HIV Self-Testing in Southern Africa: Progress and Challenges

Download as pdf or txt
Download as pdf or txt
You are on page 1of 14

International Journal of ISSN: 2582-1075

Recent Innovations in Medicine and Clinical Research https://ijrimcr.com/


Open Access, Peer Reviewed, Abstracted and Indexed Journal Volume-1, Issue-2, 2019: 73-86

HIV Self-Testing in Southern Africa: Progress and


Challenges
Sello, Ma*., Ramathebane, M.Va., Maja, L.Ja., Shelile, M.Zb. and Namole, L.Dc.
a
Department of Pharmacy, Faculty of Health Sciences, National University of Lesotho, Roma,
Lesotho
b
Department of Nursing, Faculty of Health Sciences, National University of Lesotho, Roma, Lesotho
c
Quality Assurance Department, National Drug Service Organization, Mafeteng, Lesotho
*Corresponding author: [email protected]

Received: November 6, 2019 Accepted: December 2, 2019 Published: December 29, 2019

Abstract: Pitfalls of HIV testing in health care facilities include fears over loss of privacy and
confidentiality. HIV self-testing represents an innovative strategy to expand access to HIV testing
services in the general population and also to reach individuals at high risk for HIV who may not
otherwise submit to HIV testing, including young people and key populations. We conducted a
systematic review of observational studies done in southern African countries between the 1 st
January 2016 to 15th March 2018 on HIVST with focus on progress made and challenges observed.
Thirteen (13) observational studies satisfied the inclusion criteria. These studies were published
between January 2016 and March 2018 across five southern African countries namely Zambia (3),
Malawi (2), South Africa (5), Zimbabwe (1), Botswana (1). There was also a study done in both
Malawi and Zimbabwe (1). HIVST is highly acceptable in southern Africa despite challenges
ranging from gender differences, acquisition of test kits, lack of pre-test and post-test counseling,
potential social harm and inadequate ability to following user’s instructions.
Keywords: HIV self-testing, progress and challenges, observational studies, systematic review,
southern Africa.

Introduction
The World Health Organization (WHO) (2018) estimated that only 75% of people living with HIV
know their HIV status. Countries are looking for ways to rapidly increase uptake of HIV testing
services, especially for populations with low access and those at higher risk that would otherwise not
get tested. HIV testing has always been seen as the “keystone” of the HIV response [1]. While this
view of HIV testing has not changed significantly over the years, the linkages between testing,
prevention, treatment and care have. Emphasis on HIV testing as a gateway to prevention, treatment
and care has grown tremendously over the past decade.

In turn, this emphasis on testing has created a demand for governments, public health agencies, and
HIV organizations to develop new policies, programs, and approaches [2-3].These efforts include the
90-90-90 strategy proposed by the Joint United Nations Programme on HIV/AIDS (UNAIDS) as
well as many national strategies that target high coverage of diagnosis, treatment and viral
suppression among people living with HIV in attempts to reduce HIV mortality and morbidity and
ultimately end the HIV epidemic [4].

The strategy entails that proposing that by 2020 90% of all people living with HIV will know their
status; 90% of all people diagnosed HIV infection will receive sustained antiretroviral therapy
(ART); and 90% of all people receiving ART will have viral suppression.

73
International Journal of Recent Innovations in Medicine and Clinical Research
Pitfalls of HIV testing in health care facilities include fears over loss of privacy and confidentiality,
as well as potential stigma and discrimination, especially in young people and marginalized high-risk
groups, such as female sex workers and homosexual men [5-7]. HIV self-testing (HIVST) represents
an innovative strategy to expand access to HIV testing services in the general population and also to
reach individuals at high risk for HIV who may not otherwise submit to HIV testing, including
young people and key populations. In 2012, oral HIVST was approved by the US Food and Drug
Administration [8].

HIV self-testing is a process in which a person collects his or her own specimen (oral fluid or blood)
and then performs an HIV test and interprets the result, often in a private setting, either alone or with
someone he or she trusts [9]. HIV self-testing does not provide a definitive HIV-positive diagnosis.
All reactive (positive) self-test results need to be confirmed by a trained tester using a validated
national testing algorithm. Non-reactive (negative) self-test results are considered negative. In 2016,
WHO published the first global guidelines on HIV self-testing, in which HIV self-testing was
recommended to be offered as an additional approach to HIV testing services [7].

