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    Spectroscopic Techniques For Pharmaceutical and Biopharmaceutical Industries - Unit 13 - Week 12

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    antony bevan
    The document is a summary of an assignment for an online course on spectroscopic techniques for pharmaceutical and biopharmaceutical industries. It includes 15 multiple choice questions related to techniques like mass spectroscopy, NMR spectroscopy, and their applications. The assignment evaluates the student's understanding of fundamental concepts like distinguishing isomers using different techniques, reference compounds used, interpreting NMR and mass spectra to determine molecular structure and fragmentation patterns.

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    Spectroscopic Techniques For Pharmaceutical and Biopharmaceutical Industries - Unit 13 - Week 12

    Uploaded by

    antony bevan
    201 views1 page
    The document is a summary of an assignment for an online course on spectroscopic techniques for pharmaceutical and biopharmaceutical industries. It includes 15 multiple choice questions related to techniques like mass spectroscopy, NMR spectroscopy, and their applications. The assignment evaluates the student's understanding of fundamental concepts like distinguishing isomers using different techniques, reference compounds used, interpreting NMR and mass spectra to determine molecular structure and fragmentation patterns.

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    Spectroscopic Techniques for Pharmaceutical and Biopharmaceutical Industries - - Unit 13 - Week 12

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    The document is a summary of an assignment for an online course on spectroscopic techniques for pharmaceutical and biopharmaceutical industries. It includes 15 multiple choice questions related to techniques like mass spectroscopy, NMR spectroscopy, and their applications. The assignment evaluates the student's understanding of fundamental concepts like distinguishing isomers using different techniques, reference compounds used, interpreting NMR and mass spectra to determine molecular structure and fragmentation patterns.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Download as pdf or txt
    201 views1 page

    Spectroscopic Techniques For Pharmaceutical and Biopharmaceutical Industries - Unit 13 - Week 12

    Uploaded by

    antony bevan
    The document is a summary of an assignment for an online course on spectroscopic techniques for pharmaceutical and biopharmaceutical industries. It includes 15 multiple choice questions related to techniques like mass spectroscopy, NMR spectroscopy, and their applications. The assignment evaluates the student's understanding of fundamental concepts like distinguishing isomers using different techniques, reference compounds used, interpreting NMR and mass spectra to determine molecular structure and fragmentation patterns.

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    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    antonymichealbevan04@gmail.

    com 

    NPTEL » Spectroscopic Techniques for

    Pharmaceutical and Biopharmaceutical

    Industries

    Course outline

    How does an NPTEL online course work?

    Week 1

    Week 2

    Week 3

    Week 4

    Week 5

    Week 6

    Week 7

    Week 8

    Week 9

    Week 10

    Week 11

    Week 12

    Mass Spectroscopy

    Feedback Form

    Quiz: Week 12 : Assignment 12

    Download Videos

    Lecture Slides

    Problem Solving Session

    Week 12 :
    Assignment 12
    The due date for submitting this assignment has
    passed.
    Due on 2022-10-19, 23:59 IST.

    Assignment submitted on
    2022-10-18, 21:51 IST
    1) Which of the following techniques can be 1 point
    used to distinguish between the give two isomers?

    I. Mass spectroscopy
    13
    II. C NMR
    1
    III. H NMR

    III
    II
    I, II, III
    None of the above

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    I, II, III

    2) Reference compound used in NMR 1 point


    spectroscopy is?

    Silane
    Tetramethylsilane
    Dimethylsilane
    Trimethylsilane

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    Tetramethylsilane

    3) One of the following compounds gives 3 1 point


    signals in NMR spectroscopy?

    CH3–COOH
    CH3 – CH2 – NH2
    CH3 – O – CH3
    CH3 – CH2 – Cl

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    CH3 – CH2 – NH2

    4) How many Hertz does 1 ppm corresponds 1 point


    to a PMR spectrometer operating at a radio frequency
    of 60 MHz and 100 MHz?

    60 Hz, 100 Hz
    10 Hz, 60Hz
    66 Hz, 6 Hz
    10 Hz, 60 Hz

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    60 Hz, 100 Hz

    5) How many signals do you expect to see in 1 point


    the 1H NMR spectra of 2-Bromopropane (CH3)2CHBr
    and 1-Bromopropane CH3CH2CH2Br?

    2; 3
    3;2
    1;2
    1;3

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    2; 3

    6) Mass spectrometer separates ions on the 1 point


    basis of

    Mass
    Charge
    Molecular weight
    Mass to charge ratio

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    Mass to charge ratio

    7) A PMR spectrometer operates at 300MHz. 1 point


    Find the value of the magnetic field. Given gN=5.585
    and BN =5.05 ×10-27 JT-1

    7.05 T
    6.38 T
    7.58 T
    5093 T

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    7.05 T

    8) The mass spectrum of acetone 1 point


    (CH3COCH3) shows major peaks at m/z = 58, 43 and
    15. What can be deduced from these data?

    The parent ion is observed, and fragmentation


    involves cleavage of two C–C bonds.
    The parent ion is not observed
    The parent ion is observed, and fragmentation
    involves loss of CO
    The parent ion is observed, and fragmentation
    involves cleavage of a C–C bond

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    The parent ion is observed, and fragmentation
    involves cleavage of a C–C bond

    9) Which of the following cannot be used as 1 point


    an analyser in MS?

    Ion trap
    TOF
    ESI
    Quadrupole

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    ESI

    10)But-2-yne has the structure H3C–C≡C– 1 point


    CH3. Major peaks in the mass spectrum of but- 2-yne
    appear at m/z = 54, 39 and 27. Which of the following
    is inconsistent with these data?

    But-2-yne fragments by loss of two methyl


    groups
    + The highest mass peak corresponds to [C4H6]
    But-2-yne fragments by loss of a methyl group
    But-2-yne fragments by cleavage of a C–C
    bond

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    But-2-yne fragments by loss of two methyl groups

    11)The mass spectrum of CH3NO2, shows 1 point


    major peaks at m/z 61, 46, 30 (base peak) and 15.

    Which statement is inconsistent with above data?

    The parent ion is observed


    The parent ion is observed
    [NO]+ is a fragment ion
    [NO2]+ is not formed as a fragment

    No, the answer is incorrect.


    Score: 0
    Accepted Answers:
    The parent ion is observed

    12)What is δ value of aldehyde proton in 1 point


    PMR spectrum?

    1–2
    4–5
    7–8
    9–10

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    9–10

    13)Correct order chemical shift of proton is? 1 point

    CH3F < CH3I < CH3Br < CH3Cl


    CH3I < CH3Br < CH3Cl < CH3F
    CH3I < CH3F < CH3Br < CH3Cl
    CH3F > CH3I > CH3Br > CH3Cl

    Yes, the answer is correct.


    Score: 1
    Accepted Answers:
    CH3I < CH3Br < CH3Cl < CH3F

    14)The 1H NMR of below given compound 1 point


    should have four signals. Predict the splitting pattern
    (singlet, doublet, doublet of doublets, etc) for each
    signal.

    Singlet, doublet, triplet, doublet


    Doublet, doublet, singlet, doublet of triplet
    Doublet, doublet, doublet of triplet
    Singlet, doublet, triplet

    No, the answer is incorrect.


    Score: 0
    Accepted Answers:
    Doublet, doublet, singlet, doublet of triplet

    15)How many peaks will be observed in the 1 point


    proton NMR spectrum of (CH3)2CHCOO(CH3)?

    4
    5
    1
    3

    No, the answer is incorrect.


    Score: 0
    Accepted Answers:
    3

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