Scribd Logo
Upload

Welcome to Scribd!

  • 101 views

    Lesson 3 The Sodium Potassium Pump

    Uploaded by

    anulorance98
    The sodium potassium pump uses energy from ATP to actively transport sodium and potassium ions against their concentration gradients. It pumps 3 sodium ions out of and 2 potassium ions into the cell. This creates an electrochemical gradient that provides energy for other transport processes and generates the resting potential in nerve cells. The sodium potassium pump is made up of protein subunits called Na+-K+-ATPase and goes through six stages of conformational changes to transport the ions. Inhibiting the sodium potassium pump with digoxin makes it toxic to cells, though low doses have medical uses such as for treating heart conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd

    Lesson 3 The Sodium Potassium Pump

    Uploaded by

    anulorance98
    101 views10 pages
    The sodium potassium pump uses energy from ATP to actively transport sodium and potassium ions against their concentration gradients. It pumps 3 sodium ions out of and 2 potassium ions into the cell. This creates an electrochemical gradient that provides energy for other transport processes and generates the resting potential in nerve cells. The sodium potassium pump is made up of protein subunits called Na+-K+-ATPase and goes through six stages of conformational changes to transport the ions. Inhibiting the sodium potassium pump with digoxin makes it toxic to cells, though low doses have medical uses such as for treating heart conditions.

    Original Title

    Lesson 3 the Sodium Potassium Pump

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    The sodium potassium pump uses energy from ATP to actively transport sodium and potassium ions against their concentration gradients. It pumps 3 sodium ions out of and 2 potassium ions into the cell. This creates an electrochemical gradient that provides energy for other transport processes and generates the resting potential in nerve cells. The sodium potassium pump is made up of protein subunits called Na+-K+-ATPase and goes through six stages of conformational changes to transport the ions. Inhibiting the sodium potassium pump with digoxin makes it toxic to cells, though low doses have medical uses such as for treating heart conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    101 views10 pages

    Lesson 3 The Sodium Potassium Pump

    Uploaded by

    anulorance98
    The sodium potassium pump uses energy from ATP to actively transport sodium and potassium ions against their concentration gradients. It pumps 3 sodium ions out of and 2 potassium ions into the cell. This creates an electrochemical gradient that provides energy for other transport processes and generates the resting potential in nerve cells. The sodium potassium pump is made up of protein subunits called Na+-K+-ATPase and goes through six stages of conformational changes to transport the ions. Inhibiting the sodium potassium pump with digoxin makes it toxic to cells, though low doses have medical uses such as for treating heart conditions.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    of 10

    Section 3

    Lesson 3– The Sodium


    Potassium Pump
    Active Transport

    Active transport requires energy and allows


    movement against a concentration gradient.
    The Importance of the Sodium Potassium
    Pump
    Powering the sodium potassium pump can be responsible 30% of the energy
    consumption in a cell.

    For every 3 Na + ions pumped out of a cell 2 K+ ions are pumped in. This
    creates a potential difference. This makes the cytoplasm negatively
    charged in comparison to the extracellular environment.

    The electrochemical gradient this creates provides


    energy for other active transport processes.
    The Importance of the Sodium Potassium
    Pump
    The potential difference produced is also important for
    generating resting potential in nerve cells (so they can
    fire signals).
    The Importance of the Sodium Potassium
    Pump

    Digoxin (found in foxgloves) is a sodium potassium pump


    inhibitor making it toxic to cells. At low concentrations
    it can have medicinal uses.

    It is used for the


    treatment of heart
    diseases such as
    atrial fibrillation and
    atrial flutter.
    Na+ -K+ -ATPase
    The complex responsible for
    sodium potassium pump is called
    Na+-K+-ATPase and is made up of
    4 protein subunits.
    Sodium Potassium ATPase

    Features of the Sodium Potassium Pump


    - It is a transmembrane carrier protein
    - It has 3 binding sites for Na+
    - It has 2 binding sites for K+
    - There is a phosphorylation site where a
    phosphate group is accepted fro ATP
    - The 2 different conformations of the
    protein are controlled by the phosphorylation
    Six Stages of Sodium Potassium Pump

    1. 3 binding sites for Na+ are exposed in the cytosol (inside the
    cell) and 3 Na+ ions bind.
    2. Once the 3 ions are attached a phosphate group from ATP is
    broken off and binds to the Na+K+ATPase. This phosphorylation
    causes a conformational change in the enzyme (this is an
    example of covalent modification).
    3. The change in shape affects the affinity (binding) of the Na+
    ions causing them to be released into the outside of the cell.
    4. This same change in shape allows for the exposure of 2 K+ ion
    binding sites outside the cell.
    5. The K+ ions bind to the sites causing the phosphate group inside
    the cell to be released from the pump.
    6. This in turn causes yet another change to the conformation
    causing the 2 K+ ions to be released into the cell.
    Your Tasks
    1. Create a poster showing the 6 stages of the Sodium
    Potassium Pump.
    2. Update your glossary.
    3. Complete Scholar Tasks.

    Due Monday
    December
    17th

    You might also like