ROLE OF NONI IN KIDNEY DISEASES

Chronic renal failure (CRF) is the progressive loss of kidney function. The kidneys attempt to compensate for renal damage by hyper filtration (excessive straining of the blood) within the remaining functional nephrons (filtering units that consist of a glomerulus and corresponding tubule). Over time, hyperfiltration causes further loss of function. Chronic loss of function causes generalized wasting (shrinking in size) and progressive scarring within all parts of the kidneys. In time, overall scarring obscures the site of the initial damage. Yet, it is not until over 70% of the normal combined function of both kidneys is lost that most patients begin to experience symptoms of kidney failure. Causes The cause(s) of CRF sometimes can be determined by a detailed medical history, a comprehensive physical examination, and laboratory studies. More often than not, determining the cause of CRF is difficult if not impossible. Even a kidney biopsy may be inconclusive, because all forms of kidney failure eventually progress to diffuse scarring and look the same on kidney biopsy. Pre-Renal CRF Some medical conditions cause continuous hypoperfusion (low blood flow) of the kidneys, leading to kidney atrophy (shrinking), loss of nephrons function, and chronic renal failure (CRF). These conditions include poor cardiac function, chronic liver failure, and atherosclerosis ("hardening") of the renal arteries. Each of these conditions can induce ischemic nephropathy.

Post-Renal CRF Interference with the normal flow of urine can produce backpressure within the kidneys, can damage nephrons, and lead to obstructive uropathy, a disease of the urinary tract. Abnormalities that may hamper urine flow and cause post-renal CRF include the following:

Bladder outlet obstruction due to an enlarged prostate gland or bladder stone Neurogenic bladder, an over distended bladder caused by impaired communicator nerve fibers from the bladder to the spinal cord Kidney stones in both ureters, the tubes that pass urine from each kidney to the bladder Obstruction of the tubules, the end channels of the renal nephrons Retroperitoneal fibrosis, the formation of fiber like tissue behind the peritoneum, the membrane that lines the abdominal cavity Vesicoureteral reflux (VUR), the backward flow of urine from the bladder into a ureter

Renal CRF Chronic renal failure caused by changes within the kidneys, is called renal CRF, and is broadly categorized as follows:

Diabetic nephropathy, kidney disease associated with diabetes; the most common cause of CRF

Hypertension cause of CRF

Nephrosclerosis,

condition

that

occurs

with

increased frequency in African Americans; the second leading Chronic glomerular nephritis, a condition caused by diseases that affect the glomeruli and bring about progressive dysfunction

Chronic interstitial nephritis, a condition caused by disorders that ultimately lead to progressive scarring of the interstitium Renal vascular CRF, large vessel abnormalities such as renal artery stenosis (narrowing of the large arteries that supply the kidneys) Vasculitis, inflammation of the small blood vessels Cystic kidney disease, kidney disease distinguished by multiple cysts (lined cavities or sacs) Hereditary diseases of the kidney, such as Alports syndrome (hereditary nephritis)

Role of Oxidative stress in chronic renal failure Oxidative stress defines an imbalance between formation of reactive oxygen species (ROS) and antioxidative defense mechanisms. In view of the profound biological effects of ROS, in recent years numerous clinical and experimental studies focused on detection of signs of oxidative stress in renal patients. There is good evidence indicating that uraemia in general is associated with enhanced oxidative stress and treatment of uraemic patients with haemodialysis or peritoneal dialysis has been suggested to particularly contribute to oxidative stress and reduced antioxidant levels in these patients. The latter may result from haemodialysis membrane-induced activation of macrophages on the

surface of dialysis membranes during the dialysis session. Loss or deficiency of antioxidant activity (e.g. vitamin E deficiency) could also contribute to enhanced oxidative stress in uraemia. Biological effects of oxidative stress Formation of ROS is part of the unspecific defense system of an organism against, for example, bacteria and other microbes. However, ROS may also affect cells of the host organism, in particular at sites of inflammation. The latter plays a role in a variety of renal diseases, such as glomerulonephritis, acute or progressive renal failure, or tubulointerstitial nephritis, contributing for example to proteinuria. ROS are also considered to contribute to the pathogenesis of ischaemiareperfusion injury. Furthermore, due to their impact on cell cycle regulation, oxygen radicals may contribute to hypertrophy of tubular cells.

ROLE OF NONI Antioxidants are molecules which can safely interact with free radicals and terminate the chain reaction before vital molecules are damaged. Although there are several enzyme systems within the body that scavenge free radicals, the principal micronutrient (vitamin) antioxidants are vitamin E, beta-carotene, and vitamin C. Additionally, selenium, a trace metal that is required for proper function of one of the body's antioxidant enzyme systems, is sometimes included in this category. The body cannot manufacture these micronutrients so they

must be supplied in the diet. Noni contain all those antioxidant vitamins and minerals in abundant number The easiest and most important way to stop free radical damage is to fortify your diet with antioxidant-rich foods. These will provide natural protection from environmental and inherent free radical exposure. But thats not all. Antioxidants are important for many reasons, some of which are just beginning to be explained. For instance, flavonoids, found abundant in Noni, are the largest group of several thousand compounds belonging to the antioxidant-rich polyphenol family. Flavonoids are further broken down into subclasses that you have likely heard of such as anthocyanins, flavonols, flavones, flavanones and flavanols. Research has shown very clearly that flavonoids have many health-promoting properties.

