“Naveen is exceptionally bright, and self-motivated, with a unique breadth of knowledge in both hardware and software. He is one of the most productive engineers that I know and a pleasure to work with.”
About
Neuroscientist, AI perpetrator, processor architect , entrepreneur, and…
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Always a pleasure to see the Jamjoom brothers. Mohammed and Yousuf are working on building a great company - Juleb - Digital Pharma Company - as an…
Always a pleasure to see the Jamjoom brothers. Mohammed and Yousuf are working on building a great company - Juleb - Digital Pharma Company - as an…
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At our Goldman Sachs Communacopia + Technology conference last week, I had the opportunity to discuss the evolving landscape of #AI with three…
At our Goldman Sachs Communacopia + Technology conference last week, I had the opportunity to discuss the evolving landscape of #AI with three…
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Even the best deep tech companies didn’t get it right the first time What they did get right was articulate and communicate a compelling vision…
Even the best deep tech companies didn’t get it right the first time What they did get right was articulate and communicate a compelling vision…
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Experience
Education
Publications
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Population Interactions Between Parietal and Primary Motor Cortices During Reach
Journal of neurophysiology
Interactions between parietal cortex (Brodmann area 2/5) and primary motor cortex (M1) appear to coordinate sensorimotor computations during goal-directed reach. Revealing these interareal interactions has been challenging. Here, we address this problem by using three complimentary approaches: partial spike-field coherence (PSFC) between single neurons in area 2/5 and single M1 LFP channels, PSFC between an ensemble of neurons in area 2/5 and single M1 LFPs, and linear prediction of M1 LFP…
Interactions between parietal cortex (Brodmann area 2/5) and primary motor cortex (M1) appear to coordinate sensorimotor computations during goal-directed reach. Revealing these interareal interactions has been challenging. Here, we address this problem by using three complimentary approaches: partial spike-field coherence (PSFC) between single neurons in area 2/5 and single M1 LFP channels, PSFC between an ensemble of neurons in area 2/5 and single M1 LFPs, and linear prediction of M1 LFP based on area 2/5 spiking. Neural activity in area 2/5 and M1 was simultaneously recorded using chronically implanted 96 channel microelectrode arrays. Spectral analysis from three rhesus monkeys performing a center-out, step-tracking reach task revealed three M1 LFP bands: low, medium, and high, that modulated between movement preparation and performance. We focus on the low-frequency band (1-10 Hz) containing the motor event-related potential (mERP), in which PSFC was strongest. PSFC in this range typically rose just before movement onset and peaked ~500 ms afterwards. Linear prediction of M1 LFP and a temporal-offset shifting analysis suggest that this PSFC reflects parietal input, which occurs after movement onset. PSFC was typically stronger for the subsets of area 2/5 neurons and M1 LFPs with similar directional tuning compared to those with opposite tuning, indicating that area 2/5 contributes movement direction information after movement begins. Taken together, the results of these approaches indicate that a subset of 2/5 neurons are dynamically coupled to M1 as movement evolves; this population provides M1 with reach-related information about evolving movement direction.
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Failure mode analysis of silicon-based intracortical microelectrode arrays in non-human primates
Journal of Neural Engineering
Objective. Brain–computer interfaces (BCIs) using chronically implanted intracortical microelectrode arrays (MEAs) have the potential to restore lost function to people with disabilities if they work reliably for years. Current sensors fail to provide reliably useful signals over extended periods of time for reasons that are not clear. This study reports a comprehensive retrospective analysis from a large set of implants of a single type of intracortical MEA in a single species, with a common…
Objective. Brain–computer interfaces (BCIs) using chronically implanted intracortical microelectrode arrays (MEAs) have the potential to restore lost function to people with disabilities if they work reliably for years. Current sensors fail to provide reliably useful signals over extended periods of time for reasons that are not clear. This study reports a comprehensive retrospective analysis from a large set of implants of a single type of intracortical MEA in a single species, with a common set of measures in order to evaluate failure modes. Approach. Since 1996, 78 silicon MEAs were implanted in 27 monkeys (Macaca mulatta). We used two approaches to find reasons for sensor failure. First, we classified the time course leading up to complete recording failure as acute (abrupt) or chronic (progressive). Second, we evaluated the quality of electrode recordings over time based on signal features and electrode impedance. Failure modes were divided into four categories: biological, material, mechanical, and unknown. Main results. Recording duration ranged from 0 to 2104 days (5.75 years), with a mean of 387 days and a median of 182 days (n = 78). Sixty-two arrays failed completely with a mean time to failure of 332 days (median = 133 days) while nine array experiments were electively terminated for experimental reasons (mean = 486 days). Seven remained active at the close of this study (mean = 753 days). Most failures (56%) occurred within a year of implantation, with acute mechanical failures the most common class (48%), largely because of connector issues (83%). Among grossly observable biological failures (24%), a progressive meningeal reaction that separated the array from the parenchyma was most prevalent (14.5%). In the absence of acute interruptions, electrode recordings showed a slow progressive decline in spike amplitude, noise amplitude, and number of viable channels that predicts complete signal loss by about eight years...
