Have These Symptoms Buy This Drug by Pauline Chen

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Have These Symptoms?

Buy This Drug


By PAULINE W. CHEN, M.D.

New York Times

It began suddenly a little over 10 years ago. With impressive fluency, friends, family members
and patients started asking me about random medications, the odd syncopations of those
invented, polysyllabic pharmaceutical brand names – Viagra, Lipitor — rolling perfectly off their
tongues.

The questions they asked about those drugs did not reflect breaking news or the results of
scientific studies. Rather, they were a reflection of sound bites, advertisements and the draw of
celebrities who endorsed them, all part of carefully conceived marketing schemes.

There’s no question that Americans like their prescription medications. We spend nearly twice as
much per person on pharmaceuticals as patients in other developed countries do, and we account
for nearly half of all sales worldwide. But in 1997, when the Food and Drug Administration
loosened its regulations and the United States became one of only four countries to allow direct-
to-consumer advertising (the others are New Zealand, Bangladesh and South Korea), we entered
a new era in pharmaceutical consumerism.

Players in the drug industry began aiming their advertisements at patients, and their goal was to
define in the minds of patients not only the beneficial effects of the drugs but also the diseases
they were designed to treat.

As Vince Parry, a well-known marketing expert, counseled his colleagues, “If you can define a
particular condition and its associated symptoms in the minds of physicians and patients, you can
also predicate the best treatment for that condition.”

The phenomenon is sometimes referred to as “disease mongering,” redefining what is normal


and abnormal in a way that widens potential markets for those who sell treatments. And, as
detailed in a recent study in the journal Social Science & Medicine, one marketing strategy has
accomplished more in this regard than any other by using what has come to be the very symbol
of quality and reliability for doctors and patients everywhere: the checklist.

Placed on Web sites, on downloadable apps and in pamphlets in doctors’ offices, these checklists
of symptoms have become a critical part of every major pharmaceutical marketing campaign.
What makes them so attractive is that they make it easy for patients to diagnose their own
ailments, to take some control over their own health.

What makes the checklists so powerful is their ability to influence patient preferences.
The makers of Yaz, a birth control pill, for example, used a checklist to help promote the use of
their drug as a treatment for premenstrual dysphoric disorder, a controversial diagnosis said to
affect up to 10 percent of women. Alongside links to articles on fashion, makeup, hair and
celebrity news, Yaz’s Web site offered a “Body Diary” checklist to help patients determine
whether they suffer from the disorder.

Taking its cues from the Diagnostic and Statistical Manual of Mental Disorders, or D.S.M.,
which mental health professionals use to diagnose disease, the checklist offered watered-down
and potentially more inclusive descriptions. A symptom described in the D.S.M. as “persistent
and marked anger or irritability or increased interpersonal conflicts” appeared in the Yaz
questionnaire as “Felt angry, or irritable.” “Marked change in appetite, overeating, or specific
food cravings” became “Had increased appetite or overate; or had cravings for specific foods.”
The printable results that patients could then take to their doctors (the site has since been taken
down) were on a form emblazoned with the birth control brand.

“The whole point of tools like this one is to confine people’s experiences into these categories in
order to make a diagnosis in line with the branded drug,” said the author of the study, Mary
Ebeling, an assistant professor of sociology at Drexel University in Philadelphia who got
interested in the use of checklists while doing research at a marketing firm. “I became really
intrigued when I saw a group of marketers sitting around a table in Midtown Manhattan and
coming up with symptoms.”

Some symptom checklists are clearly branded, so patients and clinicians can easily discern the
pharmaceutical interests involved. But many are less obvious or are used as part of advocacy
groups’ materials or awareness events. For example, National Depression Screening Day, held
annually at college campuses, military sites and community centers across the country, uses a
symptom checklist called the Patient Health Questionnaire, or PHQ-9. The nine questions are
based on a well-known anxiety screening tool, but its copyright is held by Pfizer, maker of the
antidepressant Zoloft.

It’s difficult to ascertain whether efforts aimed directly at consumers ultimately translate into real
sales. A recent marketing study found that fewer than 3 percent of patients mentioned a marketed
drug by name and less than 1 percent asked for a prescription. However, a separate study
comparing patients in Canada, where direct-to-consumer marketing is illegal, with those in the
United States found that American patients were more than twice as likely to request advertised
medications.

But sales may not be the only measure of success for these campaigns. “The whole point of this
marketing and branding is that the name ends up in the minds of the consumers,” Dr. Ebeling
said.

While the Obama administration is looking to force pharmaceutical companies to disclose any
payments to doctors that might influence their treatment decision, marketing efforts directed at
patients are likely to continue to grow. And with those efforts comes a widening, not shrinking,
circle of interests that can influence their care.
“There are pharmaceutical marketers, medical device makers, health insurers and whoever is
involved in the health industry sitting in the exam room, not just the doctor and patient,” Dr.
Ebeling said.

She added, “I find that disturbing, because it’s our health and the quality of our lives that are at
stake.”

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