ECRI

[INNOVATION UPDATE] Sodium Oxybate Extended-Release (Lumryz) to Treat Pediatric Narcolepsy Narcolepsy is a chronic neurologic disorder that disrupts the brain’s ability to regulate sleep-wake cycles. Sodium oxybate, also known as gamma-hydroxybutyrate, was approved by the US Food and Drug Administration in 2002 to treat adults with narcolepsy and in 2018 to treat children 7 years of age or older. Lumryz is a once-nightly extended-release formulation of sodium oxybate previously available only to adult patients. This indication was expanded on October 17, 2024, to include children 7 years of age or older based on positive clinical data in this age range. Compared with twice nightly dosing of conventional sodium oxybate formulations, this extended-release option may improve quality of life for children with narcolepsy and their caregivers. Want to learn more about this novel treatment? View the Emerging Health Care Innovation Brief: https://hubs.la/Q02-hBhY0 #narcolepsy #chronicdiseases #neurologicdisorders #neurology #patientcare #healthcare #innovation #horizonscanning #ECRI

[INNOVATION UPDATE] Orlynvah (Sulopenem Etzadroxil and Probenecid) to Treat Uncomplicated Urinary Tract Infections Uncomplicated urinary tract infections (uUTIs) are those that occur in otherwise healthy and non-pregnant patients. Bacterial resistance to standard antibiotic treatments for uUTI is increasingly common. This can lead to more serious infections requiring broad-spectrum antibiotics, which have historically been administered intravenously. Orlynvah is an oral broad-spectrum antibiotic composed of sulopenem etzadroxil, which kills bacteria by inhibiting cell wall synthesis, and a uric acid inhibitor that prolongs its effectiveness. In October 2024, the US Food and Drug Administration approved Orlynvah to treat uUTI in adult women with limited or no alternative treatment options, based on two late-stage clinical trials demonstrating it was noninferior to standard care. Want to learn more about this new intervention? View the latest Emerging Health Care Innovation Brief: Emerging Healthcare Innovation Brief Volume 2- Issue 24 https://hubs.la/Q02_LVvM0 #uncomplicatedurinarytractinfections #uutis #utis #infectiousdiseases #patientcare #healthcare #innovation #horizonscanning #ecri

In the spirit of the holiday season, we want to extend our sincere gratitude to our partners, clients and dedicated team members. Thank you for all you do to support our mission to ensure healthcare is safe and effective for everyone. We hope the warmth, joy and peace of this season reaches you and your loved ones. Here’s to a bright and successful New Year ahead!

New Blog | Fostering the "Value" of the Value Analysis Process in Healthcare Value analysis is essential for ensuring that healthcare organizations make decisions that enhance patient care while optimizing resources and managing costs effectively. It's about more than just evaluating the financial impact of purchasing decisions—it's about creating a systematic approach to evaluating the overall value of products, services, and technologies. Yet, integrating value analysis into the core operations of healthcare organizations is no small feat. Success requires not only technical expertise but also the ability to cultivate strong partnerships and foster a culture that prioritizes informed decision-making across all levels of the organization. By doing so, healthcare providers can ensure that value analysis becomes a cornerstone of their decision-making process, leading to more sustainable and patient-centered outcomes. Keep reading: https://hubs.la/Q02_-BqK0 #ValueAnalysis #HealthcareValueAnalysis #HealthcareInnovation #ValueBasedCare #ClinicalValueAnalysis #HealthcareEfficiency #CostManagement #HealthcareImprovement #HealthOutcomes #PatientCenteredCare #HealthcareOptimization #MedicalSupplyChain #ValueDrivenHealthcare #CostEffectiveness #QualityImprovement #ClinicalOutcomes #ValueBasedHealthcare #HealthcareCostReduction #HealthcareLeadership #HealthcareStrategy

Concern No. 10 | Incomplete Investigations of Infusion System Incidents Infusion therapy is a common treatment, with over 90% of inpatients receiving an IV infusion. While most infusions are completed safely, infusion-related incidents and near misses still happen regularly, as highlighted in our Top 10 Health Technology Hazards report. It’s crucial for healthcare organizations to be prepared to prevent potentially fatal medication errors and other infusion-related incidents. Download the Executive Brief now: https://hubs.la/Q02-qLvc0 #top10 #techhazards #hazards #2025hazards #PatientSafety #InfusionSafety #MedTech #HealthcareHazards #RiskManagement

