throughout the course of their recovery.8 A 1998 systematic review found that studies of the effectiveness of
case management show that the clearest demonstration of benefit is in vocational status, with studies using
different models of case management showing similar improvements.10 It reported conflicting evidence on other
effects of case management, such as improvements in disability, living status and family well-being, although
particular benefits were identified in one study where a single case manager administered insurance benefits.10
75
A more recent study found that case management for people with TBI also improves the rate of unexpected
outcomes.117
A quasi-randomised study of case management for people with severe TBI in the UK, published in 1994, was
unable to show a difference in important endpoints.118 The case-managed group was referred for more services,
but the particular model of case management did not involve budget-holding so there was no way for the case
manager to influence further the provision of services for people who needed them.
In New Zealand, the current practice is that people with TBI who require ongoing support have a case manager
appointed by ACC (provided ACC has been notified of the need for further assistance). The case manager has a
role in coordination of assessments and management throughout the lifetime of a claim. For people with severe
and very severe TBI, an ACC lifetime planner may also be appointed. There may be a need, in addition to the ACC
case manager role, for one of the clinicians involved in the rehabilitation and/or support of the person with TBI,
to provide a specific ‘key worker’ role. This can only be determined on a case-by-case basis with full discussion
among all the people involved.
It is important that the person with TBI knows who their case coordinator is and that they, and their carer(s), are
immediately advised of a change of case coordinator or ACC case manager.
The case coordinator should be central to deciding which other disciplines need to be C
involved in the planning and delivery of rehabilitation.
All health care practitioners working with people following a traumatic brain injury need to B
have had specialist training in the application of their disciplines to neurological conditions.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
76
In multidisciplinary teams, professionals work alongside each other, but not necessarily together. Discipline-
specific interventions running in parallel rehabilitation therapy services within hospital settings often adopt a
discipline-specific approach.
4
Interdisciplinary teams are more integrated in approach than multidisciplinary teams. The team members
plan an integrated rehabilitative programme together and work towards an agreed set of common goals, with
collaborative interventions and joint sessions of therapy. Most specialist brain injury rehabilitation teams work
in this way in New Zealand.
In transdisciplinary teams, the boundaries between individual disciplines of team members are relaxed, and
team members adopt a common problem-solving approach. This approach is often appropriate for community-
based rehabilitation services, where it may not be practical for the full team to meet for every therapy session
for each individual.
Whichever team approach is taken, the team will require clear, skilled leadership and efficient coordination
to provide effective rehabilitation.7 Delivery of rehabilitation is most effective when done by a coordinated,
multidisciplinary team of people from the different disciplines involved119 taking an interdisciplinary
approach.120
In New Zealand, most specialist brain injury rehabilitation teams meet and plan together with the person with
TBI and their family/whānau and carer(s) in the rehabilitation ward. However, teams in the orthopaedic, medical
and surgical wards often work in isolation and require specific measures to support interdisciplinary working.
In general, the common goals towards which the team works should be consumer centred (ie, those that the
person with TBI and their family/whānau and carer(s) consider to be important and achievable).7 This is an ideal
and there are situations, such as poor insight or suicidality, where it may not be appropriate. Teams, including
case coordinators working with people after TBI, should work in partnership with the family.
There are also providers operating teams of rehabilitation clinicians in the community.
General practitioners in some centres may fulfil the role of medical rehabilitation specialists (at least for mild
and moderate injuries). There may be specialist workplace assessors, or occupational medicine practitioners,
and for children and young people there may be Group Special Education and specialist teachers involved.
There may be little communication or collaboration between the providers of different services, and effort is
required to ensure effective coordination and communication.
78
Overview
• There is a substantial research gap in evaluating the impact of various service configurations, service delivery 5
methods and specific interventions for people with TBI in New Zealand, particularly from the perspective of
the individual with TBI and their family/whānau.
• A TBI can result in deficits that can be classified generally as physical, cognitive, behavioural/emotional
or communicative. The identification of these deficits and any consequential impact on functioning is an
important step towards helping the person with TBI, their family/whānau and carer(s).
• Diagnostic assessment within rehabilitation services aims to determine where there is a probable injury to
the brain, and if so, to determine the nature and extent of the injury and the short- and long-term effects of
the injury.
• Many of the symptoms of TBI overlap with other conditions; physical, psychological and psychiatric. It
is important to attribute symptoms correctly to TBI or other medical conditions and to identify and treat
comorbid conditions in order to develop an effective TBI rehabilitation plan.
• When TBI is sustained in childhood, neuropsychological and other assessments may need to be repeated
several times as the child matures to adulthood.
79
People who have had a traumatic brain injury should be assessed for functional deficits in C
activities of daily living and be assessed for specific impairments in:
• control over bowels and bladder
• speech and swallowing
• motor control
• sensory function
• language production and comprehension
• cognition and memory
• behaviour and emotion
• potential medical and psychiatric comorbidities, which have symptomatic overlap with
traumatic brain injury.
All people with traumatic brain injury should be considered for referral for a C
neuropsychological assessment to evaluate cognitive functioning.
Assessment should include seeking information from family/whānau and carers who knew C
the person before their injury and who are caring for the person post-injury.
Staff assessing people with traumatic brain injury should have training and expertise in the C
application of their disciplines to people with neurological disorders.
Staff assessing children and young people with traumatic brain injury should have general C
paediatric training and specific expertise in the application of their disciplines to children with
neurological disorders.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
An assessment of the Glasgow Coma Scale for the purpose of estimating the severity of ✓
traumatic brain injury should be made from 30 minutes after the injury.
The primary focus of assessment should be on the person’s participation goals, and an ✓
assessment of activity limitation and impairments should be made within this context.
Rehabilitation teams should have access to suitable health care practitioners to provide ✓
consultative services, education and oversight, especially when particular health care
practitioners are unavailable to be members of a team.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
TBI rehabilitation is a complex process. There is little robust evidence about commonly used interventions.
Many of the interventions studied have tended to be delivered from a hospital-based, clinician-driven paradigm
of TBI rehabilitation, which is at odds with the rehabilitation paradigm briefly described at the beginning of
80
In an evidence-based guideline it is necessary to draw together what evidence there is for the effectiveness of
various interventions. This will not necessarily reflect the importance of those interventions or the frequency
with which those interventions are used in everyday practice. There are many textbooks about TBI rehabilitation
practice that offer a more cohesive, pragmatic, if not necessarily formal evidence-based approach (eg,
Ponsford’s ‘rehabilitation for everyday adaptive living’ (REAL) guide121 or Rosenthal’s textbook122).
There is a substantial research gap in evaluating the impact of various service configurations, service delivery
methods and specific interventions currently offered in New Zealand for people with TBI, particularly from the 5
perspective of the individual with TBI and their family/whānau. This research could inform future versions of this
guideline and influence improvements in clinical practice to ensure best outcomes are achieved by people with
TBI and their families/whānau and carers.
This section covers the diagnostic and assessment procedures after the acute phase of TBI for people who have
been referred to rehabilitation services following a moderate to severe TBI, or people who have been referred for
specialist assessment with unresolved symptoms following mild TBI. For initial diagnosis and assessment see
Chapter 2, Pre-hospital assessment, management and referral to hospital.
A TBI can result in deficits that may generally be classified as physical, cognitive, behavioural/emotional or
communicative. Identification of these deficits and any consequential impacts on functioning is an important
first step towards being able to effectively help the person with the TBI, their carer(s) and family/whānau.
Assessment should include seeking information from family/whānau and carers who knew the person before
their injury and who are caring for the person after the injury, as they will be able to add information.8,123
The diagnostic assessment within rehabilitation services is to determine whether there is a probable injury to
the brain; and if so, the nature and extent of that injury and the short- and long-term effects that the injury is
likely to have caused. Once determined, this assessment aids in establishing the needs for immediate and long-
term medical and rehabilitative care. For example, if the person has suffered injuries which mean they are kept
prone, impairments of balance and motor control may be less apparent.
The diagnosis and assessment of the severity of a brain injury may be complicated by the presence of non-brain
injuries and brain injury symptoms that are masked by medical problems, particularly in the case of ‘mild’ TBI.69
The assessment of people with probable TBI should always be performed by people with training and expertise
in the application of their disciplines to people with neurological disorders.7,8,10 Likewise, the assessment of
children and young people under the age of 18 with probable TBI should be performed by people with training
and expertise in the application of their disciplines to children with neurological disorders.7,8,11
81
It is important to attribute symptoms correctly to TBI or other medical conditions, and to identify and treat
comorbid conditions in order to develop an effective TBI rehabilitation plan. This may require specialist
diagnosis and identification. Where progress is not as expected, and it is unclear whether a person’s symptoms
are due to TBI or one of these other disorders, they should be referred for a specialist neuropsychological
assessment.124
Also see Chapter 14, Special issues for more details of mental health disorders and other conditions, which may
or may not be resulting from the TBI.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
Assessments of the physical functioning of people with TBI should include assessment for the following:
• motor deficits:
− muscle weakness and paralysis
− abnormal muscle tone (spasticity)
− deficits in joint range of motion
− ataxia/coordination
• sensory deficits:
− visual/hearing loss
• symptoms, eg, headache, fatigue, pain
• dysphagia
• seizures
• functional mobility:
− changing and maintaining body position
− carrying, moving and handling objects
− walking and moving (including, but not limited to, crawling, climbing, running, jumping and swimming)
− mobilising with the aid of assistive technology.
There is some evidence that a specialist in physical rehabilitation medicine should lead both the physical
assessment and planning of physical therapy.10
82
A neuropsychological assessment includes an interview of the person with TBI and their family/whānau
and carer(s), plus standard assessment measures, and focuses on assessment deficits in cognitive and
behavioural/emotional functioning.
Cognitive assessment requires input from a multidisciplinary rehabilitation team along with family/whānau and
carers. Face-to-face contact is essential for assessment.
83
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
When TBI is sustained in childhood, neuropsychological assessment may need to be repeated several
times as the child matures to adulthood.
Concussion screening has the advantage that it does not require a neuropsychologist, and may be of value for
the initial assessment of people with mild TBI. When there has been a pre-injury base line measurement, these
tests, which may be recorded by team doctors in some sports, provide a simple binary indication of ‘yes there
is/no there is not a change in cognitive function’. They are therefore appropriate for medical practitioners to use
84
Test batteries, based on standardised neuropsychological measures, are intended for use by
neuropsychologists and other appropriately trained practitioners who are able to interpret the results. These
tests can be used for all levels of severity of TBI.
Although there is some recent evidence of the validity and reliability of some of these tests,127,128 there are
no good trials comparing them with the traditional (non-computerised) forms of testing. A question remains
about whether the performance measured by computerised tests equates with that measured by the non- 5
computerised tests. There is insufficient evidence to recommend them for routine use. The use of computer-
based tests inevitably results in the loss of information gained from observation of the way in which the test
participant performs a particular task.
85
Overview
• TBI is a complex process and currently there is little robust evidence about commonly used interventions.
• A person who has had a TBI may show physical effects of the injury, which may require physical rehabilitation
for which there is strong evidence for improving functional independence.
• Recovering mobility is an important goal for people who are immobile following a TBI. 6
• Both urinary and faecal incontinence are common following severe TBI. This can be distressing, socially
disruptive and can hinder progress in other areas of rehabilitation.
• When a person has post-TBI sensory (visual or hearing) disturbance, this may exacerbate disorientation and
confusion, or impact on higher cognitive function.
• Pain is frequently under-diagnosed in people with TBI, therefore specially adapted assessment tools or the
skills of a speech-language therapist and family/whānau and carers may be required to elicit symptoms
accurately.
• People may have communication impairments following a TBI and may require speech-language therapy as
an intervention.
• The nature of cognitive deficits resulting from TBI depends, to some extent, on the severity and location of
the injury. Cognitive deficits are likely to be more difficult in terms of rehabilitation than the physical and
behavioural effects of TBI, and harder for the family/whānau, carers and employers to recognise, accept and
accommodate.
• Cognitive rehabilitation has been shown to be effective, although the effectiveness of specific interventions
is unclear. There is very little evidence for the effectiveness of medications for the cognitive sequelae of TBI.
• A person who has suffered a TBI may show psychological/behavioural effects from the injury. Behavioural
rehabilitation attempts to aid the recovery, improve function where possible, and provide strategies to
minimise the negative impact of the symptoms that persist.
• Anxiety, depression and other mental health conditions are common after TBI and often increase if not
identified and treated.
• People with TBI who have difficulties in activities of daily living should be assessed and an individual
treatment programme should be developed and implemented.
• Sleep difficulties and fatigue are both common problems following TBI of all severities.
• Return to employment or an alternative occupation is a primary goal and a central factor in the restoration of
the quality of life for people with TBI.
• There is strong evidence that vocational rehabilitation improves vocational outcomes for people with TBI in
securing sustainable employment or alternative occupation, and is cost effective.
• A substantial proportion of people with TBI, particularly at the more severe end of the spectrum, may suffer
effects on sexuality, such as impaired sexual functioning.
• There is little evidence on the treatment of sexual dysfunction in people with TBI; most advice for
rehabilitation focuses on counselling, for which there is no evidence of effectiveness. There is no good
evidence for any particular medications for the control of sexually inappropriate behaviour.
• Continuous or intermittent input from a rehabilitation team may be appropriate over long periods of time
following TBI.
87
As stated in Chapter 5, in an evidence-based guideline it is necessary to draw together what evidence there
is for the effectiveness of various interventions. This will not necessarily reflect the importance of those
interventions or the frequency with which those interventions are used in everyday practice. There are many
textbooks of TBI rehabilitation practice which offer a more cohesive, pragmatic, if not necessarily formal
evidence-based approach (eg, Ponsford’s REAL guide121 or Rosenthal’s textbook122).
There remains a substantial research gap in evaluating specific interventions currently offered in New Zealand
for people with TBI, particularly from the perspective of the individual with TBI and their family/whānau.
Throughout this section and this guideline we refer the reader to the MedSafe data for details of the
contraindications and adverse effects of medications. More information can be found at www.medsafe.govt.nz.
There is a very small literature of robust research evaluating rehabilitation interventions in a TBI population. In
the following sections, many of the recommendations are extrapolated from findings in populations with other
brain injuries (particularly stroke) or in mixed populations including some people with TBI.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
Any physical treatment approaches should take account of any associated orthopaedic or C
musculoskeletal injuries.
The physical rehabilitation programme should include a written and illustrated plan for other C
members of the team, including family/whānau and carers.
Any programmes should be adapted to accommodate the person’s normal environment and ✓
activities as far as possible.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
88
The aim of physical rehabilitation is to aid the recovery of normal functioning as far as possible, and to
provide compensatory strategies to minimise the negative impact of the symptoms that persist (ie, to increase
independence through the facilitation of motor control and skills). There is strong evidence that demonstrates
the effectiveness of this approach in improving functional independence.8
Physiotherapists and occupational therapists, and in the case of children or young people, paediatric 6
physiotherapists and occupational therapists, need to be both skilled in the physical management of
neurological deficits and experienced in the recognition and handling of associated cognitive and behavioural
deficits which may impact on the ability of the injured person to engage and cooperate in therapy sessions, and
the functional application of motor control (ie, their ability to carry over physical gains into daily activities).8
Therefore, a physiotherapist or occupational therapist with neurological expertise should coordinate physical
therapy to improve the motor function for all people with brain injuries.8
Any of the current physical treatment approaches should be practised within a neurological framework
to improve the injured person’s function, but should also take account of any associated orthopaedic or
musculoskeletal injuries.8
The physical rehabilitation programme should include a written plan, with illustrations where appropriate, to
guide other members of the team (including family/whānau and carers) in carrying over motor skills into other
daily activities.8
It is the opinion of the Guideline Development Team that, where possible, and particularly when the person is
in the community, any programmes should be adapted to accommodate the person’s normal environment and
activities, eg, gardening, walking, swimming or doing structured exercises under the supervision and/or with
the assistance of family/whānau or carers.
In the case of dysphagia, speech-language therapists need to be skilled in the management of dysphagia both
in providing compensatory strategies that ameliorate the swallowing dysfunction and in physical rehabilitation
to aid the recovery of normal functioning as far as possible.
89
recommendations grade
People with traumatic brain injury who are unable to maintain their own sitting balance C
should have timely provision of an appropriate wheelchair and suitable supportive seating
package, with regular review of the seating system as their needs change.
Age-appropriate supportive seating and wheelchairs should be provided for children and C
young people.
People with complex postural needs should be referred to a specialist interdisciplinary team C
which includes expertise in specialist seating.
People with mobility problems should be considered for appropriate walking or standing aids. C
A carefully monitored and evaluated trial of botulinum toxin A (BTX-A) for the treatment of C
focal spasticity in adults with traumatic brain injury may be considered.
A carefully monitored and evaluated trial of BTX-A for the treatment of focal spasticity in C
children with traumatic brain injury may be considered, with awareness that a longer-term
treatment may be necessary before any benefits are found.
A trial of intrathecal baclofen for the treatment of severe spasticity in adults or children with C
traumatic brain injury may be considered, but should be carefully monitored for possible
complications, including pump malfunction.
A carefully monitored and evaluated trial of tizanidine may be considered, particularly for C
spasticity of the lower extremities.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Any rehabilitation programme should include a flexibility routine when there is any spasticity. ✓
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
90
People who have had a TBI who are unable to maintain their own sitting balance should have timely provision
of an appropriate wheelchair and suitable supportive seating package. The potential need for accommodating
communication devices and regular review to ensure the continued suitability of the seating system as their
needs change should also be taken into account.8 People who are unable to stand independently should be
provided with a suitable standing aid if appropriate, and this provision should be continued into the community
if still required at the time of transfer.8 In the case of children and young people, age-appropriate supportive
seating and wheelchairs should be provided.
People with complex postural needs should be referred to a specialist interdisciplinary team which includes
expertise in specialist seating.8
6
6.1.1.2 Aids and orthoses
Orthoses such as ankle-foot orthoses or hand splints may help some people to maintain normal posture and
stability during function. People with mobility problems should be considered for appropriate walking or
standing aids to improve stability, which may include ankle-foot orthoses.8 Care must be taken when fitting
orthoses to avoid pressure areas, especially where deformity exists or sensation is impaired. If an orthosis is
supplied it should be individually fitted.8
When planning a programme to improve motor control and general fitness, the following should be considered:
• treadmill training with partial bodyweight support as an adjunct to conventional therapy
• strength training to improve motor control in targeted muscle groups
• gait re-education to improve walking ability
• exercise training to promote cardiorespiratory fitness.8
6.1.2 Spasticity
Spasticity is a condition that results when the nervous system has lost control of the coordination between
the contraction and relaxation of muscles. Spasticity causes muscle stiffening, and flaccidity may also be
present. Spasticity may be exacerbated by various stimuli (such as a full bladder, pressure areas) which need
to be managed appropriately. It is the Guideline Development Team’s opinion that a sound flexibility routine is
necessary to counteract the effects of spasticity, and should be included in any rehabilitation programme for
motor control. There should be a team approach to management, with goals set prior to considering any of the
additional options outlined below.
91
There is therefore a small body of evidence that BTX-A may be effective for the treatment of spasticity in adults
with TBI, and a carefully monitored and evaluated trial of BTX-A may be considered.129,130
A longitudinal study of BTX-A in children found earlier improvement in less complex motor control tasks (hand
tapping) and pinch force tasks, but improvement in more complex, forward-reaching tasks occurred much later
or not at all, and concluded that although BTX-A reduced tone and increased range of movement of the spastic
upper extremity, the degree of motor improvement is dependent upon the complexity of the task.131 There is
limited evidence for the effectiveness of BTX-A in children with lower limb spasticity from cerebral palsy.132 Any
trial of BTX-A in children should therefore be carefully monitored for effectiveness.
For both adults and children, repeated treatments are likely to be required as BTX-A effects generally last no
longer than two to three months.
See MedSafe data at www.medsafe.govt.nz for contraindications and side effects of BTX-A.
However, a small controlled trial of intrathecal baclofen in children and young people aged between four and
19 at the start of the trial found that although there was a favourable outcome in all participants, with the
greatest benefit being a reduction of lower limb tone and carers noting improved muscle tone, behaviour, sitting
and general ease of care, significant complications were reported in some of the 12 participants, including
hypotension (2), bradycardia (2), apnoea (2), sedation (1), mechanical pump complications (10 occasions in
five years), cerebrospinal fluid fistula (1), local infection (3), and meningitis (2). The study lacked the power to
determine whether the complications noted were due to the intrathecal baclofen.134
See MedSafe data at www.medsafe.govt.nz for contraindications and side effects of intrathecal baclofen.
6.1.2.3 Tizanidine
A small randomised controlled trial examining the effectiveness of tizanidine for spasticity due to acquired brain
injury found that the average lower extremity and spasm scores decreased significantly. The treatment was
significantly better than placebo in decreasing lower and upper extremity tone. With a reduction in motor tone,
there was also an increase in motor strength.135 A non-systematic review of the antispastic effect of tizanidine
in placebo-controlled trials reported that the treatment group showed a reduction in muscle tone scores of 21–
37% compared with 4–9% for the placebo group and that 60–82% showed an improvement in muscle tone.136
Therefore, there is a small body of evidence that tizanidine may be effective for the treatment of spasticity in
adults with TBI, particularly for spasticity of the lower extremities, and a carefully monitored and evaluated trial
of tizanidine may be considered.
See MedSafe data at www.medsafe.govt.nz for contraindications and side effects of tizanidine.
92
recommendations grade
People with continence problems should not be discharged from residential care until C
continence aids and services have been arranged at home and carer(s) have been adequately
prepared.
Where the rectum is full but no spontaneous evacuation occurs, daily rectal stimulation may C
be used.
If the rectum is empty for three days running despite continuing oral intake, the use of an C
osmotic laxative or a stimulant should be considered.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
93
Bladder and bowel management plans should be developed with the full knowledge and ✓
support and help of the person’s primary carer.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
Both urinary and faecal incontinence are common following severe TBI, and may occur with less severe injury.
It is distressing, socially disruptive and a major burden to carers once injured people are discharged home and
can seriously hinder progress in other areas of rehabilitation. Active continence management and re-training of
the bladder and bowel, when needed, are therefore critical parts of a rehabilitation programme.
