Epidemiology of HIV and AIDS Among Adolescents 169
Epidemiology of HIV and AIDS Among Adolescents 169
Epidemiology of HIV and AIDS Among Adolescents 169
Methods: Data were reviewed from Joint United Nations Programme on HIV/AIDS HIV estimates, nationally representative
household surveys, behavioral surveillance surveys, and published
literature.
Results: A number of gaps exist for adolescent-specic HIVrelated data; however, important implications for programming can
be drawn. Eighty-two percent of the estimated 2.1 million adolescents aged 1019 years living with HIV in 2012 were in sub-Saharan
Africa, and the majority of these (58%) were females. Comprehensive accurate knowledge about HIV, condom use, HIV testing, and
antiretroviral treatment coverage remain low in most countries. Early
sexual debut (sex before 15 years of age) is more common among
adolescent girls than boys in low- and middle-income countries,
consistent with early marriage and early childbirth in these countries.
In low and concentrated epidemic countries, HIV prevalence is highest among key populations.
Conclusions: Although the available HIV-related data on adolescents are limited, increased HIV vulnerability in the second decade
of life is evident in the data. Improving data gathering, analysis, and
reporting systems specic to adolescents is essential to monitoring
progress and improving health outcomes for adolescents. More
systematic and better quality disaggregated data are needed to
understand differences by sex, age, geography, and socioeconomic
factors and to address equity and human rights obligations,
especially for key populations.
Key Words: HIV, AIDS, adolescents, prevention, care, treatment
(J Acquir Immune Dec Syndr 2014;66:S144S153)
From the *United Nations Childrens Fund, New York, NY; and Joint United
Nations Programme on HIV/AIDS, Geneva, Switzerland.
Initial results of this article were rst presented at a technical meeting
supported by United Nations Childrens Fund on HIV Prevention, Treatment, and Care in Adolescents at the London School of Hygiene and
Tropical Medicine, United Kingdom, 810 July, 2013.
The authors have no funding or conicts of interest to disclose.
Correspondence to: Priscilla Idele, PhD, United Nations Childrens Fund, 3
UN Plaza, New York, NY 10017 (e-mail: [email protected]).
Copyright 2014 by Lippincott Williams & Wilkins
S144
| www.jaids.com
INTRODUCTION
This article focuses on adolescents, dened as aged
1019 years.1 Adolescence is the period when many people
begin to explore their sexuality; as a result, access to sexual and
reproductive health information and services becomes increasingly important. Despite the well-known need for protection
from HIV infections and other reproductive health risks, their
age and their social and economic status limit adolescent access
to information and services in many settings. Adolescence is
typically a period of experimentation, new experiences, and
vulnerability. Some adolescents may experiment with injecting
drugs, sexuality, and sexual orientation (men may begin to
have unprotected sex with other men), and some are exploited
sexually. Millions of adolescents who are becoming sexually
active live in countries with a high burden of HIV. Adolescence provides a window of opportunity in which to intervene
early. Comprehensive data are essential to shaping accurate
HIV-related messages and services before risky behaviors are
formed and become entrenched.
Since 2000, various global declarations and commitments, with specic goals and targets, have been made and set
by world leaders and governments to respond to the HIV and
AIDS epidemic. Most are general in nature; however, the
United Nations General Assembly Special Session on HIV and
AIDS (UNGASS) in 2001 specically included a target to
reduce the prevalence of HIV in young people aged 1524
years globally by 25% by the end of 2010 and to increase
young peoples access to essential HIV prevention information,
skills, and services so as to reach 95% of those in need by the
same date.2
More recently, for the countdown to 2015, the UN
Secretary Generals High-Level Advisory Panel on the Post
Millenium Development Goals Agenda released recommendations for post-2015.3 The report emphasizes equity, empowerment, and engagement of adolescents and youth and
strengthening of data as core drivers of transformation in the
next development agenda.
Although these global commitments, goals, and targets
are relevant for adolescents, the implications and accountabilities are rarely specic to this age group. In addition,
adolescent-specic data are limited, which present a serious
impediment to measuring and monitoring progress. Although
the international reporting process recommends reporting on
disaggregated data on adolescents and youth, little of these data
are collected or published in global or national progress
reports.4 As a result, compared with infants and adults, less
is known about the burden of HIV and AIDS among
METHODS
Epidemiological HIV and AIDS data on the burden of
disease and prevalence in adolescents at global and regional
levels were derived from the 2012 Joint United Nations
Programme on HIV/AIDS (UNAIDS) HIV and AIDS
estimates and reanalysis by United Nations Childrens
Fund.1,5 In addition, HIV prevalence data from national
population-based surveys in selected countries in which
HIV testing had been included610 were used to assess differentials by age and sex.
