Uses
What is Cibinqo used for?
Cibinqo (abrocitinib) is commonly used to treat a disorder that causes inflammation and irritation of your skin called atopic dermatitis, which is the most common type of eczema.
Learn more about Cibinqo for Atopic Dermatitis.
Cibinqo may also be used for other conditions as determined by your healthcare provider.
How does Cibinqo work (mechanism of action)?
Cibinqo helps to calm your immune system by blocking specific enzymes (Janus kinase) involved in inflammation.
How is Cibinqo supplied (dosage forms)?
Cibinqo is available in the following dosage forms that are taken by mouth.
- 50 mg oral tablets
- 100 mg oral tablets
- 200 mg oral tablets
How should I store Cibinqo?
Cibinqo should be stored in the original packaging, at room temperature, between 68 F to 77 F (20 C to 25 C). It can be exposed to temperatures between 59 F to 86 F (15 C to 30 C) for shorter periods of time, such as when transporting it. Store in a cool, dry place.
Side Effects
What are the most common side effects of Cibinqo?
The most common side effects of Cibinqo are listed below. Tell your healthcare provider if you have any of these side effects that bother you.
- Infection in the nose or throat, sore throat, or common cold symptoms, flu
- Nausea, vomiting, stomach flu, stomach pain or discomfort
- Headache
- Kidney or bladder infections
- Skin rash or infections, herpes, shingles
- Increased creatine phosphokinase
- Dizziness or tiredness
- Acne
- Low blood platelet counts
There may be other side effects of Cibinqo that are not listed here. Contact your healthcare provider if you think you are having a side effect of a medicine. In the U.S., you can report side effects to the FDA at www.fda.gov/medwatch or by calling 800-FDA-1088. In Canada, you can report side effects to Health Canada at www.health.gc.ca/medeffect or by calling 866-234-2345.
What are the serious side effects of Cibinqo?
While less common, the most serious side effects of Cibinqo are described below, along with what to do if they happen.
Serious Infection. Cibinqo may increase your risk of developing a serious infection, such as tuberculosis (TB) or shingles, or other infections from bacteria, fungi, or viruses. Some infections may require treatment in the hospital or lead to death. Stop taking Cibinqo right away and contact your healthcare provider right away if you notice any of the following signs and symptoms of a serious infection.
- Cough or difficulty breathing
- Fever
- Low blood pressure or fast heartbeat
- Extreme weakness or tiredness
- Skin rash associated with severe pain
Severe Allergic Reactions. Cibinqo may cause allergic reactions, which can be serious. Stop taking Cibinqo and get help right away if you have any of the following symptoms of a serious allergic reaction.
- Breathing problems or wheezing
- Racing heart
- Fever or general ill feeling
- Swollen lymph nodes
- Swelling of the face, lips, mouth, tongue, or throat
- Trouble swallowing or throat tightness
- Itching, skin rash, or pale red bumps on the skin called hives
- Nausea or vomiting
- Dizziness, feeling lightheaded, or fainting
- Stomach cramps
- Joint pain
Deep Vein Thrombosis (DVT) and Pulmonary Embolism (PE). Cibinqo may increase your chance of developing a clot in your blood vessels (often in your legs) or your lungs. Stop Cibinqo and get emergency help right away if you notice any of the following.
- Swelling in one or both legs
- Pain or tenderness in your leg, ankle, foot, or arm. It might feel like a cramp or charley horse that you can’t get rid of. Leg and foot pain might happen only when you stand or walk.
- Warm skin on your leg
- Red or discolored skin on your leg
- Veins that are swollen, red, hard, or tender to the touch that you can see
- Shortness of breath
- Chest pain
- Cough
- A lightheaded feeling, or passing out
Heart Attack, Stroke, and Death. Cibinqo can increase your risk of a heart attack, stroke, or can lead to death. This risk may be increased in people with existing heart disease if you are 50 years or older and have risk factors for heart disease, such as high blood pressure, high blood cholesterol levels, or diabetes. Do not take Cibinqo if you have a heart attack or stroke. Get emergency help if you have any of the following symptoms of a heart attack or stroke.
- Chest pain or pressure
- Fast or abnormal heartbeat
- Trouble breathing
- Pain in your back, jaw, throat, or arm
- Sweating, upset stomach, vomiting, or dizziness
- Sudden weakness on one side of your body
- Sudden and severe headache
- Slurred speech or trouble understanding speech
Blood Disorders. Cibinqo can cause blood disorders, such as low platelet levels (thrombocytopenia) and low white blood cell levels (lymphopenia). Stop taking Cibinqo and get help right away if you have any of the following symptoms of blood disorders.
- Fever
- Shortness of breath
- Pale or yellowish skin
- Easy bruising or bleeding
- Frequent infection
Cancer. Cibinqo may increase your risk of developing certain types of cancer, such as lung cancer (especially if you ever smoked), lymphomas, or skin cancers. Follow your healthcare provider’s advice on how to minimize your risk for cancers. Discuss the risks and benefits with your healthcare provider.
Warnings & Precautions
Who should not use Cibinqo?
Allergies to Ingredients. People who are allergic to any of the following should not take Cibinqo.
