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    Reproductive Immunology

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    David Christian
    This document discusses reproductive immunology and infertility. It notes that infertility is a stressful problem that can impact society. One cause of infertility is immunological factors. Approximately 10-15% of couples are infertile, and reproductive immunology aims to understand the immune system's role in fertility and infertility. The document outlines how antibodies can impact sperm and the fetus, and discusses approaches like condom therapy and immunosuppressive treatment.

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd

    Reproductive Immunology

    Uploaded by

    David Christian
    104 views47 pages
    This document discusses reproductive immunology and infertility. It notes that infertility is a stressful problem that can impact society. One cause of infertility is immunological factors. Approximately 10-15% of couples are infertile, and reproductive immunology aims to understand the immune system's role in fertility and infertility. The document outlines how antibodies can impact sperm and the fetus, and discusses approaches like condom therapy and immunosuppressive treatment.

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    This document discusses reproductive immunology and infertility. It notes that infertility is a stressful problem that can impact society. One cause of infertility is immunological factors. Approximately 10-15% of couples are infertile, and reproductive immunology aims to understand the immune system's role in fertility and infertility. The document outlines how antibodies can impact sperm and the fetus, and discusses approaches like condom therapy and immunosuppressive treatment.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    104 views47 pages

    Reproductive Immunology

    Uploaded by

    David Christian
    This document discusses reproductive immunology and infertility. It notes that infertility is a stressful problem that can impact society. One cause of infertility is immunological factors. Approximately 10-15% of couples are infertile, and reproductive immunology aims to understand the immune system's role in fertility and infertility. The document outlines how antibodies can impact sperm and the fetus, and discusses approaches like condom therapy and immunosuppressive treatment.

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 47

    WHY WE HAVE TO DISCUSS

    REPRODUCTIVE IMMUNOLOGY ?
    EVERY HAS
    NEW
    HOPES CHILD
    COUPLE
    (REN)
     A LOT PEOPLES HAVE PROBLEM OF
    INFERTILITY
     INFERTILITY IS A STRESSING 
    DEPRESSION PROBLEM
     DEPRESSIVE PEOPLE CANNOT WORK
    OPTIMAL
     CAN INFLUENCED THE SOCIETY, NATION
    AND STATE
     ONE OF THE CAUSE OF INFERTILITY IS
    IMMUNOLOGIC FACTOR
    WHO

    50-80
    MILLIONS
    INFERTILE IN THE YEAR 2004
    COUPLES 217.9 MILLION POPULATION
    30 MILLIONS FERTILE COUPLES
    10-15% INFERTILE
    EVERY YEAR
    INCREASED 3-4.5 MILLIONS COUPLES
    2 MILLIONS 6-9 PEOPLES

    INDONESIA
    WORLD
    PREGNANCY STASTIC

    1 MTH 25 %
    6 MONTHS 63%
    NEW 9 MONTHS 80%
    COUPLES 12 MONTHS 85%
    18 MONTHS 90%
    ?
    AFTER 18 MONTHS MARRIED

    HAS
    85-90%
    NEW CHILD
    COUPLE

    HAS
    10-15% NO
    CHILD

    CANNOT
    CAN BE
    BE HELPED
    HELPED
    WHO 2 YEARS
    COUPLES TO
    NEED TIMES BE
    EXAMINED
    AFS 1 YEAR

    OLD PROBLEM
    THE FIRST HEALTH PROBLEM MENTION IN HOLY BIBLE
    ABRAHAM DAN SARA HAS BEEN OLD
    AND STILL HAS NO CHILD
    (ACT 18:11)
    INFERTIL COUPLE

    HUSBAND WIFE

    STRESS – SUSPICIOUS – VERY SENSITIVE 


    DEPRESSION

    MUST BE HANDLED WITH EMPHATY


    ANGER WITH THEIR CONDITION

    DIFFICULT COMUNICATION
    IC FEEL GUILTY

    COUPLE
    FAMILY SORROW
    SOCIETY

    STRESS
    Give me child otherwise
    I will be dead
    DEPRESSION
    (Act.30)

    PRODUKTIVITY DECREASED

    SOCIETY, NATION AND STATE


    CAUSES OF INFERTILITY

    HUSBAND WIFE

    40% 20% 40%

    IN THE SOCIETY : WIFE ALWAYS BE ACCUSED


    BASIC MANAGEMENT OF
    INFERTILITY

    HUSBAND WIFE

    PRINCIPAL : BEGIN WITH THE MOST EASY BOTH

    IN THE COUPLE AS WELL AS IN


    INDIVIDUAL
    COUPLE : HUSBAND
    INDIVIDUAL : HUSBAND  SPERM ANALYSIS
    WIFE  CERVIX CONDITION
    ETIOLOGI INFERTILITAS
    I Disturbance in production P
    Sperm Factor
    N of ovum R
    F E
    E G
    R N
    T A
    I N
    L Factors : Anatomycal Imunologic/ C
    I - Age factors Genetic factors : Y
    T - Emotional Woman -Abortus Habitualis
    - Enviroment
    Y -Cervix
    - Frequency /
    moment of coital -Tuba
    - Social Economy -Endometryosis
    -Myoma Uteri
    PRETESTICULAR

    TESTICULAR

    POSTTESTICULAR
    PRETESTICULAR

    VARICOCELE
    POST TESTICULAR

    AGENESIS
    DUCTUS
    DEFERENS

    ERECTION PROBLEM
    TUBA

    OVARIUM

    UTERUS

    CERVIX
    Progestron
    TREATMENT

     IMUNOLOGIC
    POOR POST COITAL TEST  AIH
    CONDOM THERAPY
    IMMUNOSPRESSIVE
    TREATMENT OF FACTORS INFLUENCE
    IMMUNOLOGIC FACTORS
     ENVIROMENT
    AVOID THE CONDITION
     SYSTEMIC DISEASE
    DM, TB  TREAT
    WAS DONE FIRST BY
    PROF.PANCOAST
    DI PHILADELPIA 1884
    ARTIFICIAL INSEMINATION
    IN VITRO FERTILIZATION
    (IVF)
    Reproductive Imunology

