Large Single Ulcer of The Prepuce: Ulkus Durum DG Ulkus Di KGB Inguinal

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Large single ulcer of the

prepuce

Multiple ulceration of
the sulcus corona

Multiple ulcerations of the


sulcus corona and the frenulum

Ulkus durum dg ulkus di KGB


inguinal
Chancroid di penis, kissing effect

Ulkus mole
Ulcus Molle
ULKUS MOLE
DIAGNOSIS BANDING

• Herpes genitalis (HG)


• Sifilis std I/Ulkus durum (UD)
• LimfoGranulomaVenereum(LGV)
• Granuloma inguinale (GI)
ULKUS MOLLE
PENGOBATAN

1. Tetrasiklin capsul :
Dosis : 4 x 500 mg / hari, selama 10 – 20 hari

2. Kanamisin injeksi :
Dosis : 2 x 500 mg, IM. tiap hari, 6 – 14 hari.

3. Cotrimoxazole 2 dd 2 tab selama 10 hari


ULKUS MOLE
PENGOBATAN

4. Eritromisin
Dosis : 4x500 mg/hari selama 1 minggu.
5. Kuinolon
Ofloksasin dosis tunggal 400mg.
Ciprofloksasin 2x500 mg selama 3 hari.
6. Macrolide
Azithromycin dosis tunggal 1 gram per oral.
7. Ceftriaxone IM dosis tunggal 250 mg
Viral infection
wide spectrum of clinical manifestations

HPV & MCV


Healthy Children Immundeff

Colonize Benign Extensive


Without Proliferation Persistent
Lesions Transient Refractory

HPV = Human Papiloma Virus , MCV = Moluscum Contagiosum Virus


MOLUSCUM CONTAGIOSUM
widespreading
Lesi agak banyak

ATOPIK

HIV Terapi
infection Imuno
supressif
Lesi
Lesi banyak
sangat banyak

Multiple facial MC and Trunk widespreading

suggest HIV infection


Spektrum Klinis
Moluscum Contagiosum
sesuai tingginya imunitas tubuh Hospes

MC MC + ATOPY
MC+H I V
HUMAN PAPILOMA VIRUS
• HPV subclinical or wide variety lesions
• 150 types HPV infect skin and mucosa by trauma

Cutaneus Infection
Common Plantar Flat
warts warts warts

70 % 20 – 30 % 4%
Children >> Adult >> Child & Adult

Mucosal infection  Sexually Transmitted Disease Some HPV types


CONDYLOMA Can cause SCC in situ

Maternal transmitted to neonate baby


CONDYLOMA intra URETHRA
Moluscum Contagiosum
+ CONDYLOMA accum

CONDYLOMA peri ANAL


HUMAN HERPES VIRUS

8 groups of HHV :
• HHV 1 & 2 = HSV ( Herpes Simplex Virus 1 + 2)
• HHV 3 = VZV ( Varicella Zoster Virus )
• HHV 4 = EBV ( Eipstein Barr Virus )
• HHV 5 = CMV ( Cyto Megalo Virus )
• HHV 6-7-8 = Kaposi sarcoma ascociated Virus
3 groups HHV
HumanHerpesVirus
ALPHA BETA GAMMA

HSV 1 + 2 EBV
CMV HHV 6+7+8
VZV
Restricted host Lymphotropic
Variable host
Spread slowly Specific
Rapid destruction
Retina Either T or B
Latent infection
Pulmo & Colon lymphocyte
Sensory ganglia
HERPES SIMPLEX VIRUS
• Age of onset : Infancy – Young adult – Senescence
• Etiology : HSV-1 and HSV-2

LABIALIS

HSV-1 80%
HSV-2 20%

UROGENITALIS HERPETIC WHITLOW


HSV-1 20 % < 20 yr HSV-1
HSV-2 80 %
> 20 yr HSV-2

NEONATAL
HSV-2 =70 % HSV-1 =30%:
HERPES SIMPLEX VIRUS

• Acute muco-cutaneus infection


• Herpetiform group : Erythemal based vesicles
• Constitutional state : fever, malaise, anorexia
• Bacterial secondary Infection : Lesions soon
become purulent & crusted & ulcerated
• Latent episode  Recurrent periodically with
Precipitating factors.
HERPES SIMPLEX VIRUS INFECTION