NONI works as a powerful antioxidants Antioxidant property of NONI can fight free radicals in three ways. 1. It can prevent a free radical from forming.
2. It can interrupt an oxidizing chain reaction to lessen the effects of

the free radicals.

can reduce the free radical's impact.

Noni as an antioxidant help neutralize the effects of free radicals, allowing the body to restore itself to proper balance leading to health and well-being. Noni contains many different synergistic antioxidant

nutrients, including the basic vitamins A,C & E. Drinking Noni every day can help combat the damaging effects of free radicals. The natural integrity of Noni is only part of the reason for its effectiveness. There are two additional reasons contribution to NONIs effectiveness for a broad range of conditions 1. Unique Combinations of Substances For a fruit, which sit the most digestively efficient of all foods, noni has an impressive combination of ingredients. It has a rich complement of vitamins and minerals; including A, B vitamins (including the rare B-12), C, E, Iron, calcium, sodium, potassium, zinc and several trace minerals. It also has 17 of 20 amino acids. Terpenes, fungicides, adaptogens, glycosides, polysaccharides and other unique ingredients that even in small amounts can have significant physiological effects can be found in Noni. It works like a food and acts like a medicine or herb without the side effects. 2. Synergy of its Substances The many known, and even some of the unknown substances, come together in a way that support the needs of many of our internal systems, concurrently. As the word synergy implies, these substances work far better in combination than they do separately. Many of the ingredients in noni are found in varying amounts in other foods or herbs. There seems to be no known food or herb with either the rich list of substances or the high amounts of key substances all put together in one super food. Noni aids the body's

natural

healing

abilities.

Hence in CRF Noni may help by its high antioxidant properties and by its immune enhancing property. Some times our strong immune power helps in regeneration of partly damaged nephrons in CRF. But one thing should be kept in mind that Noni contain high potassium. Hence in Renal failure case it should be given cautiously that means very low dose with starting jus 5 ml once or twice in a day NONI Works as a 'De-toxifier' Every cell in the body is like a house with doors and windows. When you have to drive a car into a garage you need to open the large door. The same goes on in our body if we have to absorb a larger protein molecule; we need to open a larger pore if we are to use it. Our cells are made up of micro particles such as neutrons, protons, cytoplasm, and Golgi bodies etc. which are genetically engineered to work well in a chemical-free environment. But because we live in a chemically polluted environment many types of toxins and pollutants are going into our body. They wrapping the cells day by day have formed multiple layers around the cell walls, thus lead to the closure or shrinking of the pores of the cell walls. Consequently, the inter cellular communication is prevented, the cells are damaged and they forget their purposes, they neither do their regular functions correctly nor efficiently. NONI, being the powerful De-toxifier removes the toxic layers on the cell walls and it enlarges the pores of the cell walls. This

enlargement allows for larger chains of peptides (amino acids or proteins) to be admitted into the cell and to feed us better. If these chains are not used they become waste and this precious source of energy is lost by going to fat or being eliminated. But because of Nonis detoxification process, the cells resume their communications; are reminded of their purposes and they are rejuvenated with greater strength and life. Now the cells are able to assimilate the nutrients and medicines easily. They are strengthened and healed at their roots. This is the basis of NONI's cellular activity that causes the enhancement of efficacy of the medicine. Noni is a not a medicine. Noni works as a Protein Regular and Activator Thanks to dr. Ralph Heinicke who found out that Morinda Citrifolia fruit is a rich resource of large molecules called Proxeronine (Prozair-o-neen) Proxeronine combines with enzymes in the body to form as essential substance known as Xeronine (zair-o neen). Once Xeronine is formed, it combines with many proteins in the body that require Xeronine to function. Not all proteins, but many vital proteins, acting as hormones, antibodies, and enzymes need Xeronine to carry out their duties.

Why is a Proxeronine rich supplement important in our diet? Some reasons include the loss of micro nutrients from the soil and poor nutrition in our diet. Even illness, a highly active or stressful lifestyle and ageing, plays an increased demand on proteins. In order to meet these demands and keep the body healthy, we need to increase the supply of Proxeronine by regularly drinking Noni. This helps to overcome low levels of Xeronine in our bodies and restores healthy

protein NONI works as a Healthy, Immune System

assimilation. Promoter

Current studies have revealed that Noni helps prompting a healthy immune system by either enhancing an already functioning system or by stimulating a sluggish one. Inaddition, as described earlier, Noni is believed to fortify and maintain cells tructure. This can be accomplished by Noni acting as an adoptogen that can aid "sick" cells in repairing themselves. A Cellular Food Noni works at the Cellular level ! Works at the root of illness ! works at the source, not with the symptoms . Hence also helpful in Renal failure cases CRF Paitents are using and getting result.