Linkon Paul

👉 #Job offer! Please share: The research group “Molecular Modeling” at Leibniz-LSB@TUM is looking for a PhD student  ▶️ to start on 27/01/2025 (65% TV-L 13). The position is to be filled for initial 1 year with the option to extend it by another 3 years. Project Advancements in structural #biology and #AI-guided #protein #structure design are providing new insights into the structures of #receptors responsible for #food #taste and #odor #perception. The project aims to make use of the structural information of the receptors for structure-based ligand design projects in order to develop prediction methods to identify new food-derived modulators of taste and odorant receptors. Please address any questions on current topics to Assoz. Prof. Dr. Antonella Di Pizio ([email protected]) and get in touch if you think you would be interested in working as part of her team.   Reference number: 2024-15-S3-ADP | Contact: Anja Albrecht (Human Resources Department), [email protected] More information: https://lnkd.in/emD97vkj https://lnkd.in/eeZBgMzf

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Superbio A33Plex STR Detection Kit (6 Colors Case Version) High Quality – Overcoming Challenges with Trace and Difficult Samples - Trace Samples: Achieves complete STR typing even with DNA concentrations as low as 30 pg. - Inhibited Samples: Performs excellently with various inhibitors (e.g., tannic acid, heme, humic acid), with inhibition resistance comparable to imported reagents. - Degraded Samples: Includes 12 mini-STR loci with amplicon lengths under 250 bp, offering better compatibility for degraded sample testing. - Mixed Samples: 100% detection rate at a 1:8 mixed ratio. - Exogenous Samples: Exhibits strong specificity against common animals and various microorganisms, preventing interference from exogenous DNA. High Standards – Freeze-Dried Reagents - Supports 10 μl of full-template sample addition without compromising performance in sensitivity, specificity, and balance. - Includes all necessary components for direct sample addition after opening the cap, with easy operation and no need for repeated freeze-thaw cycles. - Pre-packaged in eight-well tubes for single-use portions, reducing waste. High Quality – Guaranteed by ISO13485 & ISO18385 Standards - GA certification ensures guaranteed quality and performance.

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🔱 Nice review by Nature 🌻 🔱🌻 Plant–pathogen interactions (particularly involving biotrophic parasites) depend on interactions between pathogen avr (avirulence) genes and plant disease resistance (R) genes. 🔱🌻 Disease resistance occurs when both R and avr genes are active, without them disease results. 🔱🌻 R genes trigger defense mechanisms upon recognizing avr-dependent signals. 🔱🌻 Specific R-mediated immunity enhances basal defense pathways, which limit pathogen spread post-infection. 🔱🌻 Significant research has identified numerous R genes from various species, encoding resistance to diverse pathogens. 🔱🌻 Most R genes belong to the Nucleotide-Binding site plus Leucine-Rich Repeat (NB-LRR) class, highly evolved for their function. 🔱🌻 These proteins often associate with the plasma membrane and feature variable LRR domains for protein interactions and a conserved nucleotide-binding site crucial for ATP/GTP binding. 🔱🌻 R proteins activate defense mechanisms through complex formation and signal transduction. 🔱🌻 They are categorized based on their N-terminal features, such as TIR or coiled-coil domains. 🔱🌻 Sequence analyses show that R specificity resides in LRRs under diversifying selection. 🔱🌻 Some R genes also have unexpected structures, like WRKY transcription factors or protein kinases. 🔱🌻 Arabidopsis has around 100 R loci across its chromosomes, suggesting potential for dual recognition of avr proteins. 🔱🌻 The guard hypothesis mention that R proteins guard key defense components, activating upon pathogen effector targeting. 🔱🌻 Downstream of R engagement early defense responses (include calcium influx - kinase activation - reactive oxygen species production - transcriptional changes) leading to various antimicrobial defenses and systemic acquired resistance (SAR). What do you think? 👍🏻 and 🔄 the knowledge :) Follow me for more ! Dr. Hamed Altaweel

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Microbes in trees remove methane from the atmosphere Read more: 👇👇 https://buff.ly/3WQU93G University of Birmingham #laboratory #science #lab #research #scientist #laboratorio #biotechnology #medical #laboratorylife #microbiologia #biotech #dna #microscopy #lablife #bhfyp #Labs_Online

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https://lnkd.in/dr4KQqmf Effects of Organic Solvents on Acceptor Reactions for Oligosaccharide Synthesis Catalyzed by Glucansucrase URE 13-300