- Cibinqo
- Abrocitinib
- Any of the ingredients in the specific product dispensed
Your pharmacist can tell you all of the ingredients in Cibinqo.
Drug Interactions. Cibinqo should not be taken while you are using certain other medicines. Before taking Cibinqo, tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. See the Interactions section for more details.
Kidney Problems. Cibinqo should not be used if your kidneys are not working as well as they should be. If there is a concern about the health of your kidneys, your healthcare provider may do tests to determine if they are working well enough to take this medicine.
Liver Problems. Cibinqo should not be used if your liver is not working as well as it should be. If there is a concern about the health of your liver, your healthcare provider may do tests to determine if it is working well enough to take this medicine.
What should I know about Cibinqo before using it?
Do not take Cibinqo unless it has been prescribed to you by a healthcare provider. Take it as prescribed.
Do not share Cibinqo with other people, even if they have the same condition as you. It may harm them.
Keep Cibinqo out of the reach of children.
Take Cibinqo once a day, around the same time each day. It can be taken with or without food. Do not chew, cut, or crush Cibinqo, it should be swallowed whole.
Your healthcare provider will check labs before starting Cibinqo and during treatment.
When taking Cibinqo you should limit the amount of time you spend in sunlight, avoid tanning beds or sunlamps, wear protective clothing, and use sunscreen when you are in the sun, especially if you have fair skin or skin cancer runs in your family.
Cibinqo can affect your alertness or coordination. Do not drive or do other activities that require alertness or coordination until you know how Cibinqo affects you.
Cibinqo may cause you to have difficulty getting pregnant.
Call your healthcare provider right away if you notice any sudden changes in your vision while taking Cibinqo.
What should I tell my healthcare provider before using Cibinqo?
Tell your healthcare provider about all of your health conditions and any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using. This will help them determine if Cibinqo is right for you.
In particular, make sure that you discuss any of the following.
Vaccines. You should not receive any live vaccines right before or while using Cibinqo. Tell your healthcare provider if you have recently received a live vaccine or have any scheduled.
Current and Past Health Conditions. Tell your healthcare provider if you have any of the following.
- Being treated for an infection or having symptoms of an infection
- Have an infection that will not go away or keeps coming back
- Diabetes
- Chronic lung disease, such as asthma or chronic obstructive lung disease (COPD)
- Shingles
- Cancer
- Blood clots in your legs or lungs
- Tuberculosis (TB) or close contact with someone who has TB
- Human Immunodeficiency Virus (HIV)
- Live in an area with an increased risk of fungal infections, such as the Ohio or Mississippi River valley or in the Southwestern United States
- Weakened immune system
- Hepatitis B or C
- Heart problems, including a previous heart attack
- Stroke
- Low platelets or white blood cell levels
- High cholesterol
- Smoke or previous smoker
- Eye problems, such as cataracts or a previous retinal detachment
Pregnancy. It is not known if or how Cibinqo could affect pregnancy or harm an unborn baby. Tell your healthcare provider if you are or plan to become pregnant. Your healthcare provider will advise you if you should take Cibinqo while you are pregnant or trying to get pregnant. If you become pregnant while taking Cibinqo, you can register by calling 877-311-3770. This registry collects safety information about the use of Cibinqo during pregnancy.
Breastfeeding. It is not known if Cibinqo passes into breast milk. Tell your healthcare provider if you are breastfeeding or plan to breastfeed. Your healthcare provider will advise you if you should stop breastfeeding or stop Cibinqo.
How can I get more information about Cibinqo?
For more information about Cibinqo, you can visit the manufacturer’s website at www.cibinqo.com/ or call them at 833-956-DERM (833-956-3376).
Interactions
Does Cibinqo interact with foods or drinks?
There are no known interactions between Cibinqo and foods or drinks.
It is unknown if drinking alcohol will affect Cibinqo. The risk of dizziness may be increased if you drink alcohol while taking Cibinqo.
Does Cibinqo interact with other medicines (drug interactions)?
Always tell your healthcare provider about any prescription or over-the-counter (OTC) medicines, vitamins/minerals, herbal products, and other supplements you are using.
In particular, make sure that you discuss if you are using any of the following before taking Cibinqo.
- Aspirin, if dose is higher than 81 milligrams (mg) per day
- An antiplatelet medicine, such as clopidogrel (Plavix), ticagrelor (Brilinta), dipyridamole/aspirin, or cilostazol
- Digoxin (Lanoxin), which is a medicine used to treat irregular heartbeat and some types of heart failure
Many other medicines may alter the blood levels of Cibinqo, and vice versa. Tell your healthcare provider about all medicines that you take or have recently taken.
This may not be a complete list of medicines that can interact with Cibinqo. Always check with your healthcare provider.
Overdose/Missed Dose
What should I do if I accidentally use too much Cibinqo?
If you or someone else has used too much Cibinqo, get medical help right away, call 911, or contact a Poison Control center at 800-222-1222.
What should I do if I miss a dose of Cibinqo?
If you miss a dose, take it as soon as you remember, unless it is less than 12 hours before you would normally take your next dose. If it is less than 12 hours from when you normally take your dose, skip the missed dose, and only take the next dose. Do not take double or extra doses.
Are you currently using Cibinqo (abrocitinib)?
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