In 2015 the UNITAID Self-Testing Africa (STAR) Initiative began the largest evaluation of HIV
self-testing. At end 2014, just before the STAR Initiative began, it was estimated only 45% of people
with HIV in sub-Saharan Africa knew their status [4]. The STAR Initiative’s first phase generated
crucial information about how to distribute HIVST products effectively, ethically and efficiently.
Implemented initially in Malawi, Zambia and Zimbabwe, the first phase of the STAR Initiative was
designed to address critical challenges to the development of the HIVST market. The STAR
Initiative’s second phase built on the evidence generated in the first phase to scale access to HIVST
across sub-Saharan Africa and expanded implementation to three additional countries, Eswatini,
Lesotho and South Africa with the aims of generating large-scale experience and evidence,
contributing to reaching the first 90 target. By November 2018 STAR Initiative had distributed 2.3
million HIV self-test kits in Eswatini, Lesotho, Malawi, South Africa, Zambia and Zimbabwe. As a
result HIV testing coverage has increased, with HIV self-testing reaching many men, young people
and first-time testers. Now it is estimated 81% of people with HIV in sub-Saharan Africa are aware
of their status.

In this study, we conducted a systematic review of observational studies done in Southern African
countries between the 1st January 2016 to 15th March 2018 on HIVST with focus on progress made
and challenges observed.

Methods
Database search
The electronic search of relevant publications was conducted between 1st January 2016 and 15th
March 2018. Pubmed, Google scholar were searched for English language on human studies about
AIDS. The medical terms used in different combinations in the search included the following:

 ‘HIV self testing southern Africa’,


 ‘HIV self testing challenges’, and
 ‘HIV self testing OR challenges’.

Inclusion and exclusion criteria


The studies included satisfied the following criteria:
(1) All were observational studies;
(2) Conducted between January 2016 to March 2018;
(3) Conducted in southern African countries
The studies which did not satisfy the inclusion criteria were excluded. Two reviewers assessed the
eligibility for inclusion of the studies independently.

74
International Journal of Recent Innovations in Medicine and Clinical Research
Data extraction
Data was obtained using a predesigned data collection form. The information extracted was the name
of the author, year of publication, country of study, study design, sample size, gender and age of
participants, situational analysis of HIV self testing exercise and challenges observed.

Google Scholar
PubMed Search
Search

Keywords: ‘HIV Keywords: ‘HIV self-testing HIV self-testing


self-testing challenges’ using same filters OR challenges
Southern Africa’ as the first keyword

111 studies were


210 studies were found
found

194 observational
studies were found

46 studies were
found from
01/01/2016 to
15/03/2018
16 studies were 2 studies were
found found from
44 studies were 01/01/2016 to
screened using 15/03/2018
human, English
language, 19 years
and above and
AIDS subjects as
filters

13 studies were found using manual screening that satisfies inclusion criteria;
relevance and removing duplication

Figure 1. Flowchart of studies selection

Results
Description of included studies
Thirteen observational studies satisfied the inclusion criteria as indicated in Figure 1 above. These
studies were published between January 2016 and March 2018 across five southern African countries

75
International Journal of Recent Innovations in Medicine and Clinical Research
namely Zambia (3), Malawi (2), South Africa (5), Zimbabwe (1), Botswana (1). There was also a
study done in both Malawi and Zimbabwe (1). The details of the studies are summarized in Table 1
below.

Assessment of progress on HIVST


Seven observational studies reflected on progress made in southern Africa about HIVST. The
progress assessment is summarized in Table 2 below. The progress is compiled in terms of findings
of each study and implications as well as future plans emanating from the findings. The progress
covers (1) acceptability of HIVST by population groups, (2) preference of HIVST over other HIV
testing technologies, (3) willingness to link to care following positive result of HIVST (4) testing
with sex partners, and (5) willingness to purchase self-test kit.

Observed challenges to HIVST


Ten observational studies outlined several challenges to HIVST reflected by users. The compilation
of the challenges is summarized in Table 3 below. In each study, identified challenges were
presented, they cover (1) gender differences in willingness to self-test, (2) financial resources to
acquire test kits, (3) potential for social harms (4) ability to follow user’s instructions for use of the
HIVST kit, (5) commercially available kits versus their accuracy, (6) demand for ARVs and (7)
threat to HCW jobs.