[INNOVATION UPDATE] Rintatolimod (Ampligen) to Treat Post-COVID Fatigue Post-COVID Conditions (PCC), also known as long COVID, include symptoms of fatigue, shortness of breath, and cognitive dysfunction, and are currently experienced by millions of patients in the US. The underlying causes of PCC remain poorly understood but may include reactivation of latent viral infections and persistent immune disruptions. No medications are approved to treat PCC-related fatigue. Rintatolimod is an experimental antiviral and immune-modulating therapy used off-label to treat myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), a condition potentially related to PCC. According to its developer, subgroup analyses from a recently concluded trial evaluating rintatolimod to treat PCC-fatigue suggest therapeutic potential among severely affected patients. A follow-up study is planned. Want to learn more about this emerging therapy? View the latest Emerging Health Care Innovation Brief: https://hubs.la/Q02-hQwC0 #covid19 #postcovidconditions #pccs #longcovid #infectiousdiseases #patientcare #healthcare #innovation #horizonscanning #ECRI

Concern No. 9 | Skin Injuries from Medical Adhesive Products Medical adhesive products are essential in patient care, from dressing wounds to securing IV lines. However, improper selection or use of these products can cause harm, leading to "medical adhesive-related skin injuries" (MARSI). These injuries, such as skin tears, blisters, or dermatitis can occur in any care setting or patient population where adhesives are used. Download the Executive Brief now: https://hubs.la/Q02-qMq20 #top10 #techhazards #hazards #2025hazards #PatientSafety #MARSI #MedTech #WoundCare #SkinInjuryPrevention

New Blog | AI in Healthcare Applications and the Potential for Preventable Harm The advent of artificial intelligence (AI) in healthcare promises transformative changes that could significantly improve clinical outcomes, reduce operational costs, and enhance the quality of care provided to patients. By leveraging AI’s ability to process and analyze vast amounts of data with speed and accuracy, healthcare organizations are increasingly turning to AI for tasks ranging from medical diagnoses and personalized treatment plans to improving administrative processes. Yet, as with any groundbreaking technology, AI also brings a host of potential risks—especially when it comes to its application in clinical settings. When not properly managed, AI could inadvertently introduce preventable harm to patients, exacerbate health disparities, or undermine trust in the healthcare system. Keep reading: https://hubs.la/Q02-67NR0

Prepare for the 2025 CMS Patient Safety Structural Measure! ⏳ The 2025 CMS Patient Safety Structural Measure is coming! Is your organization ready? ECRI and The Just Culture Company are here to help you build a culture of safety and accountability. With ECRI and The Just Culture Company, your organization can: ✅ Learn from mistakes without fear. ✅ Build trust through fairness. ✅ Design safer, equitable systems to prevent harm. To support our valued clients and healthcare providers with implementing a just culture within their organizations, we are offering 20% off online Just Culture training programs from December 9, 2024, to February 8, 2025 using code ECRI+TJCC20. 🌟 Training programs include: • Just Culture Master Certification Course: https://hubs.la/Q02_v3dV0 • Just Culture Certification Course: https://hubs.la/Q02_vp8f0 • Just Culture for Managers and Influencers: https://hubs.la/Q02_v36k0 • The Just Culture Conduct Course for Healthcare Managers and Influencers: https://hubs.la/Q02_vZ6l0 Stay ahead of evolving standards like the 2025 CMS Patient Safety Structural Measure. Let’s build a safer, fairer healthcare system together. Learn more and sign up here 👉https://hubs.la/Q02_vsFd0 #CultureChange #JustCulture #JustCultureTraining #HealthcareSafety #Accountability #CMSPatientSafetyStructuralMeasure #HealthcareInnovation #HealthcareLeadership #PatientSafety #HealthEquity

Concern No. 8 | Infection Risks and Tripping Hazards from Poorly Managed Infusion Lines Improper management of infusion lines and connectors can cause severe harm to patients. While medication errors and misconnections are well-known risks, healthcare-associated infections (HAIs) are just as dangerous and often overlooked. Download the Executive Brief now: https://hubs.la/Q02-qMwF0 #top10 #techhazards #hazards #2025hazards #HealthcareInfections #MedTech #InfusionSafety #HAIs