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    Lia Husna Nabilah - T5 Farmakokinetik

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    LIA HUSNA NABILAH mhs2019FARD30
    This document contains 3 examples of pharmacokinetic calculations: 1) The order is zero, half-life is 10 hours, volume of distribution is 5 L, AUC is 20, clearance is 25 L/hr, and the equation is C = -5t + 100. 2) The order is one, half-life is 1.855 hours, volume of distribution is 5.79 L, AUC is 231.188, clearance is 2.162 L/hr, and the equation is C = 86.349e^(-0.3735t). 3) The order is two, half-life is 86.80 hours, volume of distribution is 58.30 L, AUC is 86.

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    Lia Husna Nabilah - T5 Farmakokinetik

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    LIA HUSNA NABILAH mhs2019FARD30
    11 views2 pages
    This document contains 3 examples of pharmacokinetic calculations: 1) The order is zero, half-life is 10 hours, volume of distribution is 5 L, AUC is 20, clearance is 25 L/hr, and the equation is C = -5t + 100. 2) The order is one, half-life is 1.855 hours, volume of distribution is 5.79 L, AUC is 231.188, clearance is 2.162 L/hr, and the equation is C = 86.349e^(-0.3735t). 3) The order is two, half-life is 86.80 hours, volume of distribution is 58.30 L, AUC is 86.

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    22330748_Lia Husna Nabilah_T5 Farmakokinetik

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    This document contains 3 examples of pharmacokinetic calculations: 1) The order is zero, half-life is 10 hours, volume of distribution is 5 L, AUC is 20, clearance is 25 L/hr, and the equation is C = -5t + 100. 2) The order is one, half-life is 1.855 hours, volume of distribution is 5.79 L, AUC is 231.188, clearance is 2.162 L/hr, and the equation is C = 86.349e^(-0.3735t). 3) The order is two, half-life is 86.80 hours, volume of distribution is 58.30 L, AUC is 86.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    11 views2 pages

    Lia Husna Nabilah - T5 Farmakokinetik

    Uploaded by

    LIA HUSNA NABILAH mhs2019FARD30
    This document contains 3 examples of pharmacokinetic calculations: 1) The order is zero, half-life is 10 hours, volume of distribution is 5 L, AUC is 20, clearance is 25 L/hr, and the equation is C = -5t + 100. 2) The order is one, half-life is 1.855 hours, volume of distribution is 5.79 L, AUC is 231.188, clearance is 2.162 L/hr, and the equation is C = 86.349e^(-0.3735t). 3) The order is two, half-life is 86.80 hours, volume of distribution is 58.30 L, AUC is 86.

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    of 2

    1.

    T C
    0 100
    2 90
    4 80
    6 70
    8 60
    10 50
    12 40
    Perhitungan kalkulator:
    A = 100
    B = -5 y = -5x + 100
    2
    R =1
    a) Orde berapakah? → Orde nol
    100
    b) T1/2 = 0,5 x = 10 jam
    5
    𝐷𝑏 500
    c) Vd = 𝐶𝑝 = 100 = 5
    𝐶𝑜 100
    d) AUC = = = 20
    𝐾.𝑒𝑙 5
    e) Klirens = Vd x K = 5 x 5 = 25
    f) Persamaan Farmakokinetik:
    C = -K0t + C0
    90 = - K0 (2) + 100
    -K0 = -10/-2 = 5
    Persamaan → C = -5t + 100
    2.
    T C ln cp
    1 65 4,1744
    2 42 3,7377
    3 27 3,2958
    4 18 2,8904
    6 8 2,0794
    8 5 1,6094

    Perhitungan kalkulator:
    A = 4,4584
    B = -0,3735 y = -0,3735x + 4,4584
    2
    R = 0,9887
    a) Orde berapakah? → Orde satu
    0,693 0,693
    b) T1/2 = 𝐾.𝑒𝑙 = 0,3735 = 1,855
    𝐷𝑏 500
    c) Vd = = = 5,79
    𝐶𝑝 86,349
    𝐶𝑜 86,349
    d) AUC = =
    𝐾.𝑒𝑙 0,3735
    = 231,188
    e) Klirens = Vd x Ke = 5,790 x 0,3735 = 2,162
    f) Persamaan → C = 86,349.e (0,3735t)
    3. T C ln cp 1/Cp
    1 30 3,401197 0,033333

    2 13 2,564949 0,076923

    3 6.5 1,871802 0,153846

    4 4.2 1,435085 0,238095

    6 2.2 0,788457 0,454545

    8 1.4 0,336472 0,714286

    Perhitungan kalkulator:
    A = -0,1166
    B = 0,0988 y = 0,0988x – 0,1166
    2
    R = 0,9887
    a) Orde berapakah? → Orde dua
    1 1
    b) Cp : = = 8,5763
    𝐴 0,1166
    1 1
    c) T1/2 = 𝐾𝑒𝑥𝐴 = 0,0988𝑥0,1166 = 86,80 𝑗𝑎𝑚
    𝐷𝑏 500𝑚𝑔
    d) Vd = 𝐶𝑝 = 8,5763 = 58, 30
    𝐶𝑜 8,5763
    e) AUC = = = 86,804
    𝐾.𝑒𝑙 0,0988
    f) Klirens = Vd x Ke = 58,30 x 0,0988 = 5,760
    g) Persamaan → C = 8,5763.e (0,0988t)

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