Table 1. Characteristics of studies included in the review


Author(s) Country(s) Study aim Study Sample size Age group
design (years)
Chipungu Zambia Examination of the Cross 1,617 (60% 16-49
et al. intention to link to sectional females)
(2017) care amongst survey
potential HIVST
users and the
suitability of three
linkage to care
strategies in Lusaka
Province, Zambia
Gotsche et Zambia Investigation of Cognitive 17 (77% 15+
al. (2014) ability of intended interviews males)
users of the
OraQuick® HIV
rapid self-test in
Zambia to
understand and
follow the
instruction for use.
Indravudh Malawi & Identifying young mixed 463 20 median
et al. Zimbabwe people’s methods age
(2017) preferences for HIV
self-testing
(HIVST) delivery,
determining the
relative strength of
preferences and
exploring
underlying
behaviors and

76
International Journal of Recent Innovations in Medicine and Clinical Research
perceptions to
inform youth-
friendly services in
southern Africa
Indravudh Malawi Assessment of user Cognitive 360 16+
et al. understanding of interviews
(2017) packaged HIVST and cross-
kits and sectional
instructions-for-use feasibility
and methods to
optimize
comprehension; and
investigating
feasibility,
acceptability and
accuracy of semi-
supervised HIVST
Kelvin et South Providing pre- Qualitative 20 Not
al. (2016) Africa approval baseline descriptive (50% provided
data about potential study females)
users of the self-test
Kumwenda Malawi Describing factors Qualitative 33 Not
et al. dissuading descriptive (61% female) provided
(2018) individuals in
couples from self-
testing with their
partner
Madanhire Zimbabwe Exploration of Qualitative 43 Not
et al. health care descriptive provided
(2016) workers’ views on
HIVST
Mokgatle South Investigating the Cross- 3,605 21.9 mean
& Madiba Africa acceptability of sectional (57% age
(2017) HIVST among survey females)
students in
Technical
Vocational
Education and
Training colleges in
two provinces in
South Africa
Moyo et al. Botswana Assessment of Qualitative 45 most were
(2017) opinions and descriptive (56% between
acceptability of females) 21-25
HIVST amongst years
tertiary students
Nkuna & South Assessing the Qualitative 300 Not
Nyazema Africa potential of HIVST descriptive (51% provided
(2016) to increase access females)
to and uptake of
HIV testing among
health sciences

77
International Journal of Recent Innovations in Medicine and Clinical Research
students, University
of Limpopo
Perez et al. South Exploring reasons Qualitative 20 20-47
(2016) Africa for declining (55%
provider-initiated females)
counseling and
testing or
counseling and
testing among
community
members of an
informal settlement,
and to ascertain the
healthcare workers’
and community
members’
perspectives on the
acceptability of
home O-HIVST as
an alternative to
clinic-based modes
of testing.
Perez et al. South Describing Cross- 2,198 Mostly
(2016) Africa implementation of sectional (66% between
counsellor- females) 18-25
introduced years
supervised OralST
in a high HIV
prevalent rural area
Zanolini et Zambia Assessing attitudes Population- 1,617 16-49
al. (2018) and preferences based (60%
toward HIV self- survey females)
testing (HIVST)
among Zambian
adolescents and
adults
Total Number of Participants 10,338 participants

Table 2. Assessment of progress on HIVST


Author Findings Remarks
Chipungu (1) Respondents were asked to imagine In the first study of HIVST in
et al. that they had taken an HIV self-test Zambia, 85% of those
(2017) and their result was positive. Out of participating in a representative
the 1,617 respondents, 85% (95%CI survey reported that they would
83±86) said they would be willing to intend to link to care within a
link to care within a week of having a week if they used an HIVST and
positive result found they were positive.

(2) Overall 53% (95%CI = 50 to 55) of In order to encourage linkage to


respondents reported preferring a care, half of the respondents
home visit from a health care worker, preferred to be followed up
and 30% preferred a phone call, through home visits and one third

78
International Journal of Recent Innovations in Medicine and Clinical Research
followed by 13% who preferred SMS preferred phone calls. SMS was
the least preferred because it was
difficult to establish a relationship
using this platform
Indravudh (1) HIVST is highly acceptable to young Being empowered to control one’s
et al. people in Malawi and Zimbabwe as it own HIV testing process seems to
(2017) empowers them to choose the be particularly appealing to young
location and timing of the test and people
control disclosure around their
results.