People with continence problems should not be discharged from residential care until adequate arrangements
have been made for continence aids and services at home and the carer(s) have been adequately prepared.8
Anticholinergic medication should only be prescribed after demonstration of an overactive bladder (eg, by the
passage of small, frequent volumes on a 24-hour voided volume chart with a postmicturition residual volume of
<100 ml, or by formal urodynamic investigation).8
6.1.3.2 Catheters
If a person has a postmicturition residual volume of >100 ml, intermittent catheterisation should be considered.8
In children, an abnormal postmicturition residual volume is >10% of maximal bladder capacity 137 and with
values above this it would be appropriate to consider a programme of intermittent catheterisation. Long-
term catheters should only be used after full assessment and consideration of less invasive forms of bladder
management. If necessary they should be used as part of a planned catheter management programme using
an agreed protocol. The impact on sexual function should be considered, particularly the potential problems
associated with an indwelling urethral catheter.8 Supra-pubic catheters should be used in preference to long-
term urethral catheters.8
94
If the rectum is empty for three days running, despite continuing oral intake, the use of an osmotic laxative (eg,
polyethylene glycol) or a stimulant (eg, senna) should be considered.8
recommendations grade
People with visual and/or hearing loss should be assessed and treated by a team with the C
appropriate experience or in conjunction with a specialist service.
People with traumatic brain injury with any visual disturbance should be assessed by a team A
which includes:
• ophthalmologists
• orthoptists where there are problems with eye movement/double vision
• people with expertise in rehabilitation for the visually impaired.
All people presenting post-traumatic brain injury with persistent visual neglect or field defects A
should be offered specific retraining strategies.
All people should be assessed for pain on a regular basis and treated actively in accordance B
with their wishes.
Practitioners should be alert to the possibility of pain in people who have difficulty C
communicating, and pay attention to non-verbal signs of pain.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
When a person has post-TBI sensory disturbance, including partial loss of hearing or vision, this may exacerbate
disorientation and confusional states or impact on higher cognitive function.8 People with visual and/or
hearing loss should be assessed and treated by an interdisciplinary team with the appropriate experience or in
conjunction with another specialist service able to meet their special needs.
6.1.4.3 Pain
Pain is frequently under-diagnosed in TBI and is associated with poor outcomes.8 People with communication
and cognitive deficits are often unable to describe their sensory symptoms. Specially adapted assessment
tools8 or the skills of a speech-language therapist, and family/whānau and carers may be required to elicit
symptoms accurately.
Painful musculoskeletal sequelae of TBI can include heterotopic ossification, contracture and deformity.
Shoulder pain is particularly common in upper limb paresis, arising from spasticity in the shoulder girdle
muscles, malalignment or subluxation due to muscle imbalance or weakness, or secondary damage to soft
tissues (eg, rotator cuff tears or impingement).
Neurogenic pain may be associated with local hypersensitivity to touch. Pain may be exacerbated by poor
handling and the uncontrolled effects of gravity. Successful management depends on an accurate assessment
and intervention depending on the contributing factors, and preventive measures to support the affected limb
in all positions.
All people should be assessed for pain on a regular basis and treated actively in accordance with their wishes.8
Health care practitioners should be alert to the possibility of pain in people who have difficulty communicating,
and should pay particular attention to non-verbal signs of pain.138 Health care practitioners and carers should
be educated about hypersensitivity and neurogenic pain, and about appropriate handling of the paretic upper
limb during transfers.8 Protocols should be in place for the management of pain, which include:
• handling, support and pain relief appropriate to the individual needs of the injured person
• review at regular intervals and adjustment in accordance with changing need.8
96
A systematic review of the evidence (which mainly involved children and young people with cerebral palsy)
for neurodevelopmental therapy found it to be contradictory and inconclusive,139 and there is no evidence to
support the routine use of neurodevelopmental therapy in children and young people with TBI.
recommendations grade
A person with traumatic brain injury who has specific communication difficulties should be B 6
assessed by a speech-language therapist for suitability for speech-language therapy.
A person with traumatic brain injury who has specific communication difficulties where A
achievable goals are identified, should be offered an appropriate treatment programme, with
monitoring of progress.
TBI can affect communication in different ways.8 Following a TBI, people may have communication impairments,
including speech production impairments, which impact on intelligibility and problems with receptive and
expressive language including reading and writing, and higher-level language skills such as pragmatics and
more general social interaction. Speech-language therapy intervention should therefore target as necessary:
• motor speech production and reduced intelligibility, including disorders of the voice
• receptive or expressive language skills (including reading and writing)
• ‘high level’ abstract language skills and social interaction skills, including social appropriateness. 97
recommendations grade
People with persistent cognitive deficits following traumatic brain injury should be offered B
functionally oriented cognitive rehabilitation.
A trial of methylphenidate may be considered for adults or children with traumatic brain injury C
who have deficits in the speed of mental processing or attention deficit hyperactivity disorder
secondary to traumatic brain injury.
A trial of donepezil hydrochloride may be considered for adults with traumatic brain injury C
who have deficits in memory and sustained attention.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
98
Any trial of medication for people with traumatic brain injury should be commenced at low ✓
doses, with cautious increases in dosage, and be monitored for effectiveness and adverse
side effects.
Any trial of medication for a person with traumatic brain injury should be preceded by a clear ✓
explanation to the person with traumatic brain injury and their carer(s), and a caution that
effects of medications are less predictable in people with traumatic brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
The nature of cognitive deficits resulting from TBI depends, to some extent, on the severity and location of the
injury. Cognitive deficits can include: difficulties in understanding and/or producing speech; difficulties with
attention, memory and the ability to concentrate; difficulties with initiating and planning daily activities; and
impairments in other cognitive tasks such as reasoning, judgement, initiation, planning, problem-solving and
decision-making. Relatively minor impairments in areas such as prioritising and decision-making can have a
profound effect on functioning.
Although the physical and behavioural effects of TBI often present significant challenges for rehabilitation, the
cognitive deficits may be the most difficult for families/whānau, carers and employers to recognise, accept
and accommodate. This difficulty may be relatively greater in the case of people with TBI who have few or no
physical symptoms detectable to the observer, when the people around them may be unable to understand
why, for example, they cannot remember and follow instructions, or why they sometimes act inappropriately.
Limitations of the injured person’s insight and awareness of their own difficulties, in particular, may impact on
their ability to engage effectively in rehabilitation, and may therefore affect the timing of intervention.
Trial-and-error learning should be avoided in people with memory impairment,8 as it tends to reinforce
unwanted outcomes/behaviours.
However, the heterogeneous nature of the population of people with TBI, the interventions used in cognitive
rehabilitation, and the various measures used means that there is little evidence for individual interventions.
The systematic review above found that there is insufficient evidence to draw any conclusions about which
cognitive rehabilitation programmes are most effective.141
Many of the complementary and alternative therapies used for TBI primarily, but not exclusively, address
cognitive deficits. See Chapter 7, Complementary and alternative medicines.
There is very little evidence for the effectiveness of medications for the cognitive sequelae of TBI, and input
from a neuropsychiatrist or other appropriately trained and experienced clinician is advisable before any trial of
medication.
See MedSafe data (www.medsafe.govt.nz) for contraindications and side effects of medications listed in this
section.
100
6.1.6.3.1.2 Bromocriptine
One small uncontrolled trial of bromocriptine to treat poor motivation in people with TBI was identified.
Improvements were found in anxiety and depression, and cognitive tests sensitive to motivation or frontal
lobe involvement were found. However, there were some methodological issues with this study, and there is
insufficient evidence from which to draw conclusions about effectiveness.148
6
6.1.6.3.1.3 Methylphenidate and amphetamines
A Cochrane review of the effectiveness of methylphenidate and amphetamines used in the acute stage to
promote recovery from TBI found no evidence of benefit.149
A further recent systematic review of methylphenidate treatment of ADHD secondary to TBI in children,
adolescents and adults found that methylphenidate showed beneficial effects on hyperactivity and impulsivity
but smaller effect sizes than observed in primary ADHD, and no robust effect on cognition. A more favourable
outcome was associated with the initiation of treatment soon after the injury, although this factor was not
systematically studied, and with trials with relatively long durations. It was concluded that robust trials in this
population were needed before any recommendation may be made for routine treatment.150
A small randomised controlled trial of 23 people aged 16 to 64 years with moderate to severe TBI found
that sub-acute administration of methylphenidate appeared to enhance the rate but not the ultimate
level of recovery as measured by the DRS and tests of vigilance.151 A further randomised controlled trial of
methylphenidate used in people with TBI who had been referred specifically for assessment and treatment
of attentional deficits found that the participants in the treatment arm showed significant improvement in
the speed of mental processing. It was concluded that methylphenidate may be a useful treatment in TBI for
symptoms that can be attributed to slowed mental processing.152
Therefore, there is insufficient evidence on which to base any recommendation for routine use of
methylphenidate and amphetamines in the treatment of people with TBI. However, a trial of methylphenidate
may be considered where the person has deficits in speed of mental processing.
One small randomised controlled trial found benefits from donepezil hydrochloride on measures of memory
and sustained attention in people with TBI, benefits which may have been sustained after treatment cessation,
although that is difficult to ascertain from this study.155 Several further uncontrolled trials of donepezil in people
with TBI also reported positive effects on cognition.156–160
101
Cognitive rehabilitation for children and young people needs to address not only the aim of regaining lost
functionality, but also the ongoing need to develop more advanced cognitive skills as the child matures. The
child with TBI will require regular monitoring for the appropriateness and effectiveness of cognitive rehabilitative
strategies, and the development and implementation of new programmes and compensatory techniques to
match the needs of the developing child.
Cognitive rehabilitation of children and young people with TBI may be delivered by teams of people from
neuropsychology, occupational therapy and speech-language therapy, or through educational interventions by
Group Special Education. See also Chapter 12, Children and young people and traumatic brain injury.
Home-based cognitive therapy becomes increasingly appropriate as children reach an age when they would
usually be expected to become more independent of their families. For example, external memory aids and
compensatory techniques to assist planning, organisation and problem-solving will help children to become
more independent of their caregivers.
6.1.6.4.1.2 Stimulants
There is little robust research on the use of stimulant medication in children and young people with TBI. One
small (n=10) randomised controlled trial of the use of methylphenidate found no significant differences
between methylphenidate and placebo on measures assessing behaviour, attention, memory and processing
speed.162 A systematic review of methylphenidate treatment of ADHD secondary to TBI in children, adolescents
and adults cited above concluded that there is insufficient evidence for any recommendation for routine
treatment.150 This echoes the evidence for use in adults above. There is therefore no evidence on which to base
a recommendation for the use of methylphenidate or other stimulant medication in this population. However,
treatment providers may consider a trial of medication, particularly if there is historical evidence of pre-injury
ADHD symptoms. In that case, target symptoms should be clearly identified before the trial, and effects (both
benefits and adverse effects) should be monitored across more than one setting. The incidence of side effects is
higher in children with neurological injury, so dosages should start low.
102
recommendations grade
People with traumatic brain injury should be provided with access to specialist psychological C
assessments and interventions to assist in the management of their behavioural difficulties,
including substance abuse.
People with severe behavioural problems, especially those with a tendency to wander, should C
be referred to specialist behavioural management services.
In the case of people with severe behavioural problems, especially those with a tendency C
6
to wander, the interdisciplinary team should develop an integrated approach to manage
behaviour and refer to specialist behavioural management services when necessary.
Families/Whānau and carers should be given information and ongoing support as required C
to help them to understand cognitive and behavioural problems, and guidance on how to
interact appropriately with the person with traumatic brain injury and how to access services.
Psychotropic medications used to manage agitation and aggression in people who have had C
a traumatic brain injury should be carefully selected for their side effect profiles, and the use
and effectiveness closely monitored.
If no effect is observed within six weeks, the drug should be ‘tailed off’ and another drug C
trialled after a suitable wash-out period.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Treating clinicians should ask about the use of any non-prescription medicines, supplements ✓
and complementary or alternative medicines.
A person with traumatic brain injury who may require medication for irritability and aggression ✓
should be referred to a neuropsychiatrist for treatment.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
103
One longitudinal study of people with TBI found that families may recognise more behavioural changes than
practitioners. It found that families identified behaviour change in about 80% of the people with TBI, and that
more behavioural problems were reported by families than by nurses at hospital. Behavioural symptoms also
appeared to worsen over the three years of the follow-up, with an increase in aggressive behaviour. There was
no correlation between behaviour change and age or the severity of the injury as measured by post-traumatic
amnesia.163
Specific issues relating to post-TBI mental health, including treatment, are addressed in Chapter 14, Special
issues.
In the case of people with severe behavioural problems, especially those with a tendency to wander, the
interdisciplinary team should develop an integrated approach to manage behaviour, and referral to specialist
behavioural management services may be required.7,8 In the event of severe behavioural disturbance,
appropriate supervision (including one-on-one supervision when required) by a professional trained in
behavioural management should be provided to ensure the safety of the person and those around them, and to
provide effective behavioural management.8
If the problems persist or worsen over more than two weeks, or if they give rise to severe concern for safety, and
cannot be managed in the community, the person should be transferred to a secure residential specialist unit to
provide a safe environment and specific assessment and treatment.8
People with TBI should be provided with access to specialist psychological assessment and interventions to
assist in the management of their behavioural difficulties, including substance abuse.8,164,165 Families/Whānau
and carers should be given specific information and ongoing support as required to help them to understand
the nature of cognitive and behavioural problems, and guidance on how to interact appropriately with the brain-
injured person and how to access services.8
Children and young people may have behavioural sequelae following severe TBI. However, there is little
evidence specifically on behaviour management interventions in children and young people with TBI.
In New Zealand, this is often managed through Group Special Education and family interventions such
as parenting initiatives. See Chapter 12, Children and young people and traumatic brain injury for more
details.
Many ‘over-the-counter’ products may cause symptoms of emotional and personality issues, and/or may
interact with prescribed medications. It is important that the treating health care practitioner asks about the use
of any supplements and complementary or alternative medicines.
Acute-onset irritability is probably primarily attributable to organic dysfunction, while late-onset irritability may
be secondary to a mood disorder arising from poor adjustment to physical and social impairment.164 Symptoms
of TBI may sometimes be mistaken for mental illness and thus lead to administration of inappropriate and
ineffectual medications. In some cases, assessment by a neuropsychiatrist can aid in differential diagnosis.
Also see Chapter 14, Special issues.
Aggression may be exhibited acutely or delayed by some time post-injury and, particularly when manifested
physically, can distress and endanger carers and practitioners. It may also impact on the rehabilitation of the
person with TBI, as it may result in exclusion from programmes. Risk assessments should be performed using
empirically validated, actuarial risk-assessment measures, which are more accurate than clinical judgement
105
6.1.7.2.1.1 Pharmacological management of post-traumatic brain injury agitation and aggression in adults
The administration of sedating medication is an appealing option in the management of aggression, as the risks
imposed by this behaviour are substantially and rapidly reduced. However, while sedation may sometimes be
appropriate as an emergency measure, it is not acceptable as a long-term solution for the majority of people. In
most cases, pharmacological restraint will not target the factors underlying irritability and aggression, and it will
hinder adequate assessment.164 A further drawback is that sedation is not specific to suppressing aggressive
behaviour; all, including appropriate, behaviour will be affected.
Another unwelcome consequence will be to depress further the person’s impaired cognitive functioning, thereby
hindering new learning (including the acquisition of adaptive behaviours). Finally, people with TBI are very
sensitive to medication, and undesirable side effects can in themselves prove debilitating. For example, while
psychostimulants are used in the treatment of distractibility and impulsivity, a potential side effect is increased
irritability.164 Therefore, it is important that people who may require medication should be discussed with, or
referred to, a neuropsychiatrist for treatment.
A Cochrane systematic review evaluated the effectiveness of various psychotropic medications used to
manage agitation and aggression in people who have had a TBI. The conclusion of the reviewers was that while
numerous drugs have been tried, there is little good evidence to support their effectiveness in this population.
They suggest that drugs be carefully selected for their side effect profiles, and the use of and effectiveness for
the individual with TBI be closely monitored. The effects of medication are generally observed within two to six
weeks from starting medication. It was suggested that if no effect is observed within six weeks, the drug should
be ‘tailed off’ and another drug trialled after a suitable wash-out period.169
All daily living tasks should be practised in the most realistic and appropriate environment, C
with the opportunity to practise skills outside therapy sessions.
Family and carers should be involved in establishing the most appropriate routines for C
activities of daily living for people with traumatic brain injury, which take account of their
lifestyles and choices.
All people with traumatic brain injury who have difficulties in activities of daily living should C
be assessed by an occupational therapist, nurse or other health care practitioner with
expertise in brain injury and experience in this area.
Services should recognise that the provision of ‘care’ for some people with traumatic brain C
injury may mean the supervision and practice of community living skills, rather than hands-on
physical care.
106
People with traumatic brain injury who have difficulties in functioning should be assessed C
by people with expertise in this area, to determine whether equipment or adaptations could
increase their safety or independence.
The need for equipment should be assessed on an individual basis and in the environment in C
which it will be used.
The prescription of equipment should take account of any cognitive and behavioural deficits C
and their constraints on the person’s ability, or their carer’s ability, to use the equipment
safely and appropriately. Where this is in doubt, arrangements should be in place for regular
review.
6
When an item of equipment has been identified as required for a person with traumatic brain C
injury, it should be provided as quickly as possible and before the person is discharged to the
community.
The person, their family/whānau or carer(s) should be trained in the safe and effective use of C
equipment.
People and their families/whānau and carers should be given clear written information on C
who to contact for repairs, replacement or future help and advice regarding the equipment.
Rehabilitation teams should consider computers and other technology as adaptive sources of C
meaningful occupation or as compensatory strategies for people with significant sequelae of
brain injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
107
Carers and family, if willing and acceptable to the person with traumatic brain injury, should ✓
be trained and supported to help with therapy.
People with traumatic brain injury should be given information and advice about changes in ✓
technology and computer use relevant to their needs.
The assessment for, and prescription of, augmentative communication devices should be ✓
made by suitably accredited clinicians.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
People with TBI who have difficulties in activities of daily living should be assessed by an occupational therapist
with expertise in brain injury, and an individual treatment programme aimed at maximising independence in
areas of self-maintenance, productivity and leisure should be developed and implemented.8
The majority of rehabilitation interventions undertaken by the TBI rehabilitation team are aimed at minimising
impairments and maximising performance in daily living tasks. These tasks include basic self-care and more
extended activities of daily living (eg, shopping and meal preparation), work and leisure activities. To maximise
new learning and the relearning of old skills, evidence suggests that activities should be practised in a
naturalistic and realistic environment. Ideally, this should be the person’s own home and local environment
with the opportunity to practise skills outside therapy sessions.8 Independence is achieved through practice,
the learning of adaptive techniques, and the provision of equipment and/or environmental adaptation. Family/
Whānau and carers should be involved in establishing the most appropriate routines for activities of daily living
which take account of the injured person’s lifestyle and choices,8 and family/whānau and carers should be
trained and supported to help with this. Services and funders should recognise that the provision of ‘care’ for
some people with TBI may mean the supervision and practice of community living skills, rather than hands-on
physical care.8
108
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
The provision of equipment or adaptations provides a solution to the individual’s unique needs within their own
environment. There is strong evidence for the general benefit and cost effectiveness of equipment provision for
people who need it, albeit not in the TBI population.8
Every person with TBI who has difficulties in functioning should be assessed to determine whether equipment
or adaptations could increase their safety or independence.8 The need for equipment should be assessed on
an individual basis and in the environment in which it will be used.8 The prescription of equipment should
take account of any cognitive and behavioural deficits and their constraints on the person’s ability to use the 6
equipment safely and appropriately. This also applies to equipment for use solely by the person’s carer(s).
Where this is in doubt the equipment provider should be responsible for ensuring that arrangements are in
place for regular review.8
Once an item of equipment has been identified as required for a person with TBI, it should be provided as
quickly as possible8 and before the person is discharged to the community. The person, their family/whānau
and/or carer(s) should be thoroughly trained in its safe and effective use. Its ongoing use and relevance should
be reviewed on a regular basis and in accordance with the manufacturer’s guidelines.8 People should be given
clear written information on who to contact for repairs, replacement or future help and advice regarding the
equipment.8
Other new technology, such as cellphones, pagers and personal digital assistants, can also be very useful. One
large study found that there were significant differences in case closure status and expenditure on vocational
rehabilitation for people with TBI who were provided with assistive technology compared with those who were
not, although there were no significant differences in the average earnings of the two groups.170
Rehabilitation teams should routinely consider computers and other technology as adaptive sources of
meaningful occupation or as compensatory strategies for people with significant sequelae of brain injury.8
People with TBI should be given information and advice about changes in technology and computer use relevant
to their needs. Where necessary, a specialist assessment of each individual’s ability to use a personal computer
should be arranged and the need for adapted hardware and software recorded.8
However, careful consideration of the appropriateness of technology for individuals with TBI is necessary.
People with symptoms of disinhibition or impaired judgement may be particularly vulnerable to the risks of
computer technology, such as internet ‘scams’ or predatory behaviour from other users. Caution and monitoring
of the use of the technology may be necessary in some cases.
109
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
Sleep difficulties and fatigue are two very common problems following TBI of all severities. The two problems do
not necessarily go together, although sleep disturbance can certainly contribute to fatigue. People with TBI and
health care practitioners recognise two ‘types’ of fatigue:
1. ‘cognitive fatigue’, where mental effort without physical exertion leads to severe tiredness and an inability to
proceed
2. ‘physical fatigue’, where smaller than expected amounts of physical exertion lead to severe tiredness and an
inability to proceed.
Fatigue is one of the most frequently reported symptoms following TBI. It often also poses a barrier to return
to work or other daily activities. There is virtually no good quality evidence relating to its extent, impact and
effective treatment. The management of fatigue is an important goal of rehabilitation post-injury. It is also
thought that fatigue may have impact on other symptoms of TBI (eg, headaches, or cognitive and behavioural
symptoms) which are often reported to be exacerbated when the person is tired.
Medications sometimes used to help with fatigue following TBI have not undergone investigation in this
population and should be used cautiously, if at all.
The management of fatigue is sometimes hampered by poor insight, so that while caregivers may recognise the
impact of the increasing fatigue, this may not be recognised by the person themselves.
One contributing factor in the development of fatigue may be the development of sleep disorders, including
difficulties in both the onset and maintenance of sleep, or changes to the sleep/wake cycle. If these difficulties
persist they can then lead to the typical symptoms associated with chronic sleep deprivation.
