Twist Bioscience’s Post

☘ Love exploring #VisiumHD data? So do we! Take a look at a recent project where we revisited a Colorectal Cancer Visium HD dataset by 10x Genomics using the Visium HD analytics suite in our #CDIAM Multi-Omics Studio platform. We were able to dive into different regions on the tissue slide, cluster, predict cell types, compare expression and predict intercellular signaling. It's great to see biology at such a resolution! Curious to explore the dataset and see our analysis? Take a look at the project on C-DIAM here: https://lnkd.in/g7mYMT_j Don't forget to request a trial license before that to gain access to the platform: https://lnkd.in/ga5ZQRtk

Illumina Connected Insights for NGS Data Analysis. Watch the Illumina sponsored keynote from the Festival of Genomics, “Expansive analysis of NGS data in solid cancer”, on-demand now! Learn how a singular DDS solution is enabling the rapid exploration of all variant classes in variety of different cancer types. Watch now here: https://lnkd.in/euewxPHm

I agree that there are enormous opportunities for single-cell technologies in the clinical space, from understanding biological processes and discovering biomarkers to disease diagnosis. However, when it comes to solid tissue cancer, hurdles arise as most of these technologies require tissue dissociation. At Resolve Biosciences, we are developing a game changing single-cell, spatially resolved multi-omic technology that will be an essential tool for whole tissue analysis. Connect with me if you want to learn more. #singlecell #clinicalgenomics #genomics #highresolutionpathology #spatialbiology Image credit: Lim, J., Chin, V., Fairfax, K. et al. Transitioning single-cell genomics into the clinic. Nat Rev Genet 24, 573–584 (2023).

Pleased to share our latest publication - a book chapter in Springer Methods in Molecular Biology, "Patient-Derived Xenograft Models for Translational Prostate Cancer Research and Drug Development"This year marks 20 years since my journey in the preclinical modelling of human disease started. The scientific community has made great advances in more sophisticated preclinical modelling, imaging and characterisation methods to fuel translational research outcomes!  Check out the publication here and a big thanks to editor Mohamed I. Saad. #SpringerProcotocols https://lnkd.in/gUEKbmk4

Uncover new biological insights with spatial sequencing and multi-modal analysis of transcript, protein, and fluorescent H&E over 40 cm² of imaging area in a single daily run. The G4X has the potential to be a breakthrough platform for cancer research, powering larger studies and cost-effective multiomic 3D reconstruction of the tumor microenvironment.    Dive into the latest G4X poster to discover how this spatial sequencing technology empowers in situ studies at unparalleled throughput: https://lnkd.in/gymFG3bV   #spatialtranscriptomics #AACR #cancerresearch 

🔬 Excited to share our latest preprint Science Cast on LinkedIn! "Drugs targeting microRNAs that regulate DNA damage sensing and repair mechanisms: A computational drug discovery approach" outlines our innovative approach to identifying potential therapies that modulate DNA damage response pathways through microRNA targeting. This research holds promise for advancing personalized medicine and enhancing cancer treatment strategies. Check out the preprint here to learn more about our computational methodologies and the implications for future drug development. https://lnkd.in/g_rJe7Qu

Do want to know more about Miltenyi spatial multi-omics solution? Come here check link🤩

If you're at #EADVCongress and want to learn about how state-of-the-art technologies such as genomics, single-cell RNAseq and spatial transcriptomics are shedding light on skin cancer pathogenesis, come join my presentation at 1640 today in the Actinic Keratosis updates session (room 7.1).

𝗘𝘅𝗽𝗹𝗼𝗿𝗲 𝘁𝗵𝗲 𝗱𝘆𝗻𝗮𝗺𝗶𝗰 𝗽𝗿𝗼𝗰𝗲𝘀𝘀 𝗼𝗳 𝗰𝗲𝗹𝗹 𝗱𝗶𝘃𝗶𝘀𝗶𝗼𝗻 𝘂𝗻𝗳𝗼𝗹𝗱𝗶𝗻𝗴 𝗶𝗻 𝗿𝗲𝗮𝗹-𝘁𝗶𝗺𝗲 🔬 Nanolive’s Mitosis Poster provides insights into the distinct steps of mitosis in living cells. Observe as cells progress naturally through each phase, revealing structures like the microtubule spindle, chromosomes and centrioles. Nanolive’s label-free technology delivers noninvasive high-resolution images, important for cell biology, cancer research and drug discovery. Download the poster here: https://bit.ly/3AVOuRA   #CellDivision #Mitosis #LiveCellImaging #LabelFreeTechnology #HighResolutionImages #CellBiology #CancerResearch #DrugDiscovery #Nanolive #SciencePoster #Microscopy

Dive into the Dynamic World of #Tumor-Immune Interactions! 🌟 Discover 10x Genomics latest breakthrough in #cancer research, showcased in new bioRxiv preprint. 📄 Explore how 10x Genomics scientists leverage Visium HD for high-resolution #spatialtranscriptomics, unraveling #heterogeneous #macrophage and #T-cell populations within the #colorectal #tumormicroenvironment. 🧬🔬 Read more: https://zurl.co/PPuW