About
Med Info and Scientific Communications lead for Acadia products. Experiences include…
Activity
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I am happy to share that I started a new role in the Clinical Safety Sciences team at Genentech / Roche. This is an overdue post as I wanted to take…
I am happy to share that I started a new role in the Clinical Safety Sciences team at Genentech / Roche. This is an overdue post as I wanted to take…
Liked by Alex Shaw
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Today we announced that Health Canada has granted marketing authorization for our #RettSyndrome treatment, the first and only drug approved in Canada…
Today we announced that Health Canada has granted marketing authorization for our #RettSyndrome treatment, the first and only drug approved in Canada…
Liked by Alex Shaw
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Hi All, I am delighted to let everyone know that I am now at X4 pharmaceuticals as Head of Medical Affairs!
Hi All, I am delighted to let everyone know that I am now at X4 pharmaceuticals as Head of Medical Affairs!
Liked by Alex Shaw
Experience
Education
Publications
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In Vitro Ceftolozane/Tazobactam Clearance During Continuous Renal Replacement Therapy
Blood Purification
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In Silico Trials Using Monte Carlo Simulation to Evaluate Ciprofloxacin and Levofloxacin Dosing in Critically Ill Patients Receiving Prolonged Intermittent Renal Replacement Therapy
Renal Replacement Therapies
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We Underdose Antibiotics in Patients on CRRT
Seminars in Dialysis
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A Comparison of Different Dialysate Phosphate Supplementation Approaches for Continuous Renal Replacement Therapy
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In preparation
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Comparison of Pharmacy Department Time-Motion Activities for Preparation of the Commercially-Available CRRT solutions
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Submitted 2017
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Influence of Effluent Rate on Antibiotic Pharmacodynamic Target Attainment Rates in Patients Receiving CRRT: Does effluent flow matter?
Advances in Chronic Kidney Disease
Submitted 2017
Projects
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Clinical Validation of Dosing Recommendations for Patients Receiving Renal Replacement Therapy Made By Monte Carlo Simulations
- Present
Project description: To determine if the dosing recommendations made by Monte Carlo simulation attain pharmacokinetic goals
Role: Clinical trial design, protocol development, creation of case report forms, drafting informed consent forms, pharmacokinetic sampling protocol and multicenter grant writing, IRB writing
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Establishing the Time Needed to Compound Antiemetic Medications
Project description: investigation into the time to prepare an antiemetic medication and quantification of supplies used.
Role: Conduct of study and manuscript preparation
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Monte Carlo Simulation of Antibiotic Dosing in Continuous Renal Replacement Therapy
- Present
Project description: To evaluate the probability of target attainment in patients receiving CRRT
Role: In-Silico study design, conduct of study, data analysis and manuscript preparation -
Ex-Vivo Regadenoson Clearance During Hemodialysis
Project description: To determine the clearance of regadenoson under varying dialytic conditions
Role: Conduct of study and data analysis
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Ex-Vivo Ceftolozane/Tazobactam Clearance During CRRT
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Project description: To determine transmembrane clearances and to develop optimal dosing regimens for patients receiving CRRT
Role: Conduct of study, data analysis, manuscript preparation and submission
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A Comparison of Two Different Dialysate Phosphate Supplementation Approaches
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Project description: Investigation into the effects of two different approaches to phosphate supplementation in patients undergoing CRRT
Role: Clinical trial protocol development, IRB submission, study design, creation of case report forms, conduct of study, safety and adverse event screening, data management, data analysis and manuscript preparation
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Monte Carlo Simulation of Antibiotic Dosing in SHIFT Dialysis
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Project description: To evaluate the probability of target attainment and to formulate dosing recommendations for critically ill patients receiving extended daily hemodialysis (SHIFT)
Role: Conduct of study, data analysis and manuscript preparation
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Stability of Investigational Drugs in Dialysate
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Project description: To determine the stability of two drugs in dialysate base concentrate and formed dialysate
Role: Protocol development, study design, conduct of study and creating project reports
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Telavancin Pharmacokinetics in Patients Receiving Hemodialysis
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Project description: to characterize the pharmacokinetics of telavancin in chronic kidney disease stage 5 patients and to determine the extent of dialytic removal and necessity of dosage adjustment
Role: Conduct of study, patient recruitment/obtaining informed consent, evaluation of adverse events, pharmacokinetic data analysis, and submitting required documentation to clinicaltrials.gov
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Comparison of Pharmacy Department Time-Motion Activities for Preparation of Continuous Renal Replacement Therapy (CRRT) Solutions
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Project description: Investigation into all economic costs associated with CRRT solutions from a pharmacy department perspective
Role: Successful submission of a grant application, protocol development, conduct of study, data analysis, presentation of data at national meetings, manuscript preparation and submission
Honors & Awards
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CD-101 Clearance During Continuous Renal Replacement Therapy and Intermittent Hemodialysis: an Ex vivo Investigation.