(2) Confidentiality was one of the main


reasons why young people preferred
HIVST. Young people’s lack of trust
of health workers and desire for
confidentiality has motivated young
people’s preference for HIVST in this
study

(3) In the context of a gap between Appropriate training of distributors


biological and psychosocial maturity, and sensitization of parents and the
as well as discrepancies in cultural, wider community would therefore
social and legal definitions of be needed.
maturity, promoting HIVST in young
people may not be without conflicts,
including denied or forced testing.
Mokgatle (1) The acceptability of HIVST as a The majority (87.1%) considered
& Madiba testing option was 87.1%. HIVST to be acceptable, and 84%
(2017) would uptake HIV self-testing
(2) The willingness of participants to with partners. Being sexually
purchase a self-test kit was 74.7%, active, having multiple sexual
while the willingness to submit partners, and having been tested
HIVST results at a local clinic for for HIV was associated with
inclusion in the HCT statistics which acceptability of HIVST.
is necessary for the targets of the
HCT uptake campaign was at 14.8%,

(3) The willingness to confirm HIV The HIVST is regarded as safe if


positive self-test results at a local implemented correctly to ensure
health facility was 75.6%. the accuracy of the tests, and there
is confirmation testing and referral
for counseling and care

(4) Logistic regression showed that HIV self-testing is acceptable in


college students who were willing to South Africa as an HIV testing
uptake HIVST were at most four time option, and self-tests kit are
more likely test using HIVST with available over the counter in
their sexual partners at unadjusted pharmacies. Nonetheless, the high
odd ratio (OR = 3.99; CI: 2.84±5.62). acceptability of HIVST among the
At adjusted odd ration statistics show students calls for extensive
that college students who had ever planning and preparation for the
tested for HIV within the HCT scaling up of HIVST beyond its
program were twice as likely to availability in pharmacies
79
International Journal of Recent Innovations in Medicine and Clinical Research
accept HIVST (OR = 2.13;
CI:1.72±2.63).
Moyo et (1) Most of the students were not aware HIV self-testing is an alternative
al. (2017) of HIVST before the interviews, most testing option that can complement
found HIVST to be acceptable as an available HCT methods such as
alternative testing option VCT and PITC provided in public
health facilities in Botswana
(2) The students indicated that they
would utilize HIVST because it
assures confidentiality and privacy,
and would reduce the stigma concern
that is associated with facility-based
HCT
Nkuna & (1) There were a significant number of The investigation on the sale of
Nyazema students who supported the HIVST kits found that they were
(2016) introduction HIVST and did not seem indeed available at some pharmacy
concerned about possible risk retail outlets.
associated with self-testing.

(2) Interestingly, female students seemed Self tests for HIV should fall
concerned more about being pregnant under the definition of a ‘medical
than contracting HIV infection and device’ in the Medicines and
appeared to be ready to know their Related Substances Control Act
HIV status (Act 101) of 1965, as amended).
Perez et (1) This research adds evidence of the In applying the knowledge this
al. (2016) need for self-testing service providers research contributes to programme
to ensure the five ‘Cs’ as outlined by implementers must consider that
the World Health Organization are efforts are necessary in ensuring
guaranteed: consent, confidentiality, that future documented evidence
the opportunity for counselling, of harms and benefits informs the
correct results, and linkage to care counselling, support, and
monitoring components of home
self-testing.
Zanolini (1) HIVST was found to be highly Zambian adults expressed
et al. acceptable and participants expressed preference for HIVST over current
(2018) relatively few concerns regarding the HIV testing approaches and on
introduction of HIVST. Importantly, average expressed a strong
those who had not recently tested reference that counseling should
reported strong willingness to learn accompany HIVST.
their HIV status through a self-test

(2) Participants also expressed a strong HIVST scale-up should therefore


preference for counseling to be made be accompanied by adequate
available with HIVST as well as a information about how and where
willingness to pay US$3–5 out-of- to access confirmatory testing
pocket for test kits. services in the event of a positive
result, as well as innovative ways
to access pre- and post-test
counseling though services such as
phone-based hotlines