Good management of sleep difficulties can be counter intuitive; for example, a common response to poor sleep
is to try to stay awake longer during the day, the thought behind this being that the person would be really tired
by the time they went to bed. However, this may generate an overtired state, with consequent sleep disturbance
and exacerbated symptoms. Advice from a professional experienced in managing fatigue and/or sleep disorders
can be useful in establishing a suitable treatment programme.
People with traumatic brain injury should be assessed for the need for vocational A
rehabilitation to assist their return to work, or for entering the workforce for those not
previously employed, and vocational rehabilitation should be provided to those found to
need it.
110
Return to employment or an alternative occupation is a primary goal and a critical factor in the restoration of
quality of life for people with TBI. If people with TBI are unable to access, return to or remain in previous or
alternative employment, there are major economic implications as well as far-reaching consequences for the
individual and their family/whānau.12
Not everyone with a TBI will need the same degree of vocational rehabilitation. A systematic review reported
that 60–85% of people with a mild TBI, 50–60% of people with a moderate TBI, and 20–30% of people with a
severe TBI were re-employed by one year post-injury,10 so the need for vocational rehabilitation is likely to be
greater the more severe the injury. Many children with severe TBI will have difficulty in establishing themselves
in employment on leaving school171 and may require specialist vocational assessment, advice and support.
There is also some evidence that women experience more difficulty with return to work than men.172
Factors associated with or predictive of return to work include:
• age36,173–175
• sex172
• pre-injury level of education45,174–176
• pre-injury employment status36
• possession of qualifications175
• pre-injury occupation177
• pre-injury psychiatric history176
• pre-injury drug and alcohol use176
• injury severity176,178
• mechanism of injury including violent mechanism176 and fall59
• duration of loss of consciousness at time of injury45,174
• post-traumatic amnesia5,178
• level of disability at discharge174,176,177
• Glasgow Outcome Scale at six months179 and at five years post-injury (in people with childhood TBI)180
111
The return to work of people with TBI who have symptoms that may impact on their employment, whether in
a previous job or a new one, such as memory problems and planning, may be more durable when any such
problems are recognised, the appropriate strategies are implemented and the person and their colleagues
are educated about TBI and its sequelae and impact on employment. Therefore, people with TBI should be
assessed for the need for vocational rehabilitation to assist their return to work, or for entering the workforce
for those not previously employed (such as people who sustained a TBI in childhood). Where need is identified,
the person with TBI should be supported in their employment, or their ability to become employed, which will
help their ability to participate in employment, and so their ability to earn an income, which will contribute to an
appropriate quality of life.
The key feature of supported employment strategies is that they are applied ‘on the job’ in the work
environment. Supported employment programmes include vocational support (eg, in placement finding
and monitoring, with job coaching, education of employers and colleagues and a plan for progression in the
workplace that is provided by a specialist vocational rehabilitation provider).
Training and practice to prepare the person for work may be important, but the job coach always accompanies
the person to the job site to help them work out on-the-spot solutions to problems as they arise and to facilitate
communication between them and the employer. Problem-solving on the job is a defining principle of supported
employment.
112
A systematic review identified that there are several models of supported employment, including
apprenticeships, small businesses and work ‘enclaves’. The most common, and the one most appropriate for
people with TBI, is individual placements, where training and support are provided on an individual basis in
ordinary work settings. The four fundamental components of supported employment for people with TBI are
identified below.10
1. Job placement, including: matching job needs to the person’s abilities and potential; facilitating
communication between the person with TBI, the employer and carers; arranging travel and/or training; and
proactive assessment of the job environment for potential problems.
2. Job site training and advocacy, which dictates an active role for the job coach. The job coach performs
6
functions usually left to the employer in conventional vocational rehabilitation (such as training), and also
needs to proactively identify problems and design solutions in cooperation with the person with TBI, carers,
employers and anyone else involved.
3. Ongoing assessment with continuous monitoring of key aspects of the person’s performance in work. This is
usually an intense intervention by the job coach at the beginning of the placement, but is expected to reduce
as the person successfully adjusts to the work placement.
4. Job retention and follow-up, where the job coach monitors progress to anticipate problems and intervenes
proactively when necessary to prevent crises from disrupting the person’s job placement. This may continue
indefinitely, but the need is expected to diminish over time.
6.5 Sexuality
recommendations grade
The opportunity to discuss issues relating to sexuality should be offered early after significant C
traumatic brain injury, to both the person and their partner. This should be initiated by the
health professionals.
Advice about sexuality should cover both physical aspects (eg, positioning, sensory deficits, C
erectile dysfunction, drugs) and psychological aspects (eg, communication, fears, altered
roles and sense of attractiveness).
Families/Whānau and carers should be reassured that sexually inappropriate behaviour is not C
unusual in people who are in the early stages of recovery from a traumatic brain injury and
that it should improve with time, and be provided with training in how to avoid inadvertently
reinforcing the behaviour.
Sexuality encompasses not only intercourse, but also intimacy, communication and psychological aspects
including the sense of self-worth, attractiveness and significance of role. Sexual functioning is important and
desirable for the majority of people, including those who have had a TBI.
113
Information, advice and open discussion can be very beneficial in overcoming sexual problems following TBI, yet
very few people receive any help. Help needs to be given early and staff need to take the initiative, thus giving
permission to talk about sex.
One study, for example, found that people with TBI, compared with a non-injured control group, reported more
frequent physiological difficulties impacting on their sexual energy and drive, and their ability to initiate sex and
achieve orgasm. The study also found that people with TBI had physical difficulties impacting on positioning,
movement and sensation; and body-image difficulties influencing feelings of attractiveness and comfort with
having a partner view one’s body during sexual activity.
Men with TBI reported less frequent sexual activity and relationships, and more frequent difficulties in
sustaining an erection. Women with TBI reported more frequent difficulties with arousal, pain, masturbation
and lubrication. Age at injury and severity of injury were negatively related to reports of sexual difficulties in
both men and women with TBI. In men with TBI but without disability, the most sensitive predictor of sexual
dysfunction was level of depression. For women with TBI, an endocrine disorder and level of depression
combined was the most sensitive predictor of sexual difficulties.190
One small uncontrolled study of adults with TBI and SSRI-induced sexual dysfunction reported a trial of the
addition of mianserin at doses of 7.5–15 mg per day. Improvement in sexual function was reported by 88%
following this intervention, with 59% reporting that sexual function achieved pre-treatment (with the SSRIs)
level. Twelve percent did not respond to this intervention and were instead given sildenafil citrate, which was
effective.192 Another small uncontrolled trial of an assistive device also reported benefits. Thirty men with
chronic neurological impotence who were offered a trial of vacuum tumescence constriction therapy were
followed up for an average of 21 months, at which time more than 50% were still actively using the device and
the average frequency of coitus had increased from 0.3 per week to 1.5 per week (p <0.0001).193
There is therefore insufficient evidence on which to base a recommendation for any routine intervention for
sexual dysfunction following TBI.
114
Sexually inappropriate behaviour can be emotionally demanding of families/whānau, carers and treatment staff,
and it may give rise to important legal and management issues and dilemmas. One review of the topic reported
previously unpublished data showing that 70% of rehabilitation professionals reported that sexual touching
was a common problem at their facilities, and 20% reported that the use of sexual force by patients was
common, while 97% claimed that the sexually inappropriate behaviour of such clients had at least a moderate
impact on the clients’ rehabilitation and community re-entry. Sixty percent of the professionals said they did not
have adequate training to deal with such behaviour.195
In acute care settings, people with TBI may display themselves in sexually inappropriate ways, masturbate, or 6
make inappropriate comments; behaviours which may be best managed by means of the provision of privacy
and distraction techniques. People with TBI who are in a confused state may make sexual jokes or attempt
sexual touching of carers or therapists. A clear statement about what is and is not appropriate and removing the
person’s hand or moving away for a few seconds should be adequate.195
Family/Whānau members and carers should be reassured that this behaviour is not unusual in people who are
in the early stages of recovery from a TBI and that it should improve with time, and be provided with training
in how to avoid inadvertently reinforcing the behaviour.195 However, if the sexually inappropriate behaviour is
severe, dangerous or persistent, it will need to be addressed as part of the rehabilitation programme for the
person. The behaviour can be very distressing for family/whānau and carers, who will need support to cope with
it.196
There is little evidence of the effectiveness of specific interventions, and most research reports individual case
studies. The following strategies are adapted from a recent review of the topic.195 A neuropsychologist should
advise which level of approach is suitable for the person with TBI.
Traumatic brain injury rehabilitation services should support people with clinically significant C
traumatic brain injury in developing alternative leisure and social activities, in liaison with
local voluntary organisations.
Assessments of all people with traumatic brain injury should include the identification of: C
• their level of participation in leisure activities
• the barriers or compounding problems which inhibit their engagement in such activities.
People with traumatic brain injury who have difficulty undertaking leisure activities of their C
choice should be offered a goal-directed, community-based programme aimed at increasing
participation in leisure and social activities.
Carers should be given advice on how to maintain their own leisure and social activities while C
in a caring role.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
A return to leisure activities will depend upon both the severity of the TBI and the demands of the leisure activity
the person wishes to resume. The person will need medical clearance before participating in some activities,
such as riding, diving and motorbike riding. For details of return to sports and physical activities see Chapter
14, Special issues. There is a lack of specific evidence in this area, and this section is adapted from the UK
publication Rehabilitation Following Acquired Brain Injury: National Clinical Guidelines.8
116
Targeted problem-solving intervention may be required to help them overcome these difficulties.
Community TBI services should guide and support people with clinically significant TBI in developing alternative
leisure and social activities, in liaison with local voluntary organisations.8,199 Assessments of all people with TBI
by a rehabilitation professional or team should include the identification of:
• their level of participation in leisure activities (including indoor and outdoor pursuits)
• the barriers or compounding problems which inhibit their engagement in such activities.8
People with TBI who have difficulty undertaking leisure activities of their choice should be offered a goal-
directed, community-based programme aimed at increasing participation in leisure and social activities.8 Some
6
targeted programmes for people with disabilities, such as riding or swimming for the disabled, may be helpful.
117
Overview
• Although many complementary and alternative medicines (CAMs) are advocated for use in people with
traumatic TBI, there is limited evidence available on their effectiveness.
• There may be risks of harm or interactions from CAMs. Health practitioners should ask and record what
people with TBI are using.
• Evidence shows unacceptable levels of harm from craniosacral therapy in people with TBI.
• There is no evidence that ginkgo helps cognitive and other impairments following TBI.
There are many therapies and products proposed for use in people with TBI. These are not routine treatments
and can be grouped under the term ‘complementary and alternative medicine’ or CAM. CAM use in people
with TBI may be targeted at a particular aspect of functioning (usually cognitive) or at the post-TBI syndrome.
This chapter focuses on the CAMs more commonly advocated for use by people with TBI. The evidence is
7
summarised in Table 7.1.
The evidence for CAM is, by nature, ‘emerging’ and this guideline has used a grading system aimed at providing
plain-language interpretations of the lower levels of evidence that currently exist around CAM. The Guideline
Development Team has avoided making recommendations in this chapter, so that consumers can weigh the
evidence presented and in consultation with their advisors reach their own conclusions about whether or not
they should use a particular treatment for a particular condition. More details of these grades can be found in
Appendix B and at www.cam.org.nz.
There may be risks of harm or interactions from CAMs. It is important that there is open communication between
rehabilitation practitioners, CAM practitioners and the person with TBI, their family/whānau and carer(s). It is
important that the rehabilitation team ask specifically about the use of CAMs, including dietary supplements,
which the person or their carer(s) may not perceive as a ‘therapy’ or ‘medication’.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
7.1 Biofeedback
Biofeedback provides feedback of information to the person about some aspect of physical behaviour or
functioning. Two studies on the use of biofeedback for rehabilitation following TBI were identified. One small
randomised controlled trial of a standing biofeedback training device for postural training in adults with
hemiplegia after TBI or stroke found a benefit from the device.200 A single case study demonstrated benefits of
visual feedback superior to traditional speech therapy for a child with TBI.201
119
The literature search found several controlled studies and systematic reviews.202–210 These showed positive
results in terms of improved outcomes for people with mild to moderate TBI, with both self-reported symptoms
and independent measures showing improvements in cognitive performance, pain and headache, in some
cases achieving premorbid functioning in the short term. Studies generally showed an effect after 18 to 20
sessions of treatment. However, there is not yet enough high-level evidence to identify whether the benefits
observed in these studies are sustained over time.
7.3 Homoeopathy
Homoeopathy is a system of treating people using very low-dose preparations according to the similia
principle: ‘like cures like’. In ‘classical’ or individualised homoeopathy, practitioners aim to identify a single
homoeopathic preparation that matches the person’s general ‘constitution’, including the symptoms for
which the person is seeking treatment. Owing to differences in elements of people’s constitutions, two people
with identical conventional diagnoses may receive different homoeopathic prescriptions. It is therefore not
appropriate to examine the effectiveness of any one remedy applied to all people with TBI.
Only one study of sufficient quality was found on the use of classical homoeopathy for TBI. This was a
randomised double-blind placebo controlled trial of 60 adults with mild TBI.211 A total of 18 different remedies
were used in individualised treatments. The study reported that at the four-month follow-up point, there were
significant reductions in self-reported symptoms in the treatment group, although there were no improvements
in standardised cognitive, linguistic or memory tests. The effect or relative benefit increased with duration from
injury. Some possible adverse reactions were reported (eg, nausea and dizziness), but the study had insufficient
power to detect whether these were reactions to the treatment.
7.4.2 Chiropractic
Chiropractic emphasises the ability of the body to heal itself by restoring and maintaining the health of the
whole person through natural means. Specifically, chiropractic aims to restore and maintain joint, muscle and
nervous system function.
The Guideline Development Team was unable to find any research that met the criteria for review on the use of
chiropractic in people with TBI.
120
The Guideline Development Team was unable to find any research that met the criteria for review on the use of
osteopathy in people with TBI.
Some of the potential benefits ascribed to ginkgo include effects on recognition memory, processing speed,
attention, concentration, mood, tinnitus, sexual dysfunction, nephrotoxicity, glaucoma and claudication.
Additional potential beneficial effects, based on analysis of the active constituents, include blockade of cell
death, antiplatelet activity, free radical scavenging, changes in blood flow and protection from anoxia.79,213,214
A Cochrane review214 and a further review213,214 of ginkgo for cognitive impairment found ginkgo superior to
placebo on a number of measures, but these did not specifically review the use of ginkgo in people with TBI. 7
A further systematic review79 concluded that ginkgo extract may be valuable for conditions that are commonly
seen following TBI. There is evidence of effectiveness for treating: tinnitus; impaired cognitive skills including
memory, concentration, attention and processing speed; and agitation, psychosis and aggression. However,
the authors caution that there is no good research on the effectiveness of ginkgo extract specifically in the TBI
population, and suggest that research focusing on this area may be warranted.
Both reviews caution about the side effect profile of ginkgo extract, as it may have an anticoagulant effect,
reducing platelet ‘stickiness’. Spontaneous bleeding related to ginkgo extract has been reported. There could
also be an interaction with other anticoagulant drugs given before surgery.
7.5.2 Ginseng
Most of the research into the effects of ginseng on cognitive skills has focused on either enhancing cognition
in healthy people or ameliorating the cognitive decline associated with aging and dementia. The Guideline
Development Team was unable to find any research specifically examining the effectiveness of ginseng in
people with TBI.
7.5.3 Ashwagandha
The use of ashwagandha, commonly known as withania, is purported to enhance mental functioning, and
because of this it is sometimes used by people with cognitive impairment post-TBI. It is also claimed to have
sedative effects, and should not be used concurrently with prescribed sedatives due to the risk of interaction.
However, there is no data in humans to provide evidence of its effectiveness or harm for people with TBI.
121
7.7 Acupuncture
Acupuncture is a Chinese therapeutic process where needles are used to stimulate points along meridians
to enhance the healing process. Evidence on the use of acupuncture for post-TBI symptoms is scarce and
inconsistent.216 Therefore, current evidence does not support the use of acupuncture to treat people with TBI.
122
ginkgo
Benefits:
Some evidence without a
• there is evidence from pathophysiological studies that ginkgo may benefit
high degree of reliability
non-clinical outcomes
• there is evidence from studies in non-TBI populations of minor
improvements in cognitive skills
123
Overview
• Symptoms commonly reported following mild TBI include headache, nausea, dizziness, blurred vision,
confusion, fatigue, poor concentration, memory problems, sleep difficulties, irritability and noise intolerance.
• There is some evidence that early, relevant information about common symptoms of mild TBI, emphasising
high rates of recovery, can positively influence the rate of later persistent symptoms.
• The presence of persistent symptoms following mild TBI necessitates further assessment.
• A careful assessment of possible alternative causes of symptoms post-mild TBI should also be made to
ensure correct treatment.
A recent systematic review of published prospective studies of mild TBI shows fairly rapid recovery occurs for
the great majority of people in the first few hours, to the first month after the injury.67 Many recover within a few 8
hours. However, these same studies also describe a group of people who fail to recover fully during that time,
and there is no predictive relationship between the apparent severity of injury (within the overall context of a
mild TBI) and the persistence of symptoms.
In New Zealand, contracts for mild TBI clinics (sometimes called ‘concussion clinics’) are currently held by
DHBs and other providers, with their primary role being to attempt to ‘sort out’ the issues for and possible
management of people with persistent symptoms after mild TBI. These contracts usually include a specialist
medical assessment, a neuropsychological assessment and a variable number of therapist (usually
occupational therapy) sessions.
Feedback from clinicians involved with the mild TBI clinics suggests that they do not see exclusively people with
mild TBI, but also, appropriately, a number of people who have actually suffered a moderate-severe TBI.
This chapter reviews evidence for the characterisation of people with persistent symptoms following mild TBI
and effective interventions that improve outcomes for this group, alongside current practice in New Zealand.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
125
The same study found a slight deficit in visual closure (the ability to fill in missing parts of a visual stimulus
such as a letter missing from a word) in the mild TBI group at six and 12 months post-injury, but this deficit did
not relate to reading ability when the children were assessed later.218 Studies reporting behavioural problems
and academic scores found no difference pre- and post-injury, although two studies suggested there were
behavioural impairments in injured children regardless of the nature of the injury.67 An injury, even one not
involving TBI, rather than mild TBI per se was shown to be associated with behavioural issues.
The overall rate of moderate to severe disability, as measured by the Glasgow Outcome Scale, ranged from 0
to 1%, although one small study reported that 2% of more severely injured children have moderate-severe
disability at six months post-injury. However, most studies have methodological shortcomings that prevent
certainty that the outcomes are definitely attributable to the mild TBI.67
A systematic review of the literature in this area concluded that there is a probable organic basis for early
symptoms (although this doesn’t explain why some people with entirely trivial injuries get the same symptoms)
but no evidence to support ongoing organic brain ‘damage’ causing persistent symptoms. It was concluded
that persistent post-concussion syndrome (PCS) after mild TBI, uncomplicated by any focal injury, is biologically
inseparable from other examples of the post-traumatic syndrome and counsels against use of the term PCS.14
A further systematic review by the WHO Collaborating Centre Task Force on Mild Traumatic Brain Injury found
that where symptoms (and associated activity limitation) persist, compensation and/or litigation is a factor,
but there is little consistent evidence for other predictors. The authors cautioned that the literature was of very
mixed quality, and that causal inferences were often mistakenly drawn.67
126
All people with possible or definite mild traumatic brain injury should receive information B
about common symptoms and reassurance that recovery over a short period of time (days to a
few weeks) is highly likely.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
There is some evidence220,221 that early, relevant information about common symptoms of mild TBI, emphasising
high rates of recovery, can influence the rate of later persistent symptoms. A large randomised controlled trial
in the UK showed that routine follow-up of a population with predominantly mild TBI resulted in lower rates of
disabling symptoms at six months.97
If a person with a mild traumatic brain injury presents because they have symptoms which ✓
are causing concern late, or re-presents to health care services after being discharged
with information, an initial assessment should be performed and the person referred, if
appropriate.
When a person, particularly a child, with mild traumatic brain injury has symptoms persisting ✓
beyond a month, a careful reassessment of possible severity should be made.
All people with persisting, clinically significant symptoms of traumatic brain injury after ✓
four to six weeks should be referred for a specialist assessment, usually including a
neuropsychological assessment.
An appraisal of the severity and impact of symptoms of traumatic brain injury should be ✓
made, and:
• minor problems should be managed symptomatically
• the person should be offered reassurance and information on symptom management
strategies.
If there are more severe symptoms, or suspicion that the traumatic brain injury is not ‘mild’, ✓
the person should be referred for further assessment and rehabilitation, as appropriate.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
127
As it seems probable that there is a high rate of misidentification of moderate-severe TBI as mild TBI, when
a person, particularly a child, with mild TBI has symptoms persisting beyond a month, there should be a
suspicion that the person’s injury may have been more severe than initially thought, and a careful reassessment
of possible severity should be made.
It is important that a careful assessment of possible alternative causes of the symptoms post-mild TBI is made
to ensure correct treatment. Referral should be made to specialists, if necessary (eg, an ear, nose and throat
[ENT] specialist for assessment for unresolved dizziness, tinnitus and vertigo).
Based on the available evidence, a pragmatic approach to people with persistent symptoms is described in ‘6
Steps’, (see Appendix D for a link to the resource).
If there are more severe symptoms, or suspicion that the TBI is not ‘mild’, the person should be referred for
further assessment and possible rehabilitation, as appropriate (see Chapter 5, Rehabilitation following clinically
significant traumatic brain injury – assessment and Chapter 6, Rehabilitation following clinically significant
traumatic brain injury – intervention). For the management of symptoms of mental health problems, including
drug and alcohol problems, see Chapter 14, Special issues.
128
Overview
• Some people who have had a mild TBI experience long-term disability following discharge from hospital,
which may include headaches, dizziness and other persistent symptoms.
• All people with any degree of severity of head injury and their carers should be made aware of the possibility
of longer-term symptoms and disabilities from TBI.
• People who have been discharged following a TBI, and their carers, should be provided with written
information and verbal instructions on what signs or symptoms require reassessment or the need for further
information, along with details of who to contact for help.
• There is good evidence that routine follow-up of people with TBI that is outside the ‘mild’ or ‘trivial’ TBI range
improves outcomes.
• Any person who has had a head injury, who may or may not have received medical attention at the time of
the injury, who later seeks contact with primary care or an Emergency Department with symptoms of TBI
should be offered an appointment with a professional trained in assessment of the sequelae of TBI.
