Department of Biotechnology

Welcome to the Official Instagram Page of the Department of Biotechnology! 🌿🔬 Your go-to destination for updates on cutting-edge research, innovations, & initiatives shaping the future of biotechnology. Visit our page: https://lnkd.in/gWb3JQAu Rajesh Gokhale BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD) BRIC-NCCS Pune BRIC-National Institute of Biomedical Genomics BRIC-National Institute of Immunology BRIC-RAJIV GANDHI CENTRE FOR BIOTECHNOLOGY BRIC-National Institute of Animal Biotechnology (NIAB) BRIC NABI Institute for Stem Cell Science and Regenerative Medicine (BRIC-inStem) Institute of Life Sciences National Institute of Plant Genome Research - NIPGR Translational Health Science and Technology Institute (THSTI) National Brain Research Centre

Catch a glimpse of the first #Biomanufacturing workshop held at the first Biomanufacturing Institute, BRIC-National Agri-Food Biotechnology Institute (NABI) Rajesh Gokhale BRIC Secretariat

#Bovinemastitis is an important condition that impacts the economy of production of milk and milk products. The condition is majorly caused by bacteria. Besides understanding the composites of bacterial species that can cause mastitis, it is important to comprehend the ability of these bacteria to cause infection and survive in the face of #antibiotic treatment. One of the predominant groups of bovine mastitis causing bacteria are staphylococci and mammaliicocci. BRIC-National Institute of Animal Biotechnology (NIAB) elucidated and explored the complete genome sequence of a Staphylococcus chromogenes strain (Genome Accession No. INGCA000000144) isolated from a bovine mastitis case as part of #collaborative research. It belonged to multi-locus sequence type 6 (ST6) and contained 2231 CDSs. Mining its ~2.33 Mbp genome revealed a few virulence determinants associated with efflux pumps, antimicrobial resistance, adherence, invasive enzymes, capsule formation, toxins and secretion systems, metal uptake and intracellular survival. Comparative genomic analyses against other non-aureus staphylococci and mammaliicocci suggest that S. chromogenes is an important pathogen of bovine mastitis. The study has wider implications for the animal health, milk quality, food security and consequences to public health. Rajesh Gokhale Office of the Principal Scientific Adviser to the Government of India CSIR India Indian Council of Medical Research (ICMR) India DST BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD) Institute for Stem Cell Science and Regenerative Medicine (BRIC-inStem) BRIC-National Institute of Immunology Institute of Bioresources and Sustainable Development (IBSD) Institute of Life Sciences BRIC-NCCS Pune BRIC - National Institute of Plant Genome Research - NIPGR RGCB - Rajiv Gandhi Centre for Biotechnology Translational Health Science and Technology Institute (THSTI)

#ResearchInsights Have you ever been amazed by the #aquatic #animals and the size of genetic materials packed into these tiny-to-medium sized animals? Well...Researchers from Dr. sandhya sukumaran's lab have unveiled the chromosome level genome assembly of the Asian green mussel! The Asian green mussel, Perna viridis is an important #aquaculture species in the family Mytilidae contributing substantially to molluscan aquaculture. The research has revealed that Asian green mussel has a genome size of #723.49 Mb anchored into #15 chromosomes. #Genomic and #transcriptomic investigations on this species are vital to understand genes, gene combinations and signaling pathways that determine economically important traits like #growth, reproduction and #disease resistance. Parasitic diseases (mainly due to protozoan parasites, Perkinsus olseni and Perkinsus beihaiensis) constitute a major threat to P. viridis aquaculture in India causing substantial mortalities in farms and understanding #genomics will help in gaining critical insights for treatments against diseases affecting these species. P. viridis is also important as a #biomonitor as it is capable of accumulating #heavymetals and other environmental #pollutants in large quantities. Whole genome information will be a valuable for understanding the genomic pathways involved in response to pollutants. The study will enhance our knowledge regarding the effect of environmental pollutants on biological systems. Furthermore, the findings benefit the aquaculture industry by improving genomic selection and breeding practices, leading to enhanced productivity and resilience in #fisheries. Read here: https://lnkd.in/gH7d3cBq Rajesh Gokhale CSIR NIScPR ICAR- Indian Council of Agricultural Research ICAR-Central Marine Fisheries Research Institute

Mark the date! 15 January 2025. Those interested in #research in #CellBiology & #biotechnology are invited to explore this #opportunity. Please see these links for further details - Advertisement in English: https://lnkd.in/g3GdEhPr Advertisement in Hindi: https://lnkd.in/gvsfErrM Advertisement in Marathi: https://lnkd.in/gdvmc-PQ #hiring #ResearchPositions #PositionsAvailable Sharmila Bapat Department of Biotechnology