80
International Journal of Recent Innovations in Medicine and Clinical Research
Table 3. Observed challenges to HIVST
Author Findings
Gotsche et al. (1) Participants struggled to open the test kit easily
(2014) (2) Difficulty in instructions on collection of oral fluid by swabbing the
gums
(3) Understanding and interpreting images and particular terms (e.g.
pouch, press firmly) was perceived challenging
Indravudh et al. (1) 4 participants did not know where instructions began
(2017) (2) 8 participants did not recognize symbols for cutlery prohibiting
eating
(3) 7 participants did not know how to tear open the package
(4) 15 participants struggled to slide tube into stand
(5) 15 participants did not understand steps to take after self-test
Kelvin et al. (1) Associated with risk of mental distress and even suicide
(2016) (2) Gender differences in willingness to use the self-administered test,
with slightly more men reporting willingness than women
(3) Women were also less confident that their partner would continue
the relationship if they tested HIV-positive
Kumwenda et (1) The community-based approach found women at home much more
al. (2018) often when HIVST was offered through door-to-door approach
(2) Conflicting work schedules between male and female sexual
partners made one of the partners, particularly men, not available to
receive HTC together with their partners
Madanhire et (1) While they generally believed that HIVST can increase testing
al. (2016) uptake among men, well-to-do clients and those living in hard-to-
reach areas, a recurrent theme was that HIVST poses a threat to
HCW jobs
(2) The potential for social harms (domestic violence, suicide, and
forced-testing) was widely discussed
(3) HCW described fear that devices showing negative results could be
''traded'' and used to deceive partners of HIV-positive individuals
Perez et al. (1) In spite of high accuracy, it must be noted that fourteen of our 2,198
(2016) study participants read their Oral-QuickTM as negative but had a
positive DetermineTM test.
(2) There are several different oral rapid diagnostics devices currently
available commercially; however, many of them have not yet been
pre-qualified by WHO for self-testing
Indravudh et al. (1) Given young people’s low access to financial resources and strong
(2017) aversion to price, the findings also show that uptake of HIVST may
be limited if kits are not provided for free or at extremely low prices.
Mokgatle & (1) There were significance gender differences for acceptability of
Madiba (2017) HIVST among the students, with more females showing
acceptability versus males (p = 0.000), more female students willing
to confirm HIV-positive test results at a health facility, more female
students citing willingness to submit HIVST test results at the
nearest health facility (p = 0.03), more females willing to use
HIVST with their sexual partners (p = 0.000), and willing to buy
HIVST kits (p = 0.000).
(2) The cost of an HIV self-test kit has been identified as a potential
barrier to adoption, willingness to use, purchase, and the uptake of
HIVST, particularly among people in poor-resource settings.
Despite the students being from poor-resource settings, we found

81
International Journal of Recent Innovations in Medicine and Clinical Research
that three quarters (75%) reported the willingness to purchase self-
testing kits
Moyo et al. (1) The students in the current study who were against HIVST,
(2017) indicated that they would not utilize HIVST because of the lack of
post-test counseling support. They indicated that they might harm
themselves because of a positive HIVST results.
(2) HIVST will also require the purchase of the test kits over the
counter at a pharmacy or from other retailers depending on how the
policy of distribution is developed. This will introduce a cost to HIV
testing; the concern for the argument against HIVST is that not
everyone will be in a position to afford the self-testing kit.
Nkuna & (1) The student Health Centre seemed not to be ready for the
Nyazema introduction of HIVST. Their main concerns were possible self-
(2016) stigmatization and increased demand of ARVs.

Discussion
The current systematic review involved 10, 338 participants consisting of mainly females aged
between 15-49 years. The review was made thirteen observational studies conducted on five
countries (Zambia, Malawi, South Africa, Botswana and Zimbabwe). Majority of the studies
qualitative studies (9/13) aimed at exploring users’ perspectives about HIVST. HIV self-testing was
implemented in different phases in these countries. Malawi, Zambia and Zimbabwe come from the
first pilot phase of implementation while South Africa was covered on expansion of implementation
in the second phase. Botswana was not part of the UNITAID Self-Testing Africa (STAR) Initiative
which was the largest evaluation of HIV self-testing in southern Africa started in December 2015.

HIV self-testing is highly acceptable by adolescents and young adults in southern Africa [11, 18-20,
15, 22]. Most people who test for HIV using HIVST are willing to refer themselves to nearby health
facilities for confirmation of positive test results and to link themselves to care and treatment of HIV
infection [15-16 & 18]. In comparison with other rapid HIV testing technologies, HIVST is regarded
as an acceptable alternative to HIV testing [11, 16, & 19-20]. Although HIVST kits are currently
available commercially in most settings, users are willing to purchase the self-test kits [18, 22].

A scoping study conducted in sub-Saharan Africa (SSA) revealed that similar to global rates, there is
a broad range of acceptability rates for HIVST in SSA; ranging between 22% and 95% [23]. HIVST
is acceptable and feasible, can be disseminated through high-risk peer networks, and increases
testing frequency and partner testing. A longitudinal HIVST study conducted in South Africa among
men who have sex with men (MSM) indicated an extremely high uptake and acceptability of HIVST
following distribution of HIV self-testing kits [24].