• Following TBI, the needs of people and their families/whānau and carers change over time, and for some,
may increase significantly. Many may require long-term counselling and emotional support.
• People who have experienced TBI, and their carers, will need a variety of information upon discharge. There is 9
evidence that the need for information is one of the most commonly unmet needs of parents of children with
TBI, yet information has been identified as the single most important form of support for families.
• Information on TBI should be given in simple, easy-to-understand language.
• People who have had a TBI and are being transferred to rehabilitation services should have a management
plan prepared, which should detail the care, rehabilitation and support needed, and how it is to be provided.
The post-discharge follow-up and support needs of people who have had a possible or definite TBI and their
families/whānau and carers range from the need for information provided at discharge to long-term support of
the person with TBI.
People with any degree of head injury or TBI should only be discharged to their homes if it is certain that there
is somebody suitable there to supervise them. People with no carers at home should only be discharged if
suitable supervision arrangements are organised.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
129
Anyone with traumatic brain injury and a recorded Glasgow Coma Scale of 13 or less at any B
stage after the first 30 minutes OR who received a CT scan of the head as part of their initial
assessment should be routinely followed up with, as a minimum, a written booklet about
managing the effects of traumatic brain injury and a phone call in the first week after the
injury. This follow-up needs to be undertaken by someone trained in identifying and managing
common problems following traumatic brain injury.
Any person who has had a head injury and later seeks contact with primary care or an C
Emergency Department with symptoms of traumatic brain injury should be referred for
assessment by a professional trained in assessment of the sequelae of brain injury.
Anyone with moderate or severe traumatic brain injury discharged from a residential B
rehabilitation setting should be considered for scheduled telephone follow-up contact using
motivational and problem-solving techniques.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
People who have been discharged from an Emergency Department, general practitioner or other community
service with none of the indications for immediate intervention or likely need for rehabilitation (see Chapter
4, Rehabilitation services and Chapter 5, Rehabilitation following clinically significant traumatic brain injury
– assessment), and their carers, should be given information and verbal instructions on what signs or symptoms
warrant reassessment or need for further information, along with details of who to contact for help (see Section
9.2, Continuing care and support).
A UK study by Wade et al (1998), especially when taken with that group’s earlier (negative) randomised
controlled study, suggested that people with more significant injuries get most benefit from routine follow-up.97
In the first UK trial by Wade and colleagues (1997),224 1156 consecutive participants with ‘head injury’
presenting to an Emergency Department or admitted to hospital were randomised to receive routine follow-up
or not to follow up. By six months there was no significant difference between the groups on various measures
although sub-group analysis suggested people with more severe injuries (post-traumatic amnesia for more than
one hour) benefited more than those with milder injuries.
130
Around 25% of the participants could not be contacted by phone. Of the remainder, 10% received a telephone
follow-up call only, 19% were assessed face to face, 34% were assessed face to face and received additional
telephone support and 12% were assessed face to face and required further outpatient contact, which included
a range of services, including neuropsychological assessment. By six months, participants in the trial group
had significantly better scores for social disability and lower symptom scores on a post-concussion symptom
checklist. For example, on the Rivermead Post Concussion Questionnaire, 68% of the intervention group versus
45% of the control participants scored in the lowest two categories, that is reporting with fewer symptoms.
In a randomised controlled trial of 202 adults with mild TBI225 in Australia (Glasgow Coma Scale score 13–15,
post traumatic amnesia <24 hours, no focal neurological signs, did not have a CT scan) the intervention group
had a neuropsychological assessment at one week from the injury (but received no feedback about the results)
and received an information booklet aimed at helping them to cope with the effects of mild TBI. The control
group received neither the assessment nor the booklet. By three months, the intervention group had lower
scores on most items on a post-concussion checklist, significantly so for anxiety and sleeping difficulty. They
also had lower scores on a ‘global severity’ score. There was no difference between the groups on formal
neuropsychological assessment. There is some uncertainty about whether these benefits are simply due to the 9
information booklet or whether having a neuropsychological assessment could also have affected the results. A
high rate of loss to follow-up (38%) means some caution needs to be applied to the findings in general.
In a USA trial of 171 people following moderate and severe TBI discharged from inpatient rehabilitation,223
intervention group participants received seven scheduled telephone follow-up calls from a ‘care manager’
over one year. This person was specifically trained in this role and used motivational interviewing principles in
carrying out goal-setting, reassurance and problem-solving. Eighty-four percent of the calls involved information
provision and/or counselling alone, with 15% involving specific referrals. The control group received no contact
from the research team. At 12 months follow-up, participants in the intervention group had significantly better
scores on the primary composite outcome index and on specific composites such as functional status and
quality of well-being. There were no significant differences on vocational status or community integration.
9.1.3 Self-referrals
Any person who has had a head injury, who may or may not have received medical attention at the time of
injury, and later seeks contact with primary care or an Emergency Department with symptoms of TBI should
be offered an appointment with a professional trained in assessment of the sequelae of brain injury.8 This
assessment should follow the process detailed in Section 2.5 First assessment – delayed and should include
assessment for the prognostic factors to meet ACC’s funding/planning needs.
131
The aim of long-term services should be to enable and sustain optimal societal participation C
for both the person with traumatic brain injury and their family/whānau and carer(s), while
supporting personal choice and helping them to adjust to the new situation.
Written information should be concise and clear, use simple, easy-to-understand language C
and be illustrated with graphics, if appropriate.
People who have had a traumatic brain injury and their carers should receive information C
including:
• symptoms and signs which may indicate what to do about them and the need for further
investigation
• reassurance about symptoms and signs which are not unexpected
• advice about safety and self-care measures
• advice on alcohol or drug misuse for people who initially presented with drug or alcohol
intoxication
• details of community resources
• information for carers on the difficulties of an injury that cannot be detected by those who
do not know about the injury.
A letter or e-mail detailing the clinical history, examination and any imaging should be sent C
to the general practitioners of all people who have attended an Emergency Department with
a head injury and been discharged. A copy of this letter should be given to the person or their
carer(s).
All people with any degree of severity of head injury and their carers should be made aware of C
the possibility of long-term problems from a traumatic brain injury and of services they could
contact should they experience long-term problems.
People who have had a traumatic brain injury and are being transferred to rehabilitation C
services should have a written management plan (of which they are given a copy) that details:
• current needs
• key contacts
• responsible services/professionals
• sources of continued information, support and advice.
Management plans should be agreed jointly between the person, their carer(s) and health and C
social care professionals from the services involved in the transition prior to transition and a
time-frame for review agreed.
Upon transfer or discharge, there should be a written discharge report which includes: C
• the results of all recent assessments
• a summary of progress made and/or reasons for case closure
• recommendations for future intervention.
132
Copies of the management plan and the discharge report should be provided to the person C
and their family/whānau and carer(s), and to all professionals relevant to the person’s current
stage of rehabilitation.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Information about possible long-term effects should be given in a practical and reassuring ✓
manner, and efforts should be made to alleviate the concerns of people with traumatic brain
injury and their carers.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
There is no adequate evidence in this area specifically for children and young people with TBI that can be
used to guide decision-making. The information and recommendations for adults should be used with
caution in these groups.
The needs of people who have sustained a TBI, and their families/whānau and carers, change over time and for
some may increase significantly. Many people who have had a TBI require long-term counselling and emotional
support to assist understanding and adjustment to altered family roles and circumstances.
Families and carers also report the need for information, practical support, continued education and easy 9
access to health and social care systems to combat isolation, emotional distress, stress and practical overload.
Ongoing support is required in the community in order to maximise independence and quality of life for what
may be, in younger people, the next 50 years or more of their lives.
The aim of long-term services should be to enable and sustain optimal societal participation for both the
person with TBI and their family/whānau and carer(s), with personal choice, and will involve helping them to
adjust to the new situation.8,113 Services will need to be delivered in a whole range of settings and, importantly,
will involve adapting and developing a range of specialised professional skills and attitudes to working with
people with TBI and their carers. A social/educational model of care is appropriate, and effective services will
emphasise on collaboration between rehabilitation specialists and people involved in the everyday life of the
person with TBI.
9.2.1 Information
People who have been in receipt of medical and rehabilitative care will need a variety of information upon
discharge, depending upon the severity of their injury, the time since the injury and at what point the
information is being given. The people who are caring for them at home, after discharge, will also need
information. There is evidence that the need for information is one of the most commonly unmet needs of
parents of children with a TBI,226 while information has been identified as the single most important form of
support for families.11,227
People who are being discharged early after an injury may require observation at home by their carers. A
systematic review identified one observational study in which carers were given specific, explicit written
information. The study reported high levels of compliance with written instructions for home observation after
Emergency Department discharge.228 Compliance was better when the injured person had experienced some
loss of consciousness, or was younger, and where the observer was the person’s mother. 133
Information needs to be concise, clear and illustrated with graphics, if appropriate. Receiving information of
this sort favourably affected the participants’ trust in, relationship with and confidence in their physicians, and
when, during therapy, they were given printouts of graphic trends depicting their responses to therapy, people
were more motivated to adhere to their treatment plans and more satisfied with their care.229 There is no reason
why this information should not apply equally to carers as well as people with TBI.
Information should be proactively offered, and it should not be assumed that carers will ask for information they
require. There is evidence that many carers will not seek information even when needed, particularly for less
severely injured people.11,230 Results of a UK study stated that information should be provided to all people with
possible TBI regardless of severity of injury or functional impairment.230 A Cochrane systematic review concluded
that both verbal and written health information should be given to people and their carers on discharge to
home.231
The combination of verbal and written health information enables the provision of standardised care
information to people and their carers, which appears to improve knowledge and satisfaction. Information
should be given in simple, easy-to-understand language.232,233
People who have had a possible or definite TBI and their carers will need clear information in the following
categories:
• symptoms and signs which may indicate a need for further investigation, including what action the person or
their carer(s) should take if they experience any of these (such as, go to a general practitioner or Emergency
Department) and an indication of urgency
• reassurance about symptoms and signs which are not unexpected and about which they need have no
concerns, specifically including the expected progress and resolution of the after-effects of the TBI, together
with details of what to do if the signs and symptoms do not resolve in the expected time-frame
• advice about safety and self-care measures, including minimising the risk of re-injury and caution with use of
drugs and alcohol
• information and advice on alcohol or drug misuse for people who initially presented with drug or alcohol
intoxication
• information about community resources
• information for carers on the difficulties of an injury that cannot be detected by those who do not know about
the injury.7
A communication (letter or e-mail) should be generated for all people who have attended an Emergency
Department with a head injury, and sent to their general practitioners when they are discharged. This letter
should include details of the clinical history, examination and any imaging. This letter should be open to the
person or their carer(s), or a copy should be given to them.7
134
Information about possible long-term effects should be given in a practical and reassuring manner, and efforts
should be made to alleviate the concerns of people with TBI or their carers. This is particularly important for
people who appear more anxious and who may, for example, attribute unrelated symptoms to the TBI, after the
TBI sequelae have resolved.
9.2.1.3 Information for people with mild traumatic brain injury on discharge from Emergency Department or
community services
People with a possible or definite TBI who have been assessed in an Emergency Department, by a general
practitioner, or by another service in the community as having no risk factors indicating immediate need for
further monitoring or intervention, should receive verbal advice and a written advice card.231 The details of
the card should be discussed with the person and their carer(s). If necessary (such as for people with literacy
or language difficulties, or with visual impairment), other formats (such as pictures, tapes or videos) should
be used to communicate this information. Communication in languages other than English should also be
facilitated.7
The risk factors outlined in the information card should be the same as those used in the initial community
setting to advise people on Emergency Department attendance (see Chapter 4, Rehabilitation services). People
and carers should also be alerted to the possibility that a few people may make a quick recovery but could go on
to experience delayed complications. Instructions should be included on contacting community services in the
event of delayed complications.
The person being discharged will need to have someone who can look after them for the first few days, and 9
sometimes longer, after discharge. The information on the card given to the injured person should be explained
to the carer as well as to the person being discharged.7 When being given the information, people should be
given the opportunity to ask questions and express concerns, and the practitioner should provide reassurance
and advice.
Management plans should be agreed jointly between the person, their carer(s) and health and social care
professionals from the services involved in the transition. The management plan should be accepted by all
parties prior to transition and a time-frame for review agreed (usually three to six months post-discharge),
although earlier review should be available if requested by the injured person or their carer(s).8
Upon transfer or discharge, there should be a written discharge report that includes:
• the results of all recent assessments
• a summary of progress made and/or reasons for case closure 135
• recommendations for future intervention.8
9.2.1.5 Information for people with traumatic brain injury and their carers on discharge from rehabilitation
services
People who have had a TBI and are being discharged from rehabilitation services, and their carers, should be
appropriately prepared for the discharge. They should be given information that details:
• management of ongoing problems for which further rehabilitation is not appropriate
• sources of continued information, support and advice.
136
Overview
• In New Zealand, there are significant ethnic disparities in the prevalence of TBI.
• Māori have high incidence rates of TBI and evidence suggests that TBI is under-reported in Māori.
• Māori are at risk of poorer outcomes following TBI.
• Māori traditionally have a holistic view of health and this should be considered in rehabilitation of Māori with
TBI.
• An increase in the Māori health workforce may improve access and improve overall outcomes for Māori with
TBI.
• Communication is increasingly regarded as central to the practice of primary health care, directly and
indirectly determining the outcome of the interaction.
• Māori with TBI have specific and unique rehabilitation needs.
recommendations grade
137
Nationally
• A national action plan aimed at improving outcomes for Māori with TBI should be ✓
developed.
• Accurate ethnicity data for TBI incidence should be collected. ✓
This chapter presents information about the epidemiology of TBI and TBI risk factors in Māori. This chapter
also includes discussion of potential improvements to service delivery that aim to provide Māori with more
appropriate and effective care. Information from the rest of this guideline applies equally to Māori, and this
chapter supplements the general guideline with information specific to Māori with TBI.
The major causes of TBI for Māori are road accidents, sports injuries and assaults.243 The high-risk groups for
these injuries include children, young adults and older people, with statistics from ACC indicating that males
aged 15 to 30 years make up the largest group, followed by children under 15 years.
138
An overview of injuries in New Zealand246 discussed the need for further research aimed at identifying
modifiable environmental factors and the initiation of preventive action. It is estimated that the risk of injury
(including TBI) for Māori is 1.5 to 2.5 times greater than the risk for non-Māori.
Predominantly anecdotal evidence suggests that Māori are at risk of poorer outcomes following TBI. One
study showed that prison populations appeared to have disproportionately high rates of TBI and recurrent
TBI compared with the general population, with the majority of those in prison with TBI being Māori.247 Dual
diagnosis of TBI and substance abuse or TBI and mental illness is also more common in Māori than non-Māori.84
See also Chapter 14, Special issues.
The Guideline Development Team considers that a TBI action plan could be adapted from the Māori
Cardiovascular Action Plan.248 The Cardiovascular Action Plan was developed to provide a guide for
cardiovascular policy development and implementation for health services in New Zealand. Within the Plan,
several areas for health service action aimed at improving outcomes for Māori were proposed. For more details,
see the guideline for The Assessment and Management of Cardiovascular Risk, available at www.nzgg.org.nz.
An action plan for improving outcomes for Māori with TBI should focus on the following:
• policy – Treaty of Waitangi-based policy and decision-making
• information systems – complete and consistent collection of ethnicity data, service provider funding
• access, delivery and standards development – TBI rehabilitation health needs assessments, kaupapa Māori
health services 10
• audit, evaluation and quality standards improvement – measurement of key performance indicators to
monitor service responsiveness to Māori TBI rehabilitation needs
• Māori TBI workforce and health service development
• kaupapa Māori research.248
Māori with a head injury and possible TBI, or their carers and whānau, may not be proactive in seeking help
because they are not aware of the risks. In particular, less serious injuries may be managed within the whānau
without seeking medical help. To Māori, the head is tapu and some iwi do not like the head being touched at
all. For providers there needs to be an awareness and cultural sensitivity, particularly in regards to imaging
processes and surgical procedures on the head following a head injury so that Māori with TBI and their whānau
139
Traditionally, Māori have a more holistic view of health than the general population. When providing health and
rehabilitation care and support for Māori with TBI, it is important to remember that the person and their needs
are not to be considered in isolation, but in the context of their environment, both physical and social (that is,
their physical circumstances and their whānau). Under a Māori culture-specific approach, the well-being of the
whānau should be considered alongside the well-being of the person with TBI. Consultation with Māori, hapū
and iwi resources should be sought when assessing the need for any interventions for the person with TBI. All
decisions, where possible, should be made collectively with the person’s whānau, with permission from the
person with TBI.
Communication is increasingly regarded as central to the practice of primary health care, directly and indirectly
determining the outcome of the interaction. International research251 has identified the impact and importance
of communication between the general practitioner and the person seeking care for that person’s health, and
the links this communication can have with perceived discrimination.252
However, a qualitative study in New Zealand has shown that when non-Māori general practitioners talk about
Māori health, they often use language that can imply or attribute ‘blame’ on Māori for their health status, or
use language that justifies existing service provision.253 This may negatively impact on the effectiveness of
interactions between Māori and their general practitioners. Practitioners working with Māori with TBI should
receive training and support in culturally safe practice. Where possible, the case coordinator/key worker for
Māori with TBI should be Māori, and preferably of the same sex as the person with TBI. Where a Māori case
coordinator is not possible, the case coordinator should have support from a Māori cultural advisor.
A study exploring TBI rehabilitation processes and outcomes in Māori, Pacific peoples and European New
Zealanders in New Zealand showed both similarities and differences,254 and highlighted where TBI rehabilitation
service delivery needs for Māori may differ from those of non-Māori. Suggestions arising from this research were:
• to involve and support the family, extended family and/or partners
• to promote the ‘Whatever It Takes’ model
• to endorse and implement cultural practices
• to recruit more Māori rehabilitation professionals
• to involve rehabilitation staff at a management level
• to appoint a cultural advisor as part of the rehabilitation team
• that spending more time with Māori may be necessary in order to ensure accurate information is provided,
and to allow them to ask questions (see also Section 9.2.1, Information, on provision of information)
• that continual clarification of understanding and probing for feedback may also be of benefit
• that managed care does not allow for ‘extra’ time in some practices, but this important aspect of culturally
appropriate services may need to be factored into policy
• that the provision of culturally, aesthetically appropriate surroundings is important to the level of comfort for
Māori, which may include physical, cultural or spiritual aspects of care
140
• to obtain input from tangata and/or mana whenua.
Where whānau members are carers of the person with TBI, and particularly where they are involved in the
provision of rehabilitation interventions, training and support should be provided (see Chapter 13, Needs of
carers).
10
141
Overview
• In New Zealand, 5% of ACC’s ‘concussion’ claimants identified as Pacific peoples in 2003. It is likely that
Pacific peoples are under-represented in TBI-related claims for a number of reasons.
• It is important to acknowledge the traditional beliefs and culture of Pacific peoples and to be cognisant of
the stigma that surrounds illness and disability. Cultural diversity between and within Pacific cultures should
also be recognised and acknowledged.
• Health care practitioners should be aware of the barriers to access for Pacific peoples (eg, cost and language)
and be proactive in offering services.
• Currently, there is a lack of high-level evidence to guide recommendations when planning TBI rehabilitation
for Pacific peoples. However, guidance on providing culturally appropriate service and improving outcomes
for Pacific peoples is summarised in this chapter.
11
• At present, there is a lack of research on outcomes of TBI for Pacific peoples in New Zealand.
143
There should be a Pacific team or at least one Pacific health care practitioner available as part C
of the multidisciplinary rehabilitation team for Pacific peoples with traumatic brain injury.
A Pacific cultural advisor and/or matua should be available to traumatic brain injury C
rehabilitation staff for consultation.
All information should be produced in Pacific languages and in oral form (eg, videos), where C
possible.
The need for culturally aesthetically appropriate physical surroundings and environments for C
Pacific peoples should be taken into account.
Caution should be used with assessment tools that have not been developed or standardised C
for Pacific peoples. Decisions regarding assessment, rehabilitation and coordination should
be based on contextual information from a variety of sources and should include Pacific input.
Traumatic brain injury assessment and rehabilitation processes for Pacific peoples should be C
structured so that they involve family, extended family and an interpreter and/or matua, and
include cultural protocols, where required.
Traumatic brain injury rehabilitation staff should be aware that there is much diversity C
between Pacific cultures, and that detailed concepts of rehabilitation will also vary between
and within cultures.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Traumatic brain injury rehabilitation staff should be aware of traditional Pacific beliefs and the ✓
stigma surrounding illness and disability in order to minimise the potential for giving offence.
Services should be offered to Pacific peoples with traumatic brain injury, rather than expecting ✓
them to initiate contact and ask for it.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
This section provides a broad overview of issues utilising a pan-Pacific approach. However, it is important to
recognise and acknowledge the cultural diversity between and within Pacific cultures. Each nation has its own
specific set of cultural beliefs, customs, values and traditions. The status, authority, tradition, obligations and
power structures are different for each group.257 Moreover, the level of familiarity a Pacific individual has with
New Zealand culture (aculturation) will determine the extent to which the content of this section applies.
In 2003, 5% of ACC’s ‘concussion’ claimants identified as Pacific peoples.258 However, Pacific peoples may be
under-represented in TBI-related claims, given that the Pacific population is comparatively younger than the
general population in New Zealand, and that younger people make the most claims. Faleafa (2004) has also
concluded that there is a relationship between Pacific peoples’ over-representation in certain social indicators
and characteristics associated with the increased likelihood of sustaining TBI, such as high involvement in
motor vehicle accidents, assaults, sports-related injuries, higher unemployment, lower educational levels,
higher crime involvement and lower socioeconomic status.259
Pan-Pacific concepts of family encompass the immediate and extended family, as well as the wider community.
Traditionally, people in need of care through illness, disability or age have been cared for by their families and
within the extended family structure. Caring for people is seen as the responsibility of the family, as only family,
it is felt, will provide care with the necessary kindness. While this may be a tremendous support and strength of
Pacific families, it could act as a barrier to obtaining services outside the family.262
Traditional Pacific concepts of health are holistic, where well-being is defined by the equilibrium of mind, body,
spirituality, family and environment. The Fonofale model263 is one example that captures this concept from a
Samoan perspective, portraying six dimensions of health:
• familial
• spiritual
11
• physical
• mental
• other (encompassing demographic and situational variables)
• cultural (the philosophical drive, attitudes and beliefs of Pacific islands’ culture).
