Comanche Biopharma

Thanks to Dr David Cox for interviewing Comanche scientific co-founder and chair of our Scientific Advisory Board, Craig Mello, Ph.D., our Chief Medical Officer Allison August, M.D., and our board member Allyson Felix for this important BBC article highlighting the devastating impact of preeclampsia on pregnant women and their babies, and the urgent unmet medical need it represents globally.  The article captures Allyson’s personal experience with preeclampsia and explores recent progress identifying root causes of the condition, including elevated levels of the protein sFlt1. The article also discusses the availability of an FDA-approved blood test that aids care providers in the clinical management of women diagnosed with preeclampsia, and Comanche’s investigational siRNA, CBP-4888, which is being studied to reduce excess sFlt1 production in the placenta. https://lnkd.in/eDHvtQm8 #preeclampsia #pregnancy #MaternalHealth

This webinar features the CEOs of Comanche Biopharma and Gameto, two startups that raised large financing rounds in 2024 to bring breakthrough innovations to Women’s Health. ► Register here: https://lnkd.in/d5Xe5aKj

Congratulations to our Chief Medical Officer Allison August, M.D. for being featured by Endpoints News in its Women in Biopharma 2024 Special Report, which highlights 20 women who are breaking new ground in #biopharma R&D. Our mission at Comanche is to develop and make globally available the first treatment targeting a root cause of preeclampsia. As CMO, Allison is overseeing the clinical development of CBP-4888, our investigational #siRNA therapy that targets an underlying cause of preeclampsia, overproduction of the protein sFlt1 in the placenta. Allison brings a unique blend of maternal health expertise as an obstetrician-gynecologist, robust clinical development experience, profound intellect, inspiring leadership, incredible grit, and unwavering compassion for patients. We are so honored to work with her every day! Read more about Allison and the other trailblazing women in biopharma R&D featured in this year's report: https://bit.ly/3BBC7dA #MaternalHealth #preeclampsia

We honor the legacy of physician-scientist Dr. Mildred Thornton Stahlman, a pioneering Vanderbilt University pediatrician whose groundbreaking work in the treatment of neonatal respiratory lung disease became the basis of the modern neonatal intensive care unit. Her dedication to science, to her patients and their families, and to increasing an appreciation of the ethical issues in the care of premature infants has provided continuing benefit to pediatric care. Read more about Dr. Stahlman in this The New York Times article: https://bit.ly/45NlIxA

We're delighted to see innovation in the detection of preeclampsia, a critical maternal health issue. This The Associated Press article by Laura Ungar highlights new blood-based biomarker tests that promise early detection for expecting mothers. Article link: https://bit.ly/4biuRQ2 #preeclampsia #MaternalHealth #pregnancy

To mark the end of Preeclampsia Awareness Month, we're honored to share a 'Preeclampsia Champions of Change' Q&A interview with Candice Privott, a Patient Advocate with Beth Israel Deaconess Medical Center and a member of Comanche's Patient Advisory Board. Candice developed preeclampsia in her first pregnancy, which ended in the devastating loss of her first son, who was stillborn. Under the care of a Maternal-Fetal Medicine specialist in her subsequent pregnancy, in which she also developed preeclampsia, Candice safely delivered her second son, Grayson. She decided to channel her personal experiences into advocacy. In this Q&A Candice discusses her journey and her work advocating for better education, communication, and care to help ensure that no woman feels unprepared and unsupported during pregnancy. Read the Q&A with Candice here: https://bit.ly/3X3iQdV It's been an honor to hear and share the inspiring stories of several members of our Patient Advisory Board this month. We look forward to sharing additional stories from our Patient Advisors in the coming months. Photo: Candice at the birth of her son Grayson. #preeclampsia #maternalhealth #pregnancy #maternalequity #PatientAdvocate #PreAM24

This week, in our 'Preeclampsia Champions of Change' series we feature a Q&A with Melissa J. Moore, Ph.D., Chief Scientific Officer Emerita, Moderna, and Professor, RNA Therapeutics Institute at UMass Chan Medical School, who is a Scientific Co-Founder of Comanche Biopharma, as well as a member of our Scientific Advisory Board. A preeclampsia survivor herself, Melissa is also a member of Comanche's Patient Advisory Board. In the Q&A, Melissa describes her personal experience with #preeclampsia and how it impacted her both personally and professionally. She shares the serendipitous story behind the discovery and development of an investigational #siRNA therapeutic for preeclampsia and explains why this project has been such a pivotal endeavor for her. Read the Q&A here: https://bit.ly/3x4yLOe #pregnancy #maternalhealth #RNA

On #WorldPreeclampsiaDay, we recognize the pioneering research being conducted by physicians and scientists, including Sarosh Rana, MD, MPH, and her colleagues at The Rana Preeclampsia Laboratory at University of Chicago, to better understand and treat #preeclampsia to improve outcomes for pregnant women and their babies in the US and globally. Read more about the Rana Preeclampsia Laboratory's mission and work here: https://bit.ly/4dSuJZV

Today, as part of our ongoing Preeclampsia Champions of Change series and in honor of #WorldPreeclampsiaDay we feature a Q&A with Kara Boeldt, Founder and Director of Endpreeclampsia.org, a group who seeks to make an impact in education, advocacy, and support. We’re also honored to have Kara serve as a member of Comanche’s Patient Advisory Board. Kara experienced liver failure, kidney failure, and cerebral edema due to severe #preeclampsia at 31 weeks gestation, resulting in the emergent delivery of her daughter. She ultimately transformed this traumatic personal experience with preeclampsia into an opportunity to help others. Kara decided to build a supportive community to help people navigate through this time of often heightened uncertainty and anxiety, giving them a safe place to share their concerns, frustrations, and grief, and to ask questions of trained peer-educators. Today, this community has over 50,000 members in 115 countries. Read more about Kara’s inspiring story: https://bit.ly/3UUX6xY Photo: Kara with her daughter, born at 31 weeks and weighing just 2.5 pounds. #maternalhealth #patientadvocacy #advocacy #pregnancy

Please take a moment to read Monica's heart-wrenching journey with preeclampsia, a condition that I too experienced. Each story, like Monica’s, deepens my commitment to defeat this condition, ensuring that no family has to suffer as we have.