Cidara Therapeutics
Co-PIs: Soo Min Jang, Alexander Shaw, Bruce A. Mueller. Sponsor: Cidara Therapeutics.
(Submitted 2017) -
Clinical Validation of Recommended Antibiotic Dosing Regimens in Patients Receiving SHIFT Dialysis
NxStage
Co-PIs: Alexander Shaw, Bruce A. Mueller.
(Submitted 2017) -
Imipenem-Relebactam Clearance by Ex Vivo Renal Replacement Therapies.
Merck
C0-PIs: Alexander Shaw, Soo Min Jang, Bruce A. Mueller.
(Submitted 2017) -
Fellow in Training Registration Grant.
Acute Kidney Injury & Continuous Renal Replacement Therapy Annual Meeting
Awarded by the AKI & CRRT annual meeting for a platform presentation and poster presentations.
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Time motion study of CRRT solution preparation.
Baxter
Successfully funded investigator initiated grant application.
C0-PIs: Alexander Shaw, Bruce A. -
Intradialytic Telavancin Administration in Chronic Hemodialysis Patients.
Theravance Pharmaceuticals
Co-PIs: Soo Min Jang, Alexander Shaw, Bruce A. Mueller.
(Submitted 2016) -
Research in Pharmaceutical Sciences Award
Nova Southeastern University College of Pharmacy
More activity by Alex
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I’m excited to announce a key opportunity at Viridian Therapeutics! We are hiring a Vice President, Regulatory CMC. If you have a strong background…
I’m excited to announce a key opportunity at Viridian Therapeutics! We are hiring a Vice President, Regulatory CMC. If you have a strong background…
Liked by Alex Shaw
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Ana Maria Castejon, Ph.D. associate dean graduate programs was selected to join the 21st cohort of the Academic Leadership Fellows Program (ALFP)…
Ana Maria Castejon, Ph.D. associate dean graduate programs was selected to join the 21st cohort of the Academic Leadership Fellows Program (ALFP)…
Liked by Alex Shaw
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We are #hiring for AD Medical Information and Review. Come work with our great team here at Acadia! Know anyone who might be interested? Let me know!…
We are #hiring for AD Medical Information and Review. Come work with our great team here at Acadia! Know anyone who might be interested? Let me know!…
Shared by Alex Shaw
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A Day in the Life of a Founder: The Ordinary Grind for an Extraordinary Vision Every day as a founder starts the same way: early mornings, getting…
A Day in the Life of a Founder: The Ordinary Grind for an Extraordinary Vision Every day as a founder starts the same way: early mornings, getting…
Liked by Alex Shaw
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Reaching out to my network of MSLs, MSL Managers, Sales Reps, Sales Managers, and MSL/Sales Trainers. Please take a moment to fill out this quick…
Reaching out to my network of MSLs, MSL Managers, Sales Reps, Sales Managers, and MSL/Sales Trainers. Please take a moment to fill out this quick…
Shared by Alex Shaw
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Today our systematic review and meta-analysis examining the "Acute Adverse Effects of Therapeutic Doses of Psilocybin," was published and accessible…
Today our systematic review and meta-analysis examining the "Acute Adverse Effects of Therapeutic Doses of Psilocybin," was published and accessible…
Liked by Alex Shaw
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