PROMICON’s Post

phenolphthalein synthesis using phenol and phthalic anhydride (conc. H2SO4 as catalyst)

🔬 Nucleic Acid Methylation Pretreatment System: Our system supports a wide range of sample types, including feces, plasma, cells, urine, and more. 🚀 High Throughput: Efficiently processes up to 16 samples simultaneously, with customization options to handle anywhere from 1 to 96 wells. ⚙️ Advanced Functions: Automates every step of the process—sampling, purification, incubation, re-purification, and precise liquid separation. 📏 Flexible Sample Size: Accommodates sample volumes from as small as 0.1 mL to as large as 10 mL. 🔗 Compatibility with Conventional Kits: Designed to work seamlessly with various conventional kits, offering enhanced flexibility for your needs. Upgrade your lab's efficiency and versatility with our state-of-the-art Nucleic Acid Methylation Pretreatment System. Contact us to learn more! #POCT #INVITRO #IVD #NucleicAcid #Methylation #Pretreatment #Biotech #LifeSciences #LabEquipment #HighThroughput #SampleProcessing #Automation #LabEfficiency #ScientificResearch #Biotechnology

𝐁𝐢𝐜𝐲𝐜𝐥𝐨𝐚𝐥𝐤𝐚𝐧𝐞 𝐁𝐮𝐢𝐥𝐝𝐢𝐧𝐠 𝐁𝐥𝐨𝐜𝐤𝐬 𝐚𝐬 𝐁𝐞𝐧𝐳𝐞𝐧𝐞 𝐁𝐢𝐨𝐢𝐬𝐨𝐬𝐭𝐞𝐫𝐬:   In recent years, there has been active research aimed at breaking the planarity of pharmacologically active #molecules to improve their solubility and 𝘪𝘯 𝘷𝘪𝘷𝘰 behavior. This approach involves replacing the #benzene ring with #bioisosteres.   TCI offers the custom synthesis of analogues and derivatives, as well as scale-up production of these building blocks.   𝐓𝐨 𝐋𝐞𝐚𝐫𝐧 𝐌𝐨𝐫𝐞:https://lnkd.in/giUSetTk   #tciuk #tciproducthighlights #chemicalmanufacturer #organicchemical #chemicalsynthesis #chemicalsustainability #researchchemicals #buildingblocks #laboratoryreagents #pharmacologically #benzene #bioisosteres

Improving the purity of extracellular vesicles by removing lipoproteins after size exclusion chromatography and ultracentrifugation: in their latest work, Cheng-Yu Chou, Andrew M. Wo at National Taiwan University and collaborators introduced LipoMin, an optimised magnetic bead reagent functionalised with glycosaminoglycans, offering a rapid and efficient alternative for lipoprotein removal in just 10 minutes during the second-step purification process https://lnkd.in/gBeMkYja ELISA results showed that LipoMin removes 98.2% of ApoB from SEC EV fractions, matching the LP removal efficiency of density gradient in the SEC + DG two-step process. An article co-authored by Po-Chieh Chiang, Chih-Chi Li, Jheng-Wun Chang, Lu Po-Han, Wei-Fan Hsu, Li-Chun Chang, Jung-Lung Hsu, Ming-Shiang Wu #extracellularvesicles #exosomes #purification #biofluids #lipoproteins #Vesiculab

Addition of Sodium Malonate Alters the Morphology and Increases the Critical Flux During Tangential Flow Filtration of Precipitated Immunoglobulins The objective of this study was to examine the effect of sodium malonate, which is known to enhance protein crystallizability, on the morphology of immunoglobulin precipitates formed using a combination of ZnCl2 and polyethylene glycol. The addition of sodium malonate significantly stabilized the precipitate particles as shown by an increase in melting temperature, as determined by differential scanning calorimetry, and an increase in the enthalpy of interaction, as determined by isothermal titration calorimetry. The sodium malonate also increased the selectivity of the precipitation, significantly reducing the coprecipitation of DNA from a clarified cell culture fluid. The resulting precipitate had a greater packing density and improved filterability, enabling continuous tangential flow filtration with minimal membrane fouling relative to precipitates formed under otherwise identical conditions but in the absence of sodium malonate. https://lnkd.in/gmzx5bNd #aspenalert #biotech #bioprocess

Selecting and optimizing the right linker for your bioconjugate drug candidate is easy in theory but difficult in practice. Enter the “Linker Selection Tool”. It allows you to select your parameters, narrow down the options, and land on your ideal linker design. Try it out: https://bit.ly/3U7ebEq #BioDesign #ADC #Bioconjugation #Therapeutics

Unlock speed, versatility, and precision with the GMI Certified Pre-Owned Microfuge 20 Series. Engineered for high performance in a compact footprint, these mini-centrifuges are tailored to meet diverse application needs, including nucleic acid and protein preparation, pelleting, extractions, purifications, concentrations, phase separations, receptor binding, and rapid sedimentation of protein precipitates, particulates, and cell debris. Key Features of the Microfuge 20 Series: → Fast, cool, and versatile operation for efficient separations → Paired with Beckman Coulter Microfuge Series rotors for flexibility → 15,000 RPM and 20,627 x g for powerful performance Experience the convenience and reliability of the Microfuge 20 Series—explore our offerings today: https://lnkd.in/gjbn8PPn #centrifuges #beckmancoulter #lifesciences #biotech #centrifuge

DMPE (14:0 PE), or 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine, is a phospholipid. This compound is made up of a glycerol backbone, with two myristoyl fatty acid chains attached. The "14:0" designation denotes that the fatty acid chains are myristoyl, meaning they consist of 14 carbon atoms with no double bonds. This specific phospholipid is of interest in biological and chemical research due to its role in cellular membranes and its potential applications in encapsulation and drug delivery systems. #DMPE #Dimyristoyl #encapsulation #membranes #drug #myristoyl #fatty #acid #chains https://lnkd.in/gKnuc_Sd

Get an overview of Capto chromatography resins. They are used in many applications, including the purification of mAbs, mAb variants, viral vectors and plasmids. https://cytiva.link/fwuhx #biotechnology #lifesciences

HPGM is an important intermediate and plays a key role in the enzymatic synthesis of amoxicillin. Early HPG was derived from chemical synthesis, but now the new synthesis method is to make it through enzyme synthesis. This process is more environmentally friendly, green and energy-saving. #Hydroxyphenylglycine #hpg #hpgm #amoxicillin #enzyme