These dimensions are interdependent with the environment, context and time relevant to the individual. As
with Māori models of health, the dimensions are considered to be interwoven and interdependent, with altered
states of wellness occurring when one or more of the dimensions is out of balance.
145
Pacific peoples tend to see health care professionals less for many reasons. This includes seeing health care
professionals for ACC matters. There may a perception amongst Pacific employees that they will not be believed
if they report an injury, especially if it happened at work. Cost can also be a reason for not seeking medical care.
People may not be able to afford the ACC co-payment that is charged, and may be anxious about paying for the
prescription of medications.
Language difficulties are a further barrier to accessing services. Trying to explain how an injury happened and
describing their symptoms can be very challenging for a Pacific person with limited English. There may be no
(similar) words in Pacific languages to describe certain symptoms, so the health care professional may become
frustrated at being unable to get a ‘good history’.
The use of therapies and medicines traditional to their culture may also be preferred by many Pacific peoples,
and lead to non-utilisation of ACC-funded providers and lack of reporting of an injury.
11.4 Rehabilitation planning for Pacific peoples with traumatic brain injury
There is a lack of high-level evidence on which to base recommendations when planning TBI rehabilitation for
Pacific peoples. However, the needs of Pacific peoples must still be addressed in order to provide a culturally
appropriate service and endeavour effectively to improve outcomes for Pacific peoples. The following guidelines
have been suggested:
• Service accessibility: In some situations, asking for help (which can extend to seeking services) for Pacific
peoples is seen as rude because help is usually offered rather than requested.262 Therefore, in order for
rehabilitation to be effective, the service will need to be offered to people with TBI, rather than expecting
them to initiate contact and ask for it. Socioeconomic circumstances must also be considered (eg, access to
transport or a telephone).
• Communication: Many Pacific peoples for whom English is a second language describe the considerable
disadvantages in not being able to communicate clearly and confidently, and the consequent reluctance
to consult outside their own small communities. Shyness resulting from this difficulty in communicating,
together with the cultural reluctance to attract attention to one’s self, exacerbates the problem so that it
becomes a significant barrier to accessing care and services.262 Language interpreters should be offered
regardless of perceived proficiency in English.
• By Pacific for Pacific: Ideally, there should be a Pacific team or at least one Pacific health care practitioner
available as part of the multidisciplinary rehabilitation team. It is also advisable to have a Pacific cultural
advisor and/or matua available to staff for consultation. For mainstream services, establishing partnerships
and consulting with Pacific health providers is essential.
• Pacific-appropriate resources: Much of the health and disability service information, as well as TBI
rehabilitation-specific information, comes in written form. Although it is important for consumers to have
written information available due to the potential deficits in memory that can occur following TBI, this is not
culturally appropriate for Pacific peoples with their oral tradition, and may require too high a proficiency in
written English.262 All written material should be produced in Pacific languages and in oral form (eg, videos)
where possible.
• Holistic approach: The role in rehabilitation of the family, extended family and community should be
acknowledged and empowered. Individual attitudes and beliefs surrounding TBI and TBI rehabilitation (eg,
spiritual beliefs) should be identified and incorporated into the rehabilitation plan. Culturally aesthetically
appropriate physical surroundings and environments are important for level of comfort for Pacific peoples
and should be taken into account.
146
Rigorous and culturally appropriate epidemiological and outcomes-focused research investigating TBI in the
Pacific population could inform both the development of evidence-based best practice and resource allocation.
Any research conducted in New Zealand should routinely specify the ethnic composition of the population
sample.
11
147
Overview
• There is a lack of robust evidence on care and support for children and young people with TBI.
• The impact of TBI on potential development is likely to be greater the younger the person is. The precise
outcomes of TBI in children are hard to establish because TBI impairments emerge over many years as
function matures.
• TBI in early childhood may have lasting effects; more specifically, there may be an impact on the child’s
attainment of developmental milestones.
• Rehabilitation of children and young people does not differ greatly from rehabilitation of adults, although
there are some aspects that differ for children, which are summarised in this chapter.
• Children who have been admitted to hospital with a TBI should be assessed for functional limitations and
referred appropriately before discharge.
• Careful management of the transition from stage to stage (ie, acute care to rehabilitation) is required for
children and young people who have experienced TBI.
• Long-term continued monitoring and follow-up of children and young people with TBI is necessary to ensure
the benefits for the individual.
• Education and training of those working in special education are recommended to minimise any
misconceptions about TBI in children and young people.
The acute management and rehabilitation of children and young people with TBI is addressed throughout
this guideline. When management for children differs from that for adults, this is highlighted; otherwise,
recommendations apply equally to adults and paediatric populations. This chapter addresses aspects of the
acute care and management which are specific to children and young people. Issues for the families and carers
of children and young people are addressed in Chapter 13, Needs of carers.
12.1 Definitions
Defining the upper age limit of ‘children and young people’ presents its own difficulties, as there are various
approaches taken to the upper limit in the literature. Many studies have taken an inclusive developmental 12
approach and included young adults in their early 20s because they may, functionally, still be in late
adolescence and in transition to independent adult life. Others, however, have used arbitrary upper age
delineators, varying between the ages of 12 and 21 years.
This guideline has adopted a flexible and pragmatic approach generally, where it is detailed if the management
and care differ due to younger age. Generally, this chapter is referring to people under the age of 18 years.
However, practitioners should use their professional experience to apply this information, and may consider
some of the information in this chapter appropriate to a physically and emotionally immature young adult,
providing that it is within the context of their normal social role.
There are differences in the way that rehabilitation may be delivered to children and young people with TBI,
particularly in the longer term. For example, some cognitive rehabilitation and behavioural management
149
There is a lack of robust evidence on many aspects of care and support for children and young people with TBI
and more research is required.
The impact of TBI on potential development is likely to be greater the younger the person is. Childhood and
adolescence are times of rapid changes physically, cognitively, socially and in capacity, and therefore the
impact on the pre-injury potential development of a child with TBI may be considerable. Impairments may
continue to emerge over many years as function matures.
This impact on potential development makes it particularly difficult to establish, from the research base, the
precise outcomes of TBI for children. It is rare that data sufficient to predict future development has been
recorded for children who later have a TBI, prior to their injury. More frequently, performance post-injury is
compared with inaccurate and incomplete pre-injury data, or post-hoc estimates of pre-injury functioning.
However, a systematic review reported the following longer-term effects of TBI in children:
• a predictable pattern of delays and deficits in language acquisition for children up to the age of three, when
compared with uninjured children
• subtle, hidden cognitive deficits in cases of apparently normal performance in children with focal TBI, where
the children were using compensatory strategies
• non-linear changes in growth related to injury variables.11
There is also good evidence that a TBI in early childhood may have lasting effects. One controlled study in
Auckland reported that children who had a mild TBI when aged between 2.5 and 4.5 years exhibited impaired
visual closure (the ability to fill in missing parts of a visual stimulus, such as a letter missing from a word) at a
year after the injury, and that this was related to impaired reading scores at age six years.218 However, although
these children’s injuries had been classified as ‘mild TBI’, the clinical histories included high proportions of risk
factors indicative of more serious injury by the criteria being used in this guideline.
In addition, there may be an impact on the child’s attainment of developmental milestones. A child’s disability
may increase with increasing age, both due to difficulty with learning and acquiring new skills as a result
of the brain injury and due to types of brain injury which have their first noticeable consequences at a later
developmental stage. Development may be delayed or disrupted by a TBI (eg, puberty may be precipitated by a
TBI)195 and by the loss of socialisation that may occur as a result of the TBI, such as the impact of an extended
hospitalisation, absence from school and other activities. This loss of socialisation, and other impacts on
development, may have age-inappropriate impacts on behaviour that persist into adulthood.
12.3 Rehabilitation of children and young people with traumatic brain injury
Rehabilitation of children and young people with TBI does not fundamentally differ greatly from rehabilitation
of adults. Most information about rehabilitation strategies and interventions is covered in Chapter 6,
Rehabilitation following clinically significant traumatic brain injury – intervention. However, there are some
aspects of rehabilitation that differ for children. One difference in the management of TBI in children is that most
children with TBI are, or will be, at school, and that many rehabilitative interventions will be implemented within
150
An analysis of data for 24,021 children aged 0 to 19 years (77.8% between 1 and 14 years of age) admitted to
hospital in the USA with at least one head injury found that 63.6% also had other injuries, 16.6% of which were
severe.264 The level of severity of TBI as assessed by the Glasgow Coma Scale was mild in 67.7%, moderate in
7.8% and severe in more than 11.5%. When discharged from hospital, 16% of these children and young people
with TBI had one to three functional limitations – about half of these were limitations in bathing, dressing and
walking – and 6.2% had four or more limitations (90% in bathing, dressing and walking, 75% in self-feeding,
cognition and behaviour, 67% in speech, 29% in vision and 16% in hearing). Ninety percent of the children
with one to three limitations and 37.7% of those with four or more were discharged to home. Despite these
limitations, referral for physiotherapy (24%), occupational therapy (13%) and speech-language therapy (10%)
was low.
It was noted that nearly all of the discharged children were scheduled for a later follow-up hospital visit and
further referrals for rehabilitative care may have been made at that time. However, rehabilitation should start
as soon as possible after the injury and be continuous, and the delay in initiating rehabilitation was seen as
undesirable in terms of the likely possible effects on outcomes for the children and their families.264
It is important that all children who have been admitted to hospital with a TBI be assessed for functional
limitations and referred appropriately before discharge.
12.3.1 Transitions
recommendation grade
The management of transitions for children and young people with traumatic brain injury
should include:
• case coordination C
• planning for re-integration starting soon after the acute injury C
• a full assessment of the needs of the young person with traumatic brain injury in an C
education environment.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
12
151
The management of transitions for children and young people with traumatic brain injury ✓
should include:
• coordinated transition plans prepared with the family/whānau and carer(s), the child/
young person with traumatic brain injury, educators, and rehabilitation specialists
• information provided to schools about traumatic brain injury and possible long-term
impairments
• the provision of updates and orientation to school peers
• clear and effective communication
• the provision of training/education on an ongoing basis to all staff involved in the child’s
education
• alternative options for learning
• supplementary therapy services
• planning for transition to adulthood with formal transition programmes
• preparation for transitions including:
− the student being prepared for new situations, environments, people and challenges
− staff who will be involved in the child’s education being advised of their strengths,
problems, needs and appropriate resources and strategies
− preparation of carers
• the adaptability and modification of the curriculum to meet the student’s needs
• monitoring during transitions for support for emergent needs.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Transitions – such as from acute care to rehabilitation, from inpatient care to home, return to school and from
school to adult life – can be particularly stressful for children and young people and their carers, and require
careful management.
Transitions are likely to require support, particularly if the child or young person has functional limitations
resulting from the TBI.8 There is little robust evidence about specific aspects of transition planning and support
specifically in this population. However, the evidence is consistent that the management of transitions should
include the following:
• case coordination265
• planning for re-integration that starts as soon after the acute injury as possible266
• a full assessment of the needs of the student265–267
• coordinated transition plans prepared with input from a multidisciplinary team consisting of the family/
whānau and carer(s), the student with TBI, educators, and rehabilitation specialists265–268
• at hospital discharge, health professionals should provide schools with information about TBI and possible
long-term impairments, so that children returning to school receive appropriate support265,266,269
• the provision of updates and orientation to school peers265
• clear and effective communication between all parties266,268
• the provision of training/education in the particular needs of the student with TBI to all staff who will be
involved directly or indirectly in the child’s education266,267 on an ongoing basis, ie, with new staff each year265
• alternative options for learning, such as within the regular classroom, special classes or home instruction,267
but with home-bound instruction as short as possible265
• supplementary and therapy services available in conjunction with class placement267
• planning for transition to adulthood that starts no later than age 16 years and preferably at age 14 years267
with formal transition programmes270
152
recommendations grade
Children with clinically significant traumatic brain injury should receive long-term continued C
monitoring and follow-up.
Teachers and other educational staff involved in the teaching and rehabilitation of children C
and young people with TBI should receive education tailored to the specific needs of the
school and the particular characteristics of the child with traumatic brain injury about:
• typical impairments in memory and learning
• common problems with behavioural and emotional self-regulation
• the high risk of academic failure in children with moderate to severe traumatic brain injury
• factors influencing the rate of recovery
• the ability of the rehabilitation team to help address learning problems as they arise.
Parents and other carers of children and young people with TBI should be provided with C
training in direct intervention and advocacy skills, including how to recognise when to seek
specialist help and advice.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
The parents and carer(s) of a child with traumatic brain injury should be closely involved in ✓
the provision of information to educational staff working with the child.
All teachers, particularly special education staff and resource teachers for learning and ✓
behaviour should be routinely trained to recognise patterns of impairment resulting from
traumatic brain injury and to seek specialist advice, where appropriate.
12
The need of siblings for support, assessment and education should be considered. ✓
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Rehabilitative interventions will be delivered by paediatric rehabilitation teams, by parents and carers, and by
special education services, sometimes through the child’s school.
There is evidence that the beneficial effects of some interventions may be lost when the intervention is
discontinued, and that long-term continued monitoring and follow-up is necessary to maintain, reinforce and
generalise the benefits for the individual.271
153
A small study of Australian students with brain injury and their parents found similarly that all the parents and
six of the seven students reported incidents of feeling misunderstood or disliked by teachers and peers.270 Lack
of awareness of brain injury sequelae resulted in reduced understanding by teachers of the students’ specific
school needs. For example, poor memory and organisation were not recognised by teachers as contributing
factors to non-completion of work. Many students experienced anguish and humiliation, leading to social
isolation, low self-esteem, and school avoidance, while all parents reported high levels of stress in relation to
their children’s schooling.270
One study found that educational psychologists were well aware of the need of younger children with TBI for
additional support, for longer, than adolescents. The authors looked at whether a now-outdated, but once
widely held theory was still adhered to: the Kennard Principle: that brain damage sustained in childhood has
less serious consequences due to the plasticity of the brain, and found that the educational psychologists were
aware that this was not the case.273
Although there is no evidence to show that education staff in New Zealand have the same extent of
misconceptions about TBI in children and young people, the need for education and training of educationalists
involved with children with TBI is well supported in the literature267,272 and will apply equally well to New
Zealand. There is evidence that the education of teachers and other educational staff involved in the teaching
and rehabilitation of children and young people with TBI should address the following areas:
• typical impairments in memory and learning
• common problems with behavioural and emotional self-regulation
• the high risk of academic failure in children with moderate to severe TBI
• factors influencing the rate of recovery
• the ability of the rehabilitation team to help address learning problems as they arise.272
It is also suggested that information be tailored to the specific needs of the school and the particular
characteristics of the child with TBI. The parents and carer(s) of the child should be closely involved in this
process.
More generally, it is important that all teachers, but particularly special education staff and resource teachers
for learning and behaviour be aware of the potential for sequelae from TBI, even from mild TBI, for possibly
extended periods of time. TBI in early childhood may be overlooked until it manifests as behavioural issues in
later years.
154
Implications
• Long-term monitoring systems must be implemented, even if the student is not receiving special education
services.
• School staff need to be alert to the possibility that the disability may gradually increase over time, so that
intervention can be implemented as promptly as possible.
Implications
• Impairments may be difficult to assess. Many of these impairments are consistent with good performance
on psychological, neuropsychological and psychoeducational testing. Therefore, necessary services and
supports may not appear to be justified on testing alone.
• Disability may be misinterpreted (eg, neurological disinhibition as a psychiatric disorder), with inappropriate
services a possible consequence.
• Traditional teaching and behaviour management that emphasise the manipulation of consequences may be
ineffective.
• Long-term, contextualised coaching in ‘executive functions’ may be necessary.
Needs related to temporal lobe (including limbic system) injury may include weak learning (new learning)
relative to the knowledge base acquired before the injury and weak emotional/behavioural regulation.
Implications
• The student may need much more repetition than would seem necessary.
• The student may need substantial antecedent support for behavioural self-regulation.
12
Needs related to widespread microscopic damage include relatively slowed processing.
Implications
• The student may need reduced assignments, evaluation of work based on quality not quantity, and time
accommodations, particularly in examination settings.
Strengths related to relative sparing of posterior parts of the brain may include the retention of much pre-injury
knowledge and skills and basic motor and sensory functions.
Implications
• Assessments must go far beyond testing academic knowledge and skill (acquired before the injury) and
sensorimotor functions.
155
Implications
• Schools should monitor students’ mental health and social relationships after an injury, and provide
counselling and support when indicated.
156
Overview
• The effects on the family/whānau and carer(s) of a child with TBI can be considerable.
• Continuity of support for people with TBI should also include support for their families/whānau and carers.
Carers should be assessed on an individual basis for their needs for support. Carers should also be provided
with relevant information and be fully involved in the development of a management plan. Carers should be
provided with specific opportunities for training and emotional support and counselling, where appropriate.
• There is good support for interventions targeted at increasing social support for families/whānau and carers
of children and young people, but little outcomes-focused research detailing the effectiveness of specific
interventions.
recommendations grade
Carers should be individually assessed when assuming the carer role and at regular intervals C
thereafter, including for:
• the care provided
• the need for support, including respite care
• the need for training
• their stress and mental health issues.
A guide to traumatic brain injury rehabilitation services and resources should be provided to C
carers.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
13
157
A holistic view should be taken of the person with traumatic brain injury and their carer(s) ✓
within the context of their wider family/whānau and social networks.
Health care practitioners working with people with traumatic brain injury should be aware of ✓
who the primary carers are, including both paid, formal carers and unpaid, informal carers
who are usually family/whānau members.
Family members, including carers, of people with traumatic brain injury should be able to ✓
maintain their previous social roles as far as possible and it should not be assumed that
family members will automatically accept the carer role.
Moderating factors of the ability to cope should be used to inform decisions about the ✓
interventions to provide for carers of people with traumatic brain injury.
In this section, ‘carers’ refers to people, usually members of the person’s family, who provide care for the person
with TBI as a result of their relationship with that person, rather than because they are professional caregivers.
This may include both paid, formal carers and unpaid, informal carers (who are usually family/whānau). Many
carers do not receive any financial recognition for their input, yet their carer role can have a serious impact on
their earning ability, as many families suffer considerable loss of income following a family member having a
TBI.10,11
13.1 Interventions for people with traumatic brain injury and their families/
whānau and carers
It is important that a holistic view of the person with TBI and their carer(s), within the context of their wider
family/whānau and social networks, is taken, as most interventions and support will need to address
interactions between more than one individual. It should not be assumed that a person will take on the role of
primary carer simply because of their relationship to the person with TBI. Therefore, it is important for the well-
being of the family of the person with TBI that the family members, including carer(s), be able to maintain their
previous social roles as far as possible. Practitioners working with people with TBI should be aware who the
primary carers might be.
The research in this area is extremely heterogeneous, with little consistency in the outcomes examined, which
makes comparison of findings particularly difficult. Furthermore, there is very little outcomes-focused research
addressing the effectiveness of interventions for these issues. However, there are considerable effects on the
families/whānau and carers of people with longer-term sequelae of TBI, which consistently include:
• loss of or difficulty in maintaining their normal (pre-injury) social and professional roles71–73,240,241,274–277
• a reduction in the family’s social and financial status11,73,276
• high levels of health problems, including high stress levels and clinical anxiety and depression in up to two-
158 thirds of carers11,70–72,240,274,278–280
Moderating factors for the ability of families and carers of people with TBI to cope with the demands of caring for
the injured people include:
• coping style, including flexibility in adjusting life goals and motivation,275 and the carer’s own satisfaction
with their ability to cope with the demands240
• a positive attitude towards seeking social support282
• good pre-injury family functioning11
• adaptation by carers, including learning ways to manage particular problems71
• the availability of social support.
Although some of these are intrinsic to the person with TBI and their family/whānau, these factors can be used
to inform decisions about the interventions to provide for carers of people with TBI.
There are reports of high levels of burden, distress and health problems for carers of people with TBI. Therefore,
it is important that continuing support for people with TBI include support for their families/whānau and carers
upon whom the TBI has also impacted, and who will, in most cases, be providing much of the day-to-day care
and support for the person with TBI. There is evidence that although friends and wider family/whānau provide
help and support in the time immediately after the injury, this support usually tails off and the burden of care
falls more and more on the immediate family as time passes.276 This makes it more difficult for the carers to
maintain their social networks.
Siblings of people with TBI can be significantly affected.121 They may become direct carers themselves when
parents are absent and they may suffer from a lack of attention because of the focus on the person with TBI.
159
Families/Whānau and carers also often express a need for a ‘map’ of TBI rehabilitation providers and
resources.241 A guide to TBI rehabilitation should be provided to carers, which details:
• the skills, roles and responsibilities of the practitioners involved in rehabilitation, such as clinical
psychologists, counsellors, psychiatrists, paediatricians, ACC case coordinators and therapists of different
disciplines
• who is responsible for the provision of what service
• who to contact for help
• entitlements to support.
The case coordinator will be able to help people with TBI and their carers to navigate the system, and should be
the first point of contact, and this should be emphasised in the guide.
For people without easy access to support groups, such as those not living in the major urban centres,
telephone support groups have been shown to be effective.284 Carers of people with TBI should be encouraged
and supported in developing and maintaining social support networks, including friends and wider family/
whānau, and support groups. In New Zealand, there is also the Brain Injury Association Liaison Service, which
can provide help and support to people with TBI and their families/whānau and carers.
Personality, behavioural and mood changes in the person with TBI can put strain on spousal and parental
family relationships, and marital and/or family counselling may be necessary.73,277,280 There may also be some
indirect effects of the TBI for which counselling is helpful. For example, a person with sexual dysfunction caused
by psychological difficulties with body image as a result of the primary physical sequelae of a TBI, and their
partner, may benefit from relationship counselling and/or counselling on sexuality.
13.1.5 Empowerment
There is some evidence from a small intervention study that the empowerment of famlies/whānau and carers
of people with TBI can improve outcomes.285 Factors which were found to lead to better adjustment by carers in
Hong Kong to a family member having a TBI included:
• clear personal expectations
• a desire to master the situation
160
Although this was a small study and not strong evidence, parental stress has such a substantial effect on
outcomes for children with TBI that the Guideline Development Team views it is reasonable to consider some
form of stress management training for parents and/or siblings who are showing signs of stress, anxiety and/or
depression.
13.1.7 Training
All families/whānau and carers need to be provided with specific opportunities for training in the residential
rehabilitation environment and after discharge. The responsibility for residential rehabilitation training should
be with residential providers, whereas the responsibility for after-discharge training should be that of the funder
of community rehabilitation services for people with TBI.
