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    EE3211 Final Exam Section B

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    Edwin Ho
    The document outlines questions for a final exam on modeling techniques, including questions on interpreting odds ratios from logistic regression, adjusting for multiple comparisons, and assessing changes in patient health after a dental program. It provides example data and asks students to perform statistical tests and analyses.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    EE3211 Final Exam Section B

    Uploaded by

    Edwin Ho
    6 views10 pages
    The document outlines questions for a final exam on modeling techniques, including questions on interpreting odds ratios from logistic regression, adjusting for multiple comparisons, and assessing changes in patient health after a dental program. It provides example data and asks students to perform statistical tests and analyses.

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    final exam for ee3211

    Original Title

    EE3211_Final_Exam_Section_B

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    The document outlines questions for a final exam on modeling techniques, including questions on interpreting odds ratios from logistic regression, adjusting for multiple comparisons, and assessing changes in patient health after a dental program. It provides example data and asks students to perform statistical tests and analyses.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    6 views10 pages

    EE3211 Final Exam Section B

    Uploaded by

    Edwin Ho
    The document outlines questions for a final exam on modeling techniques, including questions on interpreting odds ratios from logistic regression, adjusting for multiple comparisons, and assessing changes in patient health after a dental program. It provides example data and asks students to perform statistical tests and analyses.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 10

    2023/4/26 23:45 EE3211 Final Exam Section B

    EE3211 Final Exam Section B

    Due Apr 26, 2022 by 12:30pm Points 70 Submitting a file upload Attempts 1
    Allowed Attempts 1 Available Apr 26, 2022 at 9:30am - Apr 26, 2022 at 12:30pm 3 hours

    This assignment was locked Apr 26, 2022 at 12:30pm.

    CITY UNIVERSITY OF HONG KONG

    Course code & title : EE3211 Modelling Techniques

    Session : Semester B 2021/22

    Time allowed : Three hours

    This paper has TEN pages (including this cover page).


    Online questions are not to be distributed or retained in any form after the exam.

    Instructions:

    1. This paper consists of five questions.


    2. Answer ALL questions shown on the quiz section of your Canvas account and in this paper. The
    total score is 100.
    3. You are responsible for receiving the questions on Canvas, hand-write all answers on blank
    answer sheets, compile the answers into a single PDF file, and upload the file before the
    deadline of the exam.

    This is an open-book examination. Students can read the lecture notes and/or other course
    materials.

    Answering this exam paper implies your acknowledgment of the Pledge for following the Rules on
    Academic Honesty:

    “I pledge that the answers in this examination are my own and that I will not seek or obtain an unfair
    advantage in producing these answers. Specifically,

    1. I will not plagiarize (copy without citation) from any source;


    2. I will not communicate or attempt to communicate with any other person during the examination;
    neither will I give or attempt to give assistance to another student taking the examination; and
    3. I will use only approved devices (e.g., calculators) and/or approved device models.
    4. I understand that any act of academic dishonesty can lead to disciplinary action.”

    https://canvas.cityu.edu.hk/courses/45820/assignments/197449 1/6
    2023/4/26 23:45 EE3211 Final Exam Section B

    On the first page of your answer sheets, copy the following sentence and sign it:

    I pledge to follow the Rules on Academic Honesty and understand that violations may lead to severe
    penalties.

    (Signature) ___________________ (Date) _______________________

    Contact Information

    Should you have any technical problem during the exam, contact your course leader or invigilator
    via Zoom private chat, email: [email protected] (mailto:[email protected]) , rxhuang4-
    [email protected] , [email protected], or by phone call at 3442 6661.
    If you are not able to contact course leader/invigilator, you can reach the department via:
    Departmental hotline at (+852) 3442-7740
    Department Whatsapp phone: 9269-4066
    Department WeChat ID: wxid_lly7yf5fzoj722 or scan the following QR Code

    SECTION A (30 points)

    Please refer to the “quizzes” section of your Canvas account.

    SECTION B (70 points) You will only have 1 chance to upload your
    answers.