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Cue to Action Processing in Motor Cortex Populations
J Neurophysiol
The primary motor cortex (MI) commands motor output after kinematics are planned from goals, thought to occur in a larger premotor network. However, there is a growing body of evidence that MI is involved in processes beyond action generation and neuronal sub-populations may perform computations related to cue-to-action processing. Using multi-electrode array recordings in awake behaving Macaca Mulatta monkeys our results suggest that early MI ensemble activity during goal-directed reaches is…
The primary motor cortex (MI) commands motor output after kinematics are planned from goals, thought to occur in a larger premotor network. However, there is a growing body of evidence that MI is involved in processes beyond action generation and neuronal sub-populations may perform computations related to cue-to-action processing. Using multi-electrode array recordings in awake behaving Macaca Mulatta monkeys our results suggest that early MI ensemble activity during goal-directed reaches is driven by target information when cues are closely linked in time to action. Single neuron activity spanned cue presentation to movement, with the earliest responses temporally aligned to cue and the later responses better aligned to arm movements. Population decoding revealed that MI's coding of cue direction evolved temporally, likely going from cue to action generation. We confirmed that a portion of MI activity is related to visual target processing by showing changes in MI activity related to the extinguishing of a continuously pursued visual target. These findings support a view that MI is an integral part of a cue-to-action network for immediate responses to environmental stimuli.
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Simultaneous reconstruction of continuous hand movements from primary motor and posterior parietal cortex
Experimental Brain Research
Primary motor cortex (MI) and parietal area PE both participate in cortical control of reaching actions, but few studies have been able to directly compare the form of kinematic encoding in the two areas simultaneously during hand tracking movements. To directly compare kinematic coding properties in these two areas under identical behavioral conditions, we recorded simultaneously from two chronically implanted multielectrode arrays in areas MI and PE (or areas 2/5) during performance of a…
Primary motor cortex (MI) and parietal area PE both participate in cortical control of reaching actions, but few studies have been able to directly compare the form of kinematic encoding in the two areas simultaneously during hand tracking movements. To directly compare kinematic coding properties in these two areas under identical behavioral conditions, we recorded simultaneously from two chronically implanted multielectrode arrays in areas MI and PE (or areas 2/5) during performance of a continuous manual tracking task. Monkeys manually pursued a continuously moving target that followed a series of straight-line movement segments, arranged in a sequence where the direction (but not length) of the upcoming segment varied unpredictably as each new segment appeared. Based on recordings from populations of MI (31–143 units) and PE (22–87 units), we compared hand position and velocity reconstructions based on linear filters. We successfully reconstructed hand position and velocity from area PE (mean r 2 = 0.751 for position reconstruction, r 2 = 0.614 for velocity), demonstrating trajectory reconstruction from each area. Combing these populations provided no reconstruction improvements, suggesting that kinematic representations in MI and PE encode overlapping hand movement information, rather than complementary or unique representations. These overlapping representations may reflect the areas’ common engagement in a sensorimotor feedback loop for error signals and movement goals, as required by a task with continuous, time-evolving demands and feedback. The similarity of information in both areas suggests that either area might provide a suitable target to obtain control signals for brain computer interface applications.
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It is with mixed emotions that after 9 years, I am taking a voluntary separation package and departing from Intel on Sept 30th. It has been a dream…
It is with mixed emotions that after 9 years, I am taking a voluntary separation package and departing from Intel on Sept 30th. It has been a dream…
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Next stop on the Databricks Data+AI World Tour: New York! Thousands of dedicated customers, partners, Bricksters, and influencers descended on the…
Next stop on the Databricks Data+AI World Tour: New York! Thousands of dedicated customers, partners, Bricksters, and influencers descended on the…
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Amazing day yesterday at Databricks World Tour NYC!! 🔥🔥🚀🚀
Amazing day yesterday at Databricks World Tour NYC!! 🔥🔥🚀🚀
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