About
👋 Welcome! I'm a dedicated and versatile Medical Practitioner and Fellow in rural and…
Activity
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Thank you Nine news and Bianca Wylie for the opportunity to share the start of our ECMO service with the public: https://lnkd.in/gC2pB9zx Big shout…
Thank you Nine news and Bianca Wylie for the opportunity to share the start of our ECMO service with the public: https://lnkd.in/gC2pB9zx Big shout…
Liked by David Moniz
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It was a great evening last night getting together with a group of the ex-BC United/BC Liberal candidates to hang out and chat. What was a truly…
It was a great evening last night getting together with a group of the ex-BC United/BC Liberal candidates to hang out and chat. What was a truly…
Liked by David Moniz
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I am now officially free from that other social media platform that shall remain unnamed. Find me now on @https://lnkd.in/gNa4yQBV 🎉 Let's get…
I am now officially free from that other social media platform that shall remain unnamed. Find me now on @https://lnkd.in/gNa4yQBV 🎉 Let's get…
Liked by David Moniz
Experience
Education
Licenses & Certifications
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Certificate of the College of Family Physicians of Canada
The College of Family Physicians of Canada
Issued
Publications
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Regulation of early neurite morphogenesis by the Na+/H+ exchanger NHE1. *is listed Sin WC et. al. as both authors contributed equal work towards the publication
Journal of Neuroscience
The ubiquitously expressed Na+/H+ exchanger NHE1 plays an important role in regulating polarized membrane protrusion and directional motility in non-neuronal cells. Using NGF-differentiated PC12 cells and murine neocortical neurons in vitro, we now show that NHE1 plays a role in regulating early neurite morphogenesis. NHE1 was expressed in growth cones in which it gave rise to an elevated intracellular pH in actively extending neurites. The NHE1 inhibitor cariporide reversibly reduced growth…
The ubiquitously expressed Na+/H+ exchanger NHE1 plays an important role in regulating polarized membrane protrusion and directional motility in non-neuronal cells. Using NGF-differentiated PC12 cells and murine neocortical neurons in vitro, we now show that NHE1 plays a role in regulating early neurite morphogenesis. NHE1 was expressed in growth cones in which it gave rise to an elevated intracellular pH in actively extending neurites. The NHE1 inhibitor cariporide reversibly reduced growth cone filopodia number and the formation and elongation of neurites, especially branches, whereas the transient overexpression of full-length NHE1, but not NHE1 mutants deficient in either ion translocation activity or actin cytoskeletal anchoring, elicited opposite effects. In addition, compared with neocortical neurons obtained from wild-type littermates, neurons isolated from NHE1-null mice exhibited reductions in early neurite outgrowth, an effect that was rescued by overexpression of full-length NHE1 but not NHE1 mutants. Finally, the growth-promoting effects of netrin-1, but not BDNF or IGF-1, were markedly reduced by cariporide in wild-type neocortical neurons and were not observed in NHE1-null neurons. Although netrin-1 failed to increase growth cone intracellular pH or Na+/H+ exchange activity, netrin-1-induced increases in early neurite outgrowth were restored in NHE1-null neurons transfected with full-length NHE1 but not an ion translocation-deficient mutant. Collectively, the results indicate that NHE1 participates in the regulation of early neurite morphogenesis and identify a novel role for NHE1 in the promotion of early neurite outgrowth by netrin-1.
Other authorsSee publication
Courses
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Advanced Life Support Level 2
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Advanced Trauma Life Support
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Organizations
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Australian College of Rural and Remote Medicine
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- Present -
Australia Medical Association
Member
More activity by David
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Go upstream as it were. Clean the tank and moreso ensure we have systems, safeguards, policies and the will to not allow the state on the left.…
Go upstream as it were. Clean the tank and moreso ensure we have systems, safeguards, policies and the will to not allow the state on the left.…
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#fraservalley #chilliwacknorth #chilliwack #chilliwackbc #bcpoli September 08, 2024 at 08:44AM via Instagram https://lnkd.in/gr_DYZZt
#fraservalley #chilliwacknorth #chilliwack #chilliwackbc #bcpoli September 08, 2024 at 08:44AM via Instagram https://lnkd.in/gr_DYZZt
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The last 24 hours in BC politics has been a roller coaster. To be honest I am still processing everything that has happened. I decided to run because…
The last 24 hours in BC politics has been a roller coaster. To be honest I am still processing everything that has happened. I decided to run because…
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
No Provincial Income Tax for 60% of British Columbians. The largest tax cut in B.C.'s history. No provincial income tax on the first $50,000 you…
Shared by David Moniz
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