Transmission: Skin- skin & Skin-mucosa


• Incubation: average 6 days
• Crowded living & Low SocioEconomy
• Wrestler  Herpetic whitlow  also Medical Staff

Precipitating factor of Recurrence:


• UV radiation
• Hormonal : Menstruation
• Fever & Influenza
• Altered Immunity : HIV infection, ChemoTherapy, Radiotherapy,
Steroid therapy, Malignancy: Leucemia
JENIS VIRUS
• HSV-Tipe I (Herpes Simplex Virus Type I)

• HSV-Tipe II (Herpes Simplex Virus Type II).


DD/ Herpes
SIMPLEX

• Ulkus Durum
• Ulkus pada infeksi
Herpes simplex
genital pria
Herpes Simplex Genital
+ Infeksi sekunder & Phymosis
HERPES SIMPLEX GENITALIS
+ INFEKSI SEKUNDER + Synechiae
FLUOR ALBUS pada WANITA
CANDIDOSIS
VAGINAL

TRICHO BACTERIAL
MONIASIS VAGINOSIS
PASANGAN PRIA sering TANPA GEJALA , tetap harus diobati
= BLIND TREATMENT =
FLUOR ALBUS
GARDNERELLA TRICHOMONAS
CANDIDOSIS
VAGINALIS VAGINALIS

DUH PUTIH DUH ABU2


DUH KUNING HIJAU
LENGKET ENCER
BERBUSA
BERGUMPAL TIDAK GATAL
GATAL NYERI
GATAL BAU
BAU
DYSPAREUNIA HUB SEX NORMAL
DYSPAREUNIA
TH/ TH/
TH/
ITRACONAZOL METRONIDAZOL
METRONIDAZOL
2dd200 MG 1 dd 2 GR
1 dd 2 GR
FLUCONAZOL Hari 1 dan 3
Single dose
1 dd 150 mg ( 2dd 500 mg= 7hr)
( 2dd 500 mg= 7 hr)
CANDIDOSIS VULVOVAGINALIS

PREDISPOSISI
• Diabetes
• OBESITAS
• KEHAMILAN
• TERAPI ANTIBIOTIKA
• TERAPI STEROID
• INFEKSI HIV

Lab: Pseudohifa(+)
Yeast cell(+)
VAGINOSIS BAKTERIAL Gardnerella vaginalis
= cocobasil Gram negatip

PREDISPOSISI
• Vaginal douching
• Akseptor IUD
• Promiskuitas & Lesbianism

GEJALA KLINIS
• Cairan putih encer berbusa
• 50 % bau amis, asimtomatik

Bau tercium saat senggama


atau saat ditetesi lar. KOH
Laboratorium : Clue cell (+)
TRICHOMONIASIS
ETIOLOGI : Protozoa brflagel terlihat pd sediaan basah dg Lar NaCl 0,9 %
= Trichomonas vaginalis

Predisposisi : Promiskuitas & kontaminasi WC umum


Pria asimptomatik, NSU ringan
Wanita :
Gatal Panas perih = dyspareunia Strawberry vagina

Fluor Kuning kehijauan


berbusa & bau busuk .
Trichomoniasis
Vaginalis

Cervicitis
ABSES atau KISTA
Kelenjar BARTHOLIN& SKENE
FAKTOR
KENAIKAN INSIDENS IMS

PERUBAHAN PERUBAHAN
DEMOGRAFIK SIKAP& NORMA

MODERNISASI tetapi KURANG PENDIDIKAN SEKS


INDUSTRI MAJU tetapi KURANG FASILITAS KESEHATAN
BANYAK KASUS ASIMPTOMATIK CARRIER ; PSK ♀
BANYAK TERSEDIA OBAT  CARA PAKAI TDK BENAR
GOLONGAN
RISIKO TINGGI IMS