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#openposition alert for postdoc See the post/link below for detailed information To #stayinformed on the latest #jobopenings & #openpositions by #connecting with me on LinkedIn! #jobs #openpositions #Biotechjobs #microbiologyjobs #lifesciencejobs #MolecularBiologyJobs #careeroppurtunities #Labopportunities #ResearchJobs #LifeSciCareers #clinicalresearch #opportunities2024 #postdoc

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https://lnkd.in/gpb9NJf9   Article title: Comparison of hipO and ceuE Gene Based PCR Assays for the Detection of Campylobacter Jejuni   Author(S): Naim Deniz Ayaz*, Muammer Goncuoglu, Omer Cakmak and Irfan Erol   Journal: Journal of Clinical Microbiology and Biochemical Technology   Journal ISSN: 2581-527X Abstract: The objective of this study was to find out the reproducibility and specifity of hipO and ceuE genes based PCR assays for the detection of Campylobacter jejuni isolated from turkey meat samples in a previous study. A total of 44 Campylobacter isolates including 41 C. jejuni, two C. coli and one C. lari were used in this study. Although all of the C. jejuni isolates were verified by hipO based PCR assay, only 18 of the 41 C. jejuni were detected as positive by ceuE based PCR assay. Both of the methods showed negative reaction with C. coli and C. lari isolates. The results showed that, hipO gene based PCR assay is more reproducibly and specific than ceuE gene specific PCR analyze for the detection and identification of C. jejuni. #Campylobacterjejuni #hipO #ceuE #PCR   #CellularMicrobiology #EnvironmentalMicrobiology #MedicalMicrobiology #IndustrialMicrobiology #MarineMicrobiology #AquacultureMicrobiology #Bacteriology #Chlamydiology #Rickettsiology #Peertechz #PeertechzPublications #Mycobacteriology #AerobicActinomycetes #Mycology #Parasitology #Virology #ClinicalVeterinaryMicrobiology #Epidemiology #Biochemical #Endocytosis #Exocytosis #MembraneBiology #CellMigration #CellMatrix #OrganelleBiogenesis #Cytoskeleton #Proteolysis #CellDeath #CellCycle #CancerResearch #CellGrowth #CellDeath #CellDifferentiation #DrugTargets #GeneTherapy #DiseaseModels #Proteomics #StemCells #Bioenergetics #Mitochondria #FreeRadicals #RedoxSignaling #IonTransport #OxidativeStress #CellularMetabolism #XenobioticMetabolism #Metabolomics #CircadianControls #Hormones #Photosynthesis #CellSignaling #NitrogenFixation #PlantDisease #TransportProcesses #PlastidSystems #CellWallSynthesis #Phosphorylation #ProteinKinases #Phosphates #Ubiquitination #LipidSignaling #SecondMessengers #Cytokines #Receptors #GrowthFactors #GProteins #Integrins #NitricOxide #Enzymology #MolecularMechanisms #Biophysics #BiomolecularAssociations #SystemsBiology #ChemicalBiology #ProteinStructure #NucleicAcids #AminoAcids #DrugDesign #BiomolecularTargets #Lipids #Carbohydrates #EnvironmentalBiotechnology #MetabolicEngineering #TissueEngineering #Biodiversity #AgroBiotechnology #MedicalBiotechnology

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🚀 Elevate Your Research with Selleck Chemicals! 🚀 Attention researchers and scientists in the Cologne and Bonn area! Are you seeking top-tier inhibitors for cellular pathways? Look no further than Selleck Chemicals! 🔬 At Selleck Chemicals, we specialize in providing the highest quality molecular pathway inhibitors, in vivo antibodies, and comprehensive compound libraries designed to support and accelerate your research with unparalleled precision and reliability. Why Choose Selleck Chemicals? ✨ Extensive Compound Libraries: Our meticulously curated libraries enhance your high-throughput screening projects, delivering more accurate and efficient results. ✨ Quality You Can Trust: Each product undergoes rigorous testing to ensure the highest standards of purity and effectiveness. ✨ Expert Support: Our dedicated team is here to assist you with all your research needs, offering expert advice and guidance. Discover the best tools for your research at Selleck Chemicals. Explore our extensive range of compound libraries and other research products today! For personalized assistance and more information, you can reach out to me, your local Scientific Account Manager for Cologne and Bonn. Empower your discoveries with Selleck Chemicals – where innovation meets excellence. 🌟 #Research #Science #HighThroughputScreening #MolecularPathways #InVivoAntibodies #CompoundLibraries #Cologne #Bonn #SelleckChemicals #Innovation #ScientificResearch