Data on adolescent HIV knowledge and sexual behavior for selected indicatorsknowledge about HIV, HIV testing uptake, sexual debut before 15 years of age, multiple
sexual partners, and condom use among those with multiple
partnerswere drawn from nationally representative
population-based surveys, such as the Multiple Indicator
Cluster Surveys11 and the Demographic and Health Surveys,6
or other nationally representative surveys. These surveys have
standardized methods and instruments to ensure that data are
comparable between survey rounds and across countries.
Data on adolescent key populations, such as young men
who have sex with men (MSM), sexually exploited children,
and adolescents who inject drugs, were mainly drawn from
the UNAIDS 2013 Global AIDS Report,5 supplemented with
various special targeted studies, including the published
literature.
Where applicable, knowledge and behavior indicators
were analyzed to assess levels of coverage and disparities by
selected characteristicsage, sex, rural and urban residence,
RESULTS
Burden of HIV and AIDS in Adolescents
Globally, an estimated 35.3 million people were living
with HIV at the end of 2012; of these, 2.1 million were
adolescents aged 1019 years, of which the majority was girls
(56%).12 The gender disparity has persisted over time, with
this number remaining largely unchanged over the past 5
years. These estimates include both adolescents who acquired
HIV through mother-to-child transmission (perinatal and
postnatal transmission through breast-feeding) and who
acquired HIV behaviorally through unprotected sex or by
sharing nonsterile injecting equipment.
The majority of HIV infections are in sub-Saharan
Africa, where 85% of all adolescents living with HIV were
located in 2012 (1.7 million) (Table 1). About 1.3 million
adolescents living with HIV in sub-Saharan Africa were in
Eastern and Southern Africa and 390,000 in the West and
Central Africa. Outside sub-Saharan Africa, South Asia had
the highest number of adolescents living with HIV
(130,000), accounting for 6% of the global burden of HIV
among adolescents, followed by East Asia and the Pacic
(110,000), Latin America and the Caribbean (81,000), Eastern
Europe and Central Asia (22,000), and the Middle East and
North Africa (17,000).
TABLE 1. Estimated Number of Adolescents Aged 1019 years Living With HIV by United Nations Childrens Fund
Regions, 2012
Estimated Number of Adolescents Living With HIV, 2012
Sub-Saharan Africa
Eastern and Southern Africa
West and Central Africa
Middle East and North Africa
South Asia
East Asia and the Pacic
Latin America and the Caribbean
Central and Eastern Europe and the Commonwealth of
the Independent States
Global
Female, %
1,700,000
1,300,000
390,000
17,000
130,000
110,000
81,000
22,000
1,000,000
800,000
220,000
9100
62,000
55,000
35,000
11,000
720,000
550,000
170,000
8300
64,000
53,000
46,000
11,000
58
59
56
52
49
51
43
52
2,100,000
1,200,000
930,000
56
Source: United Nations Childrens Fund analysis of unpublished UNAIDS 2012 HIV and AIDS estimates.
www.jaids.com |
S145
Idele et al
early childhood for both sexes, which shifts with entry into
adolescence accompanied by increased prevalence among
females compared with males. The gap continues to widen
between the sexes during adolescence into young adulthood.8,9 HIV prevalence in Uganda is nearly double in adolescent girls aged 1519 years (3.0%) compared with boys of
the same age (1.7%)10 (Fig. 1).
FIGURE 1. HIV prevalence by age group in Swaziland (20062007), South African (2012), Botswana (2012), and Uganda
(2011).
S146
| www.jaids.com
HIV Knowledge
The overwhelming majority of new HIV infections are
transmitted through sex. A basic understanding of HIV and
how it spreads is a necessary component of prevention,
although this is not sufcient to change behavior and reduce
risk. Despite consistent calls for improving knowledge, in
general, levels of knowledge of HIV among adolescents and
young adults are appallingly low, especially in the worstaffected countries.
