Since the mid 90’s, Desktop Grid Computing - i.e the idea of using a large number of remote PCs distributed on the Internet to execute large parallel applications - has proved to be an efficient paradigm to provide a large computational power at the fraction of the cost of a dedicated computing infrastructure. This document presents my contributions over the last decade to broaden the scope of Desktop Grid Computing. My research has followed three different directions. The first direction has established new methods to observe and characterize Desktop Grid resources and developed experimental platforms to test and validate our approach in conditions close to reality. The second line of research has focused on integrating Desk- top Grids in e-science Grid infrastructure (e.g. EGI), which requires to address many challenges such as security, scheduling, quality of service, and more. The third direction has investigated how to support large-scale data management and data intensive applica- tions on such infrastructures, including support for the new and emerging data-oriented programming models. This manuscript not only reports on the scientific achievements and the technologies developed to support our objectives, but also on the international collaborations and projects I have been involved in, as well as the scientific mentoring which motivates my candidature for the Habilitation `a Diriger les Recherches.