Bunnie Xo Needed an IV After Weight-Loss Drug Tirzepatide Gave Her 'Diarrhea for Days' 

The “Dumb Blonde” podcast host shared that she’s lost 4 lbs. so far and is now “pooping normally” — but said she may be done taking “trizeppy”

Bunnie XO attends the 2024 CMT Music Awards at Moody Center on April 07, 2024 in Austin, Texas.
Bunnie Xo in Austin in April 2024. Photo:

Taylor Hill/WireImage

  • Bunnie Xo shared that she’s still taking tirzepatide — but that the medication gave her “diarrhea for days”
  • On the Friday, Oct. 25 episode of her podcast Dumb Blonde, she shared that a nurse traveling with her husband Jelly Roll’s Beautifully Broken tour had to give her an IV because she was so dehydrated 
  • Bunnie said, "I'm gonna try it one more time” — but shared she may be done taking the weight-loss medication

Bunnie Xo is sharing an update on how she’s feeling on tirzepatide, joking she’s “never gonna be a sex symbol” because she only makes headlines for “how I wear diapers and s--- myself.”

On the Friday, Oct. 25 episode of her podcast, Dumb Blonde. Bunnie, 44, said on the fifth day of taking “Trizeppy" she woke up thinking “I'm gonna have to go to the hospital. Like, I'm so sick,” she said

“By this time, I had diarrhea for days. I was dehydrated so bad.” 

“Luckily, we have a nurse on tour with us,” Bunnie, who is on the road with her husband, Jelly Roll, on his ongoing Beautifully Broken tour, said.

Jelly Roll and Bunnie XO at the 59th Academy of Country Music Awards from Ford Center at The Star on May 16, 2024 in Frisco, Texas.
Jelly Roll (left) and Bunnie Xo.

Gilbert Flores/Penske Media via Getty

“She gave me two IV bags and some magnesium, and I felt like a new woman. So that right there showed me that I was, like, severely dehydrated. After that, I was fine," she added.

Bunnie said she’s about two weeks into taking tirzepatide — commonly known by the brand names Mounjaro or Zepbound, — but said on the first day, “I felt fine until about 11 o'clock at night. All of a sudden, [I] felt like I was gonna f------ projectile vomit.” 

Previously approved to treat diabetes, tirzepatide was granted FDA approval for weight loss when a clinical trial found that high doses of tirzepatide helped patients lose an average of 22.5% of their body weight.

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The medication is taken by injection in the thigh, stomach or arm, and improves how the body breaks down sugar and fat, as well as reduces appetite.

And while Bunnie shared she’s “feeling a little skinny” after having lost 4 lbs., she was quick to point out that she isn’t taking the medication for weight loss.

“I would love to have, you know, about 10 lbs. off of me, but I'm taking it for the inflammation and to regulate my hormones because I believe I have PCOS,” she said. PCOS, or Polycystic Ovary Syndrome is a hormonal disturbance, as the Mayo Clinic explains, where “many small sacs of fluid develop along the outer edge of the ovary.”

As the National Institute of Health says, “Tirzepatide helps with weight reduction and insulin sensitivity, two of the major problems associated with PCOS.”

Eli Lilly & Co. Mounjaro brand tirzepatide medication arranged in Austin, Texas, US, on Sunday, March 3, 2024. Weight-loss shot users are looking to influencers for guidance absent proper follow-up care
Stock image of Mounjaro, one of the brand names for tirzepatide.

Montinique Monroe/Bloomberg via Getty

“I'm doing it for hormone health,” Bunnie said, adding. ”My first time taking it, I took, like ... the tiniest bit, and I'm so thankful that I did that because this s--- sent me for a ride, dude. I'm still feeling it.” 

She cautioned followers about taking the medication, especially “if you're super sensitive to things like I am and I don't even wanna take aspirin ... I don't have anything in my system. I'm literally, like, just raw-dogging life over here."

"I take the shot, start feeling like I'm gonna projectile vomit that night.”

But as Bunnie shared, there was one positive side effect: “On Trizeppy, I have been getting, like, eight hours of sleep, and it has been so great.”

“It's so good. So, that is one positive.”

However, she said, “I still don't feel great on it.”

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“The scale has gone down. I was 160. I'm now 157.2, and, I'm back to, like, pooping normally in case everybody wants to know. My logs are back.”

But she shared she might be done with taking tirzepatide.

“Everybody tells me it gives them energy, and they feel so good. I just feel like I have a chemical in my body, and I don't love it. So I think I'm gonna try it one more time.”

“I'm gonna ... start really super, super slow, see how that goes. And if that doesn't work, then I'm done," she said. "I just can't do the Trizeppy train.”

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