Carer support groups in general and specific community groups dealing with people and families/whānau with
TBI are good points of contact and sources of information for families and carers. Practitioners working with
people with TBI are encouraged to provide contact details (phone numbers and/or web addresses) for such
groups.
161
Families/Whānau of children with traumatic brain injury need provision of support aimed at C
enhancing the following:
• social support
• family relationships and functioning
• stress management
• help with adjusting to the new situation.
There should be an assessment of the individual needs of the family, and interventions C
individualised to the family’s needs and comprising some or all of the following should be
provided as needed:
• education and information
• coping strategies, including problem-solving
• specialist marital counselling
• specialist family therapy
• specialist psychotherapy for the primary carer(s)
• support for building and maintaining social support networks
• the development of sources of emotional support
• financial advice and support.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Formal support programmes should be developed and provided for the families/whānau, ✓
carers and siblings of children with traumatic brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Parents and carers of children and young people with TBI may be providing much of the rehabilitative care and
support. In addition to support in their role, parents and other carers need training in direct intervention and
advocacy skills, including how to recognise when to seek specialist help and advice.271
Siblings are also inevitably involved as carers and in the delivery of rehabilitation, so their need for support,
assessment and education should also be considered.
There was little research evidence on the impacts on a family caring for a child with TBI. Members of the
Guideline Development Team provided the following best practice advice:
1. Immediate impacts: emotional
The impact of the initial injury is great on all members of a family, particularly when there are severe
consequences, including the need for hospital (sometimes intensive care unit) care and concerns about
the immediate survival of the child. Clinicians need to understand these effects on parents and siblings.
Families/Whānau can respond with perhaps unexpected reactions, such as anger, fear and other emotional
problems. Appropriate referral to counselling services and support networks may be necessary. Much anxiety
may revolve around a lack of information about the future of the child, the future of the family/whānau, and
rehabilitation and education possibilities for children with significant TBI.
2. Immediate impacts: practical
Issues such as who cares for siblings when the mother/father is with the child with TBI, maintenance of work,
162 study and other social relationships for parents and siblings and a need to cope with day-to-day activities
Siblings of the injured child are likely to be negatively affected by impaired parental relationships and family
financial stresses. Siblings may be unaware of the nature of the injured child’s condition and prognosis, which
may be due to clinical staff and parents attempting to protect them. However, the uncertainty and confusion
that not knowing can cause may result in siblings becoming particularly anxious.121
People outside the family may also be affected by the sequelae of the TBI. Particularly in the case of more
severe TBI, or where there are cognitive and/or physical deficits, the child or young person may not be able to
return to pre-injury levels of participation and achievement in academic, sporting and social activities. This may
lead to changes in relationships with their peers.295
13.2.1 Factors mediating the psychosocial effects on children and young people with
traumatic brain injury and their families/whānau and carers
There is some evidence that outcomes for a child with TBI and their family are affected by a number of different
factors. These include factors related to the child and family prior to the injury and factors related to the TBI and
demands of care.
• The pre-injury psychosocial adjustment of the child. Children with premorbid psychosocial problems are
more likely to suffer psychosocial adjustment issues subsequent to the injury.296 13
• Pre-injury family functioning. Families with poorer functioning prior to a child’s injury are more likely to have
a greater degree of dysfunction post-injury.293,297,298 Children and young people with TBI whose families have
pre-injury dysfunction are also more likely to have psychiatric disorders post-TBI,299,300 and to have poorer
adaptive functioning.301
• The response of the primary carer(s) to the child’s injury. Behavioural outcomes for the injured child over the
first two years have been shown to be related to the emotional reaction of the primary carer acutely after the
injury.302
• Partner support available to the primary carers. Behavioural outcomes for the injured child over the first
two years have been shown to be related to whether the primary carer (usually the mother) of the child has 163
From this, it can be inferred that families of children with TBI need provision of support aimed particularly at
enhancing the following:
• social support
• family/whānau relationships and functioning
• stress management
• adjusting to the new situation.
Although there is some research on the provision of such support through various interventions, it is largely
descriptive and infers probable effectiveness from documented need. There is good support for interventions
targeted at increasing social support8,10,11,240,276,305,309–311,314,315 but little outcomes-focused research detailing
the effectiveness of specific interventions. One Hong Kong-based pilot study described a family empowerment
programme which was found to be effective and which targeted each of the four aspects described above.285
Suggested interventions are generally individualised to the families’ needs70 and comprise some or all of the
following as required:70,196,241,285,308,316
• an assessment of the individual needs of the family/whānau and carer(s)
• education and information
• coping strategies including problem-solving
• specialist marital counselling
• specialist family therapy
• specialist psychotherapy for the primary carer(s)
• support for building and maintaining social support networks
• the development of sources of emotional support
• financial advice and support.
In addition, formal support programmes should be developed and provided for families, carers and siblings as
164
they deliver much of the rehabilitation, have a high rate of stress as a result, and family/whānau functioning is a
major factor mediating psychosocial effects on children.
Overview
• Informed consent, as defined by the Health and Disability Commissioner, needs to be considered as a special
issue in the management of TBI. People who have had a TBI sometimes have cognitive and communicative
difficulties, which may limit their capacity to make informed decisions about their treatment.
• Some people with TBI may not be able to return to driving due to prohibiting conditions, such as seizures or
cognitive impairments that affect judgement, attention, reaction times and emotional/behavioural control.
However, many people with milder forms of TBI may be able to return to driving or acquire driving skills
following appropriate assessment.
• People presenting with TBI have a high premorbid rate of drug and alcohol misuse, and the highest incidence
of TBI is among young adult males who also have the highest incidence of substance misuse.
• People with TBI with a history of drug and/or alcohol misuse show higher mortality rates, poorer
neuropsychological outcomes and a greater likelihood of repeated injuries and late deterioration following
TBI.
• People with TBI who have substance misuse problems require careful assessment and management due
to the cognitive and emotional problems arising from the TBI. However, there is very little robust research
examining the effectiveness of interventions for drug and alcohol use for people with TBI.
• People who have had a TBI frequently experience mental health problems. However, there is considerable
debate about the extent to which these result from TBI and how these disorders are best addressed in this
population.
• Depression and anxiety disorders are common following TBI, particularly depression. Psychosis following TBI
is also well recognised.
• There is a high rate of mental health disorders in children and young people following TBI.
• There is some evidence of the influence of pre-existing psychological conditions on post-TBI mental health
in children and young people. ADHD and depressive disorders have been identified as the most common
mental health disorders following a TBI.
• In the diagnosis of post-TBI depression, there are key issues to consider, which include assessing the
severity of depression.
• A number of depression scales have been developed to quantify depression using a graded method.
• Interventions for post-TBI mental health disorders are frequently part of a broad neuropsychological
rehabilitation programme. However, there is little evidence about specific interventions for this population.
• There is some evidence that multiple TBIs can have cumulative effects, leading to poorer outcomes.
• The term ‘concussion’ is widely used and this chapter provides some clarity on the definition of concussion.
• Signs and symptoms associated with a suspected TBI are listed in this chapter.
• There is little evidence, variability in practice and little expert consensus on how repeated TBIs should be
managed for children.
• After controlling for demographics, pre-existing conditions and head injury severity, there is no difference in
outcomes between people with TBI from violent causes and those whose injury is from other causes.
14
165
Health care practitioners should make every effort to ascertain injured people’s wishes with C
regard to each individual intervention, and where this cannot be determined, to discover what
their attitude to treatment might have been but for the traumatic brain injury.
Where a person lacks, or may lack, capacity, and treatment is considered which appears to be C
against their wishes, the advice of a psychiatrist should be sought with regard to determining
capacity and any possible application of the Mental Health Act 1992.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Family and carers, particularly the next of kin, should be consulted about the likely wishes of ✓
the individual in light of their premorbid values and beliefs.
When the person with traumatic brain injury is Māori, a Māori facilitator should also be ✓
involved in the process of gaining consent.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Informed consent is a process requiring: effective communication between all concerned; the provision of all
necessary information about options, risks and benefits to the consumer; and the consumer’s freely given and
competent consent.317 New Zealand legislation governing informed consent is covered by the Code of Health and
Disability Services Consumers’ Rights,114 and more information can be obtained on the Code and its application
from the Health and Disability Commissioner’s website at www.hdc.org.nz.
The capacity to consent to treatment requires the injured person to be able to:
1. understand and retain information about the treatment proposed and any alternative options that may be
available
2. weigh up the benefits and risks associated with treatment, including any possible consequences of declining
treatment.
People who have a TBI sometimes have cognitive and communicative difficulties that limit their capacity
to make informed decisions about their treatment and to give consent. Alternatively, they may be able to
understand, but their judgement can be clouded by related symptoms such as depression, especially where
hopelessness is a prominent feature.
In the above situations assessment may be complex. The treating health care practitioner is required to provide
management in the best interests of the person who lacks capacity, but those ‘best interests’ must be carefully
established,13 as outlined below.
166
The capacity to consent can fluctuate in people with TBI and efforts should be made, with specialist assistance
from a neuropsychologist or neuropsychiatrist, to maximise the capacity to consent of the person. When the
person with TBI is Māori, a Māori facilitator should also be involved. Also see Chapter 10, Māori and traumatic
brain injury.
14.2 Driving
good practice points
Land Transport New Zealand should undertake discussions with relevant agencies to ✓
formulate new recommendations regarding people driving following a traumatic brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
There are a number of reasons why some people with TBI may not be able to return to driving. Prohibiting
conditions include seizures, visual field defects or cognitive impairments that affect judgement, attention,
reaction times and emotional/behavioural control. However, many people with milder forms of brain injury
may be able to return to driving or acquire driving skills following appropriate assessment. Driving is a complex
activity which requires intact cognitive abilities as well as a certain level of physical ability. Determining when
someone is unfit to drive following a TBI can be very difficult, especially when such a decision may have very
significant ramifications for the individual, eg, work loss, financial disadvantage.
The rehabilitation team should inform the person and their family/whānau and carer(s) about legal
requirements regarding fitness to drive following TBI. They should also provide clear guidance for the general
practitioner and family, as well as the person, about any concerns regarding driving. They also need to reinforce
the need for disclosure and assessment in the event that return to driving or, in young people, learning to drive,
is sought post-injury.8 14
167
Enable New Zealand (phone toll free on 0800-171-981) can provide current information on where to get driving
assessments in New Zealand.
For full details see Medical aspects of fitness to drive: a guide for medical practitioners (pages 9 and 17−20).
• 'An individual who sustains a minor head injury without loss of consciousness
or any other complication should not drive for 3 hours'
• 'An individual who sustains a minor head injury but does lose consciousness
should not drive for 24 hours and should have a medical assessment before
returning to driving'
168
• 'Most individuals with severe head injuries, including those with post
concussion syndrome, should not drive within six months of the event, and a
return to driving should be subject to a medical practitioner assessment.
The Guideline Development Team considers these categories are insufficient to describe the variety of situations
that exist after TBI. The Guideline Development Team recommends that LTNZ undertake discussions with
relevant agencies to formulate new recommendations regarding driving following TBI.
Any comorbid issues should be identified and addressed in people with traumatic brain injury C
and drug and alcohol problems.
Family/Whānau members and other carers need to be educated on how to identify high-risk C
situations, and how to identify and respond to warning signs and relapses relating to drug
and alcohol misuse in people with traumatic brain injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
14
169
People with traumatic brain injury should be advised that the effects of psychoactive drugs ✓
and alcohol may be increased, and that they should abstain from use for twice as long as the
time taken for all symptoms to resolve.
Rehabilitation professionals should refer people with traumatic brain injury and substance ✓
misuse problems to specialist drug and alcohol services.
Families/Whānau should be involved early to aid in determining drug and alcohol issues in ✓
people with traumatic brain injury.
Management strategies for drug and alcohol issues in people with traumatic brain injury ✓
should be developed in collaboration with specialist traumatic brain injury staff. Formal
systems of collaboration between specialist traumatic brain injury staff and drug and alcohol
service staff should be developed.
Drug and alcohol service staff working with people with traumatic brain injury should receive ✓
training in traumatic brain injury sequelae and their effects on drug and alcohol use.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
People presenting with TBI have a high premorbid rate of drug and alcohol misuse. In addition, the highest
incidence of TBI is among young adult males, who also have the highest incidence of substance misuse. Post-
injury, people with TBI with a history of drug and alcohol misuse have an extremely low rate of employment.319
Corrigan found that alcohol intoxication was present in one-third to half of people admitted to hospital with
TBI and that nearly two-thirds of people receiving rehabilitation after TBI may have had a history of substance
misuse that preceded their injuries.320,321
There is also a high rate of post-injury drug and alcohol misuse in people who have had a TBI. This rate,
however, at least for alcohol, appears to be similar to that in the general (non-injured) population.322
People with more severe disability post-TBI have lower alcohol consumption rates. Younger people and people
with higher blood-alcohol levels on original presentation with TBI are more likely to show an increasing
consumption of alcohol longer term following the TBI.322 People with TBI also report a reduced tolerance of
alcohol and drugs.
In the Guideline Development Team’s opinion, people with TBI should be advised that the effects of
psychoactive drugs and alcohol may be increased, and that they should abstain from use for double the time
taken for all symptoms to resolve.
A recent literature review on drug and alcohol use in people with TBI found that rehabilitation professionals
often lack comprehensive training and skills in the treatment of substance misuse.165 It suggested that
rehabilitation professionals need to refer people with TBI and substance misuse problems to relevant agencies,
including treatment outside the rehabilitation facility. It also suggested that they should recommend whether
inpatient or outpatient intervention is required.165
The converse may also be true: that drug and alcohol professionals have little understanding of the:
• way drugs and alcohol are metabolised post-TBI
• impact of impulse control and overall poor decision-making
• social isolation
• other sequelae of TBI that impact on drug and alcohol consumption (such as the difference between
170 addiction issues and the management of drug and alcohol issues related to executive dysfunction).
There is a considerable body of evidence identifying a strong relationship between post-TBI mental health
problems, such as depression and anxiety, and pre-injury psychiatric history. However, an analysis of the
research indicates that pre-injury substance use is the significant factor, and when this factor is accounted for,
other psychiatric conditions are no longer significant as predictors of post-TBI mental health issues (see Section
14.4, Mental health in adults with traumatic brain injury). Determining pre-injury drug and alcohol use may
therefore be of use in predicting an increased likelihood of post-injury mental health problems.
14.3.2 Assessment and diagnosis and interventions for drug and alcohol misuse
A review of the literature on drug and alcohol use in people with TBI concluded that there should be routine
quantitative assessment, records review and long-term monitoring to identify and follow up drug and alcohol
misuse in people with TBI.165 Assessment should use standardised tools and measures to allow for the
comparison and collection of data.323,324
It is also important that comorbid issues are identified and addressed to maximise the effectiveness of
rehabilitation and treatment for drug and alcohol misuse. For example, many women with alcohol misuse issues
have a history of sexual misuse which will impact on the success of the rehabilitation.325
People with TBI who have substance misuse problems require special treatment due to the cognitive and
emotional problems arising from the TBI.326 Although there is research describing the problem of drug
and alcohol misuse in people with TBI, there is very little robust research examining the effectiveness of
interventions aimed at this specific population.
Research has identified four ‘types’ of people who have had a recent TBI based on pre-injury alcohol
consumption, alcohol problems and alcohol dependence. These ‘types’ corresponded to people with a history
of:
1. alcohol misuse
2. alcohol dependence
3. alcohol dependence in remission
4. normal or non-drinkers.
It is suggested that if health care practitioners match people’s types to specific interventions, such as
educational and motivational interventions, as well as treatment for substance misuse, this may result in more
effective care.327
A small study of 50 adults, looking at how motivated people with recent TBI are to change their alcohol drinking
habits and what factors affect their motivation, found that after a TBI, drinkers frequently contemplate changing
their alcohol use, and that a history of alcoholism, higher daily consumption and alcohol being a factor in the
14
injury were all associated with greater readiness to change.328 Comparison with a separate medical sample also
supported a TBI being associated with greater action to change alcohol use. It was concluded that the use of
motivational interviewing techniques may facilitate change during this period.
171
If a person with TBI has significant neuropsychiatric problems, local mental health teams C
should be involved in the development of a management plan, including inpatient
management, discharge management and follow-up.
Specialist neuropsychiatry support should be available to local mental health teams in the C
management of people with complex neuropsychiatric problems following TBI.
If a person with TBI is unwilling to stay in hospital yet needs to do so because it would not be C
safe for them to go home, consideration should be given to the need for treatment under the
Mental Health Act 1992.
Staff should be aware of their duty of care to ensure the safety of people who are putting C
themselves or others at risk, including ensuring carer safety and immediately accessible
assistance and support.
should collaboratively specify and document policies for dealing with people with traumatic
brain injury who have mental health issues, whether they pre-date or follow the traumatic
brain injury.
Where traumatic brain injury is a result of deliberate self-injury, or where people with C
traumatic brain injury exhibit suicidality, they should have a psychiatric assessment including
a risk assessment and consideration of the need for further intervention from the mental
health team.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Staff of mental health services should receive training in recognition of the particular issues ✓
they may encounter in people with traumatic brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
172
Formalised close and collaborative liaison is essential between TBI rehabilitation services and mental health
services, and mental health staff should receive training in recognition of the particular issues they may
encounter in people post-TBI. If a person has significant neuropsychiatric problems, local mental health teams
should be involved in after-care planning.8
Specialist neuropsychiatry support should be available to support local mental health teams in the
management of people with complex neuropsychiatric problems following TBI.8
People who have had a severe TBI sometimes lack insight into their difficulties, so if a person is unwilling to stay
in hospital yet needs to do so because it would not be safe for them to go home, consideration should be given
to the need for treatment under the Mental Health Act 1992.8,318 However, even if people cannot be admitted
under the Mental Health Act, staff should be aware of their duty of care to ensure the safety of people who are
putting themselves or others at risk. This should include ensuring carer safety and immediately accessible
assistance and support.
The Guideline Development Team has found that a recurring message from health care practitioners working
with people with TBI is the difficulty of adequate cohesion between mental health services, rehabilitation
services and ACC. This is thought to partly reflect historical service divisions, different funding streams and
uncertainty about what services are able and willing to offer.
In the Guideline Development Team’s opinion, local acute care and rehabilitation services contracted to manage
people with TBI, along with local mental health services, need to work together to specify and document
policies for dealing with people with TBI who have mental health issues, whether they pre-date or follow the
TBI. ACC personnel need to be involved in these discussions and ‘sign off’ any local policies so that they can be
included in existing and future contracts.
Several studies of depression in the non-TBI community have found that depression inhibits cognitive
functioning, particularly executive functioning, and motivation – a reduction in ‘goal-directed’ behaviour.
In depressed people with TBI, depression-caused impairments in cognition and motivation will be additive
to the impairments caused by the TBI, increasing the level of disability and reducing the effectiveness of
rehabilitation.329 It is therefore important that depression is identified and treated in people with TBI.
14
There is less research on the incidence of mania secondary to TBI. One study of 66 adults with TBI found that
9% met the criteria for mania at some point during follow-up, a frequency significantly greater than that seen
in other brain-injured populations such as people who have had a stroke. Mania post-TBI was not found to be
associated with the severity of the injury, extent of physical or cognitive impairment, level of social functioning,
or previous family/personal history of psychiatric disorder.333 173
14.4.3 Psychosis
Psychosis following TBI is well recognised, and has a higher prevalence in the post TBI population than in the
general population, with an increased risk (RR 0.2–16.3) having been reported in various studies.335
One small study suggested that there may be a relationship between the duration of unconsciousness and the
development of PTSD. In this study, 46 people who were receiving post-TBI rehabilitation were divided into two
groups according to whether they had experienced a prolonged period of unconsciousness (>12 hours) at the
time of injury. It found that 27% of the people who were not unconscious for an extended period, but only 3%
of those who were unconscious for more than 12 hours as a result of the accident, were diagnosed as having
current PTSD.341 (See Section 14.4.10.1, Diagnosis and management of post-traumatic stress disorder for people
with traumatic brain injury.)
14.4.5 Suicidality
TBI sometimes results from self-harm or an attempted suicide. People with TBI may also become suicidal
following their injury. Where TBI is a result of deliberate self-injury, or where people with TBI exhibit suicidality,
they should have a psychiatric assessment including a risk assessment and consideration of the need for
further intervention from the mental health team.8
For more details of the management of people after a suicide attempt, see the guideline for Assessment and
Management of People at Risk of Suicide available at www.nzgg.org.nz.
14.4.6 Post-traumatic brain injury mental health disorders in children and young people
It is known that there is a high rate of mental health disorders in children and young people following a TBI.
One study of children and adolescents (aged 6–15 years), a year post-TBI, found a high rate of novel psychiatric
disorders, and that 78% of these disorders persisted in 48% of the children studied.342
Another study found that 19% of children had ADHD post-TBI, and this was novel (ie, secondary to the TBI in
nearly half).343
Another study of children and young people (aged 5–22 years) found that 30.4% had one or more psychiatric
hospitalisations following the TBI prior to admission to rehabilitation.344 A large matched-controls study of
children aged 14 years or less, three years after they had sustained a mild TBI, found that the incidence of any
psychiatric illness was 30% in the children who had a mild TBI, significantly higher than the 20% in those with
no TBI.345
174
One small prospective cohort study examined the incidence of mania in children hospitalised following TBI.
They found that 8% developed mania or hypomania, and suggested that the severity of injury, location of
lesion(s) and family history of major mood disorder may be associated with the development of mania post-TBI
in children.348 This incidence is similar to that found in adults post-TBI.333
There is a large body of literature detailing the theoretical influence of pre-injury psychological functioning on
the development of post-TBI psychological disorders.349 However, there are fewer papers testing this theoretical
approach by actually measuring the relationship. The literature search identified a number of studies examining
the prevalence of pre-injury mental health issues and comparing outcomes for adult and paediatric TBI survivors
with and without such history.
However, it is important to remember that an ‘association’ between pre-injury factors and post-injury outcomes
is merely an association. Causality in any individual case cannot be inferred from a statistical association, nor
does a lack of a statistical association mean that in individual cases there is no influence on outcomes from
pre-injury factors. Nonetheless, pre-existent mental health difficulties may be conceptualised as vulnerability
factors for post-injury psychological problems.