    In the male
    In the female
    ANTIBODY

    SPERMATOZOA
    ANTIBODY

    SPERMATOZOA
    ANTIBODY

    FOETUS

    SPERMATOZOA
    In the female
     Immunoregulation of maternal
    recognition of the fetal allograft
     Maternal immunoresponse during
    pregnancy
     Alloantigenicity of the fetoplacental unit
    & an immunologic role for the placenta
     Fetal-maternal exchange of humoral &
    cellular component
     Maternal –fetal antimicrobial immunity
     Immunologic consequences of
    transplacentally passed substance
     Immunity and spontaneus abortion
    MATERNAL
    IMMUNORESPONSE
    DURING PREGNANCY
    B
    A CAN DEVELOP
    B
    Y
    NO REJECTION
    TISSUE BE REJECTED
    MOTHER ANTI RHESUS
    MOTHER RHESUS -
    B
    A BABY RHESUS +
    B
    Y

    SEMINAL PLASMA
    ANTIBODY
    THE UTERUS AS THE
    SITE
    FOR IMMUNE

    REACTIVITY
    BOTH AFFERENT AND EFFERENT LIMBS
    IMMUNE RESPONSE ARE OPERATIVE IN THE
    REPRODUCTIVE AREA.
     PLACEMENT OF EXPERIMENTAL ALLOGRAFT IN
    THE UTERUS RESULTING IN THE REJECTION
     FOLLOWING INTERCOURSE  SPERMATOZOA
     NOT RECOGNIZED AS A FOREIGN ?
     IT IS POSSIBLE THAT IN THE SEMINAL PLASMA
     HIGH MOLECULAR WEIGHT COMPONENT 
    ACT AS IMMUNOSUPRESSANT
    POST COITAL TEST

    INTERACTION
    BETWEEN MUCUS
    OF THE CERVIX AND
    SPERMATOZOA
    CONDOM THREATMENT
    IMMUNOREGULATION OF
    MATERNAL RECOGNITION OF THE
    FETAL ALLOGRAFT

    1.Why the foetus which posseses paternal transplanta


    tion antigenic to mother – similar to allograft able
    implant and grow in the uterus
    2.Various mechanism have been proposed
    a.Physical or anatomic barier
    b.Lack of full complement of imunogenic
    paternally no immunologic response
    c.Supressor activity of foetal lymhoid
    IN THE MALE
     NATURAL IMMUNITY TO SPERMATOZOA
     ETIOLOGY OF AUTOIMMUNITY TO SPERMATOZOA
     METHODS OF DETECTING SPERM-REACTIVE ANTIBODIES
     DETECTECTION OF SPERM ASSOCIATED IMMUNOGLOBULINS
     DETECTION OF HUMORAL ANTIBODIES SPERM
    IMMOBILAZATION TEST
    SPERM AGGLTUNINATION TEST OTHE ANTIBODY TEST
     ROLE OF ANTISPERM ANTIBODY IN INFERTILITY ANTI
    SPERM IMMUNITY IN THE MALE
    OTHER CONSEQUENCES OF AUTOIMMUNITY TO SPERM IN
    THE MALE IMMUNOLOGIC CONSEQUENCES OF VASECTOMY
    Detection of sperm associated
    immunoglobulins
     Mixed aglutination reaction
     Direct antiglobulin assay using 125 I –
    radiolabelled heterologous antibody
     Immunobead
    DETECTION OF
    HUMORAL ANTIBODY
     SPERM IMMOBILIZATION TEST
    spermatozoa from donor + serum will
    checked + complement  motility

    serum Complement

    HUSBAND donor
    WIFE
    DETECTION OF
    HUMORAL ANTIBODY
     SPERM AGLUTINATION TEST
    SPERM AGLUTINATION TEST OF
    KIBRICK
    FRANKLIN DUKES METHOD

    SERUM

    AGLUTINASI
    ROLE OF ANTISPERM
    ANTIBODIES IN INFERTILITY
     ANTIBODIES TO SPERMA 
    REDUCED FERTILITY
     ANTIBODIES
    AUTOANTIBODY HUSBAND
    ALLOANTIBODY WIFE
     CAN BE DETECTED BY POST COITAL
    TEST.
    ROLE OF ANTISPERM
    ANTIBODIES IN INFERTILITY
     ANTIBODIES TO SPERMA 
    REDUCED FERTILITY
     ANTIBODIES
    AUTOANTIBODY HUSBAND
    ALLOANTIBODY WIFE
     CAN BE DETECTED BY POST COITAL
    TEST.
    NATURAL IMMUNITY TO
    SPERMATOZOA
     Sera obtained from normal fertile
    animalrabbit,mouse and human  contain
    antibodies  reacts to sperm of the own species
     Spermatozoa recovered from reproductive tract of
    female rabbit have immunoglobulins on the head
    region.
     Vigorously moving sperm did not have
    immunoglobulins
    Immotile sperm  immunoglobulins positif
    Etiolgy of autoimmunity to
    spermatozoa
     The expressions of antigens on sperm
    central consideration of their
    immungenicity auto or alloimmunity
     Development of autoimmunity:
    Genital tract infection
    Trauma to the testis  granuloma in the
    testis.
    INFERTILITY

    COMPLICATED

     MULTIPLE FACTORS
     MORE THAN ONE FACTORS IN ONE COUPLE

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