Hosp Ops II Week 3 Questions 1

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Hospital Operations II Rotation

Franciscan Health Lafayette


Question Packet #3
ANSWERS
1. What bacteria most commonly cause a urinary tract infection? What empiric antibiotic therapy do you
recommend including length of therapy for the treatment of an uncomplicated UTI and
pyelonephritis/complicated UTI?
 Gram-negative bacteria typically cause UTIs
o More than 95% of uncomplicated UTIs are monobacterial
o Most common pathogen = E. coli (75-95%), followed by Klebsiella pneumonia, Staphylococcus
saprophyticus, Enterococcus faecalis, group B streptococci
o Frequent cause of complicated UTI = Proteus mirabilis, pseudomonas aeruginosa, and
enterococcus; these are more commonly isolated in hospitals and long-term care facilities

Acute Uncomplicated UTI Treatment Pyelonephritis Treatment


Outpatient Therapy:
 Ciprofloxacin 500 mg PO BID x 7 days
Nitrofurantoin 100 mg PO BID x 5 days  Levofloxacin 750 mg PO QD x 5 days
o If local resistance is > 10%, give
Bactrim DS PO BID x 10 days ceftriaxone 1 gram IV
Inpatient Therapy:
Fosfomycin 3 grams PO once  Ciprofloxacin 400 mg IV BID x 7 days
 Levofloxacin 500 mg IV QD x 7 days
 Ceftriaxone 1-gram IV Q24H x 14 days

2. What antibiotics provide empiric coverage against most strains of Pseudomonas aeruginosa?

Piperacillin/Tazobactam Cefepime Ceftazidime

Aminoglycosides Ciprofloxacin Levofloxacin

Ceftolazone/Tazobactam Ceftazidime/Avibactam Carbapenems


(Excluding Ertapenem)

3. An 85 year old woman was admitted for a wound infection on her right foot. Cultures revealed that the wound
had MRSA. The ID physician started her on vancomycin IVPB. She has also had severe diarrhea and tested
positive for C. difficile and the hospitalist ordered vancomycin 250mg PO four times a day. Would you call the
hospitalist or the infectious disease doctor about her being on both PO and IV vancomycin? Why or why not?
 No, then patient will need both medications to treat both of her infections. Clostridioides difficile must
be treated with PO vancomycin and PO vancomycin is not adequate coverage for the MRSA within the
patient’s wound.
Hospital Operations II Rotation
Franciscan Health Lafayette
Question Packet #3

4. A nurse calls the pharmacy asking which pneumococcal vaccine she should give a 68-year-old patient with a history of diabetes and hypertension. The
patient thinks he received a pneumonia vaccine 3 years ago. Does the patient need to be re-vaccinated? If yes, which pneumococcal vaccine should be
administered?
 It depends on the vaccine the patient previously had.
o If the patient previously received Prevnar 20, they do not need another vaccine
o If the patient previously received Prevnar 13 or Pneumovax 23 ≥ 1 year ago, they would need the Prevnar 20 vaccine

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