CatSci Ltd’s Post

Explore our FREE interactive infographic to discover the steps required to advance your molecule to the clinic. #ExcellenceInMedicinesDevelopment #ProudToBeCatSci

The objective of drug development is crystal clear - deliver the drug product to patients in need, ultimately improving the overall quality of life. However, the roadmap of this journey is fraught with many complications and the route cannot be simply thought of as being A --> B! Also, each stage of the clinical pipeline has different demands, such as speed, quality and cost. At CatSci Ltd, we provide phase appropriate solutions to streamline the development of your assets using an integrated approach. I would love to tell you more...

We understand your molecule is going through a unique journey, not only through the #drugdevelopment pipeline but also through the patient. BioIVT serves as a guide on this journey, helping you navigate the right path and understand the steps along the way. We can provide #biospecimens and #contractresearch services specific to your needs to help you understand your compound’s #ADME properties and risk of #DrugInteractions so you can avoid costly pitfalls such as late-stage failure and regulatory roadblocks. Our goal is to arm you with reliable, defendable data, and our in-house experts have been around long enough to understand regulatory expectations and to help you solve unique challenges. Let BioIVT be your resource—for test systems, services, consultancy, or field-specific scientific content—we have it all: https://lnkd.in/eAxMXgNf

We understand your molecule is going through a unique journey, not only through the #drugdevelopment pipeline but also through the patient. BioIVT serves as a guide on this journey, helping you navigate the right path and understand the steps along the way. We can provide #biospecimens and #contractresearch services specific to your needs to help you understand your compound’s #ADME properties and risk of #DrugInteractions so you can avoid costly pitfalls such as late-stage failure and regulatory roadblocks. Our goal is to arm you with reliable, defendable data, and our in-house experts have been around long enough to understand regulatory expectations and to help you solve unique challenges. Let BioIVT be your resource—for test systems, services, consultancy, or field-specific scientific content—we have it all: https://hubs.ly/Q02FyQqV0

Indecisive if you should use SPECT or PET to get first-in-human data? 💭 PET and SPECT each have their own advantages and disadvantages, so the choice between them depends on the specific objectives of your study and your compound. Both methods can generate early in-human data on the dynamics of a drug. To make the comparison yourself, we’ve written a blog about PET and SPECT in clinical trials. Check the link in the comments below:   #molecularmonday #molecularimaging #PET #SPECT #drugdevelopment

Tlag isn’t your only option for modeling absorption delays! Sigmoid absorption, transit compartments, and Weibull absorption can offer more flexibility and better capture progressive drug absorption. 👉 Explore how these approaches work in #MonolixSuite with clear explanations and examples in our documentation: https://lnkd.in/eHeCV9zW ✅ Sigmoid absorption: Combines zero- and first-order processes for a smoother delay. ✅ Transit compartments: Models absorption as a series of intermediate steps. ✅ Weibull absorption: Uses a flexible function to describe time-varying absorption rates. Curious how these methods can improve your models? Check out the guide for mlxtran code and step-by-step instructions! #SimulationsPlus #Pharmacokinetics #ModelingAndSimulation #Monolix

Are you struggling with a backlog of seized drugs awaiting analysis? RADIAN ASAP could be the answer to your problems. This compact, fast, and highly specific device is designed for rapid drug screening. RADIAN ASAP is user-friendly, making it easy for operators with no mass spectrometry experience to use it effectively without extensive training. With minimal sample preparation, you can begin analysis quickly by simply dipping a glass capillary into the sample. Achieve analysis in under a minute using the 'dipping' method, significantly reducing backlog. RADIAN ASAP features full scan MS and multiple cone voltages for detailed spectral analysis, with real-time library matching via LiveID 2.0, ensuring high specificity and accuracy. In a recent study, RADIAN ASAP was instrumental in processing numerous samples from various crime scenes, providing crucial data in real-time that matched well with high-resolution MS confirmatory tests. This swift analysis supports more efficient public safety measures and legal processes. If you've encountered bottlenecks in your drug analysis workflow, immediate and accurate results are crucial for your operations. Share your experiences and let's discuss how RADIAN ASAP can address your challenges. Contact [email protected] to learn more. #WatersCorporation #ForensicScience #DrugAnalysis #PublicSafety #ForensicTechnology #DrugEnforcement #SeizedDrugs #RapidTesting

🔬 Revolutionize Your Drug Analysis with ADME-Tox™! 🔬 Are you overlooking crucial properties that could optimize your drug development process?  Dive deeper with ADME-Tox™! This powerful module allows you to predict and analyze ADME (Absorption, Distribution, Metabolism, Excretion) and toxicity properties of chemical compounds with unmatched accuracy. Easily connect it with your completed AI Doc modules, select your desired compounds, and quickly receive detailed predictions. Customize your analysis with insights into physicochemical properties, medicinal chemistry, ADME & toxicity—all in one place. From detailed substructure searches to direct SMILES string uploads, ADME-Tox™ equips you with the tools to streamline your workflow and make data-driven decisions faster. Don’t compromise on quality—enhance your drug discovery process with ADME-Tox™ today! Watch the video for more details! 🔗 https://lnkd.in/er9Jhkhb #ADMETox #DrugDiscovery #MolecularPrediction #PharmacoNet #YouTube #CALICI 

Clinical In-Use (CIU) studies are typically conducted during biotherapeutic development to assess the stability and compatibility of the biological product with administration components and/or diluents. These studies simulate product use in clinical practice, generating experimental data to ensure patient safety and product efficacy during administration. Our Clinical In-Use Center of Excellence (CIU CoE) offers comprehensive services, including customized study design for multiple administration routes, analytical testing across a wide dosing range from ng to mg, an extensive inventory of diverse CIU consumables, and global support for IND & BLA filings. https://lnkd.in/eUQJugYB #drugproducts #drugformulation #drugproductdevelopment

Access Our Application Note: https://hubs.li/Q02-ZfM50 Identifying stable polymorphs is vital for ensuring drug efficacy, stability, and manufacturability. Our XtalGazer™ CSP platform predicts all stable forms and mitigates transition risks to support robust drug development. Recently, our team successfully evaluated the relative stability of Forms A, B, and C of a targeted API across temperatures and determined the crystal structure of Form C—delivering results in just 8 weeks to de-risk the critical solid form selection process. Our Approach: - Predicted low-energy polymorphs including Forms A, B, and C using our high-accuracy CSP platform. - Determined Form C’s crystal structure using CSP and validated the predicted structure with our proprietary XRPD indexing algorithm. - Evaluated free energy trends and transition temperatures for low-risk solid form selection. #polymorphscreening #crystalstructureprediction #drugdevelopment