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    Febrele Hemoragice

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    Rotaru Mihai
    This document discusses hemorrhagic fevers, classifying them into those transmitted by ticks, mosquitoes, or direct contact. It describes several specific hemorrhagic fever viruses, including Ebola, Marburg, Lassa, and those in the families Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae. For each, it provides details on the animal hosts, transmission cycles, incubation periods, clinical symptoms in humans, and case fatality rates. Key hemorrhagic fever viruses like Crimean-Congo hemorrhagic fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Lassa fever are then described

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    Febrele Hemoragice

    Uploaded by

    Rotaru Mihai
    351 views21 pages
    This document discusses hemorrhagic fevers, classifying them into those transmitted by ticks, mosquitoes, or direct contact. It describes several specific hemorrhagic fever viruses, including Ebola, Marburg, Lassa, and those in the families Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae. For each, it provides details on the animal hosts, transmission cycles, incubation periods, clinical symptoms in humans, and case fatality rates. Key hemorrhagic fever viruses like Crimean-Congo hemorrhagic fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Lassa fever are then described

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    Febrele Hemoragice

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    This document discusses hemorrhagic fevers, classifying them into those transmitted by ticks, mosquitoes, or direct contact. It describes several specific hemorrhagic fever viruses, including Ebola, Marburg, Lassa, and those in the families Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae. For each, it provides details on the animal hosts, transmission cycles, incubation periods, clinical symptoms in humans, and case fatality rates. Key hemorrhagic fever viruses like Crimean-Congo hemorrhagic fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Lassa fever are then described

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    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    351 views21 pages

    Febrele Hemoragice

    Uploaded by

    Rotaru Mihai
    This document discusses hemorrhagic fevers, classifying them into those transmitted by ticks, mosquitoes, or direct contact. It describes several specific hemorrhagic fever viruses, including Ebola, Marburg, Lassa, and those in the families Filoviridae, Arenaviridae, Bunyaviridae, and Flaviviridae. For each, it provides details on the animal hosts, transmission cycles, incubation periods, clinical symptoms in humans, and case fatality rates. Key hemorrhagic fever viruses like Crimean-Congo hemorrhagic fever, Argentine hemorrhagic fever, Bolivian hemorrhagic fever, and Lassa fever are then described

    Copyright:

    © All Rights Reserved
    Download as PPT, PDF, TXT or read online from Scribd
    Download as ppt, pdf, or txt
    of 21

    Febrele hemoragice

    Clasificarea febrelor hemoragice

    Transmise de căpuşe De contact


     FH Crimea-Congo  FH cu sindrom renal
     FH de Omsc  Febra Lassa
     FH de Kiasanur  Febra Marburg
     Febra Ebola
    Transmise de ţânţari  Febra de Argentina
     Febra galbenă  Febra de Bolivia
     Febra Denghe  Febra de Brazilia
     Febra Cicungunia  Febra de Venesuela
     Febra văii Rift
    Four distinct viral families:
    Filoviridae
    • Ebola
    • Marburg
    Arenaviridae
    • Lassa fever
    • New world hemorrhagic fever
    • Bolivian hemorrhagic fever (Machupo)
    • Argentine hemorrhagic fever (Junin virus)
    • Venezuelan hemorrhagic fever (Guanarito
    virus)
    • Brazilian hemorrhagic fever (Sabia virus)
    Bunyaviridae
    • Crimean-Congo hemorrhagic fever
    • Rift Valley fever
    • Hantavirus
    Flaviviridae
    • Dengue
    • Yellow fever
    • Omsk hemorrhagic fever
    • Kyasanur Forest disease
    Căpuşele – vectori de transmitere a
    febrelor hemoragice
    Animals:
     Numerous wild and domestic animals, such as cattle,
    goats, sheep, and hares, serve as amplifying hosts
    Filoviridae:
     Same clinical course as that of humans
     High primate mortality rate: ~ 82%
    Bunyaviridae:
     CCHF- unapparent infection in livestock
     RVF- 100% abortion rate and mortality rate of > 90% in
    young animals and 5-60% in older animals
     Hantavirus – unapparent infection in rodents
    Flaviviridae:
     Non-human primates – varying clinical signs (Yellow
    fever); no clinical signs (Dengue)
     Livestock – no symptoms (Kyasanur Forest Disease)
     Rodents – no symptoms
    Humans:
     Clinical signs and symptoms vary by the type of VHF
     Patients usually present with the following clinical signs and
    symptoms:
    Fever ³ 38.3°C of < 3 week duration
    Fatigue
    Dizziness
    Muscle aches
    Loss of strength
    Exhaustion
    At least two of the following:
    Hemorrhagic or purple rash
    Epistaxis
    Hemoptysis
    Blood in stools
    Petechiae in nondependent areas
     No predisposing factors for hemorrhage and no established
    alternative diagnosis
    Filoviridae:

     Most severe hemorrhagic fevers with abrupt onset and death


    around day 7 to 11; painful recovery
     Incubation: 4 to 10 days
     Case fatality: 23-33% (Marburg) and 53-88% (Ebola)

    Arenaviridae:
     Incubation: 10 to 14 days
     Case fatality: 5-35%
    Bunyaviridae:

     Incubation: 3 to 7 days (CCHF); 2 to 5 days (RVF); 7 to 21 days


    (Hantavirus)
     Case fatality: 30% (CCHF); 1% (RVF); 1-50% (Hantavirus)

    Flaviviridae
     Incubation: 2 to 6 days
     Case fatality: 1-10% (Dengue); 3-5% (Kyasanur Forest virus); 0.5-
    3% (Omsk hemorrhagic fever); varies (Yellow fever)
    Febra hemoragică Crimea-Congo
    Febra hemoragică Crimea-Congo
    Febra hemoragică cu sindrom renal
    Virusul Ebola Virusul Marburg
    Familia Filivirusuri
    Febra hemoragică Ebola şi Marburg
    Manifestări clinice în FH Ebola şi Marburg

    Debut brusc cu frison


    Febră înaltă
    Cefalee intensă
    Mialgii
    Dureri în abdomen
    Diaree
    Voma
    Tusă şi dureri în torace
    Sindrom hemoragic exprimat
    Erupţii hemoragice la 4-5 zi
    Hepatomegalie
    Afectarea renală
    Letalitatea – până la 80%
    Febra de Argentina şi de Bolivia

     Debut lent cu temperaturaă


    subfebrilă
     Cefalee, mialgii
     Enantemă hemoragică la 2-3 zi
     Semne catarale
     Hiperemia feţii, conjunctivei
     Perioada de stare cu sindrom
    hemoragic exprimat
     afectarea renală cu oligurie
     encefalită
    Letalitatea 10-20%

    Massive cutaneous ecchymosis


    Febra Lassa
    Debut brusc
    Sindrom de intoxicaţie exprimat
    Sindrom dispeptic cu greaţă,
    vomă, diaree
    Limfadenopatie cervicală
    Sindrom hemoragic exprimat
    Focare de necroză în orofaringe
    Ulceraţii cu depuneri fibrinoase
    Şoc toxico-infecţios
    Insuficienţă pulmonară
    Insuficienţă renală
    Sfârşit letal la 15-20%
    Hantavirus sindrom febril
    Măsurile antiepidemice în focare

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