Recent surveys in countries with generalized epidemics
show that, in most of these countries, less than half of
adolescent boys and girls, aged 1519 years, have a basic
understanding of HIV (Fig. 2). This falls far short of the
95% target agreed in 2001 at the UNGASS. Consistent with
the higher rates of HIV among girls in the most affected
regions, girls tend to have worse knowledge levels than boys
of the same age. In sub-Saharan Africa, only 26% of adolescent girls aged 1519 years and 36% of adolescent boys of
the same age have a comprehensive and correct knowledge of
FIGURE 2. Percentage of adolescents aged 1519 years and young women and men aged 2024 years with comprehensive
correct knowledge of HIV, by country, sex, and age in selected countries, 20072012.
2014 Lippincott Williams & Wilkins
www.jaids.com |
S147
Idele et al
Sexual Debut
Early sexual debut (before 15 years of age) provides
more opportunities over time for adolescents to be exposed to
HIV, especially where higher risk partners or multiple
partners are involved and condom use is less likely. The lack
of awareness and other social pressures and power imbalances
can also conspire to put the health of adolescents at risk.
Among adolescent girls, aged 1519 years, in subSaharan Africa, a higher percentage of girls (13%) than boys
(9%) had sex before the age of 15 years. This pattern was
FIGURE 3. Percentage of adolescents aged 1519 years and young women and men aged 2024 years who had sex before 15
years of age, by country, sex, and age in selected countries, 20082012.
S148
| www.jaids.com
HIV Testing
Most adolescents do not know their HIV status.
Although most adolescents know of a place where they can
get tested for HIV, the proportion who reported ever having
had an HIV test remains low across most countries; yet, this is
a critical step toward access to HIV care and treatment (Fig. 5).
Although access and coverage vary greatly by country, survey
data from 2008 to 2012 in most sub-Saharan African countries
indicate that less than 1 in 3 adolescent girls aged 1519 years
reported having ever been tested for HIV and having received
FIGURE 4. Percentage of adolescents aged 1519 and young women and men aged 2024 reporting multiple partners in the last
12 months who used a condom at last sex, by country, age and sex in selected countries, 20072012.
2014 Lippincott Williams & Wilkins
www.jaids.com |
S149
Idele et al
FIGURE 5. Percentage of adolescents aged 1519 years and young women and men aged 2024 years who have ever been
tested for HIV and received results, by country, sex, and age in selected sub-Saharan African countries, 20072012.
S150
| www.jaids.com
Importance of Prevention
HIV prevention among adolescents is particularly
important given their evolving needssocially, physiologically, and psychologicallyas they transition from childhood
through adolescence to adulthood. Lack of attention to their
2014 Lippincott Williams & Wilkins
S151
Idele et al
S152
| www.jaids.com
Taking Action
Despite the need for better data related to adolescents,
important implications can be drawn from the emerging
global, regional, and national data sets. Adolescents constitute
about 1.2 billion of the worlds population. These adolescents
are becoming sexually active and need to understand the risks
of HIV and other sexually transmitted infections, especially
adolescents living in high HIV burden countries. Demographic projections suggest that the absolute number of adolescents is expected to increase slightly through 2050, leading
to a youth bulge in developing countries. The adolescent
population in sub-Saharan Africa is expected to double in
2050, a region where HIV infections are also highest, and
adolescents already account for 23% of the current population. Although data improvements are needed, the current
evidence makes clear that adolescents are more vulnerable
to HIV than persons in older age groups and that effective
interventions are known, invoking an obligation to take
action. Given these demographic shifts, it is vital that the
post-2015 agenda takes into account age-appropriate HIVrelated interventions aimed at reducing risk, vulnerability,
morbidity, and mortality among them.
Limitations
This article provides a snapshot of the HIV epidemic
among adolescents and progress made toward addressing the
prevention, care, and treatment needs to mitigate risk,
infection, and mortality among them. It does neither assess
the programmatic effectiveness and scientic evidence of
different high-impact interventions nor deal with interventions designed to mitigate the impact of HIV, eg, interventions with orphans and other children infected or affected by
HIV and AIDS, that are beyond the scope of this article.
Various development sectors and their program interventions, beyond those that are HIV specic, play a critical
role in reducing vulnerability to HIV infection among
adolescents. Just as critical are the political commitments
and policy and legal environments that address the issues of
poverty, low levels of education, marginalization of particular
population groups, stigma, and discrimination attached to
particular groups or behaviors, among others. Policy and
program efforts across the development sectors along with the
enabling environment are factors that have signicant inuence on the effectiveness and success of HIV-specic
interventions that enhance HIV knowledge and improve
access to testing, care, and treatment services. However,
analysis of these factors is beyond the scope of this article.
2014 Lippincott Williams & Wilkins
www.jaids.com |
S153