• Umur muda : Pria 20 – 30 th


Wanita 16 – 24 th
• Kelompok sering berpergian/ Turis
• Suami isteri hidup terpisah tempat
• Pekerja Seks Komersial
• Kelompok Homoseksual /Napi
• Kelompok tinggi Pesona & Permisif
& Promiskuitas
PERLU KERJASAMA TERPADU
SEGI MEDIS
SEGI EPIDEMIOLOGIK
SEGI SOSIAL

DIAGNOSTIK DINI & LABORATORIS


TERAPI EFEKTIF  KONTROL LAB.
KONSELING & PROMOSI KONDOM
PEMERIKSAAN SEROLOGI
PEMBERITAHUAN PADA KELUARGA
• Setiap penyakit mempunyai stadium awal dan
stadium lanjut  Usahakan kenal lebih awal
• Ciri diagnostik membantu diagnosis dini
• Diagnosis banding sangat penting
• Distribusi, konfigurasi , morfologi penting !!
• Terapi > efektif : diagnosis tepat & cepat

FOTODOKUMENTASI KASUS YG DIDAPAT


BERMANFAAT DI LAIN SAAT
Laboratory Screening
• Pemeriksaan pra nikah sangat penting
karena dapat mengungkap kelainan Serologi
yg tidak terlihat pada kondisi fisik seseorang.
• Pemeriksaan yg dianjurkan
1. Kultur sekret uretra pria : Gonorrhoea
2. Pemeriksaan Trio sekret wanita
3. Serologi VDRL, TPHA, Anti HSV-1 & 2,
HbsAg, Anti HIV
4. Wanita di + Toksoplasma, antiCMV, Rubella
5. General Medical check up
Prurigo Nodularis berat  HIV infc
Lab Hiper Eosinofilia !!
Oral Hairy Plakia  HIV and EBV
infct
Lipodystrophy Syndrome
• Terjadi setelah 1 – 2 th terapi ARV
• Terutama Obat golongan protease
inhibitor
• Gambaran klinis :
– Lipo-hipertrofi : tengkuk, leher, dada,
abdomen
– Lipo-atrofi  pipi, ekstremitas atas bwh
proksimal
• Serum trigliserid + glukosa 
• Dis Figure  Stigma AIDS orang kurus
cekung
• HIGH cure rate • PATIENT COMPLIANCE
• LOW price • CHOOSE ORALLY GIVEN
• AVAILABLE • TIME OF WELL ABSORBED
• HIGH tolerance • SAFE FOR PREGNANCY &
• LOW toxicity LACTATION
• LOW resistency • TIME TO FOLLOW UP
Usaha Penangulangan
• Segi Medis : Diagnosa tepat & Terapi efektif
Blind treatment Partner
Konseling(KIE = komunikasi, inform, edukasi)
Imunisasi Hepatitis & HPV pd remaja

• Epidemiologis : lintas sektoral pendidikan dan bidang sosial

• Sosial, Ekonomi, dan Budaya :


– Bekerjasama dengan yayasan sosial yang menangani
masalah AIDS, Narkoba, WHO, dsb
– Pendataan serologis penghuni di LP & para PSK,
– Pembinaan Medis Pra Nikah bagi calon mempelai
• Care management
• Counseling
• Contact therapy
FOUR C’s
• Condom promotion
KEPUSTAKAAN

• Wolff K, Johnson RA,Surmond D : Fitzpatrick’s color


atlas & synopsis of Clinical Dermatology, McGrawHill
USA, 5 th ed.2005
• Daili SF, Djuanda A : Ilmu Penyakit Kulit & Kelamin,
Penerbit FKUI Jakarta, 5th ed. Th. 2007
• Indriatmi W BMakes :
Materi AjarIlmuKesehatanKulit&Kelamin
Mahasiswa FKUI tahap Akademik th 2007
• Dwikarya M : Koleksi FotoDigital Dokumentasi pribadi

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