Matthew Hayes’ Post

🟢Green urine: causative agents 📍Amitriptyline 📍Doxorubicin 📍Indomethacin 📍Methylene Blue 📍Propofol 📌 What’s the 🦠 that can result in green urine 🤔 ? - 🍏 Green urine can sometimes be caused by certain bacteria that produce pigments or metabolites that can color the urine. 🦠 Here are a few bacteria that have been associated with causing green urine: 🔸Pseudomonas aeruginosa (produce a green pigment called pyocyanin) 🔸Escherichia coli (can produce a pigment called indigo) 🔸Proteus species (produce a pigment called violacein) #MedEd #MedRx #pharmacy #ClinicalPearl #antibiotics #IDTwitter

We are thrilled to share our recent work on the investigation of Rhodium-Promoted C-H Activation/ Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid, which is published in Organic Letters. Rhodium-Promoted C-H Activation/ Annulation between DNA-Linked Terminal Alkyne and Aromatic Acid: A Finding from the Se-lection Outcomes https://lnkd.in/gneS2Vtm In this study, we discovered a specific scenario where utilizing the unique environment of the on-DNA reaction resulted in improved reaction outcomes compared to its off-DNA reaction. Furthermore, our newly developed on-DNA C-H activation/annulation reaction enabled the inclusion of a valuable isocoumarin scaffold in the DNA-encoded library, and obtaining enriched SAR features in selection campaigns with pharmaceutically relevant targets. #DEL #drugdiscovery #research #drugdevelopment

Anti-Biotic & Anti-Malarial I Meropenem I Ampicillin + Cloxacillin I Artemether & lumefantrine https://lnkd.in/gnsnQ386

Anti-Biotic & Anti-Malarial I Meropenem I Ampicillin + Cloxacillin I Artemether & lumefantrine https://lnkd.in/gnsnQ386

check out our latest publication: "A sensitive GC-MS/MS method for the quantification of benzo[a]pyrene tetrol in urine." https://rdcu.be/dAHwi We developed a method for the determination of urinary benzo[a]pyrene tetrol as an alternative to existing #biomarkers for the assessment of the human exposure to benzo[a]pyrene. If you are interested and want to learn more, get in touch! www.abf-lab.com #biomonitoring, #biomarker of exposure

Q: What aspects affect the yield of de novo designed miniproteins when expressed in CHO vs. E. coli? A: The structural stability of miniproteins significantly affects their yield. Miniproteins with proper-folded, stable hydrophobic cores tend to express well in both E. coli and CHO systems. Additionally, E. coli is preferred for miniproteins with free cysteines designed for intracellular function, while CHO cells are better suited for those with disulfide bonds. For miniproteins used as building blocks for bsAbs, CHO is recommended to achieve optimal titers and yields. Want to learn more? Check out the FAQs at the end of our MiniProtein Line Service webpage: ▶️https://lnkd.in/gfZ9Hbd8 #CHOCells #ProteinProduction #BiologicsResearch #DrugDiscovery

"there is no literature data to our knowledge that tests the correlation between changes in cannabinoid content and purple coloration (probably from #anthocyanins) in trichomes, giving this research field a very exciting and unique direction for future experimentally designed studies." 📄Monitoring of #Cannabis Cultivar Technological Maturity by Trichome Morphology Analysis and HPLC Phytocannabinoid Content PharmacognRes-15-1-94.pdf https://lnkd.in/eQDAp2fE .................................................... 🤔Will trichomes that contain pigments in them, have less cannabinoids or aromatic compounds?

Thanks to Allah, Another paper has been published in an ISI-indexed journal, Q1, entitled: Zingiber officinale Uncovered: Integrating Experimental and Computational Approaches to Antibacterial and Phytochemical Profiling Highlights: 1. The Sudanese Zingiber officinale (ginger rhizome) demonstrated varying degrees of antimicrobial activity. 2. Phytochemical screening confirmed the presence of saponins, flavonoids, glycosides, alkaloids, steroids, and terpenoids, with tannins notably absent. 3. GC-MS analysis identified 22 distinct chemical compounds. 4. Molecular docking studies revealed strong binding of ginger compounds to PDB codes 1JIJ and 2QZW, with high affinities reaching −9.5 kcal/mol, aligning with their pharmacokinetic and experimental antibacterial properties. Link: https://lnkd.in/dCwedY6Q #innovation #technology #Future #socialmedia #motivation #health #Eeducation

The comment period just ended for the recent Cannabis Species Inflorescence Proposed Draft Monograph from the USP. The newest proposed monograph tightened the range of THC and CBD to 90 - 110% of the labeled amount. This is in alignment with most drug products but could be a challenge with the inherent variability of plant material. Another change to the monograph is the addition of a second option for microbial limits. The second option has significantly tighter limits for at risk populations such as immunocompromised patients. Not sure if the intent is to label product for different patient populations. Curious to hear thoughts on how this would be implemented! https://lnkd.in/gfGE6F6p

Quantitative cross-species comparison of serum albumin binding of per- and polyfluoroalkyl substances from five structural classes #PFAS https://lnkd.in/ePYcGmct