Despite the fact HIVST is a highly acceptable HIV testing technology; gender differences pose
mixed perspectives to testing [12-14, & 18]. More females showed more acceptability to HIVST than
males (p> 0.001) and willingness to confirm HIV-positive test results at a health facility (p=0.03)
[18]. In some settings, more females are willing to use HIVST with their sexual partners (p>0.001),
and willing to buy HIVST kits than males (p>0.001) [18] and other settings reveal that more men
than women said that they would test with their partner, and women were less certain that their
partners would be willing to self-test with them. Women were also less confident that their partner
would continue the relationship if they tested HIV-positive [12].

Another key issue identified with gender differences was gender unavailability. The social positions
of men and women shaped by the normative gender roles and gender stereotypes made it difficult for
men to access HIVST delivered through a community-based approach. HIVST was mostly offered
during the normal working hours, the community counselors found women at home more often, as

82
International Journal of Recent Innovations in Medicine and Clinical Research
men had gone to work. Women commonly stated that they self-tested without a partner because the
male partner was at work when HIVST was offered [13].

Furthermore on the scoping review done in SSA, there is a more unique pattern of gender disparities
in HIVST acceptability rates was observed; with acceptability rates of HIVST being much higher for
men compared to women. Men prefer HIVST as it does not require for them to present at medical
facilities for testing, often associated with loss of income due to absence from work [23]. The
disparity was consistent even is situations whereby women attending maternal and child health
(MCH) and family planning (FP) services were requested to distribute HIVST kits to their men
counterparts. Most women reported that their partners accepted and used self-test [26].

Although HIVST is highly acceptable, the cost of self-test kit has been identified as a potential
barrier to adoption, willingness to use, purchase, and the uptake of HIVST, particularly among
people in poor-resource settings [11 & 18-19]. In some settings participants revealed that even if the
test kits were subsidized, the fact that there would be a cost attached to the testing might be
prohibitive to the potential users [19]. HIVST was highly accepted by young people, if provided at
no or very low cost since young people are also rarely financially independent [11].

Although HIVST was found to reduce costs of reduced travel, clinical costs and time away from
work, purchasing of HIV self-test kit also becomes a barrier to testing. Some participants expressed
concern about potentially high fees and preferred to use existing free clinic-based HCTS than
purchase HIVST kits in a qualitative study done in Tanzania [25].

It has been noted in this review that HIV testing without adequate counseling stands a potential to
harm due to psychological distress [12, 14, & 20]. Participants indicated that they might harm
themselves because of a positive HIVST result [20]. The potential for social harms such as domestic
violence, suicide, and forced-testing were widely perceived [14].

In a public opinions and perspectives quantitative study done in Nigeria on HIV self-testing
concerned raised were that counselors are no longer concerned about suicide and self-harm after
testing since the treatment is widely available. However, these are still potential risks and there is
still the need to provide adequate messaging and information to prevent potential harm [27].

The user’s ability to perform the HIVST correctly is important to obtain a valid test result. Incorrect
usage usually results in a negative result rather than an invalid one, which may falsely reassure the
user [10-11]. HIVST pilot studies conducted in Malawi and Zambia on user ability to follow the
manufacturer's instructions for use revealed that literacy may not guarantee ability to follow
instructions for use.

The key findings of challenge to participants in following instructions for use were test preparation,
specimen collection, timing, misinterpretation of universal symbols and illustrations, understanding
purpose and use of each equipment of the kit and challenges with result interpretation [10-11].
Consistently, there were minor and major errors observed using the oral fluid (OF) and fingerstick
(FS) HIV self test kits respectively. The errors included conducting procedures randomly without
following the correct order [24].

Despite the fact that HIVST is highly acceptable with some challenges to users, it calls for
preparation and readiness for countries to implement HIVST especially in resource-limited settings.
The integration of HIVST into existing provider-initiated HIV diagnosis initiatives poses a threat to
healthcare work jobs that primarily provide testing and counseling [14]. It was perceived that while
HIVST might be cheaper, this was likely further justification for job losses. However, many of oral
rapid diagnostics devices currently available commercially have not yet been pre-qualified by WHO

83
International Journal of Recent Innovations in Medicine and Clinical Research
for self-testing [15]. In addition the staff mentioned that HIVST might lead to the demand for more
ARVs which would not be met by current consumption based procurement systems [20].

In conclusion, HIVST is highly acceptable in southern Africa despite challenges ranging from gender
differences, acquisition of test kits, lack of pre-test and post-test counseling, potential social harm
and inadequate ability to following user’s instructions. It is further recommended that for
optimization of acceptability of the test, the issues of obtaining test kits at a cost, lack of associated
counseling and frequent public education on how to use the kit be addressed.

