Scribd Logo
Upload

Welcome to Scribd!

  • 12 views

    Presentation 1

    Uploaded by

    Kamp David
    Boron neutron capture therapy (BNCT) is a type of cancer treatment that uses a stable boron atom that is made to undergo fusion radioactivity to produce radiation that kills cancerous cells. It involves delivering a beam of neutrons to the tumor site, where boron has preferentially accumulated from a boron carrier. When neutrons interact with boron-10 atoms, energetic alpha particles and lithium-7 ions are released that destroy the tumor cells. BNCT has been tested for hard to treat cancers like brain and head/neck tumors and shows promise as a targeted radiotherapy with minimal effects on healthy tissue.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd

    Presentation 1

    Uploaded by

    Kamp David
    12 views14 pages
    Boron neutron capture therapy (BNCT) is a type of cancer treatment that uses a stable boron atom that is made to undergo fusion radioactivity to produce radiation that kills cancerous cells. It involves delivering a beam of neutrons to the tumor site, where boron has preferentially accumulated from a boron carrier. When neutrons interact with boron-10 atoms, energetic alpha particles and lithium-7 ions are released that destroy the tumor cells. BNCT has been tested for hard to treat cancers like brain and head/neck tumors and shows promise as a targeted radiotherapy with minimal effects on healthy tissue.

    Copyright

    © Attribution Non-Commercial (BY-NC)

    Available Formats

    PPTX, PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Boron neutron capture therapy (BNCT) is a type of cancer treatment that uses a stable boron atom that is made to undergo fusion radioactivity to produce radiation that kills cancerous cells. It involves delivering a beam of neutrons to the tumor site, where boron has preferentially accumulated from a boron carrier. When neutrons interact with boron-10 atoms, energetic alpha particles and lithium-7 ions are released that destroy the tumor cells. BNCT has been tested for hard to treat cancers like brain and head/neck tumors and shows promise as a targeted radiotherapy with minimal effects on healthy tissue.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    12 views14 pages

    Presentation 1

    Uploaded by

    Kamp David
    Boron neutron capture therapy (BNCT) is a type of cancer treatment that uses a stable boron atom that is made to undergo fusion radioactivity to produce radiation that kills cancerous cells. It involves delivering a beam of neutrons to the tumor site, where boron has preferentially accumulated from a boron carrier. When neutrons interact with boron-10 atoms, energetic alpha particles and lithium-7 ions are released that destroy the tumor cells. BNCT has been tested for hard to treat cancers like brain and head/neck tumors and shows promise as a targeted radiotherapy with minimal effects on healthy tissue.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Download as PPTX, PDF, TXT or read online from Scribd
    Download as pptx, pdf, or txt
    of 14

    8LSLn1A1lCn 8?