One paper, reporting on two Australian studies, examined the possible relationship between pre-injury
morbidity and post-injury outcomes as a function of severity of injury. The study found that in both a matched
control study of people six years after a severe TBI and a second study of people with a mild TBI, there was no
effect of pre-injury characteristics on any of the outcomes measured.350
Another small case-controlled study of people with mild TBI and with or without a pre-injury history of
depression found no differences on self-reported post-concussive symptoms, Minnesota Multiphasic
Personality Inventory scales, or neuropsychological measures between the case-matched groups. It was 14
concluded that health care practitioners need to be cautious in attributing post-concussive symptoms or
neuropsychological deficits to a pre-existing affective disorder.351 A further study found that people with
depression post-TBI had a higher frequency of previous psychiatric disorders than people post-TBI with no
depression, but that when drug and alcohol misuse was excluded from the analysis, the difference between the
groups was no longer significant.331 175
Although the body of literature on this topic has some methodological shortcomings, it is largely consistent in
reporting post-TBI psychosis. Attributing psychosis to a TBI should only be done after much careful discussion
and investigation of pre-injury signs and symptoms. (See Section 14.4.10.2, Diagnosis and management of
post-traumatic brain injury psychosis.)
14.4.8.2 Mental health in children and young people with traumatic brain injury
There is a reasonable body of evidence around the influence of pre-existing psychological conditions in children
and young people post-TBI. However, the variation in and the width of the age groups included in the research
makes it impossible to analyse for specific age groups.
ADHD and depressive disorders have been identified as the most common new mental health diagnoses
following a TBI.342 One study showed that while pre-injury ADHD is about five times more common (ie, about
20% of the sample studied) in children and young people who have moderate-severe TBI than those who have
no TBI, about 19% of children without pre-injury ADHD develop ADHD secondary to the injury.343 Another study
found that children with mild TBI but no psychiatric history were at higher risk for hyperactivity in the first year
after injury (incidence 3%; first year relative risk 7.59; 95% CI 2.7–21.6).345
One study found a clear relationship between TBI and novel mood and anxiety disorders, and that post-
injury stress levels and the severity of the TBI were the most robust predictors of the development of a newly
diagnosed psychiatric disorder post-TBI.352 Another study comparing outcomes for children with mild or
moderate-severe TBI and those with orthopaedic injuries reported that the three groups did not differ on pre-
injury depressive symptoms, but parents of children with TBI reported more depressive symptoms at six- and
12-month follow-ups. It was suggested that TBI increases the risk of depressive symptoms, especially among
more socially disadvantaged children.353
Another study found that, in children, psychosocial adjustment deteriorated significantly after a TBI, and that
post-injury psychosocial impairments are common in children with moderate to severe TBI and are related to
injury severity.296 The study concluded that in most cases, the problems cannot be attributed exclusively to pre-
injury dysfunction.
A series of studies examining psychiatric outcomes for a cohort of children aged 6–14 years when hospitalised
for a TBI, found that at three months post-injury, a pre-injury psychiatric condition was a predictive factor for
a psychiatric disorder. However, this was not the case at either the six-month or one-year follow-up. Constant
predictors of psychiatric disorder were severity of injury (when classified as mild or severe), socioeconomic
class, intellectual functioning, behaviour/adaptive function, pre-injury family functioning and family psychiatric
history. Newly diagnosed psychiatric disorders at the two-year follow-up were again also related to pre-injury
psychiatric history.299,300,354,355
The research in this area consistently finds an increase in the risk of novel psychiatric disorders, particularly
ADHD, depression and anxiety disorders, following a TBI, which may be related to the severity of the TBI. A
proportion of these disorders may be attributable to the influence of pre-injury psychiatric history, but there are
a number of both injury-related and other factors which are equally or more important.
176
Using an appropriate depression screening tool, for adults or children, should be a part of ✓
routine practice.
Depression screening tools should not be used as the sole indication for initiation of ✓
treatment. Diagnosis should always involve clinical judgement by a specialist experienced in
managing people with TBI.
The person with TBI should be referred to a psychiatrist with expertise in treating people with ✓
TBI if:
• the risk of suicide is judged significant
• the initial treatment is not effective within two months
• the presentation is complex
• pharmacotherapy is indicated and the familiar medication strategies are contraindicated.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
In the diagnosis of post-TBI depression there are some key issues to consider, as outlined below.
1. Does the person have depression which is severe enough to affect their health or to impede their recovery?13
It is normal (ie, not clinical depression) to have ‘low’ mood post-TBI, as the person may go through a period
of grief and adjustment to their new situation, which is not depression. Standardised diagnostic criteria
should be used in the diagnosis, drawing from the criteria in the fourth edition of the Diagnostic and
Statistical Manual – Text Revision (DSM-IV-TR).356 The person with TBI with grief and other common (non-
depression) reactions to TBI will need support and treatment if depression is diagnosed.
2. Is the depression likely to respond to anti-depressant medication or are other interventions more
appropriate?13
3. If antidepressant medication is considered likely to be helpful, is it safe and acceptable for that particular
individual?13
4. How do you determine if treatment has been effective, and if so, how long do you continue treatment?13 14
Basic history-taking should include a routine general health enquiry with open questions such as ‘How do you
feel in yourself?’. However, this may not always be sufficient to identify depression in people with TBI, and it is
therefore appropriate to employ a screening method as part of routine practice. More detailed assessment is
then required for those in whom depression is suspected, to identify symptoms of actual depression or lowered
177
The simple ‘Yale question’ (‘Do you often feel sad or depressed?’) has been proposed as providing a good
screening assessment of depression.357 The advantages of this single question are its apparent simplicity and
timeliness. However, a dichotomous answer of ‘Yes’ or ‘No’ may in itself be problematic. Firstly, the answer
requires intact comprehension and at least a reliable ‘yes/no’ response, which may not be present in some
people following TBI. Secondly, the question, in fact, contains two different components, to which the responses
may be different. For example, it is not uncommon for people to feel sad about their loss, but not depressed.
Therefore, there needs to be some comparison with their normal mood state.
As with all screening tests, a dichotomous response does not provide a sensitive measure against which to
assess the benefits of treatment, particularly in cases where there may have been some partial improvement
in mood. Also, some people may not report low mood. Some people report emotional blunting and loss of
enjoyment for everyday activities (anhedonia). People from some cultures may need different phrasing. For
example, people from a Chinese culture may respond more informatively to a question on whether their energy
levels are lower than usual.
These exist in several different formats which may be chosen to suit the person’s capabilities.
• Non-verbal rating scales – such as visual analogue scales in different forms. These may be useful where
verbal communication is limited but visuo-spatial skills are adequate, although facilitation will often be
required.
• Questionnaire-based tools – may be completed at interview or by self-report where the individual has
sufficient verbal skills.
• Scales based on observation of behaviour such as crying, withdrawal and apathy may be useful where the
individual is unable to respond to either non-verbal rating scales or questionnaire-based tools.
Some of the scales require special training and experience to administer; others are more intuitive. Some,
including the Hospital Anxiety and Depression Scale, and the Beck Depression Inventory (BDI–II), are restricted
by copyright, and it is necessary to purchase a licence for their use.
Short forms have been developed for some instruments, such as the Geriatric Depression Scale (GDS-15)
and the Beck Depression Inventory (BDI FastScreen), but these have been developed in general populations
rather than for people with TBI, so their usefulness in this context is still uncertain. Preliminary work with the
BDI–II suggests that a rather different sub-set of the cognitive and affective items may be more appropriate in
a TBI population in general. However, the BDI–II has been reported to give false positives on measurement of
somatisation in some people with TBI.
It is perhaps useful for generalist clinical settings to have available a very simple set of screening tools for quick
assessment in cases of suspected depression. Of the current freely available tools, a reasonable selection for
use in general practice and rehabilitation settings for people with TBI might include:
• the Depression Intensity Scale Circles – a simplified visual analogue scale specifically designed for people
with communication or cognitive difficulties, but who have adequately preserved visuo-spatial skills
• Short-Form GDS-15 – a simple questionnaire-based tool for people with adequate verbal and language skills
• Signs of Depression Screening Scale – a simple tool based on observation of behaviour such as crying,
withdrawal and apathy, which may be useful where the individual is unable to respond to either of the
previous tools.
178
Depression scales may be useful for screening, for determining the extent of low mood and in monitoring
responses to intervention. However, tools do not provide a diagnosis, merely an indication, and may be
insufficient, particularly in the TBI population. They should not be used as the sole indication for initiation of
treatment, and diagnosis should always involve clinical judgement by a specialist experienced in people with
TBI.
There is no one tool which may be applied universally, but it is appropriate for rehabilitation teams to familiarise
themselves with a chosen selection, so that they reach a shared understanding of the meaning of a particular
score. Further to this, more detailed assessment may be undertaken through interview and/or observation.
Figure 14.1 presents a proposed schema for screening and assessment of depression at different levels, and
the extent of clinical expertise which may be required.
14
179
level ii:
simple assessment of severity
Visual analogue scales, eg,
• Depression Intensity Scale Circles
• Numeric Graphic Rating Scale
Behavioural scales
• Signs of Depression Screening Scale
• Stroke Aphasic Depression Scale
level iii:
more complex assessment by
People with TBI with
structured interview (requires Clinical psychologist
complex presentation
training) or MDT member with
or in whom the
• Present State Examination to complete appropriate training
diagnosis is in doubt
DSM-IV-TR
(see Level 1)
• Or based on standard assessment tool, eg,
BDI–II*
Severe/Resistant
level iv: Psychiatrist or
depression or
formal psychiatric assessment neuropsychiatrist
suicide risk
Adapted from the UK’s Concise Guidance for the Use of Anti-depressant Medication.13
180
The person with TBI should be referred to a psychiatrist with expertise in treating people with TBI if:
• the risk of suicide is judged significant
• the initial treatment is not effective within two months
• the presentation is complex
• pharmacotherapy is indicated and contraindicated.
14.4.10 Interventions for mental health disorders in people with traumatic brain injury
Interventions for post-TBI mental health disorders are frequently part of a broad neuropsychological
rehabilitation programme. There is very little evidence about specific interventions for this population. It is
known that mental health disorders negatively impact on the success of rehabilitation, and that early diagnosis
and treatment of psychiatric disturbances can improve rehabilitation outcomes.323,329,352,358 An interdisciplinary,
‘multi-pronged’ approach is necessary, with participation of the person with TBI, family members and health
care practitioners and therapists.323
14.4.10.1 Diagnosis and management of post-traumatic stress disorder for people with traumatic brain inury
Assessment for differential diagnosis should consider the overlap in symptoms between mild ✓
traumatic brain injury and post-traumatic stress disorder. If there is doubt, the person should
be referred for a specialist neuropsychological assessment.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
PTSD is an anxiety disorder. The DSM-IV-TR lists the following criteria for diagnosis:
1. exposure to or witnessing of an event that is threatening to one’s well-being
2. symptoms of re-experiencing, such as intrusive memories, nightmares, a sense of reliving the trauma, or
psychological and physiological distress when reminded of the trauma
3. avoidance of thoughts, feelings or reminders of the trauma, and inability to recall parts of the trauma,
withdrawal, and emotional numbing
4. arousal, as manifested in sleep disturbance, irritability, difficulty concentrating, hypervigilence or heightened
startle response.356
PTSD is frequently comorbid with other mental health problems, and is associated with impairment in social
and occupational functioning.359 PTSD may be overlooked in people with TBI due to symptomatic overlap,
particularly in someone who presents with mood or behavioural difficulties. As there is also some overlap in
symptoms between mild TBI and PTSD,360,361 it is important that assessment for differential diagnosis be done
with this in mind, and if there is doubt the person may need to be referred for a specialist neuropsychological
assessment.
People often experience a range of PTSD symptoms following trauma, but the majority of these reactions will
remit in the following months to one year.359 Cognitive-behavioural therapy is widely used for the treatment of
PTSD and may be of particular value to people with cognitive disability.359,362 14
181
People who have possible psychotic symptoms post-traumatic brain injury should be referred ✓
to a psychiatrist with expertise and experience in the management of people with traumatic
brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
The DSM-IV-TR includes a diagnostic category – psychotic disorder due to traumatic brain injury (PDTBI) – the
criteria for which are:
1. the presence of hallucinations or delusions
2. evidence that the psychosis is a direct consequence of TBI
3. the psychosis is not better accounted for by another mental disorder
4. the psychosis does not occur exclusively during a state of delirium.356
There may be some differences, compared with the non-TBI population, in presentation with post-TBI
psychosis. One study found that only 14% of people with post-TBI psychosis experienced negative symptoms of
schizophrenia (such as apathy and withdrawal) whereas between 25% and 84% of people with schizophrenia
but no TBI had such symptoms.363
The diagnosis and management of post-TBI psychosis and psychotic symptoms require specialist assessment
and management. People who, post-TBI, have possible psychotic symptoms should be referred to a psychiatrist
with expertise and experience in the management of people with TBI.
14.4.10.3 Pharmacotherapy
recommendation grade
There should be careful consideration of the sensitivity of people with traumatic brain injury C
to psychotropic medication before trial use. The use of psychotropic medication should be
avoided where possible, and used with caution where indicated.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
In any trial of psychotropic medication, the ‘start low and go slow’ approach should be ✓
adopted.
Medications that have an adverse effect on central nervous system functioning, particularly ✓
antipsychotics such as barbiturates, benzodiazepines, phenytoin and haloperidol, should be
avoided.
The risks, benefits and harms should be discussed with the injured person and their carer(s), ✓
and it should be explained that response to medication after traumatic brain injury is less
predictable than in standard practice.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
182
The Guideline Development Team endorses a proposed management approach for pharmacotherapy for post-
TBI psychiatric conditions, with observation of the following rules:
• people with TBI are frequently very sensitive to, and may have an unpredictable response to, psychotropic
medications, so there should be careful consideration before trial use. In any trial of a medication, the ‘start
low and go slow’ approach should be adopted
• as a general rule, the use of psychotropic medication should be avoided where possible, and used with
caution where indicated
• avoid, if possible, medications that have an adverse effect on central nervous system functioning,
particularly antipsychotics such as barbiturates, benzodiazepines, phenytoin and haloperidol
• monitor serum drug levels as necessary
• always discuss the risks, benefits and harms with the injured person and their carer(s), and explain that
response to medication after TBI is less predictable than in standard practice.323,324
recommendations grade
A specific selective serotonin reuptake inhibitor should be the first choice for treatment of C
post-traumatic brain injury depression unless the anticholinergic effects of a tricyclic are
considered desirable.
The person with traumatic brain injury should be kept under direct clinical monitoring while C
the drug dose is increased to an effective dose to ensure that the drug is tolerated and
producing the required improvement in mood.
People with traumatic brain injury should be asked about any over-the-counter remedies, C
herbs or supplements they are taking to check for potential interactions and adverse effects.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
If selective serotonin reuptake inhibitors have been trialled and are not effective, or have ✓
produced unwanted side effects or drug interactions, the person should be referred for review
to a psychiatrist with expertise in treating people with traumatic brain injury.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
The UK guideline for the use of antidepressant medication in people with acquired brain injury13 found that a
systematic literature search was unable to identify any formal research on which to base recommendations.
Therefore, the UK guideline used the criteria from the British Royal College of Physicians: The Psychological Care
of Medical Patients: A Practical Guide365 from which the following text is adapted.
14
The aetiology of post-TBI depression is often multifactorial. It is important to understand the reasons why it
occurs in order to determine the circumstances in which antidepressants may or may not help (see Figure 14.2).
183
Reasons why symptoms which mimic depression may occur following traumatic
brain injury
• Other emotional disorders associated with brain injury, such as apathy or emotional lability, may
give the appearance of depression, even in the absence of a depressive disorder.
• Somatic symptoms which characterise depression in the normal population may occur as a result
of hospitalisation or from the brain injury itself. This may lead to over-estimation of the degree of
depression on standard tests. These symptoms may include:
– loss of energy, appetite and libido
– altered sleeping habits
– poor concentration and inability to make decisions.
• Abnormal physical expression of emotional status may give the appearance of depression, eg:
– disorders of facial expression
– flat speech patterns
– general physical slowness.
Adapted from: British Royal College of Physicians: The Psychological Care of Medical Patients: A Practical
Guide.365
SSRIs have generally replaced tricyclic antidepressants as the drugs of first choice in depression because
of their better side effect profile. This may be particularly important in people with TBI who may have poor
tolerance of side effects such as sedation. A specific SSRI, such as citalopram or sertraline, represents a
reasonable first choice of agent unless the anticholinergic effects of a tricyclic agent are positively desirable (for
example sedation or suppression of hyper-salivation or if the tricyclic is also treating other post-TBI disorders,
such as headache).
Six SSRIs are currently available – fluoxetine, fluvoxamine, paroxetine, sertraline, citalopram and escitalopram.
There are important pharmacokinetic differences between them, notably in their ability to inhibit hepatic
cytochrome P450 iso-enzymes, which are responsible for the metabolism of many drugs. In vitro studies
suggest that citalopram and sertraline are least likely to inhibit these iso-enzymes and therefore least likely
to cause interactions with other drugs. A survey of rehabilitation consultants and geriatricians in the UK has
demonstrated these two agents to be the most common first choice for the management of depression following
acquired brain injury at the current time. However, both fluvoxamine and sertraline have limited availability in
New Zealand, and are not currently subsidised by PHARMAC.
Escitalopram is a newer agent, which appears also to be highly selective with minimal inhibition of cytochrome
P450 iso-enzymes. Trials suggest that it is at least as effective as citalopram in the management of severe
184 depression, but it has yet to be evaluated in people with TBI (www.biopsychiatry.com/escitalopram.html).
The person with TBI should be kept under direct clinical monitoring whilst the drug dose is increased to an
effective dose to ensure that it is tolerated and producing the required improvement in mood. Some people
in the community may already be taking complementary and alternative medicines and supplements, such as
St John’s Wort, which may sometimes interact with prescribed medications causing serotonin syndrome and
hypomania. It is important that people be asked about any over-the-counter remedies, herbs or supplements
they are taking.
recommendation grade
Cognitive-behaviour therapy tailored for any cognitive impairment should be used for people C
with post-traumatic brain injury, depression and anxiety.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
Cognitive-behaviour therapy should be adapted and administered for people with traumatic ✓
brain injury by clinical psychologists familiar with traumatic brain injury as well as cognitive-
behaviour therapy.
Simple problem-solving measures should be used to address factors contributing to low mood ✓
or anxiety.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
There are a number of psychotherapeutic approaches commonly used for psychological conditions such
as mood and anxiety disorders.365 However, there is very little evidence from trials specifically in the TBI
population.
Psychotherapeutic interventions are widely considered to be potentially helpful for people who have the
cognitive and communicative abilities to engage successfully (see following sections). However, at the current
time, these programmes are rarely available within general medical settings, and tend to be a longer-term
intervention.
14.5 Repeated traumatic brain injury and traumatic brain injury in sports
Repeated TBI is where a person has suffered a TBI whether diagnosed and treated or not, on more than one
occasion. There is some evidence that multiple TBIs can have cumulative effects, leading to poorer outcomes.
A USA review of sports-related recurrent brain injuries concluded that people who have had at least one
previous TBI have an increased risk for subsequent TBI.49 Where mild TBIs occur over an extended period of
months or years, they can sometimes result in cumulative neurological and cognitive deficits, but where the
repeated mild TBIs occur within a period of hours, days or weeks, the outcomes may (rarely) be ‘catastrophic or
fatal’.
One study of college athletes compared the effects of a concussion in those who had experienced three
previous concussions with the effects in matched controls with no previous TBI.50 They found that when tested
two days post-injury, athletes with multiple concussions scored significantly lower on memory testing than
athletes with a single concussion. Athletes with multiple concussions were 7.7 times more likely to demonstrate
a major drop in memory performance than athletes with no previous concussions.
Repeated or multiple TBIs are of particular concern in sports, where players may be at greater risk of a
repeated head injury. ‘Second-impact syndrome’ (SIS) occurs when an athlete sustains a second TBI before
the symptoms from the first TBI have resolved. The person’s status may rapidly worsen, and coma and death
may eventually result. Although SIS may not be as common as some have proposed,372 the identification of the
initial concussion, which may have been only mild, and appropriate immediate and longer-term management,
including return to play, is essential.
186
For the purposes of this guideline, the definition of the term concussion as given in the ‘Prague guidelines’ (see
Section 14.5.1.1, Definition of concussion)373 is being adopted.
Therefore, it can be seen that there is some overlap between the labels of ‘concussion’ and ‘injury to the head
but no TBI’, and ‘mild TBI’.
Concussion can be further described as ‘simple’ and ‘complex’ concussion. In ‘simple’ concussion, symptoms
resolve progressively over seven to 10 days after the injury, and no intervention is necessary other than limiting
play/training while symptomatic. ‘Complex’ concussion, on the other hand, gives rise to persistent symptoms
and symptom recurrence with exertion and more severe symptoms indicative of TBI, such as seizures, loss
of consciousness and prolonged cognitive impairment. Complex concussion may also result from multiple
concussions over time, or where repeated concussions occur with progressively less impact force.373 People
suffering complex concussion should always be referred for specialist assessment and management.
14
187
recommendations grade
If there is any one of the following, traumatic brain injury should be suspected and C
appropriate management instituted:
• loss of/impaired consciousness
• any seizure
• amnesia:
− unaware of period, opposition, score of game
− unaware of time, date, place
• headache
• nausea/vomiting
• unsteadiness/loss of balance and/or poor coordination
• dizziness
• feeling stunned or ‘dazed’
• seeing stars or flashing lights
• ringing in the ears
• double vision
• vacant stare/glassy eyed
• slurred speech
• inappropriate playing behaviour – for example, running in the wrong direction
• appreciably decreased playing ability
• confusion, such as being slow to answer questions or follow directions
• easily distracted, poor concentration
• other symptoms, such as sleepiness, sleep disturbance and a subjective feeling of
slowness and fatigue in the setting of an impact
• displaying unusual or inappropriate emotions, such as laughing or crying
• personality changes.
Return to play after a concussion should follow a stepwise process, proceeding to the next C
level only if asymptomatic. If any symptoms occur after concussion, the person should revert
to the previous asymptomatic level and try to progress again after 24 hours.
1. No activity. When asymptomatic, proceed to level 2.
2. Light aerobic exercise.
3. Sport-specific training.
4. Non-contact training drills.
5. Full contact training after medical clearance.
6. Game play.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
188
If any one of the following symptoms or problems is present, a TBI should be suspected, and appropriate
management instituted. A player does not need to have lost consciousness to suffer a TBI.
