Alex Shaw

Alex Shaw

San Diego, California, United States
3K followers 500+ connections

About

Med Info and Scientific Communications lead for Acadia products. Experiences include…

Activity

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Experience

  • Acadia Pharmaceuticals Inc. Graphic
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    Greater Boston Area

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    Washington D.C. Metro Area

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    Ann Arbor, MI

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    Ann Arbor, MI

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    Fort Lauderdale, Florida

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    Hilo, HI

Education

Publications

  • In Vitro Ceftolozane/Tazobactam Clearance During Continuous Renal Replacement Therapy

    Blood Purification

  • In Silico Trials Using Monte Carlo Simulation to Evaluate Ciprofloxacin and Levofloxacin Dosing in Critically Ill Patients Receiving Prolonged Intermittent Renal Replacement Therapy

    Renal Replacement Therapies

  • We Underdose Antibiotics in Patients on CRRT

    Seminars in Dialysis

  • A Comparison of Different Dialysate Phosphate Supplementation Approaches for Continuous Renal Replacement Therapy

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    In preparation

  • Comparison of Pharmacy Department Time-Motion Activities for Preparation of the Commercially-Available CRRT solutions

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    Submitted 2017

  • Influence of Effluent Rate on Antibiotic Pharmacodynamic Target Attainment Rates in Patients Receiving CRRT: Does effluent flow matter?

    Advances in Chronic Kidney Disease

    Submitted 2017

Projects

  • Clinical Validation of Dosing Recommendations for Patients Receiving Renal Replacement Therapy Made By Monte Carlo Simulations

    - Present

    Project description: To determine if the dosing recommendations made by Monte Carlo simulation attain pharmacokinetic goals
    Role: Clinical trial design, protocol development, creation of case report forms, drafting informed consent forms, pharmacokinetic sampling protocol and multicenter grant writing, IRB writing

  • Establishing the Time Needed to Compound Antiemetic Medications

    Project description: investigation into the time to prepare an antiemetic medication and quantification of supplies used.
    Role: Conduct of study and manuscript preparation

  • Monte Carlo Simulation of Antibiotic Dosing in Continuous Renal Replacement Therapy

    - Present

    Project description: To evaluate the probability of target attainment in patients receiving CRRT
    Role: In-Silico study design, conduct of study, data analysis and manuscript preparation

  • Ex-Vivo Regadenoson Clearance During Hemodialysis

    Project description: To determine the clearance of regadenoson under varying dialytic conditions
    Role: Conduct of study and data analysis

  • Ex-Vivo Ceftolozane/Tazobactam Clearance During CRRT

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    Project description: To determine transmembrane clearances and to develop optimal dosing regimens for patients receiving CRRT
    Role: Conduct of study, data analysis, manuscript preparation and submission

  • A Comparison of Two Different Dialysate Phosphate Supplementation Approaches

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    Project description: Investigation into the effects of two different approaches to phosphate supplementation in patients undergoing CRRT
    Role: Clinical trial protocol development, IRB submission, study design, creation of case report forms, conduct of study, safety and adverse event screening, data management, data analysis and manuscript preparation

  • Monte Carlo Simulation of Antibiotic Dosing in SHIFT Dialysis

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    Project description: To evaluate the probability of target attainment and to formulate dosing recommendations for critically ill patients receiving extended daily hemodialysis (SHIFT)
    Role: Conduct of study, data analysis and manuscript preparation

  • Stability of Investigational Drugs in Dialysate

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    Project description: To determine the stability of two drugs in dialysate base concentrate and formed dialysate
    Role: Protocol development, study design, conduct of study and creating project reports

  • Telavancin Pharmacokinetics in Patients Receiving Hemodialysis

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    Project description: to characterize the pharmacokinetics of telavancin in chronic kidney disease stage 5 patients and to determine the extent of dialytic removal and necessity of dosage adjustment
    Role: Conduct of study, patient recruitment/obtaining informed consent, evaluation of adverse events, pharmacokinetic data analysis, and submitting required documentation to clinicaltrials.gov

  • Comparison of Pharmacy Department Time-Motion Activities for Preparation of Continuous Renal Replacement Therapy (CRRT) Solutions

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    Project description: Investigation into all economic costs associated with CRRT solutions from a pharmacy department perspective

    Role: Successful submission of a grant application, protocol development, conduct of study, data analysis, presentation of data at national meetings, manuscript preparation and submission

Honors & Awards

  • CD-101 Clearance During Continuous Renal Replacement Therapy and Intermittent Hemodialysis: an Ex vivo Investigation.

    Cidara Therapeutics

    Co-PIs: Soo Min Jang, Alexander Shaw, Bruce A. Mueller. Sponsor: Cidara Therapeutics.
    (Submitted 2017)

  • Clinical Validation of Recommended Antibiotic Dosing Regimens in Patients Receiving SHIFT Dialysis

    NxStage

    Co-PIs: Alexander Shaw, Bruce A. Mueller.
    (Submitted 2017)

  • Imipenem-Relebactam Clearance by Ex Vivo Renal Replacement Therapies.

    Merck

    C0-PIs: Alexander Shaw, Soo Min Jang, Bruce A. Mueller.
    (Submitted 2017)

  • Fellow in Training Registration Grant.

    Acute Kidney Injury & Continuous Renal Replacement Therapy Annual Meeting

    Awarded by the AKI & CRRT annual meeting for a platform presentation and poster presentations.

  • Time motion study of CRRT solution preparation.

    Baxter

    Successfully funded investigator initiated grant application.
    C0-PIs: Alexander Shaw, Bruce A.

  • Intradialytic Telavancin Administration in Chronic Hemodialysis Patients.

    Theravance Pharmaceuticals

    Co-PIs: Soo Min Jang, Alexander Shaw, Bruce A. Mueller.
    (Submitted 2016)

  • Research in Pharmaceutical Sciences Award

    Nova Southeastern University College of Pharmacy

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