Conflict of interest: We declare that we have no conflicts of interest.

Funding: We declare that there has not been any exchange of funding between the study and
funding entities.

References
1. Scott, J.B. 2003. Risky rhetoric: AIDS and the cultural practices of HIV testing. SIU Press.
2. Johnson, C., Baggaley, R., Forsythe, S., Van Rooyen, H., Ford, N., Mavedzenge, S.N., Corbett,
E., Natarajan P. and Taegtmeyer M. 2014. Realizing the potential for HIV self-testing. AIDS and
Behavior, 18(4): 391-395.
3. Napierala, Mavedzenge, S., Baggaley, R. and Corbett, E.L. 2013. A review of self-testing for
HIV: research and policy priorities in a new era of HIV prevention. Clinical Infectious Diseases,
57(1): 126-138.
4. Joint United Nations Programme on HIV/AIDS and Joint United Nations Programme on
HIV/AIDS, 2014. 90-90-90: an ambitious treatment target to help end the AIDS
epidemic. Geneva: UNAIDS.
5. Kalichman, S.C. and Simbayi, L.C. 2003. HIV testing attitudes, AIDS stigma, and voluntary HIV
counselling and testing in a black township in Cape Town, South Africa. Sexually Transmitted
Infections, 79(6): 442-447.
6. Meiberg, A.E., Bos, A.E., Onya, H.E. and Schaalma, H.P. 2008. Fear of stigmatization as barrier
to voluntary HIV counselling and testing in South Africa. East African Journal of Public Health,
5(2): 49-54.
7. World Health Organization & UNITAID. 2016. Technology Landscape, HIV rapid diagnostic
tests for self-testing, Second Edition, 1 July 2016. http://www.who.int/hiv/pub/vct/hiv-self-
testing-2016-secondedition/en/
8. Chappelle, R. FDA approves first over-the-counter home-use rapid HIV test. 2012.
http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm310542.htm. (last
accessed 29 July 2016).
9. HIVST. 2019. About HIVST. http://www.hivst.org/about Date of access: 27 Feb. 2019.
10. Gotsche, C.I., Simwinga, M., Muzumara, A., Kapaku, K.N., Sigande, L., Neuman, M.,
Taegtmeyer, M., Corbett, E., Johnson, C., Schaap, A. and Mwinga, A. 2017. HIV self-testing in
Zambia: User ability to follow the manufacturer's instructions-for-use. In 9th IAS Conference on
HIV Science 2017 July.
11. Indravudh, P., Kumwenda, M., Neuman, M., Chisunkha, B., Hatzold, K., Nkhoma, C., Kalua, T.,
Johnson, C., Taegtmeyer, M. and Corbett, E. 2017. Providing user support for HIV self-testing
beyond instructions-for-use in Malawi. In Conference on Retroviruses and Opportunistic
Infections (CROI 2017): 389.

