Analytical Services International’s Post

With limited data in the literature for the interpretation of #bloodconcentrations of #etizolam in post-mortem cases, this study was published: Femoral blood concentrations of the designer #benzodiazepine etizolam in post-mortem cases. Hikin LJ, Smith PR, Maskell PD, Kurimbokus H, Ashong E, Couchman L, Morley SR. This publication explores that with a liquid #chromatography with tandem #massspectrometry method, the data from this study will further help forensic practitioners interpret post-mortem etizolam concentrations. 📄 Read the study: https://ow.ly/ioVx50PRb1W #academicresearch #drugdiscovery #drugresearch #druglegislation #healthresearch

I am very delighted to share that our research work on Hypervalent Iodine-based Macrocycles(HIMs) has been published in ACS, Journal of Organic Chemistry. In this work, we have demonstrated the dynamic nature of bonding in Hypervalent Iodine Macrocycles by investigating the methods to disassemble and reassemble the supramolecular structures through the addition and removal of anions such as chloride, bromide, fluoride, and cyanide. We have also probed the dynamic nature of macrocycles in solution even in the absence of anions through heterogenous mixing of two different macrocycles based on secondary bonding whereby monomers of macrocycles are free to mix with neighboring macrocycles leading to the formation of shuffled macrocycles. Furthermore, we have also explored the synthesis, crystallographic structure, kinetics, and unique reversibility of these HIMs system. I extend my heartfelt gratitude to my supervisor Professor Kyle and everyone for their heavy contributions. https://lnkd.in/ecyp9q6n

A Tutorial Review Small Lectin Ligands as a Basis for Applications in Glycoscience and Glycomedicine. https://lnkd.in/eyGDspCd

Heterobifunctional degraders are often challenged by their DMPK property space, but with the right expertise and cascades, these challenges can be assessed, understood and overcome... Read more around the latest DMPK thinking in the bR05 space in our recent book chapter!

"𝐓𝐫𝐚𝐧𝐬𝐟𝐞𝐜𝐭𝐢𝐨𝐧 𝐢𝐦𝐩𝐫𝐨𝐯𝐞𝐦𝐞𝐧𝐭 𝐛𝐲 𝐨𝐫𝐝𝐞𝐫𝐬 𝐨𝐟 𝐦𝐚𝐠𝐧𝐢𝐭𝐮𝐝𝐞" Thats catchy - here is a rundown: 𝐈 𝐚𝐦 𝐬𝐭𝐢𝐥𝐥 𝐝𝐢𝐠𝐞𝐬𝐭𝐢𝐧𝐠 𝐭𝐡𝐢𝐬 𝐩𝐫𝐞𝐩𝐫𝐢𝐧𝐭. 𝐖𝐨𝐮𝐥𝐝 𝐦𝐮𝐥𝐭𝐢-𝐬𝐭𝐚𝐠𝐞 𝐦𝐢𝐱𝐢𝐧𝐠 + 𝐜𝐆𝐀𝐒-𝐒𝐓𝐈𝐍𝐆 𝐢𝐧𝐡𝐢𝐛𝐢𝐭𝐢𝐨𝐧 𝐫𝐞𝐬𝐨𝐥𝐯𝐞 #LNP/ #pDNA 𝐭𝐨𝐱𝐢𝐜𝐢𝐭𝐲 𝐚𝐧𝐝 𝐥𝐨𝐰 𝐭𝐫𝐚𝐧𝐬𝐟𝐞𝐜𝐭𝐢𝐨𝐧 𝐞𝐟𝐟𝐢𝐜𝐢𝐞𝐧𝐜𝐲? Have a look for yourself - the team from University of Pennsylvania Perelman School of Medicine around Jacob S. Brenner and Zhicheng Wang took several approaches to improve on the outcome of pDNA/LNP transfection. Here is a link to the PDF: https://lnkd.in/d4r2X7Ur Two companies coming to mind that use 𝐃𝐍𝐀 𝐚𝐬 𝐭𝐡𝐞 𝐋𝐍𝐏 𝐜𝐚𝐫𝐠𝐨 are Generation Bio and Rampart Bioscience - I'd be intersted to see if they gave this new mixing method a shot: ➡️with or without the 𝐒𝐓𝐈𝐍𝐆 inhibitor ➡️with or without 4 𝐦𝐌 𝐌𝐠𝐂𝐥2, where Mg2+ enables compactation of the DNA ➡️with or without the 𝐛𝐮𝐟𝐟𝐞𝐫 𝐚𝐝𝐣𝐮𝐬𝐭𝐦𝐞𝐧𝐭𝐬 𝐝𝐮𝐫𝐢𝐧𝐠 𝐦𝐢𝐱𝐢𝐧𝐠 (citrate vs TRIS-based buffers) Congrats to all authors for pulling this together: Jia Nong, Xijing Gong, Quang Minh Dang, Sachchidanand Tiwari, Ph.D., Manthan Patel, Jichuan Wu, Andrew Hanna, Wook-Jin Park, Elena N. Atochina-Vasserman, Hui-Ting Huang, Oscar A. Marcos-Contreras, , Morris-Blanco, PhD, Jonathan J. Miner, Drew Weissman, Vladimir Muzykantov, Kushol Gupta, David Issadore, Jacob Myerson, Zhicheng Wang, Jacob S. Brenner

SiriSree's New Clear NMMIT Service NCCN, ACR and SNMMI guidelines, AU Criteria, AJCC TNM classification, PERCIST criteria oriented 18F-FDG Metabolic iTNM Scintigraphy Synoptic Report Templates 

Excited to share that the very first paper of my PhD journey has just been published in Angewandte Chemie IE! Grateful for the invaluable guidance and support from my colleague Dr. Nikolaos Kaplaneris and my supervisor Prof. Timothy Noel throughout the journey. Looking forward to reaching more milestones together! 🎉 #PhD #AngewandteChemie #peptides #flowchemistry

A very interesting paper (may more suitble for Friday 😅 ) from Prof. Pukala and others. Using top-down method to analysis snack venom proteofrom. To increse sequence coverage, they used MSE and target CID (on Xevo GS XS), CID, ECD, ion moblity seperatoin and post-cIM CID (on SELECT SERIES cIM ToF). I can expect that ECD is helpful to increase coverage, but post-cIM CID can also help is a suprise~.

Molecular dynamics…..

Nice work by Nathan Colwell et al at University of Oklahoma on demonstrating the ability of DESI to achieve single-cell resolution using the Waters DESI XS platform. The paper is available on ChemRxiv and can be found here; https://lnkd.in/gNh7H3y8 #msi #DESI #singlecellmetabolomics