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    Immunohematology/ Blood Banking

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    Sophia Ampatuan
    This document summarizes key aspects of immunology and blood banking. It describes blood typing techniques like ABO and Rh blood grouping to determine compatibility. A blood bank collects, tests, and stores blood, preparing compatible blood products for transfusion. Compatibility testing, including major and minor crossmatching, identifies antibodies to reduce transfusion reaction risk by matching donor and recipient blood. The document outlines various blood components and their clinical indications.

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    Immunohematology/ Blood Banking

    Uploaded by

    Sophia Ampatuan
    78 views2 pages
    This document summarizes key aspects of immunology and blood banking. It describes blood typing techniques like ABO and Rh blood grouping to determine compatibility. A blood bank collects, tests, and stores blood, preparing compatible blood products for transfusion. Compatibility testing, including major and minor crossmatching, identifies antibodies to reduce transfusion reaction risk by matching donor and recipient blood. The document outlines various blood components and their clinical indications.

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    Immunohema Finals

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    This document summarizes key aspects of immunology and blood banking. It describes blood typing techniques like ABO and Rh blood grouping to determine compatibility. A blood bank collects, tests, and stores blood, preparing compatible blood products for transfusion. Compatibility testing, including major and minor crossmatching, identifies antibodies to reduce transfusion reaction risk by matching donor and recipient blood. The document outlines various blood components and their clinical indications.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    78 views2 pages

    Immunohematology/ Blood Banking

    Uploaded by

    Sophia Ampatuan
    This document summarizes key aspects of immunology and blood banking. It describes blood typing techniques like ABO and Rh blood grouping to determine compatibility. A blood bank collects, tests, and stores blood, preparing compatible blood products for transfusion. Compatibility testing, including major and minor crossmatching, identifies antibodies to reduce transfusion reaction risk by matching donor and recipient blood. The document outlines various blood components and their clinical indications.

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Download as docx, pdf, or txt
    of 2

    IMMUNOHEMATOLOGY/ o To determine antigens in the

    RBCs of an individual by
    BLOOD BANKING
    using commercially prepared
     A branch of immunology which deals with
    antisera of known specificity
    the uses of immunologic principles to study
    2. Serum typing (Backward or
    and identify the different blood groups.
    Reverse typing)
    Blood Bank o To determine antibodies in
     A separate area in a hospital where blood is the serum/plasma of an
    collected from donors individual by using RBCs of
     Performs blood typing
    known specificity
     Prepares blood and blood components for
    transfusion
     Blood that is transfused into a recipient
    must be tested first to ensure compatibility
    with the recipient’s blood.
     To reduce the risk of transfusion
    reactions
     To ensure that the blood/blood
    components are safe
    ABO BLOOD GROUP SYSTEM
     Discovered by Karl Landsteiner (1900s) and
    received the Nobel Prize (1930).
     He categorized the blood groups as A, B,
    and O
     AB – 4th major ABO blood type
     Discovered by Alfred von Decastello
    and Adriano Sturli

    Forward and Reverse/Backward


    Blood Typing

    ABO Blood Typing


     A test to determine the blood type of an
    individual.
    1. Cell typing (Direct or Forward
    typing)
    Rh BLOOD GROUP SYSTEM  MINOR CROSSMATCHING
     Discovered by Karl Landsteiner and  Patient RBCs are mixed with the
    Alexander Wiener (1940) donor serum
     5 important antigens: D, C, E, c, e  Detects if there are antibodies in the
     Rh typing: based on the presence or donor serum that can destroy the
    absence of D antigen using an anti-D patients RBCs
    antisera  PR-DS
    o Rh antibodies + human RBCs Blood Components and their
    = AGGLUTINATION Rh Indications
    POSITIVE WHOLE BLOOD
    o Rh antibodies + human RBCs  Indication: volume replacement;
    = NO AGGLUTINATION  Rh restoration of oxygen-carrying
    NEGATIVE capacity
    PACKED RED BLOOD CELL (PRBC)
     Indication: impairment of
    oxygenation by acute or chronic
    anemia or hemorrhage
    WASHED PRBC (washed with NSS)
     Indication: patient sensitivity to
    plasma proteins
    LEUKOCYTE-REDUCED PRBC
     Indication: febrile transfusion
    reactions
    IRRADIATED PRBC (gamma rays)
     Indication: prevention of graft-
    versus-host disease
    PLATELET CONCENTRATE
     Indications: thrombocytopenia and
    COMPATIBILITY TEST platelet dysfunction (bleeding
     Blood typing and crossmatching are patients)
    procedures done to prevent harmful FRESH FROZEN PLASMA (FFP)
    transfusion reactions between the  Effect: replacement of plasma
    recipient blood and the donor blood coagulation factors
    2 parts:  Indications: severe bleeding in
     MAJOR CROSSMATCHING unknown factor deficiency
     Patient serum is mixed with the CRYOPRECIPITATE
    donor RBCs  Indications: patients with fibrinogen
     Detects if there are antibodies in the defects
    patient serum that can destroy the
    transfused RBCs from the donor
     PS-DR

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