    Q1. (16 points) A study was performed assessing the association between lifetime analgesic intake
    and change in estimated glomerular filtration rate (GFR) as measured from two blood samples
    obtained in 1989 and 2000 among 1645 participants in the Nurses’ Health Study (Curhan, et al. [45]).
    GFR is a commonly used index of kidney function with lower levels indicating worse kidney function.
    The following data were presented relating lifetime intake of acetaminophen (the active ingredient in

    https://canvas.cityu.edu.hk/courses/45820/assignments/197449 2/6
    2023/4/26 23:45 EE3211 Final Exam Section B

    Tylenol) in grams and a decline of ≥ 30% in estimated GFR, which is considered a clinically
    meaningful decline in kidney function (denoted as a case).

    a. What is the estimated odds ratio for being a case comparing Group D to Group A? ( 4 points)

    b. Provides a 95% CI for the OR computed in part a. (4 points)

    A logistic regression analysis was run using Stata relating disease status to lifetime acetaminophen
    intake divided by 100 (1 unit = 100g) denoted by ace_100. The results are given in the following
    table.

    c. Estimate the odds ratio for being a case per unit increase of lifetime acetaminophen intake (4
    points). Provides a 95% CI for this odds ratio (4 points).

    https://canvas.cityu.edu.hk/courses/45820/assignments/197449 3/6
    2023/4/26 23:45 EE3211 Final Exam Section B

    Q2. (4 points) The table below illustrates column comparisons testing for differences in cola
    preference amongst different age groups.

    To minimize the number of false discoveries that occur when testing multiple hypotheses, what are
    the two measures that can be made? (4 points)

    Q3. (20 points) Sexually transmitted disease: Suppose a study examines the relative efficacy of
    penicillin and spectinomycin in treating gonorrhea. Three treatments are considered:

    (1) penicillin

    (2) spectinomycin, low dose

    (3) spectinomycin, high dose

    Three possible responses are recorded:

    (1) positive smear

    (2) negative smear, positive culture

    (3) negative smear, negative culture

    The data is presented below:

    Table. Efficacy of different treatments for gonorrhea.

    https://canvas.cityu.edu.hk/courses/45820/assignments/197449 4/6
    2023/4/26 23:45 EE3211 Final Exam Section B

    a. Is there any relationship between the type of treatment and the response? (10 points)

    b. Suppose either a positive smear or a positive culture is regarded as a positive response and
    distinguished from the negative smear, negative culture response. Is there an association between
    the type of treatment and this measure of response? (10 points)

    Q4. (20 points) In a study, 28 adults with mild periodontal disease are assessed before and 6
    months after implementation of a dental-education program intended to promote better oral hygiene.
    After 6 months, periodontal status improved in 15 patients, declined in 8, and remained the same in
    5.

    a. Assess the impact of the program statistically (use a two-sided test). (10 points)

    b. Suppose patients are graded on the degree of change in periodontal status on a 7-point scale,
    with +3 indicating the greatest improvement, 0 indicating no change, and -3 indicating the greatest
    decline. The data are shown below:

    https://canvas.cityu.edu.hk/courses/45820/assignments/197449 5/6
    2023/4/26 23:45 EE3211 Final Exam Section B

    What test should be used to determine whether a significant change in periodontal status has
    occurred over time? (2 points)

    c. Implement the procedure in b, report a p-value, then interpret the results and make a conclusion.
    (8 points)

    Q5. (10 points) Suppose we have separately analyzed the effects of 10 SNPs comparing people
    with type 1 diabetes vs. Controls. The p-values from these separate analyses are provided below:

    a. Use the Bonferroni method to correct for multiple comparisons. Which SNPs show statistically
    significant effects? (2 points)

    b. Use the FDR method to correct for multiple comparisons using an FDR=0.05. Which SNPs show
    statistically significant effects? How do the results compare with those in a? (8 points)

    https://canvas.cityu.edu.hk/courses/45820/assignments/197449 6/6

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