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🌿 Did you know that over 40 species of medicinal plants can now be propagated through advanced micropropagation techniques? Our new volume from Prof. T. Pullaiah of Sri Krishnadevaraya University offers a comprehensive guide on these protocols, combining the latest tissue culture methods with fundamental scientific principles. This resource is invaluable for medicinal chemists, horticulturists, and pharmacists aiming to advance their knowledge and tackle challenges like deforestation and climate change. Dive into the future of plant conservation and herbal research with us! 📚🌱 🔗 https://bit.ly/4dAsZUu or https://lnkd.in/dwUyAyea Editor: T. Pullaiah #MedicinalPlants #Micropropagation #PlantResearch #PharmaceuticalScience #BenthamScience

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Based on their durability & molecular weight, #nanoparticles (NP) are classified into organic & inorganic. 🔘 Inorganic NPs: numerous industrial purposes, are used in the biomedical field for diagnostic & therapeutic purposes 🔘 Organic NPs: developed for drug delivery #science4all

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#Open_Positions /#job_openings alert See the attached image/pdf for detailed information and application deadline To #stayinformed on the latest #jobopenings & #openpositions by #connecting with me on LinkedIn! #jobs #openpositions #Biotechjobs #microbiologyjobs #lifesciencejobs #MolecularBiologyJobs #careeroppurtunities #ResearchJobs #opportunities2024 #postdoc

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Excited to be at #GCSB2024, the German Conference on Synthetic Biology, with our fantastic project partners from Leipzig University! 🎉 Our rockstar PhD students, Jule Walter and Leonhard Sidl are showcasing our latest research with a poster titled "Design of synthetic riboswitches that modulate mRNA stability." 🧬🔬 In this study we engineer functional RNAs together with RNA aptamers to form ligand-inducible molecular devices that modulate the expression and degradation of #mRNA. Our findings not only advance the field of #SyntheticBiology but also hold potential implications for future #healthcare applications, particularly in developing more precise gene regulation technologies. Find the full poster here: https://lnkd.in/d9DDfsdJ #RNA #RNAStability #HealthcareResearch #Biotechnology #GeneticEngineering #FutureOfHealthcare #ComputationalBiology #Biochemistry #ViennaRNA

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Sharing 7 selected recent publications by colleagues... ... 1. Novel DEL Hit That Binds in the Cbl-b SH2 Domain. Casitas B lymphoma-b (Cbl-b), a RING finger E3 ubiquitin ligase, is a key regulator of T cell activation and plays an important role in immune responses against tumors. Cbl-b has been identified as an attractive target for cancer immunotherapy due to its role in promoting an immunosuppressive tumor environment. Our team contributed to a study which identified a hit compound following screening of a DNA-encoded library (DEL) using activated Cbl-b. The authors employed a structure-based approach to optimize this hit, resulting in a compound with measurable cell activity. This work highlights the potential of small molecule inhibitors that can bind to SH2 domains and block protein-protein interactions. Full Text Link: https://lnkd.in/eKMq5z_r 2. Cardiac Manifestations of Fabry Disease Lysosomal storage disorders are rare genetic conditions that cause a buildup of toxic materials in the cells of various organs. Fabry disease (FD) is an X-linked disorder of glycosphingolipid metabolism caused by mutations in the GLA gene encoding alpha-galactosidase A. Manifestations of FD include life-threatening renal, cardiovascular, and cerebrovascular dysfunctions. Current treatments can preserve kidney function but are not very effective in preventing progression of cardiovascular pathology, which remains the most common cause of premature death in FD patients. There is a significant need for a translational model that could be used for testing the cardiac efficacy of new drugs to treat FD. Our colleagues contributed to a research study which revealed that GlaKO mice exhibit several cardiac dysfunctions characteristic of the initial stages of Fabry cardiac pathology. Full Text Link: https://lnkd.in/en9gN6by 3. Pharmacodynamic and Pharmacokinetic Profile of a Novel GLP-1 Receptor Biased Agonist Glucagon‐like peptide‐1 (GLP-1) receptor agonists have emerged as promising therapeutic options for addressing type‐2 diabetes, obesity, and related conditions. However, because of the continued need for injectable administration, many GLP-1 agonists face compliance challenges. To improve the design and production of GLP-1 receptor biased agonists with enhanced druggability, a novel small molecule, designated SAL0112, was developed. Our colleagues recently contributed to a study which characterized the pharmacodynamic and pharmacokinetic profile of SAL0112. The findings in this work suggest that SAL0112 exhibits effectiveness comparable to danuglipron and liraglutide in a rodent type 2 diabetes and obesity model and has the potential to offer an improved pharmacokinetic profile in the clinic. Full Text Link: https://lnkd.in/e5g2V53m If you want to take advantage of those ready to use and validated system, you know where to find those fabulous authors or scientists... ...

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