84
International Journal of Recent Innovations in Medicine and Clinical Research
12. Kelvin, E.A., Cheruvillil, S., Christian, S., Mantell, J.E., Milford, C., Rambally-Greener, L.,
Mosery, N., Greener, R. and Smit, J.A. 2016. Choice in HIV testing: the acceptability and
anticipated use of a self-administered at-home oral HIV test among South Africans. African
Journal of AIDS Research, 15(2): 99-108.
13. Kumwenda, M.K., Corbett, E.L., Chikovore, J., Phiri, M., Mwale, D., Choko, A.T., Nliwasa, M.,
Sambakunsi, R., Taegtmeyer, M., Gutteberg, T.J. and Munthali, A. 2018. Discordance, disclosure
and normative gender roles: Barriers to couple testing within a community-level HIV self-testing
intervention in urban Blantyre, Malawi. AIDS and Behavior, 22(8): 2491-2499.
14. Madanhire, C., Madanhire, C., Sibanda, E., Ruhode, N., Hatzold, K., Cowan, F.M. and
Mavedzenge, S.N. 2016 “Not without us…”: views on the introduction of HIV self-testing
among health care workers providing integrated HIV and sexual and reproductive health
services. In Journal of the International Aids Society; 19.
15. Martínez-Pérez, G., Steele, S.J., Govender, I., Arellano, G., Mkwamba, A., Hadebe, M. and van
Cutsem, G. 2016. Supervised oral HIV self‐ testing is accurate in rural Kwa Zulu‐ Natal, South
Africa. Tropical Medicine and International Health, 21(6): 759-767.
16. Chipungu, J., Bosomprah, S., Zanolini, A., Thimurthy, H., Chilengi, R., Sharma, A. and Holmes,
C.B. 2017. Understanding linkage to care with HIV self-test approach in Lusaka, Zambia-A
mixed method approach. PLoS one, 12(11): 1-12.
17. Indravudh, P.P., Sibanda, E.L., d’Elbée, M., Kumwenda, M.K., Ringwald, B., Maringwa, G.,
Simwinga, M., Nyirenda, L.J., Johnson, C.C., Hatzold, K. and Terris-Prestholt, F. 2017. ‘I will
choose when to test, where I want to test’: investigating young people's preferences for HIV self-
testing in Malawi and Zimbabwe. AIDS, 31(Suppl 3): 203-212.
18. Mokgatle, M.M. and Madiba, S. 2017. High Acceptability of HIV Self-Testing among Technical
Vocational Education and Training College Students in Gauteng and North West Province: What
Are the Implications for the Scale Up in South Africa? Public library of Science One, 12(1): 1-
14.
19. Moyo, T., Mokgatle, M. and Madiba, S. 2017. Opinions about and acceptability of HIV self-
testing amongst students at the Institute of Health Sciences-Lobatse, Botswana. Botswana
Journal of African Studies, 31(1): 6-17.
20. Nkuna, E. and Nyazema, N.Z. 2016. HIV self-testing, self-stigma and HAART treatment at the
University of Limpopo: health sciences students’ opinion and perspectives. The open AIDS
Journal, 10(7): 78-82.
21. Pérez, G.M., Cox, V., Ellman, T., Moore, A., Patten, G., Shroufi, A., Stinson, K., Van Cutsem,
G. and Ibeto, M. 2016. ‘I know that I do have HIV but nobody saw me’: oral HIV self-testing in
an informal settlement in South Africa. Public Library of Science One, 11(4): 1-15.
22. Zanolini, A., Chipungu, J., Vinikoor, M.J., Bosomprah, S., Mafwenko, M., Holmes, C.B. and
Thirumurthy, H. 2018. HIV self-testing in Lusaka Province, Zambia: acceptability,
comprehension of testing instructions, and individual preferences for self-test kit distribution in a
population-based sample of adolescents and adults. AIDS Research and Human Retroviruses,
34(3): 254-260.
23. Harichund, C. and Moshabela, M. 2018. Acceptability of HIV self-testing in sub-Saharan Africa:
scoping study. AIDS and Behavior, 22(2): 560-568.
24. Lippman, S.A., Gilmore, H.J., Lane, T., Radebe, O., Chen, Y.H., Mlotshwa, N., Maleke, K.,
Manyuchi, A.E. and McIntyre, J. 2018. Ability to use oral fluid and fingerstick HIV self-testing
(HIVST) among South African MSM. Public Library of Science One, 13(11): 1-14.

85
International Journal of Recent Innovations in Medicine and Clinical Research
25. Jennings, L., Conserve, D.F., Merrill, J., Kajula, L., Iwelunmor, J., Linnemayr, S. and Maman, S.
2017. Perceived cost advantages and disadvantages of purchasing HIV self-testing kits among
urban Tanzanian men: an inductive content analysis. Journal of AIDS and Clinical Research,
8(8): 1-21.
26. Pintye, J., Drake, A.L., Begnel, E., Kinuthia, J., Abuna, F., Lagat, H., Dettinger, J., Wagner,
A.D., Thirumurthy, H., Mugwanya, K. and Baeten, J.M. 2019. Acceptability and outcomes of
distributing HIV self-tests for male partner testing in Kenyan maternal and child health and
family planning clinics. AIDS, 33(8): 1369-1378.
27. Brown, B., Folayan, M.O., Imosili, A., Durueke, F. and Amuamuziam, A. 2015. HIV self-testing
in Nigeria: Public opinions and perspectives. Global Public Health, 10(3): 354-365.

Citation: Sello, M., Ramathebane, M.V., Maja, L.J., Shelile, M.Z. and Namole, L.D. 2019. HIV
Self-Testing in Southern Africa: Progress and Challenges. International Journal of Recent
Innovations in Medicine and Clinical Research, 1(2): 73-86.
Copyright: This is an open-access article distributed under the terms of the Creative Commons
Attribution License, which permits unrestricted use, distribution, and reproduction in any medium,
provided the original author and source are credited. Copyright©2019; Sello, M. et al., (2019).
86

You might also like