Organic Chemistry Portal’s Post

https://lnkd.in/dYXPp9b Sulfinamide Synthesis Using Organometallic Reagents, DABSO, and Amines

https://lnkd.in/dwEpKEvu Ethyl bromoacetate mediates a facile and efficient synthesis of primary phosphinamides from Ar2P(O)-H reagents

https://lnkd.in/dYDg_s7P Ethyl bromoacetate mediates a facile and efficient synthesis of primary phosphinamides from Ar2P(O)-H reagents

SYNTHESIS OF CYCLOPROPANE CARBOXYLIC ACIDS WO2024064214 The present disclosure from Takeda relates to a process for preparing plasma kallikrein (pKAL) inhibitors with a substituted cyclopropane with defined stereochemistry Cyclopropanes are important structural motifs in medicinal chemistry, as they often afford the advantages of restricting conformational freedom at the cost of minimal steric bulk and better stability towards oxidative metabolism compared to lower alkyl or other cycloalkyl substituents. https://lnkd.in/g6bqcQsF

Happy to share with you my latest publication. "Synthesis, characterization of poly l(+) lactic acid and its application in sustained release of isosorbide dinitrate" #Pharmaceutics #Controlledrelease #Biodegradablepolymers

Peptide Custom Synthesis: Methodologies, Applications, and Trends Peptide custom synthesis refers to the process of creating peptides through chemical or biological methods tailored to meet specific requirements. Methodologies of Peptide Custom Synthesis: 1. Solid-Phase Peptide Synthesis (SPPS): It involves assembling peptides on a solid support, typically resin beads, through the stepwise addition of protected amino acids. 2. Liquid-Phase Peptide Synthesis (LPPS): It involves solution-phase reactions, where amino acids are coupled sequentially in solution, followed by purification steps to isolate the desired peptide products. Know in Details: https://lnkd.in/dy25kFqi #peptide #peptidesynthesis #customsynthesis #chemicalmethods #biologicalmethods #solidphase #liquidphase #aminoacids #protectedaminoacids

RGD peptide /Arg-Gly-Asp CAS:99896-85-2 Custom Peptide Synthesis Name:RGD peptide /Arg-Gly-Asp CAS#: 99896-85-2 Chemical Formula: C12H22N6O6 Exact Mass: 346.1601 Molecular Weight: 346.34 Purity: >98% Source: synthetic Apperance: white powder Note: For research use only #peptide #RGD #RGDpeptide #custompeptide #peptidesynthesis 

Late-stage functionalization (LSF) has garnered significant interest from medicinal chemists due to its challenging nature and efficiency in derivatizing advanced intermediates. In this article, the authors demonstrate the Ru-catalyzed C-H arylation of medicinally relevant N-aryl triazoles and tetrazoles, which enables LSF. #arylation #ruthenium #triazoles #tetrazoles #LSF #drugdesign https://bit.ly/3yphWhh

In 2012, bicyclo[1.1.1]pentane (BCP) was demonstrated to mimic the para-substituted benzene ring in a biologically active compound. Since then, BCPs have been playing an important role in chemistry. This paper reports a general scalable reaction between alkyl iodides and propellane that provides bicyclo[1.1.1]pentane iodides in milligram, gram and even kilogram quantities.

DMPE (14:0 PE), or 1,2-Dimyristoyl-sn-glycero-3-phosphoethanolamine, is a phospholipid. This compound is made up of a glycerol backbone, with two myristoyl fatty acid chains attached. The "14:0" designation denotes that the fatty acid chains are myristoyl, meaning they consist of 14 carbon atoms with no double bonds. This specific phospholipid is of interest in biological and chemical research due to its role in cellular membranes and its potential applications in encapsulation and drug delivery systems. #DMPE #Dimyristoyl #encapsulation #membranes #drug #myristoyl #fatty #acid #chains https://lnkd.in/gKnuc_Sd