MCQS CNS Pathology
MCQS CNS Pathology
MCQS CNS Pathology
MCQS
Laboratory examination of the CSF obtained from a child of 2 years age. Who
presented with fever, headache, vomiting and neck rigidity, is suggestive of
acute pyogenic meningitis. The most likely etiological agent of this condition is:
a) Escherichia coli
b) Group B streptococci
c) Staphylococcus aureus
d) Hemophilus influenza
e) Streptococcus pneumonia
Alzheimer disease is the most common cause of dementia in the elderly. Autopsy
of the patient died of this disease shows characteristic histological features in the
brain which of the following is not a feature of this disease.
a. Neuritic plaques
b. Neurofibrillary tangles
C. Cerebral amyloid angiopathy
d. Granulovacuolar degeneration
e. Lewy body
A 12-year-old boy is rushed to the emergency room in a coma after falling from
an upper story window of his home. MRI shows a subdural hematoma over the
left hemisphere. What is the most likely source of intracranial bleeding in this
patient?
(A) Bridging veins
(B) Charcot-Bouchard aneurysm
(C) Internal carotid artery
(D) Middle meningeal artery
(E) Sagittal sinus
A 5-year-old boy is brought to the emergency room with fever, vomiting, and
convulsions. The patient is febrile to 39.5°C (104°F). Physical examination
reveals cervical rigidity and pain in the neck and knees. Acute inflammation
most likely involves which anatomic region of the patient’s brain?
(A) Choroid plexus
(B) Ependyma
(C) Hypothalamus
(D) Lateral ventricles
(E) Leptomeninges
A 32-year-old woman presents with a 2-day history of headache, vomiting, and
fever. Physical examination reveals cervical rigidity and knee pain with hip
flexion. Lumbar puncture demonstrates an abundance of neutrophils and
decreased levels of glucose. Which of the following diseases is most likely
associated with these clinical laboratory findings?
(A) Meningococcal meningitis
(B) Neurosarcoidosis
(C) Staphylococcal meningitis
(D) Tuberculous meningitis
(E) Viral meningitis
A female neonate is noted at birth to have a gross deformity of her lower back.
Examination of the subcutaneous lesion reveals disorganized neural tissue with
entrapment of nerve roots. What is the appropriate diagnosis?
(A) Meningocele
(B) Meningomyelocele
(C) Rachischisis
(D) Spina bifida occulta
(E) Syringomyelia
A 2-year-old boy is brought to the physician by his parents, who complain that
their son continually loses his balance. They also report that his speech seems
more slurred. Physical examination confirms the truncal ataxia and wide-based
gait. The child appears lethargic, and there is bobbing of the head while he is
sitting. Muscle tone is normal. This patient may have a midline tumor in which
anatomic portion of the brain?
(A) Cerebellum
(B) Corpus callosum
(C) Frontal lobes
(D) Hypothalamus
(E) Meninges
The following lab findings are correct In acute pyogenic meningitis except:
a) CSF color - Usually turbid
b) CSF pressure - Increased
c) Leucocyte count - High
d) CSF Protein: Elevated
e) CSF glucose: elevated
An elderly man presents with loss of memory for recent events. He frequently
forgets names of his spouse and grand children. He often losses his way while
driving to familiar location. Which of the following is he most probably
suffering from?
a) Parkinson's disease
b) Transient ischemic attacks
c) Alzheimer's disease
d) Slow viral infection,
e) Multiple sclerosis
A young patient presented with polyurea, polydipsia and visual disturbance.
The diagnosis of brain tumor was made. Which of the following brain Tumor
may be responsible for this symptoms complex:
a) Meningioma
b) Astrocytoma
c) Retinoblastoma
d) Ependymoma
e) Craniopharyngioma
A 68-year-old man presents with a 2-week history of tonic-clonic seizures that
initially involve his left arm but have more recently progressed to involve his left
leg. The seizures are accompanied by muscle weakness but no other neurologic
signs. The cranial nerves are intact, and the Babinski sign is present. A CT scan
reveals a mass in the left cerebral hemisphere. A left frontoparietal craniotomy
is performed. Which of the following is the appropriate diagnosis?
(A) Craniopharyngioma
(B) Ependymoma
(C) Ganglioglioma
(D) Glioblastoma multiforme
(E) Meningioma
A child develops a tumor of the brainstem, which on biopsy demonstrates
bizarre, pleomorphic tumor cells accompanied by necrosis and hemorrhage.
Which of the following is the likely diagnosis?
A. Glioblastoma Multiforme.
B. Ependymoma.
C. Astrocytoma.
D. Oligodendroglioma.
E. Pilocytic astrocytoma.
Which of the following CNS tumors has the best prognosis:
A. Anaplastic astrocytoma (WHO grade III)
B. Glioblastoma multiforme.
C. Well differentiated astrocytoma (WHO grade II)
D. Medulloblastoma.
E. Oligodendroglioma
Which of the following intracranial neoplasms has the best prognosis following
surgery:
a. Schwannoma
b. Glioblastoma multiforme
c. Astrocytoma
d. Medulloblastoma
e. Solitary metastasis
A 2 years old boy with gross motor delays presented with wide-based, unsteady
gait and headaches over 1 month. A brain MRI reveals a large posterior fossa
mass. He underwent total resection and microscopy showed small blue round
cell, homer wright rosettes and high mitotic count. The most likely diagnosis is:
A) Meningioma
B) Glioblastoma
C) Astrocytoma
D) Choroid plexus tumor
E) Medulloblastoma
A 5-year-old boy presents with projectile vomiting and progressive ataxia.
Workup finds obstructive hydrocephalus due to an infiltrative tumor located in
the posterior fossa and originating from the midline of the cerebellum. What is
the most likely diagnosis for a tumor located in this location in this child?
a. Glioblastoma multiforme
b. Dysembryoplastic neuroepithelial tumor
c. Primary CNS lymphoma
d. Primary germ cell tumor
e. Primitive neuroendocrine tumor
Meningioma is benign tumor arising from:
A. Glial cells
B. Squamous epithelial cells
C. Columnar epithelial cells
D. Meningothelial cells
E. Ependymal cells
Glioblastoma is:
A. Well differentiated astrocytoma
B. Poorly differentiated astrocytoma
C. Lymphoma of CNS
D. Teratoma of CNS
E. Metastatic tumor
A 48-year-old man with AIDS is admitted to the hospital with a headache, fever
of 38.7°C (103°F), and persistent cough. His CD4 cell count is less than 500/mL.
Lumbar puncture returns cloudy fluid, and microscopic examination shows
numerous encapsulated microorganisms and Soap bubble appearance in brain
on MRI Which of the following pathogens is the most likely cause of meningitis
in this patient?
(A) Aspergillus flavus
(B) Cryptococcus neoformans
(C) Mycobacterium tuberculosis
(D) Neisseria meningitidis
(E) Toxoplasma gondii