The research group led Dr. Nagendra Hegde from BRIC-National Institute of Animal Biotechnology (NIAB) in collaboration with Madurai Kamaraj University and Karnataka Veterinary Animal and Fisheries Sciences University, have elucidated the whole genome of Mammaliicoccus sciuri, a bacterium associated with mastitis in cows. Bovine mastitis is an important condition that impacts the economy of production of milk and milk products. The condition is majorly caused by bacteria. Besides understanding the composites of bacterial species that can cause mastitis, it is important to comprehend the ability of these bacteria to cause infection and survive in the face of antibiotic treatment. One of the predominant groups of bovine mastitis causing bacteria are staphylococci and mammaliicocci. The team has elucidated the complete genome of an isolate of Mammaliicoccus scuiri (Genome Accession No. INGCA000000142). Analysis showed that it contained genes which could express virulence factors relating to antibiotic resistance, adherence, enzymes, cell surface components and intracellular survival. The study has wider implications for the animal health, milk quality and food security, and consequences to public health. The genome analysis revealed genes for resistance to several antimicrobials, some metals, disinfectants and antiseptics, and those involved in adherence and intracellular survival, uncovering pathogenic potential. Some virulence determinants were located in genomic islands, suggesting possible horizontal transfer events. These findings have implications not only for milk quality and food security but also for animal health, with possible consequences to public health. Rajesh Gokhale Office of the Principal Scientific Adviser to the Government of India CSIR India Indian Council of Medical Research (ICMR) BRIC-National Institute of Biomedical Genomics BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD) Institute of Bioresources and Sustainable Development (IBSD) Institute of Life Sciences Institute for Stem Cell Science and Regenerative Medicine (BRIC-inStem) BRIC NABI National Brain Research Centre BRIC-NCCS Pune BRIC-National Institute of Immunology BRIC - National Institute of Plant Genome Research - NIPGR Rajiv Gandhi Centre For Biotechnology (RGCB) Translational Health Science and Technology Institute (THSTI)

Researchers at Translational Health Science and Technology Institute (THSTI) shows that Berbamine suppresses SARS-CoV-2 replication by inhibiting spike-mediated viral entry and enhancing antiviral gene expression during infection. Rajesh Gokhale Read: https://lnkd.in/gmAznKcu

Researchers at Christian Medical College (CMC), Vellore show BSID is vital for early childhood development research, with better predictability at 36 months than 24 months. The study provides insights for better future cognitive ability projections. DOI: 10.1136/bmjopen-2023-082624 Rajesh Gokhale DBT/Wellcome Trust India Alliance University of Virginia Universitetet i Bergen (University of Bergen) CSIR NIScPR

🎉We are thrilled to be recognised with the Ecosystem Enablers Award by the Government of Karnataka at #BTS2024 #BTSUnbound Bengaluru Tech Summit! CCAMP is grateful for the unwavering support of our partner, the Government of Karnataka, in driving innovation, bridging industry and academia, and nurturing Karnataka’s vibrant and dynamic startup ecosystem. Together, let’s continue to inspire and empower the next generation of innovators! Taslimarif Saiyed, PhD Dinesh Gundu Rao Rajesh Gokhale Priyank M Kharge Dr. Ekroop Caur Department of Biotechnology Department of Science & Technology, Government of India Office of the Principal Scientific Adviser to the Government of India IT BT Department, Karnataka Biotechnology Industry Research Assistance Council (BIRAC) Startup Karnataka Startup India K-tech Biotechnology Facilitation Cell Karnataka Innovation and Technology Society NITI Aayog Atal Innovation Mission Official MeitY Startup Hub

✨ Biotechnology Research and Innovation Council (BRIC) Annual General Meeting 2024 ✨ We are delighted to share highlights from the BRIC Society's Annual General Meeting held on December 12, 2024, at the Department of Biotechnology (DBT). The meeting was honored by the presence of Dr. Jitendra Singh, Hon'ble Minister of Science & Technology (Union MoS, Independent Charge). Key milestones were celebrated during the event, including: ✅ Launch of the First Annual Report of BRIC 2024 ✅ Release of the i3c BRIC-RCB-PhD Programme Brochure ✅ Unveiling the latest edition of BRIC News These launches reflect our ongoing commitment to fostering scientific innovation and shaping a visionary future for biotechnology. A heartfelt thank you to all stakeholders for their continued support and collaboration. Here’s to achieving greater heights together in 2024! 🚀 #Biotechnology #Innovation #BRIC #DBT #ScienceAndTechnology #AnnualMeeting #ResearchLeadership