1. Cognitive features:
− unaware of period, opposition, score of game
− confusion
− amnesia (memory loss)
− loss of consciousness
− unaware of time, date, place.
2. Typical symptoms:
− headache
− dizziness
− nausea
− unsteadiness/loss of balance
− feeling stunned or ‘dazed’
− seeing stars or flashing lights
− ringing in the ears
− double vision
− other symptoms, such as sleepiness, sleep disturbance and a subjective feeling of slowness and fatigue
in the setting of an impact may indicate that a concussion has occurred or has not resolved.
3. Physical signs:
− loss of or impaired consciousness
− poor coordination or balance
− concussive convulsion/impact seizure
− gait unsteadiness/loss of balance
− slow to answer questions or follow directions
− easily distracted, poor concentration
− displaying unusual or inappropriate emotions, such as laughing or crying
− nausea/vomiting
− vacant stare/glassy eyed
− slurred speech
− personality changes
− inappropriate playing behaviour – for example, running in the wrong direction
− appreciably decreased playing ability.
Neuropsychological testing is particularly important in evaluation and should be used as and where
appropriate, with baseline testing where possible. 14
The consensus of the Second International Conference on Concussion in Sport on immediate treatment was that
when a player shows any symptoms or signs of a concussion:
• the player should not be allowed to return to play in the current game or practice
• the player should not be left alone
189
With this stepwise progression, the athlete should proceed to the next level if asymptomatic at the current level.
If any symptoms occur after concussion, the person should revert to the previous asymptomatic level and try to
progress again after 24 hours.
190
Any recurrence
1. Complete rest until
Yes or emergence of
asymptomatic
symptoms?
Any recurrence
or emergence of 3. Sport-specific training
symptoms?
Yes
No
Any recurrence
4. Non-contact training drills or emergence of
symptoms?
No
Yes
Any recurrence
or emergence of Yes
symptoms?
No
Any recurrence
6. Game play No or emergence of
symptoms?
14
Adapted from the British Royal College of Physicians: The Psychological Care of Medical Patients: A Practical
Guide.365
191
Children and adolescents should not resume sports or training until all of the physical ✓
symptoms of concussion have fully resolved, following the ‘return-to-play’ guide.
Return to school should be carefully managed following concussion, with the child monitored ✓
for recurring or emergent symptoms.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Most of the evidence on repeated TBI comes from the literature on sports injuries, presumably because sports
are activities where people are more at risk of injuries than in other pastimes. This literature usually focuses on
adolescents and young adults. However, there is a lack of research on repeated TBIs specifically in children.374 A
child who is symptomatic following a head injury may have sustained a far greater impact force compared with
an adult with the same post-concussive symptoms. There may also be persistent effects on school performance
and behaviour long after the clinical symptoms and measurable neuropsychological impairments have resolved.
A recent review of the topic reported that there is little evidence (no evidence-based guidelines), variability in
practice and little expert consensus on how repeated TBIs should be managed in children. It was concluded that
people over 15 years of age can be managed conservatively following adult guidelines, with an awareness that
TBI symptoms may take longer to resolve than in adults. It is critical that children and adolescents not resume
sports or training until all of the physical symptoms have fully resolved, following the guide in Section 14.5.2.1,
Return to play.374
Return to school should be carefully managed, with the child monitored for recurring or emergent symptoms
(also see Chapter 12, Children and young people and traumatic brain injury).
All personnel involved in the triage and assessment of people with head injuries/traumatic C
brain injury should have training in the detection of violence and non-accidental injury.
Grades indicate the strength of the supporting evidence, rather than the importance of the recommendations – refer to Appendix B for grading details.
People with violence-related injuries often present rehabilitation challenges. After controlling for demographics,
pre-existing conditions and head injury severity, there is no difference in outcomes between people with TBI
from violent causes and those whose injury is from other causes.375 However, people with TBI resulting from a
violent injury are more likely to be young, male, members of minority groups and single, and to be premorbid
drug and/or alcohol misusers than other people with TBI. Post-injury, this group reports less community
integration and more headaches, confusion and sensory and attention disturbances than people whose TBI
results from non-violence-related causes.375–378
One study of women who presented at two Emergency Departments in Auckland with injuries found that 260
(9%) were identified as victims of assault.379 Assault-related injuries most commonly involved the head (OR
12.8; 95% CI 9.33–17.68). Women who presented with assault-related injuries and had known assailants were
most likely to have been injured by a partner or former partner, and more likely than women with unintentional
injuries to be younger and of Māori or Pacific islands origin. They were also more likely to be discharged from the
Emergency Department without referral for follow-up treatment, and were more likely to leave the Department
without completing treatment.
192
Rehabilitation is often hindered or rendered impossible when the person with TBI is threatened with further
violence. Staff assessing people with TBI should include assessment for violent cause of injury or exposure to
violence, and where it is identified, refer as appropriate.
For more information see Family Violence Intervention Guidelines: Child and Partner Abuse (www.nzgg.org.nz).
Also see Chapter 5, Rehabilitation following clinically significant traumatic brain injury – Assessment, on
assessment.
14
193
There is an imperfect evidence base to support decisions about which guideline dissemination and
implementation strategies are likely to be efficient under different circumstances.380 The principal findings of a
2004 systematic review show that the following approaches have had some effect:
• dissemination of the guideline information
• reminders of the most effective treatments
• educational outreach
• educational material, audit and feedback.380
Targeted resources
In order to facilitate the dissemination of information to the appropriate groups and individuals, tailored
information about the TBI guideline recommendations could be developed for a variety of audiences, including:
• the health care practitioners who first assess and treat people with TBI (particularly accident and emergency
service personnel and primary care practitioners)
• rehabilitation service personnel
• those working with children and young people in settings such as paediatric wards, children’s rehabilitation
facilities and Emergency Departments
• consumers and their families, whānau and carers.
15
195
ACC could also discuss the driving rules for people who have had a brain injury with Land Transport
New Zealand.
Carers
Appropriate agencies should implement processes for:
• the assessment of carers’ needs
• the allocation of respite care
• the assessment of support needs of carers of those with TBI (including financial support).
196
In order to assess whether the guideline has been operationalised throughout New Zealand and whether
there have been corresponding improvements in care and outcomes for people with TBI, evaluation of the
implementation activities should be undertaken. This evaluation should occur before the guideline is due to be
revised.
Evaluation at the programme level depends on a number of factors, including funder requirements, provider
goals and service structure. There are several key questions for a programme-level evaluation:
1. Are the overall results of the programme consistent with the expectations of:
– the service’s consumers (individuals, families/whānau and carers)?
– the providers?
– the funders?
2. Was the programme carried out as specified in the guideline?
3. How do the results of this programme compare with those of similar programmes (or similar clients in a
different type of programme) both locally and overseas?
4. Do the results justify the costs (for consumers, providers, funders)?
5. Can we improve our service to better meet the needs of consumers and funders? How?
6. Can we improve the efficiency with which we provide the service without compromising results?
7. What is the service’s case-mix?
8. What are the benefits or limitations of the programme for enhancing interdependence?
Some programmes may have poor evaluation results because people with severe TBI generally have poorer
outcomes than other individuals, whatever the rehabilitation. So the outcomes of a programme with a relatively
large percentage of people with severe TBI are likely to be generally poorer than those for a programme dealing
mainly with individuals with mild or moderate TBI, independent of programme content or quality.
In the interim, the NICE guideline7 has identified the following performance indicators relating to the criteria
used to order imaging of the head.
To audit adherence to these NICE criteria, prospective data collection on all people with suspected TBI assessed
in Emergency Departments should be undertaken.
For each of these people, data on a variety of risk factors should be collected. The following broad categories of
risk factor should be addressed:
• loss of consciousness since injury
• Glasgow Coma Scale scores since injury
• age
• mechanism of injury
• signs of open or depressed skull fracture
• signs of basal skull fracture
• results of imaging
• post traumatic seizure
• focal neurological deficit
• vomiting
• amnesia (retrograde and anterograde)
• coagulopathy
• headache
• drug or alcohol intoxication
• irritability or altered behaviour
• paraesthesia in the extremities
• neck pain or tenderness.
Collecting this data will highlight areas where people seem to be receiving imaging for inappropriate criteria, or
conversely are not being imaged despite meeting the criteria laid out in this guideline.
In some specific areas, particularly in the criteria for diagnosis and classification of injury severity and the
assessment processes for people with suspected TBI, implementation of the guideline recommendations will
lead to better practice and less variation around New Zealand.
The Guideline Development Team hopes that the implementation of this guideline and subsequent
development of TBI services in New Zealand will lead to the following situation:
Nationally
1. Definitions of TBI (and ‘not TBI’), along with severity grading for definite TBI, will be applied consistently.
198
At a service level
1. All people assessing and/or managing children and young people with possible or definite TBI will
understand the particular issues that make the assessment and management of TBI in children and young
people different from that in adults. In general the following statements, unless qualified, apply equally to
children, young people and adults.
2. People at risk of acute complications from TBI will have appropriate investigations instituted in a timely
fashion. Conversely, people at low risk of acute complications will not undergo unnecessary investigation.
3. All people with moderate and severe TBI and those people with mild TBI meeting the criteria for, or actually
having, a CT scan in the acute phase will have some form of follow-up organised, with the details of that
follow-up being developed by local services and funders.
4. People with persistent symptoms following mild TBI who have significant activity limitation or participation
restriction after four to six weeks will be considered for referral to a specialist clinic staffed by profesionals
experienced in the management of this situation and with the ability to perform neuropsychological
assessments. Such clinics will be available and have the capacity to see clients in a timely fashion following
referral.
5. People with TBI requiring admission to hospital will be managed by staff trained in the observation and
management of people with TBI.
6. People at significant risk of acute complications of TBI who are not in a tertiary referral centre will have their
case discussed with a member of the neurosurgical team at the tertiary referral centre with regard to whether
transfer to that centre is appropriate.
7. People with severe TBI requiring intensive care management will be managed according to best practice
guidelines for that situation (not covered in this guideline).
8. Rehabilitation for people following clinically significant TBI will start as early as possible and rehabilitation
services will work closely with acute care teams.
9. Rehabilitation services for people with clinically significant TBI will include, or have access to, staff skilled
in the management of the full range of issues that arise for this client group. These services will operate
with a client-centred approach and include a designated ‘case coordinator/key worker’ as described in this
guideline.
10. Residential rehabilitation services for people with clinically significant TBI will be skilled in the management
of such clients and acknowledge the special and challenging nature of this work.
11. Community rehabilitation services will provide contextualised rehabilitation to deliver meaningful outcomes
for people with TBI.
12. Vocational rehabilitation services will provide a full range of services, including job coaches where
appropriate. Funders will acknowledge the need for substantial workplace support over extended periods of
time for people with clinically significant TBI returning to the workforce. 15
199
200
201
The searches for this guideline concentrated on finding high grade evidence to answer the identified clinical
questions, such as systematic reviews, randomised controlled trials and, where these were not available,
observational studies such as well designed cohort and case control studies. Only these types of study design
were graded. Where these types of study were not available, less rigorous study designs such as cross-sectional
studies and case studies were considered but were not formally graded.
Levels of evidence
There are three levels of evidence that can be assigned to the Validity section of the GATEFRAME (Section 1):
+ strong study where all or most of the validity criteria are met
~ fair study where not all the validity criteria are met, but the results of the study are not likely to be influenced
by bias
x weak study where very few of the validity criteria are met and there is a high risk of bias.
Developing recommendations
Recommendations were formulated by joint meetings of the multidisciplinary Guideline Development Team. The
group considered the entire body of evidence (summarised in the evidence tables) and filled out Considered
Judgement forms for each clinical question that was identified as being relevant to the guideline (see www.nzgg.
org.nz). The following aspects were discussed: volume of evidence, applicability to the New Zealand setting,
consistency and clinical impact, with the aim of achieving consensus. Consensus was sought and achieved over
the wording of the recommendation and grading. In this guideline, where a recommendation is based on the
clinical experience of members of the Guideline Development Team, this is referred to as a good practice point.
205
recommendations grade
The recommendation is supported by good evidence (where there are a number of studies A
that are valid, consistent, applicable and clinically relevant).
The recommendation is supported by fair evidence (based on studies that are valid, but B
there are some concerns about the volume, consistency, applicability and clinical relevance
of the evidence that may cause some uncertainty but are not likely to be overturned by other
evidence).
Where no evidence is available, best practice recommendations are made based on the ✓
experience of the Guideline Development Team, or feedback from consultation within
New Zealand.
This is the opinion of the Guideline Development Team, or feedback from consultation within New Zealand where no evidence is available.
Due to the emerging nature of the evidence for CAMs, many studies are non-randomised or uncontrolled. Often
no Level 1 or Level 2 evidence is available. Sometimes Level 1 or Level 2 studies cannot be carried out because
it would involve a safety risk for participants. Sometimes it would be too difficult to carry out a Level 1 or Level 2
study large enough to measure rare effects. In these instances evidence is based on lower level studies.
Lower level evidence is subdivided into Level 3 and Level 4. This serves to illustrate a progression that may
occur when investigating CAMs from Level 4 through Level 3 and Level 2 to Level 1 evidence.
Although possible harms and adverse events are important aspects of any CAM, they are frequently only
reported from lower level studies. Higher level evidence is not often available for the reasons stated above.
A range of expert opinion also exists. In other grading systems, this is usually included in a fifth level. This level
of evidence has not been reviewed for the CAM chapter in this guideline. Note also that the numbers are omitted
from the level of evidence in the chapter, and that only the words are used.
206
Evidence with a Studies that use well tested methods to make comparisons in a fair way and
1 high degree of
reliability
where the results leave very little room for uncertainty.
Trial design: usually Level 1 studies are systematic reviews or large, high-
quality randomised controlled studies.
Evidence with Studies that use well tested methods to make comparisons in a fair way but
Trial design: usually Level 2 studies are systematic reviews without consistent
findings, small randomised controlled trials, randomised controlled trials in
which large numbers of participants are lost to follow-up, or cohort studies.
Some evidence Studies where the results are doubtful because the study design does not
3 without a high
degree of reliability
guarantee that fair comparisons can be made.
Some evidence Studies where there is a high probability that results are due to chance
4 but based on
studies without
comparable groups
(for example because there is no comparison group or because the groups
compared were different at the outset of the study).
Trial design: usually cohort or case-control studies where the groups were not
really comparable, or case-series studies.
Levels 3 Poor / – – Low (very Poor Level 3 Level III Level III, IV and V
and 4 low) ab, and 4 (1, 2, 3)
and IV
208
Adults
The Glasgow Coma Scale is scored between 3 and 15, 3 being the worst and 15 the best.
It is composed of three parameters: Best Eye Response, Best Verbal Response and Best Motor Response. The
definition of these parameters is given below.
best eye response (4) best verbal response (5) best motor response (6)
Paediatric version
The paediatric version of the Glasgow Coma Scale is scored between 3 and 15, 3 being the worst and 15 the
best. It is composed of three parameters: Best Eye Response, Best Verbal Response or Best Grimace Response,
and Best Motor Response. The definition of these parameters is given below.
211
Aphasia Partial or total loss of the ability to articulate ideas or comprehend spoken or written
language, resulting from damage to the brain.
Biofeedback The technique of using monitoring devices to furnish information regarding an autonomic
bodily function, such as heart rate or blood pressure, in an attempt to gain some voluntary
control over that function.
Bradycardia Slowness of the heart rate, usually fewer than 60 beats per minute in an adult human.
Chiropractic A system of therapy in which disease is considered the result of abnormal function of the
nervous system. The method of treatment usually involves manipulation of the spinal column
and other body structures.
Claudication Pain in the legs due to restriction in blood flow or sometimes nerve compression (‘spinal
claudication’).
Clavicles Either of two slender bones in humans that extend from the manubrium of the sternum to the
acromion of the scapula. Also called collarbone.
Cognition A term encompassing all the ‘thinking’ modalities of the brain, including alertness,
registration of new ideas, memory, problem-solving.
Concussion A term that is widely used, particularly in sports, to refer to the full range of severity of
injury, from ‘injury to the head without TBI’ through to ‘severe TBI’. For the purposes of this
guideline, the definition of the term concussion is as given in the ‘Prague guidelines’.141
Contractures An abnormal, often permanent shortening, as of muscle or scar tissue, that results in
distortion or deformity, especially of a joint of the body.
Dural tear A tear in the dura – the external lining covering the brain.
Dysarthria Difficulty in articulating words, caused by impairment of the muscles used in speech.
Dysgraphia Impairment of the ability to write, usually caused by brain dysfunction or disease.
Dyslexia A learning disorder marked by impairment of the ability to recognise and comprehend written
words.
Electroencephalograph
An instrument that measures electrical potentials on the scalp and generates a record of the
electrical activity of the brain. Also called encephalograph.
Emotional lability Difficulty with control of emotions and emotional responses (such as crying).
Endocrine disorders
Disorders which involve the over-production or under-production of hormone substances
from an endocrine gland. Examples include diabetes, hypothyroidism, hyperthyroidism,
hyperparathyroidism, Cushing’s syndrome and acromegaly.
Epilepsy Any of various neurological disorders characterised by sudden recurring attacks of motor,
sensory or psychic malfunction with or without loss of consciousness or convulsive seizures.
Extracerebral Located outside the cerebral hemispheres and inside the skull.
Extradural haematoma
A localised collection of blood, usually clotted, located outside the dura mater but inside the
skull.
Gaze palsies When one or both eyes does not move normally under voluntary control.
214
Haematoma A localised collection of blood, usually clotted, in an organ, space or tissue, due to a break in
the wall of a blood vessel.
Haemotympanum A collection of blood in the middle ear space. May occur secondary to severe barotitis media,
basal skull fracture or ear trauma.
Heterotopic ossification
The development of bony substances in normally soft structures.
Holistic Emphasising the importance of the whole and the interdependence of its parts.
Hydrocephalus Excess fluid and/or pressure within the ventricular system of the brain.
Intrathecal baclofen
A drug administered into the cerebrospinal fluid bathing the spinal cord and brain. It is used
in the treatment of spasticity, especially that due to spinal cord damage.
Iwi A social and political unit made up of several hapu sharing common descent; Māori tribe or
nation.
Meniere’s disease A name applied to recurrent vertigo accompanied by ringing in the ears (tinnitus) and
deafness. A dysfunction of the semi-circular canals (endolymphatic sac) in the inner ear.
Meningism The symptoms and signs of meningeal irritation associated with acute febrile illness or
dehydration without actual infection of the meninges.
Myocardial infarction
A term used to describe irreversible injury to heart muscle.
Neuropsychiatrist A medical specialist for disorders with both neurological and psychiatric features.
215
Orthopaedic The branch of medicine that deals with the prevention or correction of injuries or disorders of
the skeletal system and associated muscles, joints and ligaments.
Orthoptist One skilled in the investigation, diagnosis and treatment of defects of binocular vision and
abnormalities of eye movement.
Osteopathy A system of medicine based on the theory that disturbances in the musculoskeletal
system affect other bodily parts, causing many disorders that can be corrected by
various manipulative techniques in conjunction with conventional medical, surgical,
pharmacological, and other therapeutic procedures.
Pacific peoples The diverse range of people living in New Zealand who have migrated from nations of the
South Pacific, and/or who identify with one or more of the Pacific islands because of ancestry
or heritage.
Pathology The scientific study of the nature of disease and its causes, processes, development and
consequences.
Perilymphatic fistula
A tear or defect of the thin membranes bewteen the air filled middle ear and the fluid filled
inner ear.
Post-traumatic amnesia
Loss of memory after trauma.
Proprioceptive A sensory receptor, found chiefly in muscles, tendons, joints and the inner ear, that detects
the motion or position of the body or a limb by responding to stimuli arising within the
organism.
Psychosis A severe mental disorder, with or without organic damage, characterised by derangement
of personality and loss of contact with reality and causing deterioration of normal social
functioning.
READ codes Diagnostic codes used by primary care providers on ACC claim forms.
Retrograde amnesia
Loss of memory before the trauma/event.
216
Spasticity A condition in which certain muscles are continuously contracted. This contraction causes
stiffness or tightness of the muscles and may interfere with movement, speech and manner
of walking.
Stroke Sudden decrease in or loss of consciousness, sensation and movement caused by rupture
or obstruction (as by a blood clot) of a blood vessel of the brain. Stroke is characterised by
rapidly developing symptoms and signs of a focal brain lesion, with symptoms lasting for
more than 24 hours or leading to death, with no apparent cause other than of vascular origin.
Subdural haematoma
Bleeding into the space between the dura and the brain itself.
Tapu In Māori tradition, something that is tapu is considered inviolable or sacrosanct due to its
sacredness. Things or places which are tapu must be left alone, and may not be approached
or interfered with. In some cases, they should not even be spoken of.
Tinnitus A sound in one ear or both ears, such as buzzing, ringing or whistling, occurring without an
external stimulus and usually caused by a specific condition, such as an ear infection, the
use of certain drugs, a blocked auditory tube or canal or a head injury.
217
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222
223
225
226
227
190. Hibbard MR, Gordon WA, Flanagan S, et al. Sexual dysfunction after traumatic brain injury.
NeuroRehabilitation 2000;15(2):107–20.
191. Medlar T. Sexual counseling and traumatic brain injury. Sex Disabil 1993;11(1). [~]
192. Dolberg O, Klag E, Gross Y, et al. Relief of serotonin selective reuptake inhibitor induced sexual
dysfunction with low-dose mianserin in patients with traumatic brain injury. Psychopharmacology
2002;161(4):404–7. [~/x]
193. Heller L, Keren O, Aloni R, et al. An open trial of vacuum penile tumescence: constriction therapy for
neurological impotence. Paraplegia 1992;30(8):550–3. [~]
194. Simpson G, Blaszczynski A, Hodgkinson A. Sex offending as a psychosocial sequela of traumatic brain
injury. J Head Trauma Rehabil 1999;14(6):567–80. [~]
195. Bezeau SC, Bogod NM, Mateer CA. Sexually intrusive behaviour following brain injury: approaches to
assessment and rehabilitation. Brain Inj 2004;18(3):299–313. [~/–]
196. Tyerman A, Booth J. Family interventions after traumatic brain injury: a service example.
NeuroRehabilitation 2001;16(1):59–66. [x]
197. Britton K. Medroxprogesterone in the treatment of aggressive hypersexual behaviour in traumatic brain
injury. Brain Inj 1998;12(8):703–7. [x]
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