    uAvlu uA8kC
    (MSC AnAL?1lCAL CPLMlS18?)
    1CIC
    1nL USL CI 8CkCN IN 1nL
    1kLA1MLN1 CI CANCLk(8NC1)
    8NC1! What |s |t?
    lL ls an acronym for 8oron Nuetron
    Capture 1herapy
    lL ls a Lype of cancer LreaLmenL
    whlch lnvolves a sLable boron aLom ls
    made Lo under go fuslon radloacLlvlLy
    Lo produce radlaLlons whlch kllls or
    desLroys cancerous cells
    lL has been employed Lo LreaL head
    and neck cancers of all sLages
    8nC1 has been experlmenLally LesLed
    prlmarlly as an alLernaLlve LreaLmenL for
    mallgnanL braln Lumors called
    glloblasLoma mulLlforme as well as
    recurrenL locally advanced head and
    neck cancer
    kA1ICNALL CI NLU1kCN CA1UkL 1nLkA
    our years afLer Lhe dlscovery of neuLrons ln 1932 by !
    Chadwlck of Cambrldge unlverslLy a blophyslclsL CL
    Locher of Lhe ranklln lnsLlLuLe aL ennsylvanla
    lnLroduced Lhe concepL of neuLron CapLure 1herapy
    (nC1)
    1he physlcal prlnclple of nC1 ls slmple and eleganL lL ls
    a Lwo componenL or blnary sysLem based on Lhe
    nuclear reacLlon LhaL occurs when Lhe sLable lsoLope
    10
    8 ls lrradlaLed wlLh low energy or Lhermal neuLrons
    Lo yleld hlghly energeLlc hellum4 (
    4
    Pe) nuclel
    (lealpha parLlcles) and recolllng LlLhlum7 (
    7
    Ll) lons
    lgure 1 lllusLraLes Lhe sequence of nuclear evenLs
    I|gure 1 Schemat|c of 8oron10
    Neutron Interact|on
    1nL 8NC1 kCCLSS
    An eplLhermal beam of neuLrons ls
    dlrecLed Lowards a paLlenLs head or slLe
    of Lumour durlng Lhelr passage Lhrough
    Llssue Lhese neuLrons rapldly lose energy
    by elasLlc scaLLerlng (a process called
    LhermallzaLlon) unLll Lhey end up as
    Lhermal neuLrons
    1nL 8NC1 kCCLSS CCN1"D
    1he boron compounds have
    speclal properLles 1hey do noL
    easlly enLer healLhy braln cells
    because of Lhe bloodbraln barrler
    phenomenonbuL easlly enLer
    Lumor cells
    1nL 8NC1 kCCLSS CCN1"D
    1he Lhermal neuLrons Lhus formed are
    capLured by Lhe
    10
    8 aLoms whlch become
    11
    8
    aLoms ln Lhe exclLed sLaLe for a very shorL Llme
    ( 10
    12
    seconds) 1he
    11
    8 aLoms Lhen flsslons
    produclng alpha parLlcles
    7
    Ll recoll nuclel and
    ln 94 of Lhe reacLlons gamma rays 1umor
    cells are kllled selecLlvely by Lhe energeLlc
    alpha parLlcles and
    7
    Ll flsslon producLs
    1nL 8NC1 kCCLSS CCN1"D
    10
    3
    8 +
    1
    0
    n
    11
    3
    8 (lnLermedlaLe producL)
    11
    3
    8
    7
    3
    Ll +
    4
    2
    Pe + r
    1nL 8NC1 kCCLSS CCN1"D
    Jhy 8oron?
    8oron10 ls used as Lhe radloacLlve subsLance ln 8nC1
    because
    lL ls non radloacLlve and readlly avallable
    lL does noL accumulaLe ln Lhe Llssue
    boLh
    3
    Ll
    7
    and
    2
    Pe
    4
    parLlcles have hlgh LL1 buL a very
    shorL range (le abouL one cellular dlameLer) and cause
    slgnlflcanL damage Lo Lhe Lumor cell ln whlch lL ls
    conLalned buL llLLle or no damage Lo healLhy cells
    Lhe well undersLood chemlsLry of boron allows lL Lo be
    readlly lncorporaLed lnLo a mulLlLude of dlfferenL chemlcal
    sLrucLures
    12
    low LoxlclLy
    8oron carr|ers for 8NC1
    8oron carrlers lnclude boronphenylalanlne
    sodlum borocapLaLe (na
    2
    8
    12
    P
    11
    SP) or 8SP
    A new generaLlon of boron carrlers for use ln
    8nC1 conslsLs of blopolymers conLalnlng one
    or more carboranyl unlLs 1hese are modlfled
    proLelns ollgophosphaLes and nuclelc aclds
    Such molecules accumulaLe ln cells whlch
    become bullL lnLo unA (nucleosldes) and
    undergo accumulaLlon ln cell nuclel
    (ollgonucleoLldes) lmporLanLly Lhey are
    poLenLlally speclflc and can be deslgned Lo flL"
    cerLaln cellular Lypes of unA and 8nA
    8oron carr|ers for 8NC1
    Structure of S8n Structure of boronpheny|a|an|ne
    8LL8LnCLS
    1hLLp//wwwpharmalnfoneL/revlews/boronneuLron
    capLureLherapyovervlew
    2hLLp//www[aeago[p/[aerl/engllsh/press/980708/ref0
    7hLml
    3 8arLh 8 Soloway A PCoodman ! P Cahbauer
    8 A CupLa n 8lue 1 L ?ang J 1[arks
    J neurosurg 1999 pgs 44 433 431
    4Locher CL 8lologlcal effecLs and LherapeuLlc
    posslblllLles of neuLrons Am ! 8oenLgenol 8adlum
    1her 1936 36 113
    3hLLp//wwwsupersLockcom/sLockphoLos
    lmages/410220299
    6wwwocoJemlopoopl/pJfeo/cbooqes_stt20J6
    J